ATE283068T1 - Biologisch wirksame konjugate mit einem reporterrest und verfahren zu dessen nachweis - Google Patents
Biologisch wirksame konjugate mit einem reporterrest und verfahren zu dessen nachweisInfo
- Publication number
- ATE283068T1 ATE283068T1 AT99973261T AT99973261T ATE283068T1 AT E283068 T1 ATE283068 T1 AT E283068T1 AT 99973261 T AT99973261 T AT 99973261T AT 99973261 T AT99973261 T AT 99973261T AT E283068 T1 ATE283068 T1 AT E283068T1
- Authority
- AT
- Austria
- Prior art keywords
- detection
- biologically effective
- effective conjugates
- reporter residue
- aim
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98123307A EP1008355A1 (de) | 1998-12-08 | 1998-12-08 | Verfahren zur Identifizierung der Bindungsstellen eines Polymeren an Makromolekülen mit Markierungsbindung von Aminosäuren |
PCT/IB1999/001957 WO2000033881A1 (en) | 1998-12-08 | 1999-12-08 | Biologically active conjugates having a detectable reporter moiety and method of identification of said derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE283068T1 true ATE283068T1 (de) | 2004-12-15 |
Family
ID=8233105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99973261T ATE283068T1 (de) | 1998-12-08 | 1999-12-08 | Biologisch wirksame konjugate mit einem reporterrest und verfahren zu dessen nachweis |
Country Status (10)
Country | Link |
---|---|
US (1) | US6790942B1 (de) |
EP (2) | EP1008355A1 (de) |
JP (1) | JP2002531529A (de) |
AT (1) | ATE283068T1 (de) |
AU (1) | AU757665B2 (de) |
CA (1) | CA2354868A1 (de) |
DE (1) | DE69922245T2 (de) |
DK (1) | DK1137442T3 (de) |
ES (1) | ES2233107T3 (de) |
WO (1) | WO2000033881A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100396983B1 (ko) * | 2000-07-29 | 2003-09-02 | 이강춘 | 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체 |
WO2003078461A1 (en) | 2002-03-20 | 2003-09-25 | Biopolymed Inc. | Preparation of g-csf stoichiometrically conjugated with biocompatible polymers at cystein residue |
ES2323465T3 (es) | 2003-05-12 | 2009-07-16 | Affymax, Inc. | Peptidos novedosos que se unen al receptor de la eritropoyetina. |
ES2395413T3 (es) | 2003-05-12 | 2013-02-12 | Affymax, Inc. | Péptidos que se unen al receptor de eritropoyetina |
MXPA05012314A (es) | 2003-05-12 | 2006-04-18 | Affymax Inc | Radical separador para peptido modificado con polietilenglicol. |
US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
EP2118127A4 (de) | 2007-01-31 | 2010-12-01 | Affymax Inc | Linker auf stickstoffbasis zur bindung modifizierender gruppen an polypeptide und andere makromoleküle |
US8609621B2 (en) | 2010-11-15 | 2013-12-17 | E I Du Pont De Nemours And Company | Acid-cleavable linkers exhibiting altered rates of acid hydrolysis |
US9879059B2 (en) * | 2013-04-26 | 2018-01-30 | Agency For Science, Technology And Research | Tailoring multivalent interactions of biopolymers with a polyproline scaffold |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1219454B (it) * | 1988-02-17 | 1990-05-18 | Serono Cesare Ist Ricerca | Metodo di rottura alla metionina di polipeptidi contenenti pontidisolfuro |
DK0437563T3 (da) * | 1989-08-07 | 1995-05-29 | Debio Rech Pharma Sa | Bioligiske aktive lægemiddelpolymerderivater |
US5286637A (en) * | 1989-08-07 | 1994-02-15 | Debiopharm, S.A. | Biologically active drug polymer derivatives and method for preparing same |
WO1992020362A1 (en) * | 1991-05-14 | 1992-11-26 | Shashoua Victor E | Nerve growth peptides and uses therefor |
DK0536671T3 (da) * | 1991-10-07 | 1996-08-12 | Hoechst Ag | Carboxylsyreester-beskyttelsesgrupper, en fremgangsmåde til deres fremstilling, kobling til funktionelle grupper samt deres anvendelser |
-
1998
- 1998-12-08 EP EP98123307A patent/EP1008355A1/de not_active Withdrawn
-
1999
- 1999-12-08 AU AU14028/00A patent/AU757665B2/en not_active Ceased
- 1999-12-08 DK DK99973261T patent/DK1137442T3/da active
- 1999-12-08 ES ES99973261T patent/ES2233107T3/es not_active Expired - Lifetime
- 1999-12-08 WO PCT/IB1999/001957 patent/WO2000033881A1/en active IP Right Grant
- 1999-12-08 AT AT99973261T patent/ATE283068T1/de not_active IP Right Cessation
- 1999-12-08 DE DE69922245T patent/DE69922245T2/de not_active Expired - Fee Related
- 1999-12-08 CA CA002354868A patent/CA2354868A1/en not_active Abandoned
- 1999-12-08 EP EP99973261A patent/EP1137442B1/de not_active Expired - Lifetime
- 1999-12-08 JP JP2000586371A patent/JP2002531529A/ja active Pending
- 1999-12-08 US US09/857,469 patent/US6790942B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1137442B1 (de) | 2004-11-24 |
ES2233107T3 (es) | 2005-06-01 |
AU1402800A (en) | 2000-06-26 |
DE69922245D1 (de) | 2004-12-30 |
CA2354868A1 (en) | 2000-06-15 |
AU757665B2 (en) | 2003-02-27 |
US6790942B1 (en) | 2004-09-14 |
WO2000033881A1 (en) | 2000-06-15 |
DK1137442T3 (da) | 2005-03-14 |
DE69922245T2 (de) | 2005-11-24 |
EP1137442A1 (de) | 2001-10-04 |
JP2002531529A (ja) | 2002-09-24 |
EP1008355A1 (de) | 2000-06-14 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification |
Ref document number: 1137442 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |