FR2806722B1 - Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique - Google Patents

Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique

Info

Publication number
FR2806722B1
FR2806722B1 FR0003724A FR0003724A FR2806722B1 FR 2806722 B1 FR2806722 B1 FR 2806722B1 FR 0003724 A FR0003724 A FR 0003724A FR 0003724 A FR0003724 A FR 0003724A FR 2806722 B1 FR2806722 B1 FR 2806722B1
Authority
FR
France
Prior art keywords
heterocyclylbutyl
benzene
preparation
therapeutic application
sulfonamide derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0003724A
Other languages
English (en)
French (fr)
Other versions
FR2806722A1 (fr
Inventor
Jean Michel Altenburger
Gerard Cremer
Gilbert Lassalle
Mostafa Matrougui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0003724A priority Critical patent/FR2806722B1/fr
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Priority to EA200200838A priority patent/EA004986B1/ru
Priority to DE60103868T priority patent/DE60103868T2/de
Priority to PL364988A priority patent/PL204660B1/pl
Priority to IL15161901A priority patent/IL151619A0/xx
Priority to HK03103771.6A priority patent/HK1051537B/xx
Priority to ES01919537T priority patent/ES2222358T3/es
Priority to DK01919537T priority patent/DK1268469T3/da
Priority to HR20020762A priority patent/HRP20020762B1/xx
Priority to TW090106733A priority patent/TWI290141B/zh
Priority to MXPA02009276A priority patent/MXPA02009276A/es
Priority to UA2002097272A priority patent/UA71667C2/uk
Priority to HU0300695A priority patent/HUP0300695A2/hu
Priority to EEP200200540A priority patent/EE05084B1/xx
Priority to CA002401637A priority patent/CA2401637C/en
Priority to PT01919537T priority patent/PT1268469E/pt
Priority to AU2001246617A priority patent/AU2001246617B2/en
Priority to US10/221,404 priority patent/US6680329B2/en
Priority to TR2004/02343T priority patent/TR200402343T4/xx
Priority to KR1020027012432A priority patent/KR100791693B1/ko
Priority to ARP010101337A priority patent/AR029900A1/es
Priority to MEP-174/08A priority patent/MEP17408A/xx
Priority to SK1351-2002A priority patent/SK286687B6/sk
Priority to AT01919537T priority patent/ATE269325T1/de
Priority to AU4661701A priority patent/AU4661701A/xx
Priority to EP01919537A priority patent/EP1268469B1/fr
Priority to CNB018084974A priority patent/CN1183128C/zh
Priority to JP2001568937A priority patent/JP2003528098A/ja
Priority to YUP-670/02A priority patent/RS50370B/sr
Priority to BR0109385-1A priority patent/BR0109385A/pt
Priority to SI200130152T priority patent/SI1268469T1/xx
Priority to PCT/FR2001/000861 priority patent/WO2001070736A1/fr
Publication of FR2806722A1 publication Critical patent/FR2806722A1/fr
Application granted granted Critical
Publication of FR2806722B1 publication Critical patent/FR2806722B1/fr
Priority to IS6535A priority patent/IS2304B/is
Priority to ZA200206996A priority patent/ZA200206996B/en
Priority to IL151619A priority patent/IL151619A/en
Priority to NO20024496A priority patent/NO324835B1/no
Priority to BG107130A priority patent/BG65863B1/bg
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FR0003724A 2000-03-23 2000-03-23 Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique Expired - Fee Related FR2806722B1 (fr)

Priority Applications (37)

