CN1495182A - 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺 - Google Patents

用于抑制细胞增殖的取代的双吲哚基马来酰亚胺 Download PDF

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Publication number
CN1495182A
CN1495182A CNA031275400A CN03127540A CN1495182A CN 1495182 A CN1495182 A CN 1495182A CN A031275400 A CNA031275400 A CN A031275400A CN 03127540 A CN03127540 A CN 03127540A CN 1495182 A CN1495182 A CN 1495182A
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CN
China
Prior art keywords
alkyl
methyl
hydrogen
compound
indol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA031275400A
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English (en)
Chinese (zh)
Inventor
M
唐娜·M·赫因
D
丹尼斯·D·基思
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1495182A publication Critical patent/CN1495182A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNA031275400A 1996-07-29 1997-07-19 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺 Pending CN1495182A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2207996P 1996-07-29 1996-07-29
US60/022,079 1996-07-29

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB971967768A Division CN1151149C (zh) 1996-07-29 1997-07-19 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺

Publications (1)

Publication Number Publication Date
CN1495182A true CN1495182A (zh) 2004-05-12

Family

ID=21807711

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA031275400A Pending CN1495182A (zh) 1996-07-29 1997-07-19 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺
CNB971967768A Expired - Fee Related CN1151149C (zh) 1996-07-29 1997-07-19 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB971967768A Expired - Fee Related CN1151149C (zh) 1996-07-29 1997-07-19 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺

Country Status (23)

Country Link
US (2) US5856517A (enExample)
EP (1) EP0915872B1 (enExample)
JP (1) JP2000516589A (enExample)
KR (1) KR20000029637A (enExample)
CN (2) CN1495182A (enExample)
AR (1) AR008267A1 (enExample)
AT (1) ATE240318T1 (enExample)
AU (1) AU739742B2 (enExample)
BR (1) BR9711605A (enExample)
CA (1) CA2262092A1 (enExample)
CO (1) CO4900055A1 (enExample)
CY (1) CY2483B1 (enExample)
DE (1) DE69722003T2 (enExample)
DK (1) DK0915872T3 (enExample)
ES (1) ES2198001T3 (enExample)
HR (1) HRP970414A2 (enExample)
MA (1) MA24287A1 (enExample)
PE (1) PE91698A1 (enExample)
PT (1) PT915872E (enExample)
SA (1) SA97180473A (enExample)
TR (1) TR199900157T2 (enExample)
WO (1) WO1998004552A1 (enExample)
ZA (1) ZA976492B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2208612C2 (ru) * 1998-03-17 2003-07-20 Ф.Хоффманн-Ля Рош Аг Замещенные бисиндолималеимиды, предназначенные для ингибирования пролиферации клеток
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
WO2001044235A2 (en) * 1999-12-16 2001-06-21 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
EP1242420A2 (en) * 1999-12-16 2002-09-25 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US6743785B2 (en) * 1999-12-16 2004-06-01 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
MY142390A (en) * 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7012100B1 (en) * 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
WO2006086484A1 (en) 2005-02-09 2006-08-17 Arqule, Inc. Meleimide derivatives, pharmaceutical compositions and methods for treatment of cancer
MX2009006533A (es) * 2006-12-19 2009-06-26 Novartis Ag Derivados de indolil-maleimida como inhibidores de cinasa.
WO2009002808A2 (en) 2007-06-22 2008-12-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
EP2170870B1 (en) 2007-06-22 2014-03-05 ArQule, Inc. Pyrrolidinone, pyrrolidine-2, 5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
JP5490688B2 (ja) 2007-06-22 2014-05-14 アークル インコーポレイテッド 癌の治療のためのインドリルピロリジン
JP2009035537A (ja) * 2007-07-10 2009-02-19 Nippon Synthetic Chem Ind Co Ltd:The Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
AU2015217152A1 (en) 2014-02-11 2016-08-11 Mitokinin, Inc. Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
EP3741375A1 (en) 2014-07-17 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
CA3067695A1 (en) 2017-06-21 2018-12-27 Mitokinin, Inc. Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
PT93947B (pt) * 1989-05-05 1996-11-29 Goedecke Ag Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JPH0539289A (ja) * 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
EP0630241A1 (en) * 1992-03-20 1994-12-28 The Wellcome Foundation Limited Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
US6030994A (en) 2000-02-29
TR199900157T2 (xx) 1999-04-21
ZA976492B (en) 1998-01-29
DE69722003D1 (de) 2003-06-18
CN1226247A (zh) 1999-08-18
SA97180473A (ar) 2005-12-03
PE91698A1 (es) 1998-12-24
AU739742B2 (en) 2001-10-18
JP2000516589A (ja) 2000-12-12
EP0915872A1 (en) 1999-05-19
BR9711605A (pt) 1999-08-24
KR20000029637A (ko) 2000-05-25
CY2483B1 (en) 2005-06-03
HRP970414A2 (en) 1998-06-30
US5856517A (en) 1999-01-05
DE69722003T2 (de) 2004-04-01
EP0915872B1 (en) 2003-05-14
MA24287A1 (fr) 1998-04-01
ES2198001T3 (es) 2004-01-16
CN1151149C (zh) 2004-05-26
CA2262092A1 (en) 1998-02-05
AU3769097A (en) 1998-02-20
WO1998004552A1 (en) 1998-02-05
ATE240318T1 (de) 2003-05-15
AR008267A1 (es) 1999-12-29
PT915872E (pt) 2003-09-30
CO4900055A1 (es) 2000-03-27
DK0915872T3 (da) 2003-09-08

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