DE69429338T2 - Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotiden - Google Patents

Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotiden

Info

Publication number
DE69429338T2
DE69429338T2 DE69429338T DE69429338T DE69429338T2 DE 69429338 T2 DE69429338 T2 DE 69429338T2 DE 69429338 T DE69429338 T DE 69429338T DE 69429338 T DE69429338 T DE 69429338T DE 69429338 T2 DE69429338 T2 DE 69429338T2
Authority
DE
Germany
Prior art keywords
nucleosidic
polynucleotides
crosslinking
reagents
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69429338T
Other languages
English (en)
Other versions
DE69429338D1 (de
Inventor
L Wood
C Cheng
Y Thien
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Naxcor Inc
Original Assignee
Naxcor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Naxcor Inc filed Critical Naxcor Inc
Publication of DE69429338D1 publication Critical patent/DE69429338D1/de
Application granted granted Critical
Publication of DE69429338T2 publication Critical patent/DE69429338T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C07F9/65522—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Silicon Polymers (AREA)
DE69429338T 1993-04-13 1994-03-23 Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotiden Expired - Fee Related DE69429338T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4656893A 1993-04-13 1993-04-13
PCT/US1994/003160 WO1994024120A1 (en) 1993-04-13 1994-03-23 Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents

Publications (2)

Publication Number Publication Date
DE69429338D1 DE69429338D1 (de) 2002-01-17
DE69429338T2 true DE69429338T2 (de) 2002-08-14

Family

ID=21944142

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429338T Expired - Fee Related DE69429338T2 (de) 1993-04-13 1994-03-23 Nicht-nucleosidische cumarin-derivate als reagenzien zum crosslinking von polynucleotiden

Country Status (10)

Country Link
US (1) US6005093A (de)
EP (1) EP0693065B1 (de)
JP (1) JPH08511002A (de)
AT (1) ATE210128T1 (de)
CA (1) CA2159356A1 (de)
DE (1) DE69429338T2 (de)
DK (1) DK0693065T3 (de)
ES (1) ES2169071T3 (de)
PT (1) PT693065E (de)
WO (1) WO1994024120A1 (de)

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US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
WO1994024120A1 (en) * 1993-04-13 1994-10-27 Naxcor Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6495676B1 (en) * 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
EP0827501A4 (de) * 1995-03-09 1998-06-10 Naxcor Nichtnukleosidische cumarinderivate als polynukleotidevernetzer
AU724506B2 (en) * 1995-11-03 2000-09-21 Naxcor Double-stranded conformational polymorphism analysis
US20040266706A1 (en) * 2002-11-05 2004-12-30 Muthiah Manoharan Cross-linked oligomeric compounds and their use in gene modulation
US6124099A (en) * 1998-06-22 2000-09-26 The University Of Vermont And State Agricultural College Method for placing a photo-cross-linking agent at specific internal sites within the sequence of synthetic strands of ribonucleic acids
US6696246B1 (en) 1998-08-21 2004-02-24 Naxcor, Inc. Assays using crosslinkable immobilized nucleic acids
US6303799B1 (en) 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6573048B1 (en) 2000-04-18 2003-06-03 Naxcor Degradable nucleic acid probes and nucleic acid detection methods
US20050013996A1 (en) * 2002-03-08 2005-01-20 Hatfield Stephen F. Hot melt pressure sensitive adhesives for disposable articles
JP4216732B2 (ja) * 2002-03-11 2009-01-28 フリースケール セミコンダクター インコーポレイテッド 超広帯域システムでサブレート・スロットを使用するための方法
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
AU2003259352A1 (en) 2002-08-23 2004-03-11 Solexa Limited Labelled nucleotides
AU2003268269A1 (en) * 2002-08-29 2004-03-19 Naxcor Polymorphism detection among homologous sequences
AU2003265482A1 (en) * 2002-09-06 2004-03-29 Naxcor, Inc. Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6800768B1 (en) * 2002-09-06 2004-10-05 Naxcor, Inc. Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US20050136414A1 (en) * 2003-12-23 2005-06-23 Kevin Gunderson Methods and compositions for making locus-specific arrays
WO2010056577A1 (en) * 2008-11-17 2010-05-20 Magic Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
EP2358898B1 (de) * 2008-11-17 2016-08-31 Headway Technologies, Inc. Verfahren und zusammensetzungen bei dem nachweis von zielmolekülen auf partikelbasis unter verwendung von kovalente bindungen ausbildenden reaktiven paaren
WO2012108864A1 (en) 2011-02-08 2012-08-16 Illumina, Inc. Selective enrichment of nucleic acids
WO2012112563A2 (en) 2011-02-16 2012-08-23 Magic Technologies, Inc. Methods and compositions for the target-localized anchoring of detectable label
ITMI20130162A1 (it) * 2013-02-06 2014-08-07 Fidia Farmaceutici Derivati fotoreticolati di acido ialuronico, loro processo di preparazione ed impiego
JP6190534B2 (ja) * 2013-08-22 2017-08-30 ソニー株式会社 水溶性蛍光染料又は有色染料及びその使用方法
CN105837544B (zh) * 2016-04-27 2018-01-30 广西师范大学 一种有机叠氮与香豆素合成3‑氨基苯并吡喃‑2‑酮类衍生物的新方法
WO2018013999A1 (en) 2016-07-15 2018-01-18 Am Chemicals Llc Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis
CN116120269A (zh) * 2023-01-04 2023-05-16 山东滨州金盛新材料科技有限责任公司 一种水溶性聚甘油基生育酚及其制备方法