Application Number Priority Date Filing Date Title
FR0003724A FR2806722B1 (fr) 2000-03-23 2000-03-23 Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique
MEP-174/08A MEP17408A (en) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene or pyridine sulphonamides as antithrombotic agents and anticoagulants
PL364988A PL204660B1 (pl) 2000-03-23 2001-03-22 N-(heterocyklilo)benzeno- lub pirydynosulfonoamidy, sposób ich wytwarzania, związki pośrednie i środek farmaceutyczny
IL15161901A IL151619A0 (en) 2000-03-23 2001-03-22 N-(heterocyclyl) benzene or pyridine sulphonamides as antithrombotic agents and anticoagulants
HK03103771.6A HK1051537B (en) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene or pyridine sulphonamides as antithrombotic agents and anticoagulants
ES01919537T ES2222358T3 (es) 2000-03-23 2001-03-22 Derivados n-(heterociclil)benceno- o piridinasulfonamina.
DK01919537T DK1268469T3 (da) 2000-03-23 2001-03-22 N-(heterocyklyl)-benzen- eller -pyridin-sulfonamider som antitrombotiske midler og antikoagulationsmidler
HR20020762A HRP20020762B1 (en) 2000-03-23 2001-03-22 N-(heterocyklyl)benzene or pyridine sulphonamides as antithrombotic agens and anticoagulants
TW090106733A TWI290141B (en) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene-or-pyridinesulphonamides derivatives, their preparation and their therapeutic application
MXPA02009276A MXPA02009276A (es) 2000-03-23 2001-03-22 N-(heterociclil) bencen o piridin sulfonamidas como agentes antitromboticos y anticoagulantes.
UA2002097272A UA71667C2 (uk) 2000-03-23 2001-03-22 N-(гетероцикліл)бензол- або -піридинсульфонаміди як антитромботичні та антикоагуляційні засоби
HU0300695A HUP0300695A2 (hu) 2000-03-23 2001-03-22 Antitrombotikus és antikoaguláns hatású N-heterociklusos benzol- vagy piridin-szulfonsavamidok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
EEP200200540A EE05084B1 (et) 2000-03-23 2001-03-22 N-(heterotskll)benseen- v?i -pridiinsulfoonamiidid kui tromboosi- ja hbimisvastased ained
CA002401637A CA2401637C (en) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene- or - pyridinesulphonamides as antithrombotic and anticoagulant agents
PT01919537T PT1268469E (pt) 2000-03-23 2001-03-22 N-(heterociclil)benzeno ou piridino-sulfonamidas como agentes anti-tromboticos eanti-coagulantes
AU2001246617A AU2001246617B2 (en) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene or pyridine sulphonamides as antithrombotic agents and anticoagulants
US10/221,404 US6680329B2 (en) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene or pyridinesulphonamides as antithrombotic agents and anticoagulants
TR2004/02343T TR200402343T4 (tr) 2000-03-23 2001-03-22 Antitrombotik ve antikoagulant etken olarak kullanım için N-(Heterosiklil) benzen veya piridin sulfonamit
EA200200838A EA004986B1 (ru) 2000-03-23 2001-03-22 N-(гетероциклил)бензол- или пиридинсульфонамиды в качестве антитромботических агентов и антикоагулянтов
ARP010101337A AR029900A1 (es) 2000-03-23 2001-03-22 Compuestos derivados de n-(heterociclil)benceno- o piridinsulfonamida, procedimiento para su preparacion y medicamento y composicion farmaceutica que los contienen
AT01919537T ATE269325T1 (de) 2000-03-23 2001-03-22 N-heterocyclyl-benzen oder -pyridin-sulfonamide zur verwendung als anti-thrombogene und antikoagulierende verbindungen
DE60103868T DE60103868T2 (de) 2000-03-23 2001-03-22 N-heterocyclyl-benzen oder -pyridin-sulfonamide zur verwendung als anti-thrombogene und antikoagulierende verbindungen
SK1351-2002A SK286687B6 (sk) 2000-03-23 2001-03-22 Sulfónamidy, spôsob ich výroby, medziprodukty, liečivo a farmaceutická kompozícia s ich obsahom
AU4661701A AU4661701A (en) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene or pyridine sulphonamides as antithrombotic agents and anticoagulants
EP01919537A EP1268469B1 (fr) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene-ou pyridine sulfonamides comme agents antithrombotiques et anticoagulants
CNB018084974A CN1183128C (zh) 2000-03-23 2001-03-22 作为抗血栓形成剂或抗凝血剂的n-(杂环)-苯-或吡啶磺酰胺
JP2001568937A JP2003528098A (ja) 2000-03-23 2001-03-22 抗血栓症薬および抗凝血薬としてのｎ−（ヘテロ環式）ベンゼン−または−ピリジンスルホンアミド
YUP-670/02A RS50370B (sr) 2000-03-23 2001-03-22 N-(heterociklil)benzen-ili-piridinsulfonamidi kao antitrombički i antikoagulirajući agensi
BR0109385-1A BR0109385A (pt) 2000-03-23 2001-03-22 N-(heterociclil) benzeno - ou piridina sulfonamidas como agentes antitrombóticos e anticoagulantes
SI200130152T SI1268469T1 (en) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene or pyridine sulphonamides as antithrombotic agents and anticoagulants
PCT/FR2001/000861 WO2001070736A1 (fr) 2000-03-23 2001-03-22 N-(heterocyclyl)benzene-ou pyridine sulfonamides comme agents antithrombotiques et anticoagulantes
KR1020027012432A KR100791693B1 (ko) 2000-03-23 2001-03-22 항혈전제 및 항응고제로서의 ｎ-(헤테로시클릴)벤젠 또는피리딘 술폰아미드
IS6535A IS2304B (is) 2000-03-23 2002-08-30 N-(heterósýklýl)bensen eða pýridín súlfónamíð semandsegamyndunarmiðlar og segavarnarlyf
ZA200206996A ZA200206996B (en) 2000-03-23 2002-08-30 N-(heterocyclyl)benzene or pyridine sulphonamides as antithrombotic agents and anticoagulants.
IL151619A IL151619A (en) 2000-03-23 2002-09-04 N - (Tirocyclil) Gasoline or pyridine sulfonamides, processes for their preparation in their pharmaceutical preparations
NO20024496A NO324835B1 (no) 2000-03-23 2002-09-19 N-(heterocyklyl)benzen- eller pyridinsulfonamider, fremgangsmate for fremstilling derav samt medisinsk produkt og farmasoytisk preparat inneholdende minst en av forbindelsene.
BG107130A BG65863B1 (bg) 2000-03-23 2002-09-20 N-(хетероциклил) бензенови или пиридинови сулфонамиди като антитромбозни средства и антикоагуланти

