ES2169071T3 - Derivados de cumarina no nucleosidicos como agentes de entrecruzamiento de polinucleotidos. - Google Patents

Derivados de cumarina no nucleosidicos como agentes de entrecruzamiento de polinucleotidos.

Info

Publication number
ES2169071T3
ES2169071T3 ES94914724T ES94914724T ES2169071T3 ES 2169071 T3 ES2169071 T3 ES 2169071T3 ES 94914724 T ES94914724 T ES 94914724T ES 94914724 T ES94914724 T ES 94914724T ES 2169071 T3 ES2169071 T3 ES 2169071T3
Authority
ES
Spain
Prior art keywords
polinucleotid
numleosidic
derivatives
crossing agents
cumarine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94914724T
Other languages
English (en)
Inventor
Michael L Wood
Peter C Cheng
Douglas Y Thien
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Naxcor Inc
Original Assignee
Naxcor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Naxcor Inc filed Critical Naxcor Inc
Application granted granted Critical
Publication of ES2169071T3 publication Critical patent/ES2169071T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Abstract

SE PRESENTAN NUEVOS DERIVADOS DE LA CUMARINA FOTOACTIVABLES QUE COMPRENDE UNA MOLECULA DE CUMARINA ENLAZADA A UNA MOLECULA DE RESPALDO NO NUCLEOSIDICA. LAS MOLECULAS RESULTANTES SE UTILIZAN TIPICAMENTE COMO GRUPOS ENLAZADORES CUANDO SE INCORPORAN EN POLINUCLEOTIDOS COMO SUSTITUCIONES PARA UNA O MAS BASES DE NUCLEOSIDOS COMPLEMENTARIAS PRESENTES EN LAS SONDAS UTILIZADAS EN PROCEDIMIENTOS QUE COMPRENDEN REACCIONES DE HIBRIDIZACION DEL ACIDO NUCLEICO.
ES94914724T 1993-04-13 1994-03-23 Derivados de cumarina no nucleosidicos como agentes de entrecruzamiento de polinucleotidos. Expired - Lifetime ES2169071T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4656893A 1993-04-13 1993-04-13

Publications (1)

Publication Number Publication Date
ES2169071T3 true ES2169071T3 (es) 2002-07-01

Family

ID=21944142

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94914724T Expired - Lifetime ES2169071T3 (es) 1993-04-13 1994-03-23 Derivados de cumarina no nucleosidicos como agentes de entrecruzamiento de polinucleotidos.

Country Status (10)

Country Link
US (1) US6005093A (es)
EP (1) EP0693065B1 (es)
JP (1) JPH08511002A (es)
AT (1) ATE210128T1 (es)
CA (1) CA2159356A1 (es)
DE (1) DE69429338T2 (es)
DK (1) DK0693065T3 (es)
ES (1) ES2169071T3 (es)
PT (1) PT693065E (es)
WO (1) WO1994024120A1 (es)

