ATE360033T1 - Ortsspezifische proteinmodifizierung durch mutagenese - Google Patents
Ortsspezifische proteinmodifizierung durch mutageneseInfo
- Publication number
- ATE360033T1 ATE360033T1 AT99930486T AT99930486T ATE360033T1 AT E360033 T1 ATE360033 T1 AT E360033T1 AT 99930486 T AT99930486 T AT 99930486T AT 99930486 T AT99930486 T AT 99930486T AT E360033 T1 ATE360033 T1 AT E360033T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- polyethylene glycol
- amino acid
- acid residue
- mutagenesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/102,530 US6451986B1 (en) | 1998-06-22 | 1998-06-22 | Site specific protein modification |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE360033T1 true ATE360033T1 (de) | 2007-05-15 |
Family
ID=22290346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99930486T ATE360033T1 (de) | 1998-06-22 | 1999-06-18 | Ortsspezifische proteinmodifizierung durch mutagenese |
Country Status (10)
Country | Link |
---|---|
US (5) | US6451986B1 (de) |
EP (2) | EP1829554A3 (de) |
JP (1) | JP3578991B2 (de) |
AT (1) | ATE360033T1 (de) |
AU (1) | AU767630B2 (de) |
CA (1) | CA2331337C (de) |
DE (1) | DE69935855T2 (de) |
ES (1) | ES2285843T3 (de) |
NZ (1) | NZ509424A (de) |
WO (1) | WO1999067291A2 (de) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6451986B1 (en) * | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
US6531122B1 (en) | 1999-08-27 | 2003-03-11 | Maxygen Aps | Interferon-β variants and conjugates |
US7144574B2 (en) | 1999-08-27 | 2006-12-05 | Maxygen Aps | Interferon β variants and conjugates |
US7431921B2 (en) | 2000-04-14 | 2008-10-07 | Maxygen Aps | Interferon beta-like molecules |
YU32402A (sh) | 1999-11-12 | 2005-03-15 | Maxygen Holdings Ltd. | Konjugati gama interferona |
CA2390292A1 (en) * | 1999-11-12 | 2001-05-25 | Maxygen Holdings Ltd. | Interferon gamma conjugates |
US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6646110B2 (en) | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
US6831158B2 (en) | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
AU4541101A (en) * | 2000-03-02 | 2001-09-12 | Xencor Inc | Design and discovery of protein based tnf-alpha variants for the treatment of tnf-alpha related disorders |
WO2002036626A1 (en) * | 2000-11-02 | 2002-05-10 | Maxygen Aps | Single-chain multimeric polypeptides |
EP1366075B1 (de) | 2001-02-27 | 2009-05-27 | Maxygen Aps | Neue interferon-beta-ähnliche moleküle |
US7038015B2 (en) | 2001-04-06 | 2006-05-02 | Maxygen Holdings, Ltd. | Interferon gamma polypeptide variants |
US6958388B2 (en) | 2001-04-06 | 2005-10-25 | Maxygen, Aps | Interferon gamma polypeptide variants |
AU2002325819B2 (en) | 2001-07-11 | 2008-06-19 | Maxygen, Inc. | G-CSF Conjugates |
US6908963B2 (en) | 2001-10-09 | 2005-06-21 | Nektar Therapeutics Al, Corporation | Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith |
US7138134B2 (en) * | 2001-12-18 | 2006-11-21 | Arizona Health Consulting Group, Llc | Preparation and administration of jojoba product for reducing weight, fat and blood lipid levels |
US7524931B2 (en) | 2002-07-03 | 2009-04-28 | Maxygen Holdings Ltd. | Full-length interferon gamma polypeptide variants |