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US4196281A (en) * 1976-10-20 1980-04-01 Regents Of The University Of California Psoralens
US4378458A (en) * 1981-03-30 1983-03-29 Baker Instruments Corporation Novel chromogenic and/or fluorogenic substrates for monitoring catalytic or enzymatic activity
US4713326A (en) * 1983-07-05 1987-12-15 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
US4737454A (en) * 1983-07-14 1988-04-12 Molecular Diagnostics, Inc. Fast photochemical method of labelling nucleic acids for detection purposes in hybridization assays
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US4617261A (en) * 1984-03-21 1986-10-14 Cetus Corporation Process for labeling nucleic acids and hybridization probes
US5026840A (en) * 1985-01-10 1991-06-25 Molecular Diagnostics, Inc. Photochemical nucleic acid-labeling reagent having a polyalklamine spacer
JPS61254855A (ja) * 1985-05-08 1986-11-12 Yoshinori Nagai 螢光色素による化学修飾を目印としたｄｎａ断片の螢光検出方法
US4822731A (en) * 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US4826967A (en) * 1987-06-16 1989-05-02 Naxcor Psoralen-nucleoside adducts and method for their preparation
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
DE3738460A1 (de) * 1987-11-12 1989-05-24 Max Planck Gesellschaft Modifizierte oligonukleotide
US5449602A (en) * 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
JPH0812168B2 (ja) * 1988-04-04 1996-02-07 株式会社ナカボーテック コンクリート中の鉄筋に対する分極低抗測定方法
FR2642074B1 (fr) * 1989-01-20 1994-04-29 Oris Ind Derives de molecules polyhydroxylees permettant l'introduction d'au moins une ramification dans un oligonucleotide
US5082934A (en) * 1989-04-05 1992-01-21 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
WO1992013629A1 (en) * 1991-01-31 1992-08-20 Wayne State University A method for analyzing an organic sample
DE4114482A1 (de) * 1991-05-03 1992-11-05 Bayer Ag Polymere farbstoffe, verfahren zu deren herstellung und deren verwendung
WO1994024120A1 (en) * 1993-04-13 1994-10-27 Naxcor Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents

Also Published As

Publication number Publication date
EP0693065B1 (de) 2001-12-05
CA2159356A1 (en) 1994-10-27
DE69429338D1 (de) 2002-01-17
DK0693065T3 (da) 2002-03-04
AU6697494A (en) 1994-11-08
ES2169071T3 (es) 2002-07-01
EP0693065A1 (de) 1996-01-24
AU688765B2 (en) 1998-03-19
ATE210128T1 (de) 2001-12-15
US6005093A (en) 1999-12-21
PT693065E (pt) 2002-05-31
WO1994024120A1 (en) 1994-10-27
JPH08511002A (ja) 1996-11-19
EP0693065A4 (de) 1996-03-20

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee