DE69900462D1 - Konjugate von dns und pns und verfahren zu deren herstellung - Google Patents
Konjugate von dns und pns und verfahren zu deren herstellungInfo
- Publication number
- DE69900462D1 DE69900462D1 DE69900462T DE69900462T DE69900462D1 DE 69900462 D1 DE69900462 D1 DE 69900462D1 DE 69900462 T DE69900462 T DE 69900462T DE 69900462 T DE69900462 T DE 69900462T DE 69900462 D1 DE69900462 D1 DE 69900462D1
- Authority
- DE
- Germany
- Prior art keywords
- carboxylic acid
- disclosed
- methods
- conjugates
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001732 carboxylic acid derivatives Chemical group 0.000 abstract 3
- 108020003215 DNA Probes Proteins 0.000 abstract 2
- 239000003298 DNA probe Substances 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 2
- -1 aminooxyacetyl moiety Chemical group 0.000 abstract 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7438898P | 1998-02-11 | 1998-02-11 | |
| PCT/US1999/002908 WO1999041273A2 (en) | 1998-02-11 | 1999-02-10 | Pna and dna conjugates and methods for preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69900462D1 true DE69900462D1 (de) | 2001-12-20 |
| DE69900462T2 DE69900462T2 (de) | 2002-07-11 |
Family
ID=22119288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69900462T Expired - Lifetime DE69900462T2 (de) | 1998-02-11 | 1999-02-10 | Konjugate von dns und pns und verfahren zu deren herstellung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6197513B1 (de) |
| EP (1) | EP1053355B1 (de) |
| JP (1) | JP2002503456A (de) |
| AT (1) | ATE208827T1 (de) |
| AU (1) | AU742241B2 (de) |
| CA (1) | CA2320390C (de) |
| DE (1) | DE69900462T2 (de) |
| DK (1) | DK1053355T3 (de) |
| WO (1) | WO1999041273A2 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0907889B1 (de) | 1996-04-25 | 2007-07-04 | BioArray Solutions Ltd. | Licht-regulierte, elektrokinetische zusammensetzung von partikeln an oberflächen |
| US7060432B1 (en) | 1999-06-15 | 2006-06-13 | Applera Corporation | Methods for the detection, identification, and/or enumeration of yeast, particularly in wine |
| US9709559B2 (en) | 2000-06-21 | 2017-07-18 | Bioarray Solutions, Ltd. | Multianalyte molecular analysis using application-specific random particle arrays |
| DK1412517T3 (da) | 2001-03-09 | 2007-03-05 | Boston Probes Inc | Fremgangsmåder, kits og sammensætninger af kombinationsoligomerer |
| US7262063B2 (en) | 2001-06-21 | 2007-08-28 | Bio Array Solutions, Ltd. | Directed assembly of functional heterostructures |
| EP2722395B1 (de) | 2001-10-15 | 2018-12-19 | Bioarray Solutions Ltd | Gemultiplexte Analyse polymorphischer Stellen durch gleichzeitige Abfrage und enzymvermittelte Detektion |
| US6942972B2 (en) | 2001-10-24 | 2005-09-13 | Beckman Coulter, Inc. | Efficient synthesis of protein-oligonucleotide conjugates |
| JP2005523707A (ja) * | 2002-04-23 | 2005-08-11 | ユー．エス． ジェノミクス， インコーポレイテッド | ２アーム核酸プローブに関する組成物および方法 |
| WO2004007692A2 (en) * | 2002-07-17 | 2004-01-22 | U.S.Genomics, Inc. | Methods and compositions for analyzing polymers using chimeric tags |
| US7041453B2 (en) | 2002-08-22 | 2006-05-09 | Bioarray Solutions Ltd. | Molecular constructs and methods of use for detection of biochemical reactions |
| US20040038331A1 (en) * | 2002-08-23 | 2004-02-26 | Reddy M. Parameswara | Solid phase synthesis of biomolecule conjugates |
| US7526114B2 (en) | 2002-11-15 | 2009-04-28 | Bioarray Solutions Ltd. | Analysis, secure access to, and transmission of array images |
| JP2007501003A (ja) * | 2003-08-01 | 2007-01-25 | ユー．エス． ジェノミクス， インコーポレイテッド | 非切断条件下で核酸を分析するための配列特異的エンドヌクレアーゼの使用に関連した方法および組成物 |
| WO2005031305A2 (en) | 2003-09-22 | 2005-04-07 | Bioarray Solutions, Ltd. | Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules |
| JP2007521017A (ja) | 2003-10-28 | 2007-08-02 | バイオアレイ ソリューションズ リミテッド | 固定化捕捉プローブを用いる遺伝子発現分析法の最適化 |
| US7848889B2 (en) | 2004-08-02 | 2010-12-07 | Bioarray Solutions, Ltd. | Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification |
| US20060292559A1 (en) * | 2005-06-23 | 2006-12-28 | Beckman Coulter, Inc. | Cell-based microarrays, and methods for their preparation and use |
| CA2641026A1 (en) * | 2006-02-01 | 2007-08-09 | The Johns Hopkins University | Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders |
| AU2008283802A1 (en) * | 2007-07-31 | 2009-02-05 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders |