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0003724A FR2806722B1 (fr) 2000-03-23 2000-03-23 Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2806722A1 FR2806722A1 (fr) 2001-09-28
FR2806722B1 true FR2806722B1 (fr) 2002-05-17

Family

ID=8848428

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0003724A Expired - Fee Related FR2806722B1 (fr) 2000-03-23 2000-03-23 Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique

Country Status (34)

Country Link
US (1) US6680329B2 (enExample)
EP (1) EP1268469B1 (enExample)
JP (1) JP2003528098A (enExample)
KR (1) KR100791693B1 (enExample)
CN (1) CN1183128C (enExample)
AR (1) AR029900A1 (enExample)
AT (1) ATE269325T1 (enExample)
AU (2) AU2001246617B2 (enExample)
BG (1) BG65863B1 (enExample)
BR (1) BR0109385A (enExample)
CA (1) CA2401637C (enExample)
DE (1) DE60103868T2 (enExample)
DK (1) DK1268469T3 (enExample)
EA (1) EA004986B1 (enExample)
EE (1) EE05084B1 (enExample)
ES (1) ES2222358T3 (enExample)
FR (1) FR2806722B1 (enExample)
HR (1) HRP20020762B1 (enExample)
HU (1) HUP0300695A2 (enExample)
IL (2) IL151619A0 (enExample)
IS (1) IS2304B (enExample)
ME (1) MEP17408A (enExample)
MX (1) MXPA02009276A (enExample)
NO (1) NO324835B1 (enExample)
PL (1) PL204660B1 (enExample)
PT (1) PT1268469E (enExample)
RS (1) RS50370B (enExample)
SI (1) SI1268469T1 (enExample)
SK (1) SK286687B6 (enExample)
TR (1) TR200402343T4 (enExample)
TW (1) TWI290141B (enExample)
UA (1) UA71667C2 (enExample)
WO (1) WO2001070736A1 (enExample)
ZA (1) ZA200206996B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2508165C (en) 2002-12-06 2014-05-06 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
US8729107B2 (en) * 2002-12-06 2014-05-20 Purdue Research Foundation Pyridines for treating injured mammalian nerve tissue
US7750162B2 (en) 2004-04-19 2010-07-06 Daiso Co., Ltd. Process for preparation of nonnatural amino acid and intermediate thereof
WO2005102991A1 (ja) * 2004-04-19 2005-11-03 Daiso Co., Ltd. 非天然型アミノ酸の製造方法およびその中間体
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
US8586748B2 (en) * 2008-04-09 2013-11-19 Boehringer Ingelheim International Gmbh 2-sulfonylamino-4-heteroaryl butyramide antagonists of CCR10
JP2011522801A (ja) * 2008-05-22 2011-08-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ＣＣＲ１０のα−置換Ｎ−スルホニルグリシン（ＧＹＬＣＩＮＥ）アミドアンタゴニスト、それらを含有する組成物およびそれらを使用するための方法
WO2011094496A2 (en) * 2010-01-28 2011-08-04 The Medicines Company Trypsin-like serine protease inhibitors, and their preparation and use
FR2981071B1 (fr) * 2011-10-10 2014-02-07 Centre Nat Rech Scient Synthese versatile et stereospecifique d'acides amines gamma,delta-insatures par la reaction de wittig

