CN1231481C - 制备噻唑烷－2,4－二酮衍生物的改进方法 - Google Patents

制备噻唑烷－2,4－二酮衍生物的改进方法 Download PDF

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Publication number
CN1231481C
CN1231481C CNB99811992XA CN99811992A CN1231481C CN 1231481 C CN1231481 C CN 1231481C CN B99811992X A CNB99811992X A CN B99811992XA CN 99811992 A CN99811992 A CN 99811992A CN 1231481 C CN1231481 C CN 1231481C
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CN
China
Prior art keywords
formula
method described
compound
reaction
thiazolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB99811992XA
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English (en)
Chinese (zh)
Other versions
CN1323305A (zh
Inventor
P·切比亚姆
R·K·普特拉帕里
C·B·R·加德
B·M·萨迪施
R·S·马米拉帕里
O·R·加达姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Reddys Research Foundation
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Dr Reddys Research Foundation
Dr Reddys Laboratories Ltd
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Publication of CN1323305A publication Critical patent/CN1323305A/zh
Application granted granted Critical
Publication of CN1231481C publication Critical patent/CN1231481C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CNB99811992XA 1998-09-14 1999-09-10 制备噻唑烷－2,4－二酮衍生物的改进方法 Expired - Fee Related CN1231481C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2060/MAS/98 1998-09-14
IN2060MA1998 IN187716B (enExample) 1998-09-14 1998-09-14
IN2060/MAS/1998 1998-09-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100826925A Division CN1295222C (zh) 1998-09-14 1999-09-10 制备噻唑烷－2,4－二酮衍生物的改进方法

Publications (2)

Publication Number Publication Date
CN1323305A CN1323305A (zh) 2001-11-21
CN1231481C true CN1231481C (zh) 2005-12-14

Family

ID=11096874

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB2004100826925A Expired - Fee Related CN1295222C (zh) 1998-09-14 1999-09-10 制备噻唑烷－2,4－二酮衍生物的改进方法
CNB99811992XA Expired - Fee Related CN1231481C (zh) 1998-09-14 1999-09-10 制备噻唑烷－2,4－二酮衍生物的改进方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNB2004100826925A Expired - Fee Related CN1295222C (zh) 1998-09-14 1999-09-10 制备噻唑烷－2,4－二酮衍生物的改进方法

Country Status (24)

Country Link
US (1) US6469167B1 (enExample)
EP (1) EP1114047B1 (enExample)
JP (2) JP2002524563A (enExample)
KR (1) KR100448179B1 (enExample)
CN (2) CN1295222C (enExample)
AT (1) ATE234834T1 (enExample)
AU (1) AU762353B2 (enExample)
BR (1) BR9914493A (enExample)
CA (1) CA2343883C (enExample)
CZ (1) CZ300933B6 (enExample)
DE (1) DE69906100T2 (enExample)
DK (1) DK1114047T3 (enExample)
ES (1) ES2195600T3 (enExample)
HU (1) HU229519B1 (enExample)
IL (1) IL141737A0 (enExample)
IN (2) IN187716B (enExample)
NO (1) NO317383B1 (enExample)
NZ (1) NZ510316A (enExample)
PL (1) PL195617B1 (enExample)
PT (1) PT1114047E (enExample)
RU (1) RU2223961C2 (enExample)
UA (1) UA70962C2 (enExample)
WO (1) WO2000015638A1 (enExample)
ZA (1) ZA200101699B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE531713T1 (de) * 2002-03-15 2011-11-15 Reddys Lab Ltd Dr Polymorphin von 5-ä4-ää3-methyl-4-oxo-3,4- dihydrochinazolin-2-ylümethoxyübenzylü thiazolidin-2,4-dion kalium salz
CN103288757B (zh) * 2013-05-16 2015-07-01 苏州明锐医药科技有限公司 6-氨基-7-羟基-3,4-二氢喹唑啉-4-酮的制备方法
KR101677340B1 (ko) 2014-11-28 2016-11-29 이청주 광고용 열기구
KR20160134615A (ko) 2016-11-11 2016-11-23 이청주 광고용 열기구
CN109867765A (zh) * 2019-02-28 2019-06-11 中山大学惠州研究院 一种长效缓释可降解防污聚氨酯及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB306228A (en) * 1927-12-15 1929-02-21 Bohn Aluminium & Brass Corp Improvements in pistons
EP0842925A1 (en) * 1987-09-04 1998-05-20 Beecham Group Plc Substituted thiazolidinedione derivatives
EP0454501B1 (en) * 1990-04-27 2001-09-05 Sankyo Company Limited Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides
DE69326736T2 (de) * 1992-08-31 2000-06-08 Sankyo Co., Ltd. Oxazolidin-Derivate mit Antidiabetika und Anti-Fettleibigkeit-Eigenschaften, ihre Herstellung und therapeutische Verwendung
FR2696743B1 (fr) * 1992-10-12 1994-12-23 Adir Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant.
TW399051B (en) * 1996-01-31 2000-07-21 Ssp Co Ltd A novel benzoazine thiazolidinedione derivative and pharmaceutical composition for reducing blood glucose
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5985884A (en) * 1996-07-01 1999-11-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
RU2200161C2 (ru) * 1996-12-31 2003-03-10 Др. Редди'З Рисерч Фаундейшн Новые производные азолидиндиона, способ их получения (варианты), фармацевтические композиции на их основе, способ предупреждения или лечения, способ снижения глюкозы и промежуточное соединение

