CN1284603C - 杂双官能聚乙二醇衍生物和它们的制备方法 - Google Patents

杂双官能聚乙二醇衍生物和它们的制备方法 Download PDF

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Publication number
CN1284603C
CN1284603C CNB998169714A CN99816971A CN1284603C CN 1284603 C CN1284603 C CN 1284603C CN B998169714 A CNB998169714 A CN B998169714A CN 99816971 A CN99816971 A CN 99816971A CN 1284603 C CN1284603 C CN 1284603C
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China
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poly
group
alkyl
peg
substituted
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Expired - Lifetime
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CNB998169714A
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English (en)
Chinese (zh)
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CN1374875A (zh
Inventor
M·D·本特利
J·M·哈里斯
A·科兹罗斯基
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Nektar Therapeutics
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SHEARWATER Inc
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Publication of CN1374875A publication Critical patent/CN1374875A/zh
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB998169714A 1999-10-08 1999-10-08 杂双官能聚乙二醇衍生物和它们的制备方法 Expired - Lifetime CN1284603C (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1999/023536 WO2001026692A1 (en) 1999-10-08 1999-10-08 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation

Publications (2)

Publication Number Publication Date
CN1374875A CN1374875A (zh) 2002-10-16
CN1284603C true CN1284603C (zh) 2006-11-15

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CNB998169714A Expired - Lifetime CN1284603C (zh) 1999-10-08 1999-10-08 杂双官能聚乙二醇衍生物和它们的制备方法

Country Status (17)

Country Link
EP (1) EP1455839B1 (enExample)
JP (1) JP4344110B2 (enExample)
KR (1) KR100499655B1 (enExample)
CN (1) CN1284603C (enExample)
AU (1) AU781336B2 (enExample)
BR (1) BR9917517A (enExample)
CA (1) CA2386762C (enExample)
CY (1) CY1114128T1 (enExample)
DK (1) DK1455839T3 (enExample)
ES (1) ES2404685T3 (enExample)
HU (1) HU228491B1 (enExample)
IL (2) IL148890A0 (enExample)
MX (1) MXPA02003540A (enExample)
NO (1) NO331781B1 (enExample)
NZ (1) NZ518143A (enExample)
PT (1) PT1455839E (enExample)
WO (1) WO2001026692A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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CN103044677A (zh) * 2012-12-28 2013-04-17 上海景宇生物科技有限公司 一种异端基遥爪聚乙二醇及其制备方法
CN108137459A (zh) * 2015-10-07 2018-06-08 海名斯精细化工公司 润湿-防泡剂

