FR2880890B1 - Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique - Google Patents

Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique

Info

Publication number
FR2880890B1
FR2880890B1 FR0500570A FR0500570A FR2880890B1 FR 2880890 B1 FR2880890 B1 FR 2880890B1 FR 0500570 A FR0500570 A FR 0500570A FR 0500570 A FR0500570 A FR 0500570A FR 2880890 B1 FR2880890 B1 FR 2880890B1
Authority
FR
France
Prior art keywords
thienyl
diphenyl
methyl
preparation
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0500570A
Other languages
English (en)
Other versions
FR2880890A1 (fr
Inventor
Francis Barth
Christian Congy
Jean Philippe Ducoux
Carmona Murielle Rinaldi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Aventis France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35197793&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2880890(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis France filed Critical Sanofi Aventis France
Priority to FR0500570A priority Critical patent/FR2880890B1/fr
Priority to ARP060100142A priority patent/AR053116A1/es
Priority to EP06709122A priority patent/EP1841754A1/fr
Priority to UY29338A priority patent/UY29338A1/es
Priority to KR1020077018890A priority patent/KR20070107048A/ko
Priority to PCT/FR2006/000115 priority patent/WO2006077320A1/fr
Priority to CNA2006800049789A priority patent/CN101119985A/zh
Priority to BRPI0606450-7A priority patent/BRPI0606450A2/pt
Priority to CA002595045A priority patent/CA2595045A1/fr
Priority to JP2007551704A priority patent/JP2008527026A/ja
Priority to TW095101890A priority patent/TW200637838A/zh
Priority to MX2007008792A priority patent/MX2007008792A/es
Priority to AU2006207382A priority patent/AU2006207382A1/en
Priority to RU2007131275/04A priority patent/RU2007131275A/ru
Publication of FR2880890A1 publication Critical patent/FR2880890A1/fr
Publication of FR2880890B1 publication Critical patent/FR2880890B1/fr
Application granted granted Critical
Priority to IL184487A priority patent/IL184487A0/en
Priority to US11/775,557 priority patent/US7589120B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR0500570A 2005-01-19 2005-01-19 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique Expired - Fee Related FR2880890B1 (fr)

Priority Applications (16)

Application Number Priority Date Filing Date Title
FR0500570A FR2880890B1 (fr) 2005-01-19 2005-01-19 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique
ARP060100142A AR053116A1 (es) 2005-01-19 2006-01-13 Derivados de la n-(( 4,5-difenil-2- tienil)metil)sulfonamida,su preparacion y su aplicacion en terapeutica
CA002595045A CA2595045A1 (fr) 2005-01-19 2006-01-18 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique
MX2007008792A MX2007008792A (es) 2005-01-19 2006-01-18 Derivados de la n-[(4,5-difenil-2-tienil)metil]sulfonamida, su preparacion y su aplicacion terapeutica.
KR1020077018890A KR20070107048A (ko) 2005-01-19 2006-01-18 Ｎ―［（4,5―디페닐―2―티에닐）메틸］술폰아미드유도체, 그의 제조 방법 및 그의 치료 용도
PCT/FR2006/000115 WO2006077320A1 (fr) 2005-01-19 2006-01-18 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique
CNA2006800049789A CN101119985A (zh) 2005-01-19 2006-01-18 N-[(4,5-二苯基-2-噻吩基)甲基]磺酰胺衍生物、它们的制备与在治疗上的用途
BRPI0606450-7A BRPI0606450A2 (pt) 2005-01-19 2006-01-18 derivados de n-[(4,5-difenil-2-tienil)metil]sulfonamida, o respectivo preparo e a respectiva aplicação em terapêutica
EP06709122A EP1841754A1 (fr) 2005-01-19 2006-01-18 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique
JP2007551704A JP2008527026A (ja) 2005-01-19 2006-01-18 Ｎ−［（４，５−ジフェニル−２−チエニル）メチル］スルホンアミド誘導体、これらの調製およびこれらの治療的使用
TW095101890A TW200637838A (en) 2005-01-19 2006-01-18 N-[(4,5-diphenyl-2-thienyl)methyl]sulphonamide derivatives, their preparation and their application in therapeutics
UY29338A UY29338A1 (es) 2005-01-19 2006-01-18 Derivados de la n-((4,5-difenil-2-tienil)metil)sulfonamida, su preparación y su aplicación en terapéutica
AU2006207382A AU2006207382A1 (en) 2005-01-19 2006-01-18 N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application
RU2007131275/04A RU2007131275A (ru) 2005-01-19 2006-01-18 Производные n-[(4, 5-дифенил-2-тиенил)метил]сульфонамида, их получение и их применение в терапии
IL184487A IL184487A0 (en) 2005-01-19 2007-07-08 N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application
US11/775,557 US7589120B2 (en) 2005-01-19 2007-07-10 N-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide derivatives, preparation thereof and their therapeutic application

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0500570A FR2880890B1 (fr) 2005-01-19 2005-01-19 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2880890A1 FR2880890A1 (fr) 2006-07-21
FR2880890B1 true FR2880890B1 (fr) 2007-03-30

Family

ID=35197793

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0500570A Expired - Fee Related FR2880890B1 (fr) 2005-01-19 2005-01-19 Derives de n-[(4,5-diphenyl-2-thienyl)methyl]sulfonamide, leur preparation et leur application en therapeutique

Country Status (16)

Country Link
US (1) US7589120B2 (fr)
EP (1) EP1841754A1 (fr)
JP (1) JP2008527026A (fr)
KR (1) KR20070107048A (fr)
CN (1) CN101119985A (fr)
AR (1) AR053116A1 (fr)
AU (1) AU2006207382A1 (fr)
BR (1) BRPI0606450A2 (fr)
CA (1) CA2595045A1 (fr)
FR (1) FR2880890B1 (fr)
IL (1) IL184487A0 (fr)
MX (1) MX2007008792A (fr)
RU (1) RU2007131275A (fr)
TW (1) TW200637838A (fr)
UY (1) UY29338A1 (fr)
WO (1) WO2006077320A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2881744B1 (fr) * 2005-02-09 2007-04-27 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique
FR2894579B1 (fr) * 2005-12-12 2008-01-18 Sanofi Aventis Sa Derives diaryltriazolmethylamine, leur preparation et leur application en therapeutique.
CA2794054C (fr) 2008-01-08 2014-11-25 Purdue Pharma L.P. Analogues de la proline comme ligands pour les recepteurs des cannabinoides pour le traitement de la douleur
FR2934594B1 (fr) * 2008-08-01 2010-09-10 Sanofi Aventis Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique.

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302461A (en) * 1979-08-09 1981-11-24 E. I. Du Pont De Nemours And Company Antiinflammatory 5-substituted-2,3-diarylthiophenes
EP0055471A1 (