Also Published As

Publication number Publication date
DK1114047T3 (da) 2003-06-23
IN189187B (enExample) 2003-01-04
HUP0103517A2 (hu) 2002-05-29
KR20010075088A (ko) 2001-08-09
NO20011265L (no) 2001-05-14
ES2195600T3 (es) 2003-12-01
JP2011144179A (ja) 2011-07-28
NZ510316A (en) 2002-11-26
CA2343883C (en) 2010-02-16
CN1616439A (zh) 2005-05-18
AU5439999A (en) 2000-04-03
NO20011265D0 (no) 2001-03-13
RU2223961C2 (ru) 2004-02-20
EP1114047B1 (en) 2003-03-19
JP2002524563A (ja) 2002-08-06
PL346532A1 (en) 2002-02-11
NO317383B1 (no) 2004-10-18
HK1077814A1 (en) 2006-02-24
EP1114047A1 (en) 2001-07-11
CA2343883A1 (en) 2000-03-23
WO2000015638A1 (en) 2000-03-23
ZA200101699B (en) 2002-05-28
UA70962C2 (uk) 2004-11-15
BR9914493A (pt) 2001-06-26
CN1323305A (zh) 2001-11-21
CZ300933B6 (cs) 2009-09-16
ATE234834T1 (de) 2003-04-15
AU762353B2 (en) 2003-06-26
DE69906100D1 (de) 2003-04-24
US6469167B1 (en) 2002-10-22
HU229519B1 (en) 2014-01-28
CN1295222C (zh) 2007-01-17
HUP0103517A3 (en) 2003-06-30
IN187716B (enExample) 2002-06-15
CZ2001825A3 (cs) 2001-08-15
KR100448179B1 (ko) 2004-09-10
PL195617B1 (pl) 2007-10-31
DE69906100T2 (de) 2003-12-11
IL141737A0 (en) 2002-03-10
PT1114047E (pt) 2003-07-31

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Owner name: REDDY LAB CO LTD

Free format text: FORMER OWNER: DR. LEI DI RESEARCH FOUNDATION

Effective date: 20030814

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Address after: Hyderabad

Applicant after: Dr. Reddy's Research Foundation

Address before: Hyderabad

Applicant before: Dr. Reddy's research Foundation

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20051214

Termination date: 20160910

CF01 Termination of patent right due to non-payment of annual fee