IL148890A0 - Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation - Google Patents

Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation

Info

Publication number
IL148890A0
IL148890A0 IL14889099A IL14889099A IL148890A0 IL 148890 A0 IL148890 A0 IL 148890A0 IL 14889099 A IL14889099 A IL 14889099A IL 14889099 A IL14889099 A IL 14889099A IL 148890 A0 IL148890 A0 IL 148890A0
Authority
IL
Israel
Prior art keywords
derivatives
preparation
methods
ethylene glycol
heterobifunctional poly
Prior art date
Application number
IL14889099A
Other languages
English (en)
Original Assignee
Shearwater Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shearwater Corp filed Critical Shearwater Corp
Publication of IL148890A0 publication Critical patent/IL148890A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
IL14889099A 1999-10-08 1999-10-08 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation IL148890A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1999/023536 WO2001026692A1 (en) 1999-10-08 1999-10-08 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation

Publications (1)

Publication Number Publication Date
IL148890A0 true IL148890A0 (en) 2002-09-12

Family

ID=22273776

Family Applications (2)

Application Number Title Priority Date Filing Date
IL14889099A IL148890A0 (en) 1999-10-08 1999-10-08 Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
IL148890A IL148890A (en) 1999-10-08 2002-03-26 Polyfunctional derivatives of poly (ethylene glycol) and methods for their preparation

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL148890A IL148890A (en) 1999-10-08 2002-03-26 Polyfunctional derivatives of poly (ethylene glycol) and methods for their preparation

Country Status (17)

Country Link
EP (1) EP1455839B1 (enExample)
JP (1) JP4344110B2 (enExample)
KR (1) KR100499655B1 (enExample)
CN (1) CN1284603C (enExample)
AU (1) AU781336B2 (enExample)
BR (1) BR9917517A (enExample)
CA (1) CA2386762C (enExample)
CY (1) CY1114128T1 (enExample)
DK (1) DK1455839T3 (enExample)
ES (1) ES2404685T3 (enExample)
HU (1) HU228491B1 (enExample)
IL (2) IL148890A0 (enExample)
MX (1) MXPA02003540A (enExample)
NO (1) NO331781B1 (enExample)
NZ (1) NZ518143A (enExample)
PT (1) PT1455839E (enExample)
WO (1) WO2001026692A1 (enExample)

