HUP0300695A2 - Antitrombotikus és antikoaguláns hatású N-heterociklusos benzol- vagy piridin-szulfonsavamidok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents
Antitrombotikus és antikoaguláns hatású N-heterociklusos benzol- vagy piridin-szulfonsavamidok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0300695A2 HUP0300695A2 HU0300695A HUP0300695A HUP0300695A2 HU P0300695 A2 HUP0300695 A2 HU P0300695A2 HU 0300695 A HU0300695 A HU 0300695A HU P0300695 A HUP0300695 A HU P0300695A HU P0300695 A2 HUP0300695 A2 HU P0300695A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- optionally substituted
- general formula
- preparation
- sulphonamides
- Prior art date
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 3
- 239000003146 anticoagulant agent Substances 0.000 title 2
- 230000002785 anti-thrombosis Effects 0.000 title 1
- 229940127219 anticoagulant drug Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DWJMBQYORXLGAE-UHFFFAOYSA-N pyridine-2-sulfonamide Chemical class NS(=O)(=O)C1=CC=CC=N1 DWJMBQYORXLGAE-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 hexahydro-1H-azepinyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000005943 1,2,3,6-tetrahydropyridyl group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000005936 piperidyl group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A találmány (I) általános képletű vegyületekre, a képletben Xjelentése =CR4- általános képletű csoport vagy nitrogénatom, Wjelentése -(CH2)2-, -(CH2)3-, -CH2-C=C- vagy -CH2-CH=CH- csoport, R2jelentése adott esetben helyettesített piperidil-, 1,2,3,6-tetrahidropiridil- vagy hexahidro-1H-azepinilcsoport,heptahidroazocin-l-il- vagy oktahidro-1H-azonin-1-alcsoport, egy (b)általános képletű csoport, a képletben a-b jelentése -CONR' általánosképletű csoport, m értéke 1 vagy 2, p értéke 1 vagy 2 és R' jelentésehidrogénatom vagy alkilcsoport, vagy adott esetben helyettesítettamino- vagy piperazinilcsoport, vagy rnorfolinilcsoport, R4 jelentésehalogén- vagy hidrogénatom, R3 jelentése alkil- vagy -COR1 általánosképletű csoport, ahol R1 jelentése hidrogénatom vagy adott esetbenhelyettesített alkil-, szulfonil-, karbamoil- vagyaminoszulfonilcsoport, A jelentése adott esetben helyettesített fenil-vagy heterociklusos csoport, és B jelentése adott esetbenhelyettesített nitrogéntartalmú heterociklusos vagy fenilcsoport, avegyületek előállítására és a vegyületeket tartalmazó gyógyászatikészítményekre vonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0003724A FR2806722B1 (fr) | 2000-03-23 | 2000-03-23 | Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique |
| PCT/FR2001/000861 WO2001070736A1 (fr) | 2000-03-23 | 2001-03-22 | N-(heterocyclyl)benzene-ou pyridine sulfonamides comme agents antithrombotiques et anticoagulantes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0300695A2 true HUP0300695A2 (hu) | 2003-07-28 |
Family
ID=8848428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0300695A HUP0300695A2 (hu) | 2000-03-23 | 2001-03-22 | Antitrombotikus és antikoaguláns hatású N-heterociklusos benzol- vagy piridin-szulfonsavamidok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6680329B2 (hu) |
| EP (1) | EP1268469B1 (hu) |
| JP (1) | JP2003528098A (hu) |
| KR (1) | KR100791693B1 (hu) |
| CN (1) | CN1183128C (hu) |
| AR (1) | AR029900A1 (hu) |
| AT (1) | ATE269325T1 (hu) |
| AU (2) | AU4661701A (hu) |
| BG (1) | BG65863B1 (hu) |
| BR (1) | BR0109385A (hu) |
| CA (1) | CA2401637C (hu) |
| DE (1) | DE60103868T2 (hu) |
| DK (1) | DK1268469T3 (hu) |
| EA (1) | EA004986B1 (hu) |
| EE (1) | EE05084B1 (hu) |
| ES (1) | ES2222358T3 (hu) |
| FR (1) | FR2806722B1 (hu) |
| HK (1) | HK1051537A1 (hu) |
| HR (1) | HRP20020762B1 (hu) |
| HU (1) | HUP0300695A2 (hu) |
| IL (2) | IL151619A0 (hu) |
| IS (1) | IS2304B (hu) |
| ME (1) | MEP17408A (hu) |
| MX (1) | MXPA02009276A (hu) |
| NO (1) | NO324835B1 (hu) |
| PL (1) | PL204660B1 (hu) |
| PT (1) | PT1268469E (hu) |
| RS (1) | RS50370B (hu) |
| SI (1) | SI1268469T1 (hu) |
| SK (1) | SK286687B6 (hu) |
| TR (1) | TR200402343T4 (hu) |
| TW (1) | TWI290141B (hu) |
| UA (1) | UA71667C2 (hu) |
| WO (1) | WO2001070736A1 (hu) |
| ZA (1) | ZA200206996B (hu) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE443699T1 (de) * | 2002-12-06 | 2009-10-15 | Purdue Research Foundation | Pyridine zur behandlung von verletztemsäugetiernervengewebe |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| WO2005102991A1 (ja) * | 2004-04-19 | 2005-11-03 | Daiso Co., Ltd. | 非天然型アミノ酸の製造方法およびその中間体 |
