BR9917517A - Derivados poliméricos heterobifuncionais e processo para a preparação dos mesmos - Google Patents

Derivados poliméricos heterobifuncionais e processo para a preparação dos mesmos

Info

Publication number
BR9917517A
BR9917517A BR9917517-7A BR9917517A BR9917517A BR 9917517 A BR9917517 A BR 9917517A BR 9917517 A BR9917517 A BR 9917517A BR 9917517 A BR9917517 A BR 9917517A
Authority
BR
Brazil
Prior art keywords
preparation
heterobifunctional
group
poly
polymer derivatives
Prior art date
Application number
BR9917517-7A
Other languages
English (en)
Inventor
Michael David Bentley
J Milton Harris
Antoni Kozlowski
Original Assignee
Shearwater Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shearwater Corp filed Critical Shearwater Corp
Publication of BR9917517A publication Critical patent/BR9917517A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"DERIVADOS POLIMéRICOS HETEROBIFUNCIONAIS E PROCESSO PARA A PREPARAçãO DOS MESMOS". A invenção propõe um processo para a preparação, com um alto grau de pureza e alto grau de rendimento, de derivados heterobifuncionais de poli (etileno glicol) ou de polímeros correlatos. Não é necessária uma etapa de purificação cromatográfica no processo. De acordo com o processo da invenção, é proposto um polímero intermediário tendo uma fórmula de W-Poli-OH contendo em um terminal um grupamento W removível. O polímero intermediário W-Poli-OH é alterado em primeiro lugar pela modificação do grupamento OH, que é convertido em um primeiro grupamento funcional X, seguindo-se a remoção de W para gerar um segundo grupamento hidroxila. Este último grupamento hidroxila pode então ser ainda convertido em um segundo grupamento funcional Y, fornecendo assim o derivado heterobifuncional desejado.
BR9917517-7A 1999-10-08 1999-10-08 Derivados poliméricos heterobifuncionais e processo para a preparação dos mesmos BR9917517A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1999/023536 WO2001026692A1 (en) 1999-10-08 1999-10-08 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation

Publications (1)

Publication Number Publication Date
BR9917517A true BR9917517A (pt) 2002-07-30

Family

ID=22273776

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9917517-7A BR9917517A (pt) 1999-10-08 1999-10-08 Derivados poliméricos heterobifuncionais e processo para a preparação dos mesmos

Country Status (17)

Country Link
EP (1) EP1455839B1 (pt)
JP (1) JP4344110B2 (pt)
KR (1) KR100499655B1 (pt)
CN (1) CN1284603C (pt)
AU (1) AU781336B2 (pt)
BR (1) BR9917517A (pt)
CA (1) CA2386762C (pt)
CY (1) CY1114128T1 (pt)
DK (1) DK1455839T3 (pt)
ES (1) ES2404685T3 (pt)
HU (1) HU228491B1 (pt)
IL (2) IL148890A0 (pt)
MX (1) MXPA02003540A (pt)
NO (1) NO331781B1 (pt)
NZ (1) NZ518143A (pt)
PT (1) PT1455839E (pt)
WO (1) WO2001026692A1 (pt)

