EA200200838A1 - N-(гетероциклил)бензол- или пиридинсульфонамиды в качестве антитромботических агентов и антикоагулянтов - Google Patents
N-(гетероциклил)бензол- или пиридинсульфонамиды в качестве антитромботических агентов и антикоагулянтовInfo
- Publication number
- EA200200838A1 EA200200838A1 EA200200838A EA200200838A EA200200838A1 EA 200200838 A1 EA200200838 A1 EA 200200838A1 EA 200200838 A EA200200838 A EA 200200838A EA 200200838 A EA200200838 A EA 200200838A EA 200200838 A1 EA200200838 A1 EA 200200838A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- substituted
- possibly substituted
- pyridinsulphonamides
- anticoagulants
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Изобретение относится к соединениям формулы (I), где W может представлять собой группу -(СН)-, -(CH)-C≡C- или -СН-СН=СН-; Rможет, в частности, представлять собой группу пиперидинил, группу 1,2,3,6-тетрагидропиридинил, возможно замещенную, группу гексагидро-1H-азепинил, группу пиперазинил, возможно замещенную, или группу морфолинил; Rможет представлять собой группу -COR; А может, в частности, представлять собой группу фенил, возможно замещенную, группу гетероцикл или циклопентил и В может, в частности, представлять собой группу пиридил, группу аминопиразинил, группу аминопиридазинил, группу пиримидинил, возможно замещенную аминогруппой, группу пиперидинил или группу аминопиридинил, возможно замещенную по пиридину группой (С-С)алкил или (С-С)алкокси, причем аминогруппа может быть замещена группой (С-С)алкил. Изобретение также относится к получению указанных соединений и к их терапевтическому применению.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0003724A FR2806722B1 (fr) | 2000-03-23 | 2000-03-23 | Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique |
| PCT/FR2001/000861 WO2001070736A1 (fr) | 2000-03-23 | 2001-03-22 | N-(heterocyclyl)benzene-ou pyridine sulfonamides comme agents antithrombotiques et anticoagulantes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200200838A1 true EA200200838A1 (ru) | 2003-04-24 |
| EA004986B1 EA004986B1 (ru) | 2004-10-28 |
Family
ID=8848428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200200838A EA004986B1 (ru) | 2000-03-23 | 2001-03-22 | N-(гетероциклил)бензол- или пиридинсульфонамиды в качестве антитромботических агентов и антикоагулянтов |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US6680329B2 (ru) |
| EP (1) | EP1268469B1 (ru) |
| JP (1) | JP2003528098A (ru) |
| KR (1) | KR100791693B1 (ru) |
| CN (1) | CN1183128C (ru) |
| AR (1) | AR029900A1 (ru) |
| AT (1) | ATE269325T1 (ru) |
| AU (2) | AU4661701A (ru) |
| BG (1) | BG65863B1 (ru) |
| BR (1) | BR0109385A (ru) |
| CA (1) | CA2401637C (ru) |
| DE (1) | DE60103868T2 (ru) |
| DK (1) | DK1268469T3 (ru) |
| EA (1) | EA004986B1 (ru) |
| EE (1) | EE05084B1 (ru) |
| ES (1) | ES2222358T3 (ru) |
| FR (1) | FR2806722B1 (ru) |
| HK (1) | HK1051537A1 (ru) |
| HR (1) | HRP20020762B1 (ru) |
| HU (1) | HUP0300695A2 (ru) |
| IL (2) | IL151619A0 (ru) |
| IS (1) | IS2304B (ru) |
| ME (1) | MEP17408A (ru) |
| MX (1) | MXPA02009276A (ru) |
| NO (1) | NO324835B1 (ru) |
| PL (1) | PL204660B1 (ru) |
| PT (1) | PT1268469E (ru) |
| RS (1) | RS50370B (ru) |
| SI (1) | SI1268469T1 (ru) |
| SK (1) | SK286687B6 (ru) |
| TR (1) | TR200402343T4 (ru) |
| TW (1) | TWI290141B (ru) |
| UA (1) | UA71667C2 (ru) |
| WO (1) | WO2001070736A1 (ru) |
| ZA (1) | ZA200206996B (ru) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE443699T1 (de) * | 2002-12-06 | 2009-10-15 | Purdue Research Foundation | Pyridine zur behandlung von verletztemsäugetiernervengewebe |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| WO2005102991A1 (ja) * | 2004-04-19 | 2005-11-03 | Daiso Co., Ltd. | 非天然型アミノ酸の製造方法およびその中間体 |
| US7750162B2 (en) | 2004-04-19 | 2010-07-06 | Daiso Co., Ltd. | Process for preparation of nonnatural amino acid and intermediate thereof |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| US8586748B2 (en) * | 2008-04-09 | 2013-11-19 | Boehringer Ingelheim International Gmbh | 2-sulfonylamino-4-heteroaryl butyramide antagonists of CCR10 |