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CA2414076A1 (en) 2000-06-08 2001-12-13 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
US6761824B2 (en) 2000-08-17 2004-07-13 Reeve Lorraine E Process for the fractionation of polymers
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
US7829074B2 (en) 2001-10-18 2010-11-09 Nektar Therapeutics Hydroxypatite-targeting poly(ethylene glycol) and related polymers
US7053150B2 (en) 2000-12-18 2006-05-30 Nektar Therapeutics Al, Corporation Segmented polymers and their conjugates
TW593427B (en) * 2000-12-18 2004-06-21 Nektar Therapeutics Al Corp Synthesis of high molecular weight non-peptidic polymer derivatives
US7550512B2 (en) 2001-11-28 2009-06-23 Keio University Medical polymers and uses thereof
JP3493608B2 (ja) * 2001-11-28 2004-02-03 学校法人慶應義塾 医用高分子及びその用途
GB0209539D0 (en) * 2002-04-26 2002-06-05 Avecia Ltd Monomer Polymer and process
BR0313212A (pt) 2002-07-24 2005-06-28 Hoffmann La Roche Aditivos de ácido de polialquileno glicol
US20040062748A1 (en) 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US8129330B2 (en) 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
WO2004035657A1 (en) * 2002-10-15 2004-04-29 Baxter International Inc. Process for the preparation of polyethylene glycol bis amine
AU2003303595A1 (en) 2002-12-30 2004-07-29 Gryphon Therapeutics, Inc. Water-soluble thioester and selenoester compounds and methods for making and using the same
DE60322111D1 (de) 2002-12-31 2008-08-21 Nektar Therapeutics Al Co Verfahren zur herstellung von hydrogelen aus thiosulfonat-zusammensetzungen und ihre verwendungen
CN1777440A (zh) 2003-04-11 2006-05-24 Pr药品有限公司 位点特异性蛋白质偶联物的制备方法
US8637650B2 (en) 2003-11-05 2014-01-28 Genovoxx Gmbh Macromolecular nucleotide compounds and methods for using the same
US20050214250A1 (en) * 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
WO2006105993A2 (en) 2005-04-05 2006-10-12 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Method for shielding functional sites or epitopes on proteins
WO2007022780A1 (en) * 2005-08-26 2007-03-01 Novo Nordisk A/S A method of modifying a macromolecular system
EP2049148B1 (en) 2006-07-06 2016-09-28 Daewoong Co., Ltd. A stable liquid formulation of human growth hormone
US7985783B2 (en) 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
CN106139123A (zh) 2009-08-05 2016-11-23 爱力根公司 脂质运载蛋白突变蛋白的控制释放制剂
WO2011050938A1 (de) 2009-10-26 2011-05-05 Genovoxx Gmbh Konjugate von nukleotiden und methoden zu deren anwendung
EP2717917B1 (en) 2011-07-05 2016-04-20 biOasis Technologies Inc P97-antibody conjugates
CA3140358A1 (en) 2012-07-31 2014-02-06 Bioasis Technologies, Inc. Dephosphorylated lysosomal storage disease proteins and methods of use thereof
JP2016500058A (ja) 2012-11-12 2016-01-07 レッドウッド バイオサイエンス， インコーポレイテッド 化合物および抱合体を生成するための方法
US9310374B2 (en) 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
JP2016505528A (ja) 2012-11-16 2016-02-25 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア タンパク質の化学修飾のためのピクテ−スペングラーライゲーション
CN103044677A (zh) * 2012-12-28 2013-04-17 上海景宇生物科技有限公司 一种异端基遥爪聚乙二醇及其制备方法
AU2014243816B2 (en) 2013-03-13 2019-01-31 Bioasis Technologies Inc. Fragments of p97 and uses thereof
WO2015031673A2 (en) 2013-08-28 2015-03-05 Bioasis Technologies Inc. Cns-targeted conjugates having modified fc regions and methods of use thereof
CA3178867A1 (en) 2013-11-27 2015-06-04 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
CN104774161B (zh) * 2014-01-13 2017-08-25 成都福瑞康生物科技有限公司 多肽、蛋白质peg修饰剂合成方法
PL3359515T3 (pl) * 2015-10-07 2020-07-27 Elementis Specialties, Inc. Środek zwilżający i przeciwpieniący
ES2908470T3 (es) 2015-11-09 2022-04-29 Scherer Technologies Llc R P Conjugados de anticuerpo anti-CD22-maitansina y métodos de uso de los mismos
KR102247701B1 (ko) 2016-02-26 2021-05-03 한미정밀화학주식회사 폴리에틸렌글리콜 디알데히드 유도체의 제조방법
EP4183853B1 (en) 2016-04-15 2024-10-02 Beckman Coulter, Inc. Photoactive macromolecules and uses thereof
US11492493B2 (en) 2017-12-26 2022-11-08 Becton, Dickinson And Company Deep ultraviolet-excitable water-solvated polymeric dyes
CN119220109A (zh) 2018-03-30 2024-12-31 贝克顿·迪金森公司 含侧基发色团的水溶性聚合染料
CA3107332A1 (en) 2018-07-22 2020-01-30 Bioasis Technologies Inc. Treatment of lymphatic metastases
EP3950655B1 (en) * 2019-03-29 2023-11-15 NOF Corporation Method for producing hetero type monodisperse polyethylene glycol derivative
US20210355468A1 (en) 2020-05-18 2021-11-18 Bioasis Technologies, Inc. Compositions and methods for treating lewy body dementia
US20210393787A1 (en) 2020-06-17 2021-12-23 Bioasis Technologies, Inc. Compositions and methods for treating frontotemporal dementia
CN113583230A (zh) * 2021-06-30 2021-11-02 苏州欣影生物医药技术有限公司 一种peg双胺选择性反应制备异双官能团的方法
EP4155349A1 (en) 2021-09-24 2023-03-29 Becton, Dickinson and Company Water-soluble yellow green absorbing dyes
US20250383357A1 (en) 2022-07-01 2025-12-18 Beckman Coulter, Inc. Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
WO2024044327A1 (en) 2022-08-26 2024-02-29 Beckman Coulter, Inc. Dhnt monomers and polymer dyes with modified photophysical properties
CN115959992A (zh) * 2022-12-13 2023-04-14 武汉翱飞科技有限公司 一种单分子量聚乙二醇单乙酸的合成方法
WO2024196805A1 (en) 2023-03-17 2024-09-26 Beckman Coulter, Inc. Benzothienopyrrole cyanine dyes
WO2025064842A1 (en) 2023-09-21 2025-03-27 Beckman Coulter, Inc. Dihydrophenanthrene (dhp) bridged dyes for use in flow cytometry

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JP3871713B2 (ja) * 1995-05-10 2007-01-24 協和醗酵工業株式会社 新規毒素複合体
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
AU755051B2 (en) * 1998-01-07 2002-12-05 Debio Recherche Pharmaceutique S.A. Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom
ES2222689T3 (es) * 1998-03-12 2005-02-01 Nektar Therapeutics Al, Corporation Derivados del polietilenglicol con grupos reactivos proximales.

Also Published As

Publication number Publication date
HUP0203149A2 (en) 2002-12-28
WO2001026692A1 (en) 2001-04-19
NZ518143A (en) 2004-04-30
JP2003511422A (ja) 2003-03-25
CN1284603C (zh) 2006-11-15
CA2386762C (en) 2009-06-16
IL148890A (en) 2007-09-20
NO331781B1 (no) 2012-03-26
NO20021555D0 (no) 2002-04-02
CN1374875A (zh) 2002-10-16
JP4344110B2 (ja) 2009-10-14
EP1455839A1 (en) 2004-09-15
BR9917517A (pt) 2002-07-30
CY1114128T1 (el) 2016-07-27
HU228491B1 (en) 2013-03-28
NO20021555L (no) 2002-06-04
PT1455839E (pt) 2013-04-24
KR20020040841A (ko) 2002-05-30
KR100499655B1 (ko) 2005-07-07
EP1455839B1 (en) 2013-01-23
AU6423099A (en) 2001-04-23
DK1455839T3 (da) 2013-05-06
CA2386762A1 (en) 2001-04-19
ES2404685T3 (es) 2013-05-28
MXPA02003540A (es) 2003-09-12
AU781336B2 (en) 2005-05-19

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