KR100499655B1 - 헤테로 이작용성 폴리(에틸렌 글리콜) 유도체 및 그의제조 방법 - Google Patents

헤테로 이작용성 폴리(에틸렌 글리콜) 유도체 및 그의제조 방법 Download PDF

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Publication number
KR100499655B1
KR100499655B1 KR10-2002-7004507A KR20027004507A KR100499655B1 KR 100499655 B1 KR100499655 B1 KR 100499655B1 KR 20027004507 A KR20027004507 A KR 20027004507A KR 100499655 B1 KR100499655 B1 KR 100499655B1
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KR
South Korea
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poly
group
peg
alkyl
aryl
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Expired - Lifetime
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KR10-2002-7004507A
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English (en)
Korean (ko)
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KR20020040841A (ko
Inventor
벤틀리마이클데이비드
해리스제이.밀톤
코즐로우스키안토니
Original Assignee
넥타르 테라퓨틱스 에이엘, 코포레이션
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Publication of KR20020040841A publication Critical patent/KR20020040841A/ko
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Publication of KR100499655B1 publication Critical patent/KR100499655B1/ko
Assigned to 넥타르 테라퓨틱스 reassignment 넥타르 테라퓨틱스 권리의 전부이전등록 Assignors: 넥타르 테라퓨틱스 에이엘, 코포레이션
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR10-2002-7004507A 1999-10-08 1999-10-08 헤테로 이작용성 폴리(에틸렌 글리콜) 유도체 및 그의제조 방법 Expired - Lifetime KR100499655B1 (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1999/023536 WO2001026692A1 (en) 1999-10-08 1999-10-08 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation

Publications (2)

Publication Number Publication Date
KR20020040841A KR20020040841A (ko) 2002-05-30
KR100499655B1 true KR100499655B1 (ko) 2005-07-07

Family

ID=22273776

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-2002-7004507A Expired - Lifetime KR100499655B1 (ko) 1999-10-08 1999-10-08 헤테로 이작용성 폴리(에틸렌 글리콜) 유도체 및 그의제조 방법

Country Status (17)

Country Link
EP (1) EP1455839B1 (enExample)
JP (1) JP4344110B2 (enExample)
KR (1) KR100499655B1 (enExample)
CN (1) CN1284603C (enExample)
AU (1) AU781336B2 (enExample)
BR (1) BR9917517A (enExample)
CA (1) CA2386762C (enExample)
CY (1) CY1114128T1 (enExample)
DK (1) DK1455839T3 (enExample)
ES (1) ES2404685T3 (enExample)
HU (1) HU228491B1 (enExample)
IL (2) IL148890A0 (enExample)
MX (1) MXPA02003540A (enExample)
NO (1) NO331781B1 (enExample)
NZ (1) NZ518143A (enExample)
PT (1) PT1455839E (enExample)
WO (1) WO2001026692A1 (enExample)

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TW593427B (en) 2000-12-18 2004-06-21 Nektar Therapeutics Al Corp Synthesis of high molecular weight non-peptidic polymer derivatives
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US7550512B2 (en) 2001-11-28 2009-06-23 Keio University Medical polymers and uses thereof
JP3493608B2 (ja) * 2001-11-28 2004-02-03 学校法人慶應義塾 医用高分子及びその用途
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
CN100337689C (zh) 2002-07-24 2007-09-19 弗·哈夫曼-拉罗切有限公司 聚亚烷基二醇酸加合物
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US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
AU2002353814A1 (en) * 2002-10-15 2004-05-04 Baxter Healthcare S.A. Process for the preparation of polyethylene glycol bis amine
US8034900B2 (en) 2002-12-30 2011-10-11 Amylin Pharmaceuticals, Inc. Water-soluble thioester and selenoester compounds and methods for making and using the same
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US8637650B2 (en) 2003-11-05 2014-01-28 Genovoxx Gmbh Macromolecular nucleotide compounds and methods for using the same
US20050214250A1 (en) * 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
EP1868652A2 (en) 2005-04-05 2007-12-26 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Method for shielding functional sites or epitopes on proteins
DE602006005686D1 (de) * 2005-08-26 2009-04-23 Novo Nordisk As Verfahren zur modifizierung eines makromolekularen systems
JP5021649B2 (ja) * 2005-08-26 2012-09-12 ノヴォ ノルディスク アクティーゼルスカブ 高分子システムを変性する方法
LT2049148T (lt) 2006-07-06 2016-11-25 Daewoong Co., Ltd. Žmogaus augimo hormono skysta stabili kompozicija
US7985783B2 (en) 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
BR112012002709A2 (pt) 2009-08-05 2019-04-30 Pieris Ag formulações de liberação controlada de muteínas de lipocalina
WO2011050938A1 (de) 2009-10-26 2011-05-05 Genovoxx Gmbh Konjugate von nukleotiden und methoden zu deren anwendung
AU2012278944B2 (en) 2011-07-05 2015-09-17 Bioasis Technologies Inc. p97-antibody conjugates and methods of use
WO2014022515A1 (en) 2012-07-31 2014-02-06 Bioasis Technologies, Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
CN104884056A (zh) 2012-11-12 2015-09-02 雷德伍德生物科技股份有限公司 用于制备缀合物的化合物和方法
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
WO2014078733A1 (en) 2012-11-16 2014-05-22 The Regents Of The University Of California Pictet-spengler ligation for protein chemical modification
CN103044677A (zh) * 2012-12-28 2013-04-17 上海景宇生物科技有限公司 一种异端基遥爪聚乙二醇及其制备方法
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JP7342757B2 (ja) * 2019-03-29 2023-09-12 日油株式会社 ヘテロ型単分散ポリエチレングリコール誘導体の製造方法
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Also Published As

Publication number Publication date
BR9917517A (pt) 2002-07-30
NZ518143A (en) 2004-04-30
IL148890A0 (en) 2002-09-12
JP4344110B2 (ja) 2009-10-14
AU6423099A (en) 2001-04-23
HUP0203149A2 (en) 2002-12-28
KR20020040841A (ko) 2002-05-30
EP1455839A1 (en) 2004-09-15
IL148890A (en) 2007-09-20
DK1455839T3 (da) 2013-05-06
CN1284603C (zh) 2006-11-15
NO331781B1 (no) 2012-03-26
ES2404685T3 (es) 2013-05-28
JP2003511422A (ja) 2003-03-25
PT1455839E (pt) 2013-04-24
NO20021555D0 (no) 2002-04-02
AU781336B2 (en) 2005-05-19
CA2386762A1 (en) 2001-04-19
WO2001026692A1 (en) 2001-04-19
NO20021555L (no) 2002-06-04
CN1374875A (zh) 2002-10-16
CA2386762C (en) 2009-06-16
CY1114128T1 (el) 2016-07-27
EP1455839B1 (en) 2013-01-23
HU228491B1 (en) 2013-03-28
MXPA02003540A (es) 2003-09-12

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