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US5767259A (en) * 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US6495676B1 (en) * 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
EP0693065B1 (en) * 1993-04-13 2001-12-05 Naxcor Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
CA2214835A1 (en) * 1995-03-09 1996-09-19 Peter C. Cheng Non-nucleosidic coumarin derivatives as polynucleotide-cross-linking agents
WO1997016567A1 (en) * 1995-11-03 1997-05-09 Naxcor Double-stranded conformational polymorphism analysis
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
US6124099A (en) * 1998-06-22 2000-09-26 The University Of Vermont And State Agricultural College Method for placing a photo-cross-linking agent at specific internal sites within the sequence of synthetic strands of ribonucleic acids
EP1105539A2 (en) 1998-08-21 2001-06-13 Naxcor Assays using crosslinkable immobilized nucleic acids
US6303799B1 (en) 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6573048B1 (en) 2000-04-18 2003-06-03 Naxcor Degradable nucleic acid probes and nucleic acid detection methods
US20050013996A1 (en) * 2002-03-08 2005-01-20 Hatfield Stephen F. Hot melt pressure sensitive adhesives for disposable articles
WO2003079579A1 (en) * 2002-03-11 2003-09-25 Xtremespectrum, Inc. Method of using sub-rate slots in an ultrawide bandwidth system
ES2694651T3 (es) 2002-08-23 2018-12-26 Illumina Cambridge Limited Nucleótidos etiquetados
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
AU2003268269A1 (en) * 2002-08-29 2004-03-19 Naxcor Polymorphism detection among homologous sequences
US6800768B1 (en) * 2002-09-06 2004-10-05 Naxcor, Inc. Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
WO2004022703A2 (en) * 2002-09-06 2004-03-18 Naxcor, Inc. Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US20050136414A1 (en) * 2003-12-23 2005-06-23 Kevin Gunderson Methods and compositions for making locus-specific arrays
JP5744743B2 (ja) * 2008-11-17 2015-07-08 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 共有結合形成反応ペアを用いた標的分子の粒子ベースの検出における方法および組成物
WO2010056577A1 (en) * 2008-11-17 2010-05-20 Magic Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
US9365897B2 (en) 2011-02-08 2016-06-14 Illumina, Inc. Selective enrichment of nucleic acids
CN103476951B (zh) 2011-02-16 2017-07-28 海德威技术公司 用于可检测的标记的靶标定位锚定的方法和组合物
ITMI20130162A1 (it) * 2013-02-06 2014-08-07 Fidia Farmaceutici Derivati fotoreticolati di acido ialuronico, loro processo di preparazione ed impiego
EP3019559A4 (en) * 2013-08-22 2017-04-05 Sony Corporation Water soluble fluorescent or colored dyes and methods for their use
CN105837544B (zh) * 2016-04-27 2018-01-30 广西师范大学 一种有机叠氮与香豆素合成3‑氨基苯并吡喃‑2‑酮类衍生物的新方法
IL291323B2 (en) 2016-07-15 2023-09-01 Am Chemicals Llc Solid non-nucleoside supports and phosphoramidite building blocks for oligonucleotide synthesis
CN116120269A (zh) * 2023-01-04 2023-05-16 山东滨州金盛新材料科技有限责任公司 一种水溶性聚甘油基生育酚及其制备方法

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US4196281A (en) * 1976-10-20 1980-04-01 Regents Of The University Of California Psoralens
US4378458A (en) * 1981-03-30 1983-03-29 Baker Instruments Corporation Novel chromogenic and/or fluorogenic substrates for monitoring catalytic or enzymatic activity
US4713326A (en) * 1983-07-05 1987-12-15 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
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US4826967A (en) * 1987-06-16 1989-05-02 Naxcor Psoralen-nucleoside adducts and method for their preparation
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FR2642074B1 (fr) * 1989-01-20 1994-04-29 Oris Ind Derives de molecules polyhydroxylees permettant l'introduction d'au moins une ramification dans un oligonucleotide
US5082934A (en) * 1989-04-05 1992-01-21 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
WO1992013629A1 (en) * 1991-01-31 1992-08-20 Wayne State University A method for analyzing an organic sample
DE4114482A1 (de) * 1991-05-03 1992-11-05 Bayer Ag Polymere farbstoffe, verfahren zu deren herstellung und deren verwendung
EP0693065B1 (en) * 1993-04-13 2001-12-05 Naxcor Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents

Also Published As

Publication number Publication date
PT693065E (pt) 2002-05-31
JPH08511002A (ja) 1996-11-19
DE69429338D1 (de) 2002-01-17
WO1994024120A1 (en) 1994-10-27
EP0693065A4 (en) 1996-03-20
DK0693065T3 (da) 2002-03-04
AU688765B2 (en) 1998-03-19
EP0693065B1 (en) 2001-12-05
AU6697494A (en) 1994-11-08
US6005093A (en) 1999-12-21
ATE210128T1 (de) 2001-12-15
DE69429338T2 (de) 2002-08-14
CA2159356A1 (en) 1994-10-27
EP0693065A1 (en) 1996-01-24

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