AR018042A1 - Uso de compuestos de quinolina para la preparacion de medicamentos para el tratamiento de infecciones bacterianas en mamiferos, particularmenteen el hombre, composiciones farmaceuticas formuladas con dichos compuestos y procedimiento de preparacion de dichos compuestos de quinolina - Google Patents

Uso de compuestos de quinolina para la preparacion de medicamentos para el tratamiento de infecciones bacterianas en mamiferos, particularmenteen el hombre, composiciones farmaceuticas formuladas con dichos compuestos y procedimiento de preparacion de dichos compuestos de quinolina

Info

Publication number
AR018042A1
AR018042A1 ARP990100304A ARP990100304A AR018042A1 AR 018042 A1 AR018042 A1 AR 018042A1 AR P990100304 A ARP990100304 A AR P990100304A AR P990100304 A ARP990100304 A AR P990100304A AR 018042 A1 AR018042 A1 AR 018042A1
Authority
AR
Argentina
Prior art keywords
preparation
compounds
treatment
pharmaceutical compositions
bacterial infections
Prior art date
Application number
ARP990100304A
Other languages
English (en)
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801630.6A external-priority patent/GB9801630D0/en
Priority claimed from GBGB9821072.7A external-priority patent/GB9821072D0/en
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AR018042A1 publication Critical patent/AR018042A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se trata del uso de compuestos de quinolina 4-sustituidos de formula (I), donde A es NR, -O-, -S(O)x o -CR6R7 y B es un grupo -S(O)x, o mayor que CR8R9,siendo x cero, 1 o 2; m es 1 o 2 y n es cero, 1 o 2, y los grupos restantes tienen los valores indicados en las descripcion. Dichos compuestos son deaplicacion en la preparacion de medicamentos para el tratamiento de infecciones bacterianas. También se preparan composiciones farmacéuticas formuladascon dichos compuestos y procedimientos de preparacion de dichos compuestos de quinolina de formula (I).
ARP990100304A 1998-01-26 1999-01-26 Uso de compuestos de quinolina para la preparacion de medicamentos para el tratamiento de infecciones bacterianas en mamiferos, particularmenteen el hombre, composiciones farmaceuticas formuladas con dichos compuestos y procedimiento de preparacion de dichos compuestos de quinolina AR018042A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9801630.6A GB9801630D0 (en) 1998-01-26 1998-01-26 Novel compounds
GBGB9821072.7A GB9821072D0 (en) 1998-09-29 1998-09-29 Medicaments

Publications (1)

Publication Number Publication Date
AR018042A1 true AR018042A1 (es) 2001-10-31

Family

ID=26313018

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP990100304A AR018042A1 (es) 1998-01-26 1999-01-26 Uso de compuestos de quinolina para la preparacion de medicamentos para el tratamiento de infecciones bacterianas en mamiferos, particularmenteen el hombre, composiciones farmaceuticas formuladas con dichos compuestos y procedimiento de preparacion de dichos compuestos de quinolina

Country Status (8)

