BR0109385A - N-(heterociclil) benzeno - ou piridina sulfonamidas como agentes antitrombóticos e anticoagulantes - Google Patents

N-(heterociclil) benzeno - ou piridina sulfonamidas como agentes antitrombóticos e anticoagulantes

Info

Publication number
BR0109385A
BR0109385A BR0109385-1A BR0109385A BR0109385A BR 0109385 A BR0109385 A BR 0109385A BR 0109385 A BR0109385 A BR 0109385A BR 0109385 A BR0109385 A BR 0109385A
Authority
BR
Brazil
Prior art keywords
group
optionally substituted
represent
pyridine
anticoagulant agents
Prior art date
Application number
BR0109385-1A
Other languages
English (en)
Inventor
Jean-Michel Altenburger
Gerard Cremer
Gilbert Lassalle
Mostafa Matrougui
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of BR0109385A publication Critical patent/BR0109385A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

"N-(HETREOCICLIL) BENZENO - OU PIRIDINA SULFONAMIDAS COMO AGENTES ANTITROMBóTICOS E ANTICOAGULANTES". Compostos de fórmula (I), na qual: W pode representar um grupo -(CH~ 2~)~ 2~-, -(CH~ 2~)~ 3~-, -CH~ 2~-C=C-, OU CH~ 2~-CH=CH-, R~ 2~ pode notadamente representar um grupo piperidinila, um grupo 1,2,3,6-tetrahidropiridinila eventualmente substituído, um grupo hexahidro-1H-azepinila, um grupo piperazinila eventualmente substituído ou um grupo amorfolinila, R~ 3~ pode notadamente representar um grupo -COR~ 1~, A pode notadamente representar um grupo fenila eventualmente substituído, um heterociclo ou um grupo ciciopentila e B pode notadamente representar um grupo piridila, um grupo aminopirazinila, um grupo aminopiridazinila, um grupo pirimidinila eventualmente substituído por um grupo amino, um grupo piperidinila ou um grupo aminopiridinila eventualmente substituído sobre a piridina por um grupo (C~ 1~-C~ 4~)aquila ou (C~ 1~-C~ 4~)alcóxi, o grupo amino podendo eventualmente também ser substituído por um grupo (C~ 1~-C~ 4~)alquila, seu preparo e sua aplicação em terapêutica.
BR0109385-1A 2000-03-23 2001-03-22 N-(heterociclil) benzeno - ou piridina sulfonamidas como agentes antitrombóticos e anticoagulantes BR0109385A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0003724A FR2806722B1 (fr) 2000-03-23 2000-03-23 Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique
PCT/FR2001/000861 WO2001070736A1 (fr) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene-ou pyridine sulfonamides comme agents antithrombotiques et anticoagulantes

Publications (1)

Publication Number Publication Date
BR0109385A true BR0109385A (pt) 2003-06-03

Family

ID=8848428

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109385-1A BR0109385A (pt) 2000-03-23 2001-03-22 N-(heterociclil) benzeno - ou piridina sulfonamidas como agentes antitrombóticos e anticoagulantes

Country Status (35)

