CA2343883C - An improved process for the preparation of thiazolidine-2,4-dione derivatives - Google Patents

An improved process for the preparation of thiazolidine-2,4-dione derivatives Download PDF

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Publication number
CA2343883C
CA2343883C CA2343883A CA2343883A CA2343883C CA 2343883 C CA2343883 C CA 2343883C CA 2343883 A CA2343883 A CA 2343883A CA 2343883 A CA2343883 A CA 2343883A CA 2343883 C CA2343883 C CA 2343883C
Authority
CA
Canada
Prior art keywords
formula
compound
reaction
dione
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2343883A
Other languages
English (en)
French (fr)
Other versions
CA2343883A1 (en
Inventor
Prabhakar Chebiyyam
Rajender Kumar Potlapally
Chinna Bakki Reddy Gade
Balaram Mahanti Satish
Ramabhadra Sarma Mamillapalli
Om Reddy Gaddam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Dr Reddys Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Reddys Laboratories Ltd filed Critical Dr Reddys Laboratories Ltd
Publication of CA2343883A1 publication Critical patent/CA2343883A1/en
Application granted granted Critical
Publication of CA2343883C publication Critical patent/CA2343883C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2343883A 1998-09-14 1999-09-10 An improved process for the preparation of thiazolidine-2,4-dione derivatives Expired - Lifetime CA2343883C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2060/MAS/98 1998-09-14
IN2060MA1998 IN187716B (enExample) 1998-09-14 1998-09-14
PCT/IB1999/001530 WO2000015638A1 (en) 1998-09-14 1999-09-10 An improved process for the preparation of thiazolidine-2,4-dione derivatives

Publications (2)

Publication Number Publication Date
CA2343883A1 CA2343883A1 (en) 2000-03-23
CA2343883C true CA2343883C (en) 2010-02-16

Family

ID=11096874

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2343883A Expired - Lifetime CA2343883C (en) 1998-09-14 1999-09-10 An improved process for the preparation of thiazolidine-2,4-dione derivatives

Country Status (24)

Country Link
US (1) US6469167B1 (enExample)
EP (1) EP1114047B1 (enExample)
JP (2) JP2002524563A (enExample)
KR (1) KR100448179B1 (enExample)
CN (2) CN1231481C (enExample)
AT (1) ATE234834T1 (enExample)
AU (1) AU762353B2 (enExample)
BR (1) BR9914493A (enExample)
CA (1) CA2343883C (enExample)
CZ (1) CZ300933B6 (enExample)
DE (1) DE69906100T2 (enExample)
DK (1) DK1114047T3 (enExample)
ES (1) ES2195600T3 (enExample)
HU (1) HU229519B1 (enExample)
IL (1) IL141737A0 (enExample)
IN (2) IN187716B (enExample)
NO (1) NO317383B1 (enExample)
NZ (1) NZ510316A (enExample)
PL (1) PL195617B1 (enExample)
PT (1) PT1114047E (enExample)
RU (1) RU2223961C2 (enExample)
UA (1) UA70962C2 (enExample)
WO (1) WO2000015638A1 (enExample)
ZA (1) ZA200101699B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8377950B2 (en) * 2002-03-15 2013-02-19 Dr. Reddy's Laboratories Limited Crystalline form of 5-[4-[[3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl]methoxy]benzyl]thiazolidine-2,4-dione potassium salt
CN103288757B (zh) * 2013-05-16 2015-07-01 苏州明锐医药科技有限公司 6-氨基-7-羟基-3,4-二氢喹唑啉-4-酮的制备方法
KR101677340B1 (ko) 2014-11-28 2016-11-29 이청주 광고용 열기구
KR20160134615A (ko) 2016-11-11 2016-11-23 이청주 광고용 열기구
CN109867765A (zh) * 2019-02-28 2019-06-11 中山大学惠州研究院 一种长效缓释可降解防污聚氨酯及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB306228A (en) * 1927-12-15 1929-02-21 Bohn Aluminium & Brass Corp Improvements in pistons
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
EP0454501B1 (en) * 1990-04-27 2001-09-05 Sankyo Company Limited Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides
ATE185564T1 (de) * 1992-08-31 1999-10-15 Sankyo Co Oxazolidin-derivate mit antidiabetika und anti- fettleibigkeit-eigenschaften, ihre herstellung und therapeutische verwendung
FR2696743B1 (fr) * 1992-10-12 1994-12-23 Adir Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant.
TW399051B (en) * 1996-01-31 2000-07-21 Ssp Co Ltd A novel benzoazine thiazolidinedione derivative and pharmaceutical composition for reducing blood glucose
WO1997041097A2 (en) * 1996-12-31 1997-11-06 Dr. Reddy's Research Foundation Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
AU744518B2 (en) * 1996-07-01 2002-02-28 Dr. Reddy's Laboratories Limited Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases

Also Published As

Publication number Publication date
CZ2001825A3 (cs) 2001-08-15
CZ300933B6 (cs) 2009-09-16
NO20011265L (no) 2001-05-14
CN1616439A (zh) 2005-05-18
CN1323305A (zh) 2001-11-21
PT1114047E (pt) 2003-07-31
DK1114047T3 (da) 2003-06-23
WO2000015638A1 (en) 2000-03-23
ZA200101699B (en) 2002-05-28
ATE234834T1 (de) 2003-04-15
US6469167B1 (en) 2002-10-22
DE69906100T2 (de) 2003-12-11
JP2011144179A (ja) 2011-07-28
RU2223961C2 (ru) 2004-02-20
NO317383B1 (no) 2004-10-18
JP2002524563A (ja) 2002-08-06
BR9914493A (pt) 2001-06-26
PL346532A1 (en) 2002-02-11
HU229519B1 (en) 2014-01-28
AU5439999A (en) 2000-04-03
CN1295222C (zh) 2007-01-17
HUP0103517A2 (hu) 2002-05-29
IN187716B (enExample) 2002-06-15
CN1231481C (zh) 2005-12-14
EP1114047A1 (en) 2001-07-11
NO20011265D0 (no) 2001-03-13
AU762353B2 (en) 2003-06-26
ES2195600T3 (es) 2003-12-01
NZ510316A (en) 2002-11-26
KR20010075088A (ko) 2001-08-09
IL141737A0 (en) 2002-03-10
CA2343883A1 (en) 2000-03-23
HK1077814A1 (en) 2006-02-24
PL195617B1 (pl) 2007-10-31
KR100448179B1 (ko) 2004-09-10
HUP0103517A3 (en) 2003-06-30
DE69906100D1 (de) 2003-04-24
EP1114047B1 (en) 2003-03-19
IN189187B (enExample) 2003-01-04
UA70962C2 (uk) 2004-11-15

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