EP1491554A1 (de) * | 2003-06-23 | 2004-12-29 | CONARIS research institute AG | PEGlierte lösliche gp130-Dimeren geignet als Medikament |
JP4870569B2 (ja) | 2003-11-13 | 2012-02-08 | ハンミ ホールディングス カンパニー リミテッド | 免疫グロブリン断片を用いた蛋白質結合体およびその製造方法 |
WO2005070973A2 (en) * | 2004-01-21 | 2005-08-04 | Nektar Therapeutics Al, Corporation | Method of preparing propionic acid-terminated polymers |
WO2005074650A2 (en) | 2004-02-02 | 2005-08-18 | Ambrx, Inc. | Modified human four helical bundle polypeptides and their uses |
AU2005265163B2 (en) | 2004-06-18 | 2009-10-01 | Ambrx, Inc. | Novel antigen-binding polypeptides and their uses |
AU2005286763A1 (en) * | 2004-09-17 | 2006-03-30 | Biomarin Pharmaceutical, Inc. | Variants and chemically-modified variants of phenylalanine ammonia-lyase |
CN101087875B (zh) | 2004-12-22 | 2012-08-22 | Ambrx公司 | 氨酰基-tRNA合成酶的组合物及其用途 |
BRPI0518661A2 (pt) | 2004-12-22 | 2008-12-02 | Ambrx Inc | mÉtodos para expressço e purificaÇço do hormânio do crescimento humano recombinante |
BRPI0519430A2 (pt) | 2004-12-22 | 2009-02-10 | Ambrx Inc | hormânio do crescimento humano modificado |
US7816320B2 (en) | 2004-12-22 | 2010-10-19 | Ambrx, Inc. | Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35 |
EP1674113A1 (de) | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Konjugate von insulinähnlichem Wachstumfaktor-1 und Poly(Ethylenglykol) |
WO2006105993A2 (en) * | 2005-04-05 | 2006-10-12 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Method for shielding functional sites or epitopes on proteins |
DE102005016824A1 (de) | 2005-04-12 | 2006-10-19 | Giesecke & Devrient Gmbh | Vorrichtung und Verfahren zur Prüfung von Wertdokumenten |
US7833979B2 (en) * | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
KR20080027291A (ko) | 2005-06-01 | 2008-03-26 | 맥시겐 홀딩스 엘티디 | 피이지화된 지-씨에스에프 폴리펩타이드 및 그 제조방법 |
KR20080026135A (ko) | 2005-06-03 | 2008-03-24 | 암브룩스, 인코포레이티드 | 개선된 인간 인터페론 분자 및 이의 용도 |
US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
WO2007058894A2 (en) * | 2005-11-10 | 2007-05-24 | The University Of North Carolina At Chapel Hill | Splice switching oligomers for tnf superfamily receptors and their use in treatment of disease |
US7785834B2 (en) * | 2005-11-10 | 2010-08-31 | Ercole Biotech, Inc. | Soluble TNF receptors and their use in treatment of disease |
EP2339014B1 (de) | 2005-11-16 | 2015-05-27 | Ambrx, Inc. | Verfahren und Zusammensetzungen mit nichtnatürlichen Aminosäuren |
US8841255B2 (en) | 2005-12-20 | 2014-09-23 | Duke University | Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides |
US20130172274A1 (en) | 2005-12-20 | 2013-07-04 | Duke University | Methods and compositions for delivering active agents with enhanced pharmacological properties |
US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
US7534595B2 (en) | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
KR20090060294A (ko) | 2006-09-08 | 2009-06-11 | 암브룩스, 인코포레이티드 | 변형된 인간 혈장 폴리펩티드 또는 Fc 스캐폴드 및 그의 용도 |
MX2009002526A (es) | 2006-09-08 | 2009-04-16 | Ambrx Inc | Transcripcion de tarn supresor en celulas de vertebrados. |
WO2008051383A2 (en) * | 2006-10-19 | 2008-05-02 | Amgen Inc. | Use of alcohol co-solvents to improve pegylation reaction yields |
