TR199900157T2 - H�cre proliferasyon inhibisyonu i�in ikame edilmi� bisindolilmaleimidleri. - Google Patents

H�cre proliferasyon inhibisyonu i�in ikame edilmi� bisindolilmaleimidleri.

Info

Publication number
TR199900157T2
TR199900157T2 TR1999/00157T TR9900157T TR199900157T2 TR 199900157 T2 TR199900157 T2 TR 199900157T2 TR 1999/00157 T TR1999/00157 T TR 1999/00157T TR 9900157 T TR9900157 T TR 9900157T TR 199900157 T2 TR199900157 T2 TR 199900157T2
Authority
TR
Turkey
Prior art keywords
cell proliferation
proliferation inhibition
formula
bisindolylmaleimides
substituted
Prior art date
Application number
TR1999/00157T
Other languages
English (en)
Turkish (tr)
Inventor
Mary Huryn Donna
Dalton Keith Denn�S
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR199900157T2 publication Critical patent/TR199900157T2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TR1999/00157T 1996-07-29 1997-07-19 H�cre proliferasyon inhibisyonu i�in ikame edilmi� bisindolilmaleimidleri. TR199900157T2 (xx)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2207996P 1996-07-29 1996-07-29

Publications (1)

Publication Number Publication Date
TR199900157T2 true TR199900157T2 (xx) 1999-04-21

Family

ID=21807711

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00157T TR199900157T2 (xx) 1996-07-29 1997-07-19 H�cre proliferasyon inhibisyonu i�in ikame edilmi� bisindolilmaleimidleri.

Country Status (23)

Country Link
US (2) US5856517A (enExample)
EP (1) EP0915872B1 (enExample)
JP (1) JP2000516589A (enExample)
KR (1) KR20000029637A (enExample)
CN (2) CN1495182A (enExample)
AR (1) AR008267A1 (enExample)
AT (1) ATE240318T1 (enExample)
AU (1) AU739742B2 (enExample)
BR (1) BR9711605A (enExample)
CA (1) CA2262092A1 (enExample)
CO (1) CO4900055A1 (enExample)
CY (1) CY2483B1 (enExample)
DE (1) DE69722003T2 (enExample)
DK (1) DK0915872T3 (enExample)
ES (1) ES2198001T3 (enExample)
HR (1) HRP970414A2 (enExample)
MA (1) MA24287A1 (enExample)
PE (1) PE91698A1 (enExample)
PT (1) PT915872E (enExample)
SA (1) SA97180473A (enExample)
TR (1) TR199900157T2 (enExample)
WO (1) WO1998004552A1 (enExample)
ZA (1) ZA976492B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1064279E (pt) * 1998-03-17 2003-10-31 Hoffmann La Roche Bisindolilmaleimidas substituidas para a inibicao da proliferacao celular
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
WO2001044247A2 (en) * 1999-12-16 2001-06-21 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US6743785B2 (en) * 1999-12-16 2004-06-01 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
EP1250334B1 (en) * 1999-12-16 2004-05-19 Eli Lilly And Company Medicaments useful for the treatment of proliferative diseases
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
MY142390A (en) * 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
RS51826B (sr) 2005-02-09 2012-02-29 Arqule Inc. Maleimid derivati, farmaceutske kompozicije i postupak lečenja kancera
JP2010513386A (ja) * 2006-12-19 2010-04-30 ノバルティス アーゲー キナーゼ阻害剤としてのインドリルマレイミド誘導体
CA2690782C (en) 2007-06-22 2016-02-02 Arqule, Inc. Compositions and methods for treatment of cancer
CA2690799C (en) 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
CN101801937A (zh) 2007-06-22 2010-08-11 艾科尔公司 喹唑啉酮化合物及其使用方法
JP2009035537A (ja) * 2007-07-10 2009-02-19 Nippon Synthetic Chem Ind Co Ltd:The Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
ES2919024T3 (es) 2014-02-11 2022-07-21 Mitokinin Inc Composiciones y procedimientos que utilizan las mismas para el tratamiento de enfermedades neurodegenerativas y mitocondriales
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
WO2018237145A1 (en) * 2017-06-21 2018-12-27 Mitokinin, Inc. Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JPH0539289A (ja) * 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
AU3761393A (en) * 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
AU739742B2 (en) 2001-10-18
AU3769097A (en) 1998-02-20
US6030994A (en) 2000-02-29
MA24287A1 (fr) 1998-04-01
EP0915872A1 (en) 1999-05-19
DK0915872T3 (da) 2003-09-08
CY2483B1 (en) 2005-06-03
CO4900055A1 (es) 2000-03-27
DE69722003T2 (de) 2004-04-01
CN1226247A (zh) 1999-08-18
DE69722003D1 (de) 2003-06-18
EP0915872B1 (en) 2003-05-14
ATE240318T1 (de) 2003-05-15
HRP970414A2 (en) 1998-06-30
CN1151149C (zh) 2004-05-26
ES2198001T3 (es) 2004-01-16
CA2262092A1 (en) 1998-02-05
WO1998004552A1 (en) 1998-02-05
CN1495182A (zh) 2004-05-12
BR9711605A (pt) 1999-08-24
JP2000516589A (ja) 2000-12-12
PT915872E (pt) 2003-09-30
SA97180473A (ar) 2005-12-03
PE91698A1 (es) 1998-12-24
ZA976492B (en) 1998-01-29
AR008267A1 (es) 1999-12-29
US5856517A (en) 1999-01-05
KR20000029637A (ko) 2000-05-25

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