Country Link
EP (1) EP1051413B1 (es)
JP (1) JP2002501061A (es)
AR (1) AR018042A1 (es)
AU (1) AU2717899A (es)
CA (1) CA2318842A1 (es)
DE (1) DE69908555T2 (es)
ES (1) ES2201674T3 (es)
WO (1) WO1999037635A1 (es)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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GB9822440D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
GB9822450D0 (en) * 1998-10-14 1998-12-09 Smithkline Beecham Plc Medicaments
EP1144404A1 (en) * 1999-01-20 2001-10-17 Smithkline Beecham Plc Piperidinylquinolines as protein tyrosine kinase inhibitors
GB9914486D0 (en) 1999-06-21 1999-08-18 Smithkline Beecham Plc Medicaments
GB9917408D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
GB9917406D0 (en) 1999-07-23 1999-09-22 Smithkline Beecham Plc Compounds
US6403610B1 (en) 1999-09-17 2002-06-11 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation and the compositions which comprise them
FR2798656B1 (fr) * 1999-09-17 2004-12-17 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
US6803369B1 (en) 2000-07-25 2004-10-12 Smithkline Beecham Corporation Compounds and methods for the treatment of neoplastic disease
KR20030019621A (ko) * 2000-07-26 2003-03-06 스미스클라인비이참피이엘시이 항균 활성을 갖는 아미노피페리딘 퀴놀린 및 그의아자이소스테릭 유사체
FR2816618B1 (fr) * 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
US6603005B2 (en) 2000-11-15 2003-08-05 Aventis Pharma S.A. Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them
GB0031088D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0031086D0 (en) * 2000-12-20 2001-01-31 Smithkline Beecham Plc Medicaments
GB0101577D0 (en) 2001-01-22 2001-03-07 Smithkline Beecham Plc Compounds
FR2822154B1 (fr) * 2001-03-13 2005-10-21 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent
US6602884B2 (en) 2001-03-13 2003-08-05 Aventis Pharma S.A. Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them
GB0112836D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
GB0112834D0 (en) 2001-05-25 2001-07-18 Smithkline Beecham Plc Medicaments
AR038240A1 (es) 2002-01-29 2005-01-05 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para su preparacion
JP4508650B2 (ja) * 2002-01-29 2010-07-21 グラクソ グループ リミテッド アミノピペリジン化合物、当該化合物の製法および当該化合物を含有する医薬組成物
AR040336A1 (es) 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
FR2842807A1 (fr) 2002-07-23 2004-01-30 Aventis Pharma Sa Derives de la quinolyl propyl piperidine, procede et intermediaires de preparation et compositions les renfermant
GB0217294D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicaments
NZ538391A (en) * 2002-07-25 2005-10-28 Janssen Pharmaceutica Nv Quinoline derivatives and their use as mycobacterial inhibitors
US7223776B2 (en) 2002-10-10 2007-05-29 Morphochem Ag Compounds with anti-bacterial activity
JP4704755B2 (ja) 2002-11-05 2011-06-22 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー 抗菌剤
ATE479683T1 (de) 2002-11-05 2010-09-15 Glaxo Group Ltd Antibakterielle mittel
ES2312839T3 (es) 2002-12-04 2009-03-01 Glaxo Group Limited Quinolinas y sus derivados nitrogenados y su uso como agentes antibacterianos.
JP2006521344A (ja) * 2003-03-28 2006-09-21 ファイザー・プロダクツ・インク アテローム性動脈硬化症および肥満の治療のためのｃｅｔｐ阻害剤としての１，２，４−置換１，２，３，４−テトラヒドロ−および１，２−ジヒドロ−キノリンおよび１，２，３，４−テトラヒドロ−キノキサリン誘導体
MXPA05012839A (es) * 2003-05-27 2006-05-17 Pfizer Prod Inc Quinazolinas y pirido[3,4-d] pirimidinas como inhibidores de receptores tirosina quinasa.
FR2858619B1 (fr) * 2003-08-08 2006-12-22 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
US7348434B2 (en) 2003-08-08 2008-03-25 Antony Bigot 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them
DE602005006744D1 (de) * 2004-01-29 2008-06-26 Janssen Pharmaceutica Nv Chinolinderivate zur verwendung als inhibitoren von mycobakterien
US7709472B2 (en) 2005-01-25 2010-05-04 Glaxo Group Limited Antibacterial agents
EP1846411A4 (en) 2005-01-25 2010-08-04 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
EP1846418A4 (en) 2005-01-25 2009-12-23 Glaxo Group Ltd ANTIBACTERIAL ACTIVE SUBSTANCES
WO2006081264A1 (en) 2005-01-25 2006-08-03 Glaxo Group Limited Antibacterial agents
EP1846416A4 (en) * 2005-01-25 2009-07-01 Glaxo Group Ltd ANTIBACTERIAL AGENTS
CA2528849C (en) 2005-06-08 2014-01-14 Janssen Pharmaceutica N.V. Quinoline derivatives as antibacterial agents
EA010601B1 (ru) * 2005-06-09 2008-10-30 Янссен Фармацевтика Н.В. Производные хинолина в качестве антибактериальных агентов
CA2635126A1 (en) 2006-01-26 2007-08-02 Actelion Pharmaceuticals Ltd Tetrahydropyrane antibiotics
WO2007118130A2 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Antibacterial agents
CA2669635A1 (en) * 2006-11-16 2008-05-22 Astellas Pharma Inc. Piperidine derivative or salt thereof
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JP6362235B2 (ja) * 2014-07-14 2018-07-25 ツーセン ファーマシューティカル カンパニー リミテッド ピリジン誘導体およびその抗マイコバクテリウムにおける使用
WO2016172436A1 (en) 2015-04-23 2016-10-27 Temple University-Of The Commonwealth System Of Higher Education Polycationic amphiphiles and polymers thereof as antimicrobial agents and methods using same
US11111216B2 (en) 2016-10-26 2021-09-07 Temple University-Of The Commonwealth System Of Higher Education Polycationic amphiphiles as antimicrobial agents and methods using same
WO2020169593A1 (en) 2019-02-19 2020-08-27 Univerza V Ljubljani Antibacterials based on monocyclic fragments coupled to aminopiperidine naphthyridine scaffold

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US3362875A (en) * 1965-06-04 1968-01-09 Richardson Merrell Inc N4, n4'-decamethylene-bis(4-amino)-quinaldine diacetate compositions for controllingtopical infections
FR2177511A1 (en) * 1972-03-28 1973-11-09 Omnium Chimique Sa Quinolyl pipiridylethyl ketones - with vasodilatory and antispasmodic activity
GB1496371A (en) * 1975-08-18 1977-12-30 Serdex 4-amino-quinoline derivatives process for their preparation and therapeutic applications thereof
NL7908031A (nl) * 1979-11-01 1981-06-01 Acf Chemiefarma Nv Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werk- wijze voor het bereiden van deze verbindingen.

Also Published As

Publication number Publication date
CA2318842A1 (en) 1999-07-29
ES2201674T3 (es) 2004-03-16
DE69908555T2 (de) 2004-05-06
EP1051413A1 (en) 2000-11-15
AU2717899A (en) 1999-08-09
JP2002501061A (ja) 2002-01-15
DE69908555D1 (de) 2003-07-10
WO1999037635A1 (en) 1999-07-29
EP1051413B1 (en) 2003-06-04

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