US20090264353A1 (en) * | 2007-10-19 | 2009-10-22 | Santaris Pharma A/S | Splice Switching Oligomers for TNF Superfamily Receptors and their Use in Treatment of Disease |
US7825093B2 (en) | 2006-10-25 | 2010-11-02 | Amgen Inc. | Methods of using OSK1 peptide analogs |
BRPI0809583B1 (pt) | 2007-03-30 | 2022-02-22 | Ambrx, Inc | Polipeptídeo fgf-21 modificado, composição compreendendo o mesmo, método para produzir o referido polipetídeo fgf-21 e célula compreendendo um polinucleotídeo |
BRPI0810622A2 (pt) | 2007-05-02 | 2020-10-13 | Ambrx, Inc. | polipeptídeos de interferon beta modificados e seus usos |
JP5591691B2 (ja) | 2007-05-22 | 2014-09-17 | アムジエン・インコーポレーテツド | 生物活性を有する融合タンパク質を作製するための組成物及び方法 |
US7537923B2 (en) * | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
CN101918026B (zh) | 2007-11-20 | 2016-03-02 | Ambrx公司 | 经修饰胰岛素多肽和其用途 |
JP5702150B2 (ja) | 2008-02-08 | 2015-04-15 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 修飾されているレプチンポリペプチドおよびそれらの使用 |
EP2926825A1 (de) | 2008-06-27 | 2015-10-07 | Duke University | Therapeutika mit elastinähnlichen peptiden |
UA103774C2 (uk) | 2008-07-23 | 2013-11-25 | Амбркс, Інк. | Модифіковані поліпептиди бичачого гранулоцитарного колонієстимулювального фактора (g-csf) та їх застосування |
WO2010014225A2 (en) | 2008-07-30 | 2010-02-04 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
MX343802B (es) | 2008-09-26 | 2016-11-23 | Ambrx Inc | Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales. |
CN107022020A (zh) | 2008-09-26 | 2017-08-08 | Ambrx公司 | 修饰的动物促红细胞生成素多肽和其用途 |
BR112012013330A2 (pt) * | 2009-12-02 | 2017-03-28 | Acceleron Pharma Inc | composições e métodos para aumentar meia vida do soro de proteínas de fusão fc |
EA201290541A1 (ru) | 2009-12-21 | 2013-05-30 | Амбркс, Инк. | Модифицированные бычьи соматотропиновые полипептиды и их применение |
CN104017063A (zh) | 2009-12-21 | 2014-09-03 | Ambrx公司 | 经过修饰的猪促生长素多肽和其用途 |
EP3025728B1 (de) | 2010-02-04 | 2018-08-08 | BioMarin Pharmaceutical Inc. | Reinigungsverfahren von prokaryotischen phenylalanin-ammoniak-lyase-varianten |
US9782454B2 (en) | 2010-04-22 | 2017-10-10 | Longevity Biotech, Inc. | Highly active polypeptides and methods of making and using the same |
JP2012034668A (ja) * | 2010-08-12 | 2012-02-23 | Tohoku Univ | ヒト型化抗egfr抗体リジン置換可変領域断片及びその利用 |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
MA34521B1 (fr) | 2010-08-17 | 2013-09-02 | Ambrx Inc | Polypeptides de relaxine modifiés et leurs utilisations |
TWI480288B (zh) | 2010-09-23 | 2015-04-11 | Lilly Co Eli | 牛顆粒細胞群落刺激因子及其變體之調配物 |
US9340590B2 (en) | 2011-03-16 | 2016-05-17 | Amgen Inc. | Potent and selective inhibitors of NaV1.3 and NaV1.7 |
DK2694095T3 (en) | 2011-04-05 | 2018-05-28 | Longevity Biotech Inc | COMPOSITIONS COMPREHENSIVE GLUCAGON ANALOGS AND METHODS FOR PREPARING AND USING THE SAME |
US8883982B2 (en) | 2011-06-08 | 2014-11-11 | Acceleron Pharma, Inc. | Compositions and methods for increasing serum half-life |
WO2014099984A1 (en) | 2012-12-20 | 2014-06-26 | Amgen Inc. | Apj receptor agonists and uses thereof |
US10344060B2 (en) | 2013-03-12 | 2019-07-09 | Amgen Inc. | Potent and selective inhibitors of Nav1.7 |
US9789164B2 (en) | 2013-03-15 | 2017-10-17 | Longevity Biotech, Inc. | Peptides comprising non-natural amino acids and methods of making and using the same |
