AU739742B2 - Substituted bisindolylmaleimides for the inhibition of cell proliferation - Google Patents

Substituted bisindolylmaleimides for the inhibition of cell proliferation Download PDF

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Publication number
AU739742B2
AU739742B2 AU37690/97A AU3769097A AU739742B2 AU 739742 B2 AU739742 B2 AU 739742B2 AU 37690/97 A AU37690/97 A AU 37690/97A AU 3769097 A AU3769097 A AU 3769097A AU 739742 B2 AU739742 B2 AU 739742B2
Authority
AU
Australia
Prior art keywords
methyl
compound
hydrogen
alkyl
indol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU37690/97A
Other languages
English (en)
Other versions
AU3769097A (en
Inventor
Donna Mary Huryn
Dennis Dalton Keith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU3769097A publication Critical patent/AU3769097A/en
Application granted granted Critical
Publication of AU739742B2 publication Critical patent/AU739742B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
AU37690/97A 1996-07-29 1997-07-19 Substituted bisindolylmaleimides for the inhibition of cell proliferation Ceased AU739742B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2207996P 1996-07-29 1996-07-29
US60/022079 1996-07-29
PCT/EP1997/003889 WO1998004552A1 (en) 1996-07-29 1997-07-19 Substituted bisindolylmaleimides for the inhibition of cell proliferation

Publications (2)

Publication Number Publication Date
AU3769097A AU3769097A (en) 1998-02-20
AU739742B2 true AU739742B2 (en) 2001-10-18

Family

ID=21807711

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37690/97A Ceased AU739742B2 (en) 1996-07-29 1997-07-19 Substituted bisindolylmaleimides for the inhibition of cell proliferation

Country Status (23)

Country Link
US (2) US5856517A (enExample)
EP (1) EP0915872B1 (enExample)
JP (1) JP2000516589A (enExample)
KR (1) KR20000029637A (enExample)
CN (2) CN1151149C (enExample)
AR (1) AR008267A1 (enExample)
AT (1) ATE240318T1 (enExample)
AU (1) AU739742B2 (enExample)
BR (1) BR9711605A (enExample)
CA (1) CA2262092A1 (enExample)
CO (1) CO4900055A1 (enExample)
CY (1) CY2483B1 (enExample)
DE (1) DE69722003T2 (enExample)
DK (1) DK0915872T3 (enExample)
ES (1) ES2198001T3 (enExample)
HR (1) HRP970414A2 (enExample)
MA (1) MA24287A1 (enExample)
PE (1) PE91698A1 (enExample)
PT (1) PT915872E (enExample)
SA (1) SA97180473A (enExample)
TR (1) TR199900157T2 (enExample)
WO (1) WO1998004552A1 (enExample)
ZA (1) ZA976492B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20000585B1 (en) * 1998-03-17 2009-02-28 F. Hoffmann - La Roche Ag Substituted bisindolymaleimides for the inhibition of cell proliferation
US6743785B2 (en) * 1999-12-16 2004-06-01 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US6867198B2 (en) 1999-12-16 2005-03-15 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
DE60010934T2 (de) * 1999-12-16 2005-05-19 Eli Lilly And Co., Indianapolis Medikamente geeignet zur Behandlung von proliferativen Erkrankungen
US6281356B1 (en) 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
TWI335221B (en) * 2001-09-27 2011-01-01 Alcon Inc Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
AR040083A1 (es) * 2002-05-22 2005-03-16 Smithkline Beecham Corp Compuesto bis-(monoetanolamina) del acido 3'-[(2z)-[1-(3,4-dimetilfenil) -1,5-dihidro-3-metil-5-oxo-4h-pirazol-4-iliden] hidrazino] -2'-hidroxi-[1,1'-bifenil]-3-carboxilico, procedimiento para prepararlo, composicion farmaceutica que lo comprende, procedimiento para preparar dicha composicion farmac
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
DK1846406T5 (da) 2005-02-09 2011-10-31 Arqule Inc Maleimidderivater, farmaceutiske sammensætninger og fremgangsmåder til behandling af cancer
MX2009006533A (es) * 2006-12-19 2009-06-26 Novartis Ag Derivados de indolil-maleimida como inhibidores de cinasa.
JP5490688B2 (ja) 2007-06-22 2014-05-14 アークル インコーポレイテッド 癌の治療のためのインドリルピロリジン
CA2690799C (en) 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
CN101801937A (zh) 2007-06-22 2010-08-11 艾科尔公司 喹唑啉酮化合物及其使用方法
JP2009035537A (ja) * 2007-07-10 2009-02-19 Nippon Synthetic Chem Ind Co Ltd:The Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
CA2939219C (en) 2014-02-11 2023-02-28 Mitokinin Llc Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease
EP3741375A1 (en) 2014-07-17 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for treating neuromuscular junction-related diseases
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
KR20200019228A (ko) * 2017-06-21 2020-02-21 미토키닌, 인크. 신경퇴행성 및 미토콘드리아 질환의 치료를 위한 조성물 및 이를 사용하는 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK75289A3 (en) * 1988-02-10 1998-05-06 Hoffmann La Roche Substituted pyrroles, their use for producing a drug, and the drug on their base
IL94274A0 (en) * 1989-05-05 1991-03-10 Goedecke Ag Maleinimide derivatives,process for the preparation thereof and pharmaceutical compositions containing the same
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JPH0539289A (ja) * 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
AU3761393A (en) * 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
EP0915872B1 (en) 2003-05-14
AU3769097A (en) 1998-02-20
PE91698A1 (es) 1998-12-24
PT915872E (pt) 2003-09-30
ES2198001T3 (es) 2004-01-16
US5856517A (en) 1999-01-05
CA2262092A1 (en) 1998-02-05
WO1998004552A1 (en) 1998-02-05
MA24287A1 (fr) 1998-04-01
US6030994A (en) 2000-02-29
CO4900055A1 (es) 2000-03-27
TR199900157T2 (xx) 1999-04-21
DE69722003T2 (de) 2004-04-01
CN1151149C (zh) 2004-05-26
AR008267A1 (es) 1999-12-29
CN1495182A (zh) 2004-05-12
HRP970414A2 (en) 1998-06-30
ATE240318T1 (de) 2003-05-15
DK0915872T3 (da) 2003-09-08
EP0915872A1 (en) 1999-05-19
KR20000029637A (ko) 2000-05-25
DE69722003D1 (de) 2003-06-18
CY2483B1 (en) 2005-06-03
ZA976492B (en) 1998-01-29
JP2000516589A (ja) 2000-12-12
BR9711605A (pt) 1999-08-24
CN1226247A (zh) 1999-08-18
SA97180473A (ar) 2005-12-03

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Publication Publication Date Title
EP0915872B1 (en) Substituted bisindolylmaleimides for the inhibition of cell proliferation
US5057614A (en) Substituted pyrroles
EP0915870B1 (en) Substituted bisindolylmaleimides for the inhibition of cell proliferation
EP0429257A2 (en) Indole derivatives
KR100659411B1 (ko) 세포 증식 억제를 위한 치환된 비스인돌리말레이미드
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MXPA99000961A (en) Substituted bisindolylmaleimides for the inhibition of cell proliferation
MXPA99001027A (en) Substituted bisindolylmaleimides for the inhibition of cell proliferation
MXPA00008923A (en) Substituted bisindolymaleimides for the inhibition of cell proliferation
JPH09208580A (ja) ピロリルベンズイミダゾール誘導体

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