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JP2003535208A (ja) 2000-06-08 2003-11-25 ラ ホヤ ファーマシューティカル カンパニー 高分子量ポリエチレン・オキシドを含む多価プラットホーム分子
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US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
US7829074B2 (en) 2001-10-18 2010-11-09 Nektar Therapeutics Hydroxypatite-targeting poly(ethylene glycol) and related polymers
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US7053150B2 (en) 2000-12-18 2006-05-30 Nektar Therapeutics Al, Corporation Segmented polymers and their conjugates
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JP3493608B2 (ja) * 2001-11-28 2004-02-03 学校法人慶應義塾 医用高分子及びその用途
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
WO2004012773A1 (en) 2002-07-24 2004-02-12 F. Hoffmann-La Roche Ag Polyalkylene glycol acid additives
US20040062748A1 (en) 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
WO2004035657A1 (en) * 2002-10-15 2004-04-29 Baxter International Inc. Process for the preparation of polyethylene glycol bis amine
EP1616003A4 (en) 2002-12-30 2007-06-20 Gryphon Therapeutics Inc WATER-SOLUBLE THIOESTER AND SELENOESTER COMPOUNDS AND METHOD FOR THE PRODUCTION AND USE THEREOF
WO2004060967A1 (en) 2002-12-31 2004-07-22 Nektar Therapeutics Al, Corporation Methods for the formation of hydrogels using thiosulfonate compositions and uses thereof
BRPI0409322B8 (pt) 2003-04-11 2021-05-25 Antriabio Inc método para preparar um conjugado de insulina-polímero
US8637650B2 (en) 2003-11-05 2014-01-28 Genovoxx Gmbh Macromolecular nucleotide compounds and methods for using the same
US20050214250A1 (en) * 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
JP2008534640A (ja) 2005-04-05 2008-08-28 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー タンパク質の機能部位またはエピトープの遮蔽方法
ATE425204T1 (de) * 2005-08-26 2009-03-15 Novo Nordisk As Verfahren zur modifizierung eines makromolekularen systems
CN101505789A (zh) 2006-07-06 2009-08-12 株式会社大熊 稳定的人生长激素液体制剂
US7985783B2 (en) 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
CA2770149A1 (en) 2009-08-05 2011-02-10 Pieris Ag Controlled release formulations of lipocalin muteins
US9315860B2 (en) 2009-10-26 2016-04-19 Genovoxx Gmbh Conjugates of nucleotides and method for the application thereof
EP2717917B1 (en) 2011-07-05 2016-04-20 biOasis Technologies Inc P97-antibody conjugates
AU2013296557B2 (en) 2012-07-31 2019-04-18 Bioasis Technologies Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
KR20150083121A (ko) 2012-11-12 2015-07-16 레드우드 바이오사이언스 인코포레이티드 화합물, 및 컨쥬게이트의 제조방법
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
WO2014078733A1 (en) 2012-11-16 2014-05-22 The Regents Of The University Of California Pictet-spengler ligation for protein chemical modification
WO2014160438A1 (en) 2013-03-13 2014-10-02 Bioasis Technologies Inc. Fragments of p97 and uses thereof
AU2014312190A1 (en) 2013-08-28 2016-02-18 Bioasis Technologies Inc. CNS-targeted conjugates of antibodies
CN115504924A (zh) 2013-11-27 2022-12-23 雷德伍德生物科技股份有限公司 肼基-吡咯并化合物及用于生成缀合物的方法
CN104774161B (zh) * 2014-01-13 2017-08-25 成都福瑞康生物科技有限公司 多肽、蛋白质peg修饰剂合成方法
US12102689B2 (en) 2015-11-09 2024-10-01 R.P. Scherer Technologies, Llc Anti-CD22 antibody-maytansine conjugates and methods of use thereof
KR102247701B1 (ko) * 2016-02-26 2021-05-03 한미정밀화학주식회사 폴리에틸렌글리콜 디알데히드 유도체의 제조방법
CN113801297B (zh) 2016-04-15 2024-08-23 拜克门寇尔特公司 光敏大分子及其用途
WO2019133399A1 (en) 2017-12-26 2019-07-04 Becton, Dickinson And Company Deep ultraviolet-excitable water-solvated polymeric dyes
CN119220109A (zh) 2018-03-30 2024-12-31 贝克顿·迪金森公司 含侧基发色团的水溶性聚合染料
EP3813867A1 (en) 2018-07-22 2021-05-05 Bioasis Technologies Inc. Treatment of lymmphatic metastases
KR102762225B1 (ko) * 2019-03-29 2025-02-10 니치유 가부시키가이샤 헤테로형 단분산 폴리에틸렌글리콜 유도체의 제조 방법
US20210355468A1 (en) 2020-05-18 2021-11-18 Bioasis Technologies, Inc. Compositions and methods for treating lewy body dementia
US20210393787A1 (en) 2020-06-17 2021-12-23 Bioasis Technologies, Inc. Compositions and methods for treating frontotemporal dementia
CN113583230A (zh) * 2021-06-30 2021-11-02 苏州欣影生物医药技术有限公司 一种peg双胺选择性反应制备异双官能团的方法
EP4155349A1 (en) 2021-09-24 2023-03-29 Becton, Dickinson and Company Water-soluble yellow green absorbing dyes
CN119630747A (zh) 2022-07-01 2025-03-14 贝克曼库尔特有限公司 新的来自二氢菲衍生物的荧光染料和聚合物
WO2024044327A1 (en) 2022-08-26 2024-02-29 Beckman Coulter, Inc. Dhnt monomers and polymer dyes with modified photophysical properties
CN115959992A (zh) * 2022-12-13 2023-04-14 武汉翱飞科技有限公司 一种单分子量聚乙二醇单乙酸的合成方法
WO2024196805A1 (en) 2023-03-17 2024-09-26 Beckman Coulter, Inc. Benzothienopyrrole cyanine dyes
WO2025064842A1 (en) 2023-09-21 2025-03-27 Beckman Coulter, Inc. Dihydrophenanthrene (dhp) bridged dyes for use in flow cytometry

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Cited By (3)

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Publication number Priority date Publication date Assignee Title
CN103044677A (zh) * 2012-12-28 2013-04-17 上海景宇生物科技有限公司 一种异端基遥爪聚乙二醇及其制备方法
CN108137459A (zh) * 2015-10-07 2018-06-08 海名斯精细化工公司 润湿-防泡剂
CN108137459B (zh) * 2015-10-07 2021-06-18 海名斯精细化工公司 润湿-防泡剂

Also Published As

Publication number Publication date
NO331781B1 (no) 2012-03-26
DK1455839T3 (da) 2013-05-06
HUP0203149A2 (en) 2002-12-28
AU781336B2 (en) 2005-05-19
KR100499655B1 (ko) 2005-07-07
ES2404685T3 (es) 2013-05-28
NZ518143A (en) 2004-04-30
PT1455839E (pt) 2013-04-24
NO20021555L (no) 2002-06-04
JP4344110B2 (ja) 2009-10-14
BR9917517A (pt) 2002-07-30
EP1455839B1 (en) 2013-01-23
MXPA02003540A (es) 2003-09-12
WO2001026692A1 (en) 2001-04-19
NO20021555D0 (no) 2002-04-02
JP2003511422A (ja) 2003-03-25
CY1114128T1 (el) 2016-07-27
CN1374875A (zh) 2002-10-16
IL148890A0 (en) 2002-09-12
HU228491B1 (en) 2013-03-28
IL148890A (en) 2007-09-20
EP1455839A1 (en) 2004-09-15
CA2386762A1 (en) 2001-04-19
CA2386762C (en) 2009-06-16
AU6423099A (en) 2001-04-23
KR20020040841A (ko) 2002-05-30

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