AU2015274574B2 (en) | 2014-06-10 | 2019-10-10 | Amgen Inc. | Apelin polypeptides |
CN114805533A (zh) | 2014-10-24 | 2022-07-29 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
KR20180077271A (ko) | 2015-11-03 | 2018-07-06 | 암브룩스, 인코포레이티드 | 항-cd3-폴레이트 컨쥬게이트 및 이의 용도 |
EP3960760A1 (de) * | 2015-11-16 | 2022-03-02 | Ubiprotein, Corp. | Verfahren zur verlängerung der halbwertszeit eines proteins |
CN109689079A (zh) | 2016-08-22 | 2019-04-26 | 伊兰科美国公司 | 牛成纤维细胞生长因子21和乳畜中的酮病 |
TW201837051A (zh) | 2017-02-08 | 2018-10-16 | 美商必治妥美雅史谷比公司 | 包含藥物動力學增強劑之經修飾之鬆弛素(relaxin)多肽及其用途 |
MX2020002206A (es) | 2017-09-08 | 2020-07-20 | Bristol Myers Squibb Co | Factor de crecimiento de fibroblastos 21 (fgf-21) modificado para usarse en metodos para tratar la esteatohepatitis no alcoholica (nash). |
US20210015940A1 (en) | 2018-03-29 | 2021-01-21 | Ambrx, Inc. | Humanized anti-prostate -specific membrane antigen (psma) antibody drug conjugates |
CN114903978A (zh) | 2018-07-03 | 2022-08-16 | 百时美施贵宝公司 | Fgf-21配制品 |
MX2021002301A (es) | 2018-08-28 | 2021-04-28 | Ambrx Inc | Bioconjugados de anticuerpo-foliato anti-cd3 y sus usos. |
US20220017570A1 (en) | 2018-11-05 | 2022-01-20 | Bristol-Meyers Squibb Company | Method for purifying pegylated protein |
WO2021173889A1 (en) | 2020-02-26 | 2021-09-02 | Ambrx, Inc. | Uses of anti-cd3 antibody folate bioconjugates |
WO2023155872A1 (zh) * | 2022-02-18 | 2023-08-24 | 江苏众红生物工程创药研究院有限公司 | 一种实现生物活性分子其活性控释和缓释的方法及药物应用 |
WO2024077277A1 (en) | 2022-10-07 | 2024-04-11 | Ambrx, Inc. | Drug linkers and antibody conjugates thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
US5235028A (en) | 1990-08-31 | 1993-08-10 | University Of Minnesota | Polyethylene glycol derivatives for solid-phase applications |
EP0575545B1 (de) * | 1991-03-15 | 2003-05-21 | Amgen Inc. | Pegylation von polypeptiden |
US6565841B1 (en) | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
IT1260468B (it) | 1992-01-29 | 1996-04-09 | Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole | |
GB9225448D0 (en) | 1992-12-04 | 1993-01-27 | Erba Carlo Spa | Improved synthesis of polymer bioactive conjugates |
CA2139385C (en) * | 1994-02-04 | 2001-12-25 | Gottfried Alber | Products containing g-csf and tnf binding protein |
WO1996011213A1 (en) | 1994-10-07 | 1996-04-18 | Amgen Boulder Inc. | Dimeric il-4 inhibitors |
DE122006000003I1 (de) | 1995-09-21 | 2006-05-04 | Genentech Inc | Varianten des Menschlichen Wachstumshormons |
US5882141A (en) | 1996-08-02 | 1999-03-16 | Nibco, Inc. | Low energy precision flooding irrigation apparatus and method |
CA2279986A1 (en) | 1997-02-06 | 1998-08-13 | Novo Nordisk A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
US6451986B1 (en) * | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
-
1998
- 1998-06-22 US US09/102,530 patent/US6451986B1/en not_active Expired - Lifetime
-
1999
- 1999-06-18 CA CA002331337A patent/CA2331337C/en not_active Expired - Fee Related
- 1999-06-18 AU AU47020/99A patent/AU767630B2/en not_active Ceased
- 1999-06-18 ES ES99930486T patent/ES2285843T3/es not_active Expired - Lifetime
- 1999-06-18 JP JP2000555941A patent/JP3578991B2/ja not_active Expired - Fee Related