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US7550512B2 (en) 2001-11-28 2009-06-23 Keio University Medical polymers and uses thereof
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WO2004012773A1 (en) 2002-07-24 2004-02-12 F. Hoffmann-La Roche Ag Polyalkylene glycol acid additives
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US20040062748A1 (en) 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
AU2002353814A1 (en) * 2002-10-15 2004-05-04 Baxter Healthcare S.A. Process for the preparation of polyethylene glycol bis amine
WO2004061094A1 (en) 2002-12-30 2004-07-22 Gryphon Therapeutics, Inc. Water-soluble thioester and selenoester compounds and methods for making and using the same
ATE400602T1 (de) 2002-12-31 2008-07-15 Nektar Therapeutics Al Corp Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen
EP1613272B1 (en) 2003-04-11 2013-12-18 Antriabio, Inc. Method for preparation of site-specific protein conjugates
WO2005044836A2 (de) 2003-11-05 2005-05-19 Genovoxx Gmbh Makromolekulare nukleotidverbindungen und methoden zu deren anwendung
US20050214250A1 (en) * 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
WO2006105993A2 (en) 2005-04-05 2006-10-12 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Method for shielding functional sites or epitopes on proteins
EP2045282B1 (en) * 2005-08-26 2011-03-23 Novo Nordisk A/S A method of modifying a macromolecular system
EP2049148B1 (en) 2006-07-06 2016-09-28 Daewoong Co., Ltd. A stable liquid formulation of human growth hormone
US7985783B2 (en) 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
KR20120099371A (ko) 2009-08-05 2012-09-10 피어이스 에이지 리포칼린 뮤테인의 조절 방출 제형
DE102010049607A1 (de) 2009-10-26 2011-06-30 Becker, Claus, Prof., 76470 Konjugate von Nukleotiden und Methoden zu deren Anwendung
CN103747807B (zh) 2011-07-05 2016-12-07 比奥阿赛斯技术有限公司 P97‑抗体缀合物和使用方法
CA2880162C (en) 2012-07-31 2023-04-04 Bioasis Technologies, Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
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KR20150085064A (ko) 2012-11-16 2015-07-22 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 단백질 화학적 변형을 위한 피크테 스펭글러 결합
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
CN103044677A (zh) * 2012-12-28 2013-04-17 上海景宇生物科技有限公司 一种异端基遥爪聚乙二醇及其制备方法
JP6586412B2 (ja) 2013-03-13 2019-10-02 バイオアシス テクノロジーズ インコーポレイテッド ｐ９７のフラグメントおよびその使用
AU2014312190A1 (en) 2013-08-28 2016-02-18 Bioasis Technologies Inc. CNS-targeted conjugates of antibodies
AU2014354643B2 (en) 2013-11-27 2020-03-05 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
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KR102247701B1 (ko) * 2016-02-26 2021-05-03 한미정밀화학주식회사 폴리에틸렌글리콜 디알데히드 유도체의 제조방법
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ES2211033T3 (es) * 1998-01-07 2004-07-01 Debio Recherche Pharmaceutique S.A. Acrilatos de polietilenglicol heterobifuncionales degradables y geles y conjugados derivados de dichos acrilatos.
WO1999045964A1 (en) * 1998-03-12 1999-09-16 Shearwater Polymers, Incorporated Poly(ethylene glycol) derivatives with proximal reactive groups

Also Published As

Publication number Publication date
CA2386762C (en) 2009-06-16
CY1114128T1 (el) 2016-07-27
NZ518143A (en) 2004-04-30
NO331781B1 (no) 2012-03-26
HU228491B1 (en) 2013-03-28
WO2001026692A1 (en) 2001-04-19
HUP0203149A2 (en) 2002-12-28
AU781336B2 (en) 2005-05-19
KR20020040841A (ko) 2002-05-30
CA2386762A1 (en) 2001-04-19
AU6423099A (en) 2001-04-23
ES2404685T3 (es) 2013-05-28
IL148890A (en) 2007-09-20
MXPA02003540A (es) 2003-09-12
EP1455839B1 (en) 2013-01-23
IL148890A0 (en) 2002-09-12
PT1455839E (pt) 2013-04-24
EP1455839A1 (en) 2004-09-15
NO20021555L (no) 2002-06-04
KR100499655B1 (ko) 2005-07-07
DK1455839T3 (da) 2013-05-06
JP2003511422A (ja) 2003-03-25
JP4344110B2 (ja) 2009-10-14
CN1374875A (zh) 2002-10-16
NO20021555D0 (no) 2002-04-02
CN1284603C (zh) 2006-11-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A ANUIDADE.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.

B15K Others concerning applications: alteration of classification

Ipc: C08G 65/329 (2006.01), A61K 47/60 (2017.0