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2727410B1 (fr) * 1994-11-25 1996-12-20 Synthelabo Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese
FR2728570B1 (fr) * 1994-12-23 1997-04-11 Synthelabo Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique
FR2756285B1 (fr) * 1996-11-22 1998-12-18 Synthelabo Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique
FR2756220B1 (fr) * 1996-11-27 1998-12-24 Lorraine Laminage Roue pour vehicule terrestre a moteur
FR2771094B1 (fr) * 1997-11-19 2000-02-04 Synthelabo Derives de piperidine-2-carboxylate, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
ZA200206996B (en) 2003-09-01
IL151619A (en) 2009-05-04
SK286687B6 (sk) 2009-03-05
YU67002A (sh) 2005-07-19
HRP20020762A2 (en) 2003-12-31
AU4661701A (en) 2001-10-03
TR200402343T4 (tr) 2004-12-21
CN1183128C (zh) 2005-01-05
PL364988A1 (en) 2004-12-27
HK1051537A1 (en) 2003-08-08
DK1268469T3 (da) 2004-10-11
BR0109385A (pt) 2003-06-03
UA71667C2 (uk) 2004-12-15
ATE269325T1 (de) 2004-07-15
KR20020081476A (ko) 2002-10-26
PL204660B1 (pl) 2010-01-29
IL151619A0 (en) 2003-04-10
EP1268469B1 (fr) 2004-06-16
IS2304B (is) 2007-10-15
TWI290141B (en) 2007-11-21
EA004986B1 (ru) 2004-10-28
CA2401637C (en) 2009-11-10
WO2001070736A1 (fr) 2001-09-27
CN1426407A (zh) 2003-06-25
FR2806722A1 (fr) 2001-09-28
BG107130A (bg) 2003-06-30
NO20024496D0 (no) 2002-09-19
SK13512002A3 (sk) 2003-03-04
AU2001246617B2 (en) 2006-03-02
NO324835B1 (no) 2007-12-17
EA200200838A1 (ru) 2003-04-24
MXPA02009276A (es) 2003-05-23
RS50370B (sr) 2009-11-10
DE60103868D1 (de) 2004-07-22
DE60103868T2 (de) 2005-06-09
EP1268469A1 (fr) 2003-01-02
MEP17408A (en) 2010-06-10
ES2222358T3 (es) 2005-02-01
AR029900A1 (es) 2003-07-23
IS6535A (is) 2002-08-30
BG65863B1 (bg) 2010-03-31
HRP20020762B1 (en) 2005-02-28
EE200200540A (et) 2004-04-15
NO20024496L (no) 2002-11-22
JP2003528098A (ja) 2003-09-24
KR100791693B1 (ko) 2008-01-03
US20030207920A1 (en) 2003-11-06
SI1268469T1 (en) 2004-10-31
US6680329B2 (en) 2004-01-20
HUP0300695A2 (hu) 2003-07-28
PT1268469E (pt) 2004-10-29
EE05084B1 (et) 2008-10-15
CA2401637A1 (en) 2001-09-27

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