Country Link
US (1) US6680329B2 (pt)
EP (1) EP1268469B1 (pt)
JP (1) JP2003528098A (pt)
KR (1) KR100791693B1 (pt)
CN (1) CN1183128C (pt)
AR (1) AR029900A1 (pt)
AT (1) ATE269325T1 (pt)
AU (2) AU2001246617B2 (pt)
BG (1) BG65863B1 (pt)
BR (1) BR0109385A (pt)
CA (1) CA2401637C (pt)
DE (1) DE60103868T2 (pt)
DK (1) DK1268469T3 (pt)
EA (1) EA004986B1 (pt)
EE (1) EE05084B1 (pt)
ES (1) ES2222358T3 (pt)
FR (1) FR2806722B1 (pt)
HK (1) HK1051537A1 (pt)
HR (1) HRP20020762B1 (pt)
HU (1) HUP0300695A2 (pt)
IL (2) IL151619A0 (pt)
IS (1) IS2304B (pt)
ME (1) MEP17408A (pt)
MX (1) MXPA02009276A (pt)
NO (1) NO324835B1 (pt)
PL (1) PL204660B1 (pt)
PT (1) PT1268469E (pt)
RS (1) RS50370B (pt)
SI (1) SI1268469T1 (pt)
SK (1) SK286687B6 (pt)
TR (1) TR200402343T4 (pt)
TW (1) TWI290141B (pt)
UA (1) UA71667C2 (pt)
WO (1) WO2001070736A1 (pt)
ZA (1) ZA200206996B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
DE60329415D1 (de) * 2002-12-06 2009-11-05 Purdue Research Foundation Pyridine zur behandlung von verletztemsäugetiernervengewebe
US7750162B2 (en) 2004-04-19 2010-07-06 Daiso Co., Ltd. Process for preparation of nonnatural amino acid and intermediate thereof
EP1739077A4 (en) * 2004-04-19 2008-04-16 Daiso Co Ltd PROCESS FOR THE PRODUCTION OF NON-NATURAL AMINO ACIDS AND INTERMEDIATES THEREFOR
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
US8586748B2 (en) * 2008-04-09 2013-11-19 Boehringer Ingelheim International Gmbh 2-sulfonylamino-4-heteroaryl butyramide antagonists of CCR10
EP2294051B1 (en) * 2008-05-22 2014-08-13 Boehringer Ingelheim International GmbH Alpha-substituted n-sulfonyl gylcine amides antagonists of ccr10, compositions containing the same and methods for using them
ES2569983T3 (es) * 2010-01-28 2016-05-13 The Medicines Company (Leipzig) Gmbh Inhibidores de serinproteasa de tipo tripsina y su preparación y uso
FR2981071B1 (fr) * 2011-10-10 2014-02-07 Centre Nat Rech Scient Synthese versatile et stereospecifique d'acides amines gamma,delta-insatures par la reaction de wittig

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2727410B1 (fr) * 1994-11-25 1996-12-20 Synthelabo Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese
FR2728570B1 (fr) * 1994-12-23 1997-04-11 Synthelabo Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique
FR2756285B1 (fr) * 1996-11-22 1998-12-18 Synthelabo Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique
FR2756220B1 (fr) * 1996-11-27 1998-12-24 Lorraine Laminage Roue pour vehicule terrestre a moteur
FR2771094B1 (fr) * 1997-11-19 2000-02-04 Synthelabo Derives de piperidine-2-carboxylate, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
JP2003528098A (ja) 2003-09-24
EE200200540A (et) 2004-04-15
ES2222358T3 (es) 2005-02-01
MEP17408A (en) 2010-06-10
HUP0300695A2 (hu) 2003-07-28
WO2001070736A1 (fr) 2001-09-27
EA004986B1 (ru) 2004-10-28
IL151619A0 (en) 2003-04-10
YU67002A (sh) 2005-07-19
AR029900A1 (es) 2003-07-23
IL151619A (en) 2009-05-04
EP1268469A1 (fr) 2003-01-02
TR200402343T4 (tr) 2004-12-21
PL364988A1 (en) 2004-12-27
NO20024496D0 (no) 2002-09-19
PL204660B1 (pl) 2010-01-29
FR2806722B1 (fr) 2002-05-17
US20030207920A1 (en) 2003-11-06
UA71667C2 (uk) 2004-12-15
CA2401637A1 (en) 2001-09-27
ATE269325T1 (de) 2004-07-15
BG65863B1 (bg) 2010-03-31
EP1268469B1 (fr) 2004-06-16
US6680329B2 (en) 2004-01-20
PT1268469E (pt) 2004-10-29
IS6535A (is) 2002-08-30
SK286687B6 (sk) 2009-03-05
HRP20020762A2 (en) 2003-12-31
KR20020081476A (ko) 2002-10-26
FR2806722A1 (fr) 2001-09-28
HK1051537A1 (en) 2003-08-08
HRP20020762B1 (en) 2005-02-28
NO324835B1 (no) 2007-12-17
DK1268469T3 (da) 2004-10-11
DE60103868D1 (de) 2004-07-22
DE60103868T2 (de) 2005-06-09
ZA200206996B (en) 2003-09-01
AU2001246617B2 (en) 2006-03-02
MXPA02009276A (es) 2003-05-23
EA200200838A1 (ru) 2003-04-24
AU4661701A (en) 2001-10-03
CN1426407A (zh) 2003-06-25
TWI290141B (en) 2007-11-21
SI1268469T1 (en) 2004-10-31
CN1183128C (zh) 2005-01-05
IS2304B (is) 2007-10-15
BG107130A (bg) 2003-06-30
SK13512002A3 (sk) 2003-03-04
RS50370B (sr) 2009-11-10
EE05084B1 (et) 2008-10-15
KR100791693B1 (ko) 2008-01-03
CA2401637C (en) 2009-11-10
NO20024496L (no) 2002-11-22

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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