FR2860792B1 - Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique - Google Patents

Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique

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Publication number
FR2860792B1
FR2860792B1 FR0311861A FR0311861A FR2860792B1 FR 2860792 B1 FR2860792 B1 FR 2860792B1 FR 0311861 A FR0311861 A FR 0311861A FR 0311861 A FR0311861 A FR 0311861A FR 2860792 B1 FR2860792 B1 FR 2860792B1
Authority
FR
France
Prior art keywords
thiophene
preparation
therapeutic use
carboxamide derivatives
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0311861A
Other languages
English (en)
Other versions
FR2860792A1 (fr
Inventor
Francis Barth
Carmona Murielle Rinaldi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Priority to FR0311861A priority Critical patent/FR2860792B1/fr
Priority to ARP040103632A priority patent/AR046056A1/es
Priority to JP2006530423A priority patent/JP2007508279A/ja
Priority to TW093130467A priority patent/TW200526647A/zh
Priority to EP04791498A priority patent/EP1678159A2/fr
Priority to PCT/FR2004/002546 priority patent/WO2005035488A2/fr
Publication of FR2860792A1 publication Critical patent/FR2860792A1/fr
Application granted granted Critical
Publication of FR2860792B1 publication Critical patent/FR2860792B1/fr
Priority to US11/400,702 priority patent/US7462631B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
FR0311861A 2003-10-10 2003-10-10 Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique Expired - Fee Related FR2860792B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0311861A FR2860792B1 (fr) 2003-10-10 2003-10-10 Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique
ARP040103632A AR046056A1 (es) 2003-10-10 2004-10-07 Derivados de tiofeno-2-carboxamida y su uso como antagonistas de los receptores canabinoides cb1
TW093130467A TW200526647A (en) 2003-10-10 2004-10-08 Thiophene-2-carboxamide derivatives, their preparation and their therapeutic application
EP04791498A EP1678159A2 (fr) 2003-10-10 2004-10-08 Derives de thiophene-2-carboxamide et leurs utilisation comme antagonistes des recepteurs cb1 des cannabinoides
JP2006530423A JP2007508279A (ja) 2003-10-10 2004-10-08 チオフェン−２−カルボキサミド誘導体、それらの製造、および治療適用
PCT/FR2004/002546 WO2005035488A2 (fr) 2003-10-10 2004-10-08 Derives de thiophene-2-carboxamide et leurs utilisation comme antagonistes des recepteurs cb1 des cannabinoides
US11/400,702 US7462631B2 (en) 2003-10-10 2006-04-07 Thiophene-2-carboxamide derivatives, preparation and therapeutic application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0311861A FR2860792B1 (fr) 2003-10-10 2003-10-10 Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2860792A1 FR2860792A1 (fr) 2005-04-15
FR2860792B1 true FR2860792B1 (fr) 2006-02-24

Family

ID=34355379

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0311861A Expired - Fee Related FR2860792B1 (fr) 2003-10-10 2003-10-10 Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique

Country Status (7)

Country Link
US (1) US7462631B2 (fr)
EP (1) EP1678159A2 (fr)
JP (1) JP2007508279A (fr)
AR (1) AR046056A1 (fr)
FR (1) FR2860792B1 (fr)
TW (1) TW200526647A (fr)
WO (1) WO2005035488A2 (fr)

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Publication number Priority date Publication date Assignee Title
FR2880023B1 (fr) * 2004-12-23 2007-02-23 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique
FR2880890B1 (fr) * 2005-01-19 2007-03-30 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique
FR2881744B1 (fr) 2005-02-09 2007-04-27 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
DE102008015032A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte Pyrazolamide und ihre Verwendung
DE102008015033A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
FR2934594B1 (fr) * 2008-08-01 2010-09-10 Sanofi Aventis Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique.
DE102008062863A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062878A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung
FR2943672B1 (fr) * 2009-03-27 2011-03-25 Sanofi Aventis Derives de 3-alcoxy-4,5-diarylthiophene-2-carboxamide,leur preparation et leur application en therapeutique.
MX2019004214A (es) * 2016-10-12 2019-06-10 Res Triangle Inst Agonistas heterociclicos del receptor de apelina (apj) y usos de los mismos.
US11306067B2 (en) 2018-03-05 2022-04-19 Denovamed Inc. Diphenyl substituted thiophene-2-amide derivatives and pharmaceutical compositions thereof useful as antimicrobial

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JPH0753716B2 (ja) * 1986-07-02 1995-06-07 吉富製薬株式会社 イミダゾ−ルカルボキサミド誘導体
GB9012936D0 (en) * 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
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AU2002319627A1 (en) * 2001-07-20 2003-03-03 Merck And Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
EP1412347B1 (fr) * 2001-08-01 2006-01-11 Basell Polyolefine GmbH Procede de preparation de derives heterocycliques de pentalene
WO2003037886A2 (fr) * 2001-10-30 2003-05-08 Pharmacia Corporation Derives de carboxamide heteroaromatique destines au traitement des inflammations
AR038966A1 (es) * 2002-03-18 2005-02-02 Solvay Pharm Bv Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial de cb1

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US7462631B2 (en) 2008-12-09
US20060264470A1 (en) 2006-11-23
JP2007508279A (ja) 2007-04-05
FR2860792A1 (fr) 2005-04-15
TW200526647A (en) 2005-08-16
WO2005035488A3 (fr) 2005-06-23
EP1678159A2 (fr) 2006-07-12
AR046056A1 (es) 2005-11-23

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