DK1137442T3 - Biologisk aktive konjugater havende en detekterbar rapportermoietet og fremgangsmåde til identificering af nævnte derivat - Google Patents
Biologisk aktive konjugater havende en detekterbar rapportermoietet og fremgangsmåde til identificering af nævnte derivatInfo
- Publication number
- DK1137442T3 DK1137442T3 DK99973261T DK99973261T DK1137442T3 DK 1137442 T3 DK1137442 T3 DK 1137442T3 DK 99973261 T DK99973261 T DK 99973261T DK 99973261 T DK99973261 T DK 99973261T DK 1137442 T3 DK1137442 T3 DK 1137442T3
- Authority
- DK
- Denmark
- Prior art keywords
- identifying
- derivative
- biologically active
- active conjugates
- detectable reporting
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98123307A EP1008355A1 (de) | 1998-12-08 | 1998-12-08 | Verfahren zur Identifizierung der Bindungsstellen eines Polymeren an Makromolekülen mit Markierungsbindung von Aminosäuren |
| PCT/IB1999/001957 WO2000033881A1 (en) | 1998-12-08 | 1999-12-08 | Biologically active conjugates having a detectable reporter moiety and method of identification of said derivative |
| EP99973261A EP1137442B1 (de) | 1998-12-08 | 1999-12-08 | Biologisch wirksame konjugate mit einem reporterrest und verfahren zu dessen nachweis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1137442T3 true DK1137442T3 (da) | 2005-03-14 |
Family
ID=8233105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99973261T DK1137442T3 (da) | 1998-12-08 | 1999-12-08 | Biologisk aktive konjugater havende en detekterbar rapportermoietet og fremgangsmåde til identificering af nævnte derivat |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6790942B1 (de) |
| EP (2) | EP1008355A1 (de) |
| JP (1) | JP2002531529A (de) |
| AT (1) | ATE283068T1 (de) |
| AU (1) | AU757665B2 (de) |
| CA (1) | CA2354868A1 (de) |
| DE (1) | DE69922245T2 (de) |
| DK (1) | DK1137442T3 (de) |
| ES (1) | ES2233107T3 (de) |
| WO (1) | WO2000033881A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100396983B1 (ko) * | 2000-07-29 | 2003-09-02 | 이강춘 | 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체 |
| KR100508358B1 (ko) | 2002-03-20 | 2005-08-17 | 주식회사 바이오폴리메드 | 생체적합성 고분자가 시스테인 잔기에 화학양론적으로 결합된 ｇ-ｃｓｆ의 제조 방법 |
| EA010099B1 (ru) | 2003-05-12 | 2008-06-30 | Афимакс, Инк. | Пептиды, которые связываются с рецептором к эритропоэтину, и способы их применения |
| EP2204193A3 (de) | 2003-05-12 | 2010-08-18 | Affymax, Inc. | Spacer-Bestandteile für Poly(ethylenglykol)-modifizierte Verbindungen auf Peptidbasis |
| CA2525568C (en) | 2003-05-12 | 2017-07-25 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| JP2010520855A (ja) | 2007-01-31 | 2010-06-17 | アフィーマックス・インコーポレイテッド | 修飾基をポリペプチドおよびその他の高分子に結合するための窒素ベースのリンカー |
| US8609621B2 (en) | 2010-11-15 | 2013-12-17 | E I Du Pont De Nemours And Company | Acid-cleavable linkers exhibiting altered rates of acid hydrolysis |
| CN105324116B (zh) * | 2013-04-26 | 2019-03-29 | 新加坡科技研究局 | 调适具有聚脯氨酸支架的生物聚合物的多价相互作用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1219454B (it) * | 1988-02-17 | 1990-05-18 | Serono Cesare Ist Ricerca | Metodo di rottura alla metionina di polipeptidi contenenti pontidisolfuro |
| US5286637A (en) * | 1989-08-07 | 1994-02-15 | Debiopharm, S.A. | Biologically active drug polymer derivatives and method for preparing same |
| DK0437563T3 (da) * | 1989-08-07 | 1995-05-29 | Debio Rech Pharma Sa | Bioligiske aktive lægemiddelpolymerderivater |
| WO1992020362A1 (en) * | 1991-05-14 | 1992-11-26 | Shashoua Victor E | Nerve growth peptides and uses therefor |
| DE59205565D1 (de) * | 1991-10-07 | 1996-04-11 | Hoechst Ag | Carbonsäureester-Schutzgruppen, ein Verfahren zu ihrer Herstellung, ihre Kopplung an eine funktionelle Gruppe sowie ihre Verwendung |
-
1998
- 1998-12-08 EP EP98123307A patent/EP1008355A1/de not_active Withdrawn
-
1999
- 1999-12-08 DK DK99973261T patent/DK1137442T3/da active
- 1999-12-08 EP EP99973261A patent/EP1137442B1/de not_active Expired - Lifetime
- 1999-12-08 CA CA002354868A patent/CA2354868A1/en not_active Abandoned
- 1999-12-08 WO PCT/IB1999/001957 patent/WO2000033881A1/en active IP Right Grant
- 1999-12-08 DE DE69922245T patent/DE69922245T2/de not_active Expired - Fee Related
- 1999-12-08 AT AT99973261T patent/ATE283068T1/de not_active IP Right Cessation
- 1999-12-08 JP JP2000586371A patent/JP2002531529A/ja active Pending
- 1999-12-08 AU AU14028/00A patent/AU757665B2/en not_active Ceased
- 1999-12-08 US US09/857,469 patent/US6790942B1/en not_active Expired - Fee Related
- 1999-12-08 ES ES99973261T patent/ES2233107T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2233107T3 (es) | 2005-06-01 |
| ATE283068T1 (de) | 2004-12-15 |
| WO2000033881A1 (en) | 2000-06-15 |
| US6790942B1 (en) | 2004-09-14 |
| CA2354868A1 (en) | 2000-06-15 |
| AU757665B2 (en) | 2003-02-27 |
| EP1008355A1 (de) | 2000-06-14 |
| AU1402800A (en) | 2000-06-26 |
| EP1137442B1 (de) | 2004-11-24 |
| JP2002531529A (ja) | 2002-09-24 |
| EP1137442A1 (de) | 2001-10-04 |
| DE69922245D1 (de) | 2004-12-30 |
| DE69922245T2 (de) | 2005-11-24 |
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