- 1999-06-18 EP EP07003818A patent/EP1829554A3/de not_active Withdrawn
- 1999-06-18 EP EP99930486A patent/EP1090036B1/de not_active Expired - Lifetime
- 1999-06-18 AT AT99930486T patent/ATE360033T1/de active
- 1999-06-18 NZ NZ509424A patent/NZ509424A/en unknown
- 1999-06-18 WO PCT/US1999/013953 patent/WO1999067291A2/en active IP Right Grant
- 1999-06-18 DE DE69935855T patent/DE69935855T2/de not_active Expired - Lifetime
-
2000
- 2000-05-26 US US09/580,235 patent/US6433158B1/en not_active Expired - Lifetime
- 2000-05-26 US US09/580,181 patent/US6441136B1/en not_active Expired - Lifetime
-
2002
- 2002-09-12 US US10/243,230 patent/US7129203B2/en not_active Expired - Lifetime
-
2006
- 2006-10-26 US US11/588,655 patent/US20070048837A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20070048837A1 (en) | 2007-03-01 |
JP3578991B2 (ja) | 2004-10-20 |
DE69935855T2 (de) | 2008-01-10 |
US7129203B2 (en) | 2006-10-31 |
US6441136B1 (en) | 2002-08-27 |
US6451986B1 (en) | 2002-09-17 |
EP1090036A2 (de) | 2001-04-11 |
US20030023049A1 (en) | 2003-01-30 |
EP1829554A3 (de) | 2007-09-26 |
NZ509424A (en) | 2002-05-31 |
ES2285843T3 (es) | 2007-11-16 |
US20020081309A1 (en) | 2002-06-27 |
EP1829554A2 (de) | 2007-09-05 |
WO1999067291A3 (en) | 2000-03-09 |
WO1999067291A2 (en) | 1999-12-29 |
DE69935855D1 (de) | 2007-05-31 |
AU767630B2 (en) | 2003-11-20 |
JP2002518522A (ja) | 2002-06-25 |
CA2331337A1 (en) | 1999-12-29 |
AU4702099A (en) | 2000-01-10 |
US6433158B1 (en) | 2002-08-13 |
CA2331337C (en) | 2008-07-29 |
EP1090036B1 (de) | 2007-04-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE360033T1 (de) | Ortsspezifische proteinmodifizierung durch mutagenese | |
ATE277084T1 (de) | Stellenspezifische proteinmodifizierung | |
BR9812267A (pt) | Derivados de hormonio de crescimento eproteìnas relacionadas | |
IL130403A (en) | Oil bodies and associated proteins as affinity matrices | |
MY126352A (en) | Modified/chimeric superantigens and their use | |
DE69942231D1 (de) | Ortspezifische duale pegylation von proteine | |
MX9709265A (es) | Superantigenos modificados/quimericos y sus usos. | |
EP2107123A3 (de) | Zusammensetzung zum Testen glykierter Proteine | |
WO2002002627A3 (en) | Interferon-like protein zcyto21 | |
ATE212059T1 (de) | Methoden zur identifizierung heterofunktionaler fusionsproteine | |
DK0909312T3 (da) | Fremgangsmåde til fremstilling af polypeptider | |
EP1282722A4 (de) | Stabilisierte proteine | |
ZA200007776B (en) | Enzyme-protein complex. | |
AU3257197A (en) | Process for the activation of denatured protein | |
TR199801027T2 (xx) | Epitelyom te�his ve tedavisi i�in y�ntem. | |
TR200000416T2 (tr) | Neisseria loctoferrin bağlayıcı protein. | |
DK1137442T3 (da) | Biologisk aktive konjugater havende en detekterbar rapportermoietet og fremgangsmåde til identificering af nævnte derivat | |
ATE405646T1 (de) | Ein verfahren zum auffinden vom prostatakrebs | |
AU3733199A (en) | Antibodies and utilization thereof | |
Yanagisawa et al. | The basic study on the binding reaction between bovine serum albumin and methamphetamine | |
KR970001373A (ko) | 글루탐산 탈수소효소에 대한 단일클론 항체 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1090036 Country of ref document: EP |