| CA2725140A1 (en) * | 2008-05-22 | 2009-11-26 | Boehringer Ingelheim International Gmbh | Alpha-substituted n-sulfonyl gylcine amides antagonists of ccr10, compositions containing the same and methods for using them |
| CA2788417C (en) * | 2010-01-28 | 2017-02-14 | The Medicines Company (Leipzig) Gmbh | Trypsin-like serine protease inhibitors, and their preparation and use |
| FR2981071B1 (fr) * | 2011-10-10 | 2014-02-07 | Centre Nat Rech Scient | Synthese versatile et stereospecifique d'acides amines gamma,delta-insatures par la reaction de wittig |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2727410B1 (fr) * | 1994-11-25 | 1996-12-20 | Synthelabo | Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese |
| FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
| FR2756285B1 (fr) * | 1996-11-22 | 1998-12-18 | Synthelabo | Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique |
| FR2756220B1 (fr) * | 1996-11-27 | 1998-12-24 | Lorraine Laminage | Roue pour vehicule terrestre a moteur |
| FR2771094B1 (fr) * | 1997-11-19 | 2000-02-04 | Synthelabo | Derives de piperidine-2-carboxylate, leur preparation et leur application en therapeutique |
-
2000
- 2000-03-23 FR FR0003724A patent/FR2806722B1/fr not_active Expired - Fee Related
-
2001
- 2001-03-22 WO PCT/FR2001/000861 patent/WO2001070736A1/fr active IP Right Grant
- 2001-03-22 AU AU4661701A patent/AU4661701A/xx active Pending
- 2001-03-22 IL IL15161901A patent/IL151619A0/xx unknown
- 2001-03-22 SK SK1351-2002A patent/SK286687B6/sk not_active IP Right Cessation
- 2001-03-22 AR ARP010101337A patent/AR029900A1/es active IP Right Grant
- 2001-03-22 PL PL364988A patent/PL204660B1/pl not_active IP Right Cessation
- 2001-03-22 TW TW090106733A patent/TWI290141B/zh active
- 2001-03-22 EE EEP200200540A patent/EE05084B1/xx not_active IP Right Cessation
- 2001-03-22 AU AU2001246617A patent/AU2001246617B2/en not_active Ceased
- 2001-03-22 MX MXPA02009276A patent/MXPA02009276A/es active IP Right Grant
- 2001-03-22 TR TR2004/02343T patent/TR200402343T4/xx unknown
- 2001-03-22 BR BR0109385-1A patent/BR0109385A/pt not_active Application Discontinuation
- 2001-03-22 DE DE60103868T patent/DE60103868T2/de not_active Expired - Lifetime
- 2001-03-22 EA EA200200838A patent/EA004986B1/ru not_active IP Right Cessation
- 2001-03-22 KR KR1020027012432A patent/KR100791693B1/ko not_active IP Right Cessation
- 2001-03-22 RS YUP-670/02A patent/RS50370B/sr unknown
- 2001-03-22 CA CA002401637A patent/CA2401637C/en not_active Expired - Fee Related
- 2001-03-22 PT PT01919537T patent/PT1268469E/pt unknown
- 2001-03-22 DK DK01919537T patent/DK1268469T3/da active
- 2001-03-22 ME MEP-174/08A patent/MEP17408A/xx unknown
- 2001-03-22 SI SI200130152T patent/SI1268469T1/xx unknown
- 2001-03-22 AT AT01919537T patent/ATE269325T1/de active
- 2001-03-22 CN CNB018084974A patent/CN1183128C/zh not_active Expired - Fee Related
- 2001-03-22 HU HU0300695A patent/HUP0300695A2/hu unknown
- 2001-03-22 EP EP01919537A patent/EP1268469B1/fr not_active Expired - Lifetime
- 2001-03-22 ES ES01919537T patent/ES2222358T3/es not_active Expired - Lifetime
- 2001-03-22 JP JP2001568937A patent/JP2003528098A/ja not_active Ceased
- 2001-03-22 UA UA2002097272A patent/UA71667C2/ru unknown
- 2001-03-22 US US10/221,404 patent/US6680329B2/en not_active Expired - Fee Related
-
2002
- 2002-08-30 ZA ZA200206996A patent/ZA200206996B/en unknown
- 2002-08-30 IS IS6535A patent/IS2304B/is unknown
- 2002-09-04 IL IL151619A patent/IL151619A/en not_active IP Right Cessation
- 2002-09-19 HR HR20020762A patent/HRP20020762B1/xx not_active IP Right Cessation
- 2002-09-19 NO NO20024496A patent/NO324835B1/no not_active IP Right Cessation
- 2002-09-20 BG BG107130A patent/BG65863B1/bg unknown
-
2003
- 2003-05-27 HK HK03103771A patent/HK1051537A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC4A | Change in name of a patent proprietor in a eurasian patent |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY KZ KG RU |