BRPI0518661A2 - mÉtodos para expressço e purificaÇço do hormânio do crescimento humano recombinante - Google Patents

mÉtodos para expressço e purificaÇço do hormânio do crescimento humano recombinante

Info

Publication number
BRPI0518661A2
BRPI0518661A2 BRPI0518661-7A BRPI0518661A BRPI0518661A2 BR PI0518661 A2 BRPI0518661 A2 BR PI0518661A2 BR PI0518661 A BRPI0518661 A BR PI0518661A BR PI0518661 A2 BRPI0518661 A2 BR PI0518661A2
Authority
BR
Brazil
Prior art keywords
purification
human growth
expression
methods
growth hormone
Prior art date
Application number
BRPI0518661-7A
Other languages
English (en)
Inventor
Ying Buechler
Ricky Lieu
Michael Ong
Stuart Bussell
Nick Knudsen
Ho Sung Cho
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of BRPI0518661A2 publication Critical patent/BRPI0518661A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Abstract

MÉTODOS PARA EXPRESSçO E PURIFICAÇçO DO HORMâNIO DO CRESCIMENTO HUMANO RECOMBINANTE. A presente invenção se refere em linhas gerais à produção, purificação e isolamento de hormônio de crescimento humano (Hgh). Mais especificamente, a invenção se refere à produção, purificação e isolamento de hGH substancialmente purificado a partir de células hospedeiras recombinantes ou do meio de cultura, incluindo, por exemplo, células de levedura, de insetos, de mamíferos e bacterianas. O processo da presente invenção é também útil para a purificação de hGH ligado a polímeros ou a outras moléculas.
BRPI0518661-7A 2004-12-22 2005-12-21 mÉtodos para expressço e purificaÇço do hormânio do crescimento humano recombinante BRPI0518661A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63861604P 2004-12-22 2004-12-22
US65574405P 2005-02-23 2005-02-23
US68097705P 2005-05-13 2005-05-13
US72796805P 2005-10-17 2005-10-17
PCT/US2005/046486 WO2006073846A2 (en) 2004-12-22 2005-12-21 Methods for expression and purification of recombinant human growth hormone

Publications (1)

Publication Number Publication Date
BRPI0518661A2 true BRPI0518661A2 (pt) 2008-12-02

Family

ID=36647995

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518661-7A BRPI0518661A2 (pt) 2004-12-22 2005-12-21 mÉtodos para expressço e purificaÇço do hormânio do crescimento humano recombinante

Country Status (14)

Country Link
US (4) US8080391B2 (pt)
EP (1) EP1836316A4 (pt)
JP (1) JP2008525032A (pt)
KR (1) KR20070100299A (pt)
CN (1) CN103290084A (pt)
AU (2) AU2005323106B2 (pt)
BR (1) BRPI0518661A2 (pt)
CA (1) CA2590462C (pt)
GB (1) GB2438760A (pt)
IL (2) IL183344A (pt)
MX (1) MX2007007591A (pt)
NZ (1) NZ555206A (pt)
SG (1) SG161210A1 (pt)
WO (1) WO2006073846A2 (pt)

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