| US7811810B2 (en) | 2007-10-25 | 2010-10-12 | Industrial Technology Research Institute | Bioassay system including optical detection apparatuses, and method for detecting biomolecules |
| US7767441B2 (en) | 2007-10-25 | 2010-08-03 | Industrial Technology Research Institute | Bioassay system including optical detection apparatuses, and method for detecting biomolecules |
| US9778188B2 (en) * | 2009-03-11 | 2017-10-03 | Industrial Technology Research Institute | Apparatus and method for detection and discrimination molecular object |
| US8927271B1 (en) | 2010-01-21 | 2015-01-06 | Jack T. Johansen | Compositions and methods for detecting target analytes |
| US9482615B2 (en) | 2010-03-15 | 2016-11-01 | Industrial Technology Research Institute | Single-molecule detection system and methods |
| US9670243B2 (en) | 2010-06-02 | 2017-06-06 | Industrial Technology Research Institute | Compositions and methods for sequencing nucleic acids |
| US8865078B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| US8865077B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| EP4060345A1 (de) | 2016-12-19 | 2022-09-21 | Ventana Medical Systems, Inc. | Peptid-nukleinsäure-konjugate |
| WO2019120635A1 (en) | 2017-12-18 | 2019-06-27 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992000989A1 (en) * | 1990-07-10 | 1992-01-23 | Imperial Chemical Industries Plc | Non-isotopic nucleic acid labelling method |
| KR100252547B1 (ko) | 1991-09-05 | 2000-09-01 | 프레드 마리얀스키 | 폴리-또는 올리고누클레오티드의 세포로의 표적화된 전달 |
| WO1994004550A1 (en) | 1992-08-21 | 1994-03-03 | Triplex Pharmaceutical Corporation | Cholesteryl-modified triple-helix forming oligonucleotides and uses thereof |
| US5574142A (en) | 1992-12-15 | 1996-11-12 | Microprobe Corporation | Peptide linkers for improved oligonucleotide delivery |
| US6133444A (en) | 1993-12-22 | 2000-10-17 | Perseptive Biosystems, Inc. | Synthons for the synthesis and deprotection of peptide nucleic acids under mild conditions |
| US5705333A (en) * | 1994-08-05 | 1998-01-06 | The Regents Of The University Of California | Peptide-based nucleic acid mimics(PENAMS) |
| US5580731A (en) * | 1994-08-25 | 1996-12-03 | Chiron Corporation | N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith |
| ATE222589T1 (de) | 1994-10-06 | 2002-09-15 | Isis Pharmaceuticals Inc | Peptid-nukleinsäure-konjugate |
| EP0840741B1 (de) | 1995-06-07 | 2004-04-28 | Perseptive Biosystems, Inc. | Pna-dna-chimäre und pna-synthone zu deren herstellung |
| US6110676A (en) | 1996-12-04 | 2000-08-29 | Boston Probes, Inc. | Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays |
| DE69827260T2 (de) | 1997-07-24 | 2006-02-16 | PerSeptive Biosystems, Inc., Framingham | Konjugate von transportpeptiden und nukleinsäureanaloga und deren verwendung |
-
1999
- 1999-02-10 WO PCT/US1999/002908 patent/WO1999041273A2/en active IP Right Grant
- 1999-02-10 AU AU25973/99A patent/AU742241B2/en not_active Ceased
- 1999-02-10 CA CA2320390A patent/CA2320390C/en not_active Expired - Lifetime
- 1999-02-10 AT AT99905934T patent/ATE208827T1/de not_active IP Right Cessation
- 1999-02-10 JP JP2000531464A patent/JP2002503456A/ja not_active Withdrawn
- 1999-02-10 DK DK99905934T patent/DK1053355T3/da active
- 1999-02-10 DE DE69900462T patent/DE69900462T2/de not_active Expired - Lifetime
- 1999-02-10 US US09/247,996 patent/US6197513B1/en not_active Expired - Lifetime
- 1999-02-10 EP EP99905934A patent/EP1053355B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1053355A2 (de) | 2000-11-22 |
| WO1999041273A2 (en) | 1999-08-19 |
| DK1053355T3 (da) | 2002-02-11 |
| EP1053355B1 (de) | 2001-11-14 |
| CA2320390A1 (en) | 1999-08-19 |
| CA2320390C (en) | 2010-06-08 |
| AU2597399A (en) | 1999-08-30 |
| US6197513B1 (en) | 2001-03-06 |
| DE69900462T2 (de) | 2002-07-11 |
| ATE208827T1 (de) | 2001-11-15 |
| AU742241B2 (en) | 2001-12-20 |
| WO1999041273A3 (en) | 1999-09-23 |
| JP2002503456A (ja) | 2002-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: APPLERA CORP., FOSTER CITY, CALIF., US |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: APPLIED BIOSYSTEMS, LLC (N. D. GES. D. STAATES, US |
|
| 8380 | Miscellaneous part iii |
Free format text: PFANDRECHT |
|
| 8380 | Miscellaneous part iii |
Free format text: PFANDRECHT AUFGEHOBEN |