CN1183128C - 作为抗血栓形成剂或抗凝血剂的n-(杂环)-苯-或吡啶磺酰胺 - Google Patents
作为抗血栓形成剂或抗凝血剂的n-(杂环)-苯-或吡啶磺酰胺 Download PDFInfo
- Publication number
- CN1183128C CN1183128C CNB018084974A CN01808497A CN1183128C CN 1183128 C CN1183128 C CN 1183128C CN B018084974 A CNB018084974 A CN B018084974A CN 01808497 A CN01808497 A CN 01808497A CN 1183128 C CN1183128 C CN 1183128C
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- CN
- China
- Prior art keywords
- amino
- alkyl
- carbonyl
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0003724A FR2806722B1 (fr) | 2000-03-23 | 2000-03-23 | Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique |
| FR00/03724 | 2000-03-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1426407A CN1426407A (zh) | 2003-06-25 |
| CN1183128C true CN1183128C (zh) | 2005-01-05 |
Family
ID=8848428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB018084974A Expired - Fee Related CN1183128C (zh) | 2000-03-23 | 2001-03-22 | 作为抗血栓形成剂或抗凝血剂的n-(杂环)-苯-或吡啶磺酰胺 |
Country Status (34)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4903385B2 (ja) | 2002-12-06 | 2012-03-28 | パーデュー・リサーチ・ファウンデーション | 損傷した哺乳類神経組織を治療するためのピリジン類 |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| WO2005102991A1 (ja) * | 2004-04-19 | 2005-11-03 | Daiso Co., Ltd. | 非天然型アミノ酸の製造方法およびその中間体 |
| US7750162B2 (en) | 2004-04-19 | 2010-07-06 | Daiso Co., Ltd. | Process for preparation of nonnatural amino acid and intermediate thereof |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| JP5492189B2 (ja) * | 2008-04-09 | 2014-05-14 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ１０アンタゴニストである２−スルホニルアミノ−４−ヘテロアリールブチロアミド |
| US8859814B2 (en) * | 2008-05-22 | 2014-10-14 | Boehringer Ingelheim International Gmbh | Alpha-substituted N-sulfonyl gylcine amides antagonists of CCR10, compositions containing the same and methods for using them |
| BR112012019042A8 (pt) * | 2010-01-28 | 2017-12-26 | The Medicines Company Leipzig Gmbh | compostos inibidores de serina protease tipo tripsina, seu uso, e seus processos de preparação |
| FR2981071B1 (fr) * | 2011-10-10 | 2014-02-07 | Centre Nat Rech Scient | Synthese versatile et stereospecifique d'acides amines gamma,delta-insatures par la reaction de wittig |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2727410B1 (fr) * | 1994-11-25 | 1996-12-20 | Synthelabo | Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese |
| FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
| FR2756285B1 (fr) * | 1996-11-22 | 1998-12-18 | Synthelabo | Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique |
| FR2756220B1 (fr) * | 1996-11-27 | 1998-12-24 | Lorraine Laminage | Roue pour vehicule terrestre a moteur |
| FR2771094B1 (fr) * | 1997-11-19 | 2000-02-04 | Synthelabo | Derives de piperidine-2-carboxylate, leur preparation et leur application en therapeutique |
-
2000
- 2000-03-23 FR FR0003724A patent/FR2806722B1/fr not_active Expired - Fee Related
-
2001
- 2001-03-22 KR KR1020027012432A patent/KR100791693B1/ko not_active Expired - Fee Related
- 2001-03-22 EP EP01919537A patent/EP1268469B1/fr not_active Expired - Lifetime
- 2001-03-22 SI SI200130152T patent/SI1268469T1/xx unknown
- 2001-03-22 SK SK1351-2002A patent/SK286687B6/sk not_active IP Right Cessation
- 2001-03-22 ME MEP-174/08A patent/MEP17408A/xx unknown
- 2001-03-22 HU HU0300695A patent/HUP0300695A2/hu unknown
- 2001-03-22 DK DK01919537T patent/DK1268469T3/da active
- 2001-03-22 CA CA002401637A patent/CA2401637C/en not_active Expired - Fee Related
- 2001-03-22 EE EEP200200540A patent/EE05084B1/xx not_active IP Right Cessation
- 2001-03-22 TW TW090106733A patent/TWI290141B/zh active
- 2001-03-22 EA EA200200838A patent/EA004986B1/ru not_active IP Right Cessation
- 2001-03-22 PT PT01919537T patent/PT1268469E/pt unknown
- 2001-03-22 AU AU4661701A patent/AU4661701A/xx active Pending
- 2001-03-22 DE DE60103868T patent/DE60103868T2/de not_active Expired - Lifetime
- 2001-03-22 PL PL364988A patent/PL204660B1/pl not_active IP Right Cessation
- 2001-03-22 BR BR0109385-1A patent/BR0109385A/pt not_active Application Discontinuation
- 2001-03-22 AU AU2001246617A patent/AU2001246617B2/en not_active Ceased
- 2001-03-22 AR ARP010101337A patent/AR029900A1/es active IP Right Grant
- 2001-03-22 TR TR2004/02343T patent/TR200402343T4/xx unknown
- 2001-03-22 AT AT01919537T patent/ATE269325T1/de active
- 2001-03-22 IL IL15161901A patent/IL151619A0/xx unknown
- 2001-03-22 HR HR20020762A patent/HRP20020762B1/xx not_active IP Right Cessation
- 2001-03-22 UA UA2002097272A patent/UA71667C2/uk unknown
- 2001-03-22 JP JP2001568937A patent/JP2003528098A/ja not_active Ceased
- 2001-03-22 RS YUP-670/02A patent/RS50370B/sr unknown
- 2001-03-22 ES ES01919537T patent/ES2222358T3/es not_active Expired - Lifetime
- 2001-03-22 CN CNB018084974A patent/CN1183128C/zh not_active Expired - Fee Related
- 2001-03-22 MX MXPA02009276A patent/MXPA02009276A/es active IP Right Grant
- 2001-03-22 WO PCT/FR2001/000861 patent/WO2001070736A1/fr not_active Ceased
- 2001-03-22 US US10/221,404 patent/US6680329B2/en not_active Expired - Fee Related
-
2002
- 2002-08-30 ZA ZA200206996A patent/ZA200206996B/en unknown
- 2002-08-30 IS IS6535A patent/IS2304B/is unknown
- 2002-09-04 IL IL151619A patent/IL151619A/en not_active IP Right Cessation
- 2002-09-19 NO NO20024496A patent/NO324835B1/no not_active IP Right Cessation
- 2002-09-20 BG BG107130A patent/BG65863B1/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: SANOFI - AVENTIS Free format text: FORMER NAME OR ADDRESS: ST. SANOFI - SYNTHELABO CORPORATION |
|
| CP03 | Change of name, title or address |
Address after: France Patentee after: Sanofi-Aventis Address before: France Patentee before: Sanofi-Synthelabo |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050105 Termination date: 20120322 |