CY1114128T1 - Ετεροδιλειτουργικα παραγωγα πολυ(αιθυλενογλυκολης) και μεθοδοι για την παρασκευη τους - Google Patents

Ετεροδιλειτουργικα παραγωγα πολυ(αιθυλενογλυκολης) και μεθοδοι για την παρασκευη τους

Info

Publication number
CY1114128T1
CY1114128T1 CY20131100332T CY131100332T CY1114128T1 CY 1114128 T1 CY1114128 T1 CY 1114128T1 CY 20131100332 T CY20131100332 T CY 20131100332T CY 131100332 T CY131100332 T CY 131100332T CY 1114128 T1 CY1114128 T1 CY 1114128T1
Authority
CY
Cyprus
Prior art keywords
group
poly
preparation
methods
multiple products
Prior art date
Application number
CY20131100332T
Other languages
English (en)
Inventor
Michael David Bentley
J Milton Harris
Antoni Kozlowski
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of CY1114128T1 publication Critical patent/CY1114128T1/el

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Abstract

Η εφεύρεση παρέχει μία μέθοδο για την παρασκευή, σε υψηλή καθαρότητα και υψηλή απόδοση, ετεροδιλειτουργικών παραγώγων πολυ(αιθυλενογλυκόλης) ή σχετικών πολυμερών. Ένα στάδιο χρωματογραφικού καθαρισμού δεν είναι απαραίτητο στη μέθοδο. Σύμφωνα με τη μέθοδο της εφεύρεσης, παρέχεται ένα ενδιάμεσο πολυμερές, που έχει έναν τύπο W-Πολυ-ΟΗ, το οποίο φέρει μία αφαιρούμενη ομάδα W στο ένα άκρο. Το ενδιάμεσο πολυμερές W-Πολυ-ΟΗ πρώτα μετατρέπεται με τροποποίηση της ομάδας ΟΗ σε μία πρώτη λειτουργική ομάδα Χ, ακολουθούμενη από την αφαίρεση του W για να παράγει μία δεύτερη ομάδα υδροξυλίου. Η τελευταία ομάδα υδροξυλίου μπορεί τότε να μετατραπεί περαιτέρω σε μία δεύτερη λειτουργική ομάδα Υ, παρέχοντας έτσι το επιθυμητό ετεροδιλειτουργικά παράγωγο.
CY20131100332T 1999-10-08 2013-04-23 Ετεροδιλειτουργικα παραγωγα πολυ(αιθυλενογλυκολης) και μεθοδοι για την παρασκευη τους CY1114128T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1999/023536 WO2001026692A1 (en) 1999-10-08 1999-10-08 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
EP99951885A EP1455839B1 (en) 1999-10-08 1999-10-08 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation

Publications (1)

Publication Number Publication Date
CY1114128T1 true CY1114128T1 (el) 2016-07-27

Family

ID=22273776

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131100332T CY1114128T1 (el) 1999-10-08 2013-04-23 Ετεροδιλειτουργικα παραγωγα πολυ(αιθυλενογλυκολης) και μεθοδοι για την παρασκευη τους

Country Status (17)

Country Link
EP (1) EP1455839B1 (el)
JP (1) JP4344110B2 (el)
KR (1) KR100499655B1 (el)
CN (1) CN1284603C (el)
AU (1) AU781336B2 (el)
BR (1) BR9917517A (el)
CA (1) CA2386762C (el)
CY (1) CY1114128T1 (el)
DK (1) DK1455839T3 (el)
ES (1) ES2404685T3 (el)
HU (1) HU228491B1 (el)
IL (2) IL148890A0 (el)
MX (1) MXPA02003540A (el)
NO (1) NO331781B1 (el)
NZ (1) NZ518143A (el)
PT (1) PT1455839E (el)
WO (1) WO2001026692A1 (el)

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Also Published As

Publication number Publication date
JP2003511422A (ja) 2003-03-25
KR100499655B1 (ko) 2005-07-07
PT1455839E (pt) 2013-04-24
NO20021555D0 (no) 2002-04-02
DK1455839T3 (da) 2013-05-06
BR9917517A (pt) 2002-07-30
NO331781B1 (no) 2012-03-26
AU6423099A (en) 2001-04-23
EP1455839B1 (en) 2013-01-23
NO20021555L (no) 2002-06-04
HU228491B1 (en) 2013-03-28
IL148890A0 (en) 2002-09-12
KR20020040841A (ko) 2002-05-30
CN1374875A (zh) 2002-10-16
HUP0203149A2 (en) 2002-12-28
IL148890A (en) 2007-09-20
CN1284603C (zh) 2006-11-15
CA2386762A1 (en) 2001-04-19
CA2386762C (en) 2009-06-16
MXPA02003540A (es) 2003-09-12
AU781336B2 (en) 2005-05-19
EP1455839A1 (en) 2004-09-15
ES2404685T3 (es) 2013-05-28
WO2001026692A1 (en) 2001-04-19
NZ518143A (en) 2004-04-30
JP4344110B2 (ja) 2009-10-14

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