| US7750162B2 (en) | 2004-04-19 | 2010-07-06 | Daiso Co., Ltd. | Process for preparation of nonnatural amino acid and intermediate thereof |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| US8586748B2 (en) * | 2008-04-09 | 2013-11-19 | Boehringer Ingelheim International Gmbh | 2-sulfonylamino-4-heteroaryl butyramide antagonists of CCR10 |
| CA2725140A1 (en) * | 2008-05-22 | 2009-11-26 | Boehringer Ingelheim International Gmbh | Alpha-substituted n-sulfonyl gylcine amides antagonists of ccr10, compositions containing the same and methods for using them |
| CA2788417C (en) * | 2010-01-28 | 2017-02-14 | The Medicines Company (Leipzig) Gmbh | Trypsin-like serine protease inhibitors, and their preparation and use |
| FR2981071B1 (fr) * | 2011-10-10 | 2014-02-07 | Centre Nat Rech Scient | Synthese versatile et stereospecifique d'acides amines gamma,delta-insatures par la reaction de wittig |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2727410B1 (fr) * | 1994-11-25 | 1996-12-20 | Synthelabo | Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese |
| FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
| FR2756285B1 (fr) * | 1996-11-22 | 1998-12-18 | Synthelabo | Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique |
| FR2756220B1 (fr) * | 1996-11-27 | 1998-12-24 | Lorraine Laminage | Roue pour vehicule terrestre a moteur |
| FR2771094B1 (fr) * | 1997-11-19 | 2000-02-04 | Synthelabo | Derives de piperidine-2-carboxylate, leur preparation et leur application en therapeutique |
-
2000
- 2000-03-23 FR FR0003724A patent/FR2806722B1/fr not_active Expired - Fee Related
-
2001
- 2001-03-22 WO PCT/FR2001/000861 patent/WO2001070736A1/fr active IP Right Grant
- 2001-03-22 AU AU4661701A patent/AU4661701A/xx active Pending
- 2001-03-22 IL IL15161901A patent/IL151619A0/xx unknown
- 2001-03-22 SK SK1351-2002A patent/SK286687B6/sk not_active IP Right Cessation
- 2001-03-22 AR ARP010101337A patent/AR029900A1/es active IP Right Grant
- 2001-03-22 PL PL364988A patent/PL204660B1/pl not_active IP Right Cessation
- 2001-03-22 TW TW090106733A patent/TWI290141B/zh active
- 2001-03-22 EE EEP200200540A patent/EE05084B1/xx not_active IP Right Cessation
- 2001-03-22 AU AU2001246617A patent/AU2001246617B2/en not_active Ceased
- 2001-03-22 MX MXPA02009276A patent/MXPA02009276A/es active IP Right Grant
- 2001-03-22 TR TR2004/02343T patent/TR200402343T4/xx unknown
- 2001-03-22 BR BR0109385-1A patent/BR0109385A/pt not_active Application Discontinuation
- 2001-03-22 DE DE60103868T patent/DE60103868T2/de not_active Expired - Lifetime
- 2001-03-22 EA EA200200838A patent/EA004986B1/ru not_active IP Right Cessation
- 2001-03-22 KR KR1020027012432A patent/KR100791693B1/ko not_active IP Right Cessation
- 2001-03-22 RS YUP-670/02A patent/RS50370B/sr unknown
- 2001-03-22 CA CA002401637A patent/CA2401637C/en not_active Expired - Fee Related
- 2001-03-22 PT PT01919537T patent/PT1268469E/pt unknown
- 2001-03-22 DK DK01919537T patent/DK1268469T3/da active
- 2001-03-22 ME MEP-174/08A patent/MEP17408A/xx unknown
- 2001-03-22 SI SI200130152T patent/SI1268469T1/xx unknown
- 2001-03-22 AT AT01919537T patent/ATE269325T1/de active
- 2001-03-22 CN CNB018084974A patent/CN1183128C/zh not_active Expired - Fee Related
- 2001-03-22 HU HU0300695A patent/HUP0300695A2/hu unknown
- 2001-03-22 EP EP01919537A patent/EP1268469B1/fr not_active Expired - Lifetime
- 2001-03-22 ES ES01919537T patent/ES2222358T3/es not_active Expired - Lifetime
- 2001-03-22 JP JP2001568937A patent/JP2003528098A/ja not_active Ceased
- 2001-03-22 UA UA2002097272A patent/UA71667C2/uk unknown
- 2001-03-22 US US10/221,404 patent/US6680329B2/en not_active Expired - Fee Related
-
2002
- 2002-08-30 ZA ZA200206996A patent/ZA200206996B/en unknown
- 2002-08-30 IS IS6535A patent/IS2304B/is unknown
- 2002-09-04 IL IL151619A patent/IL151619A/en not_active IP Right Cessation
- 2002-09-19 HR HR20020762A patent/HRP20020762B1/xx not_active IP Right Cessation
- 2002-09-19 NO NO20024496A patent/NO324835B1/no not_active IP Right Cessation
- 2002-09-20 BG BG107130A patent/BG65863B1/bg unknown
-
2003
- 2003-05-27 HK HK03103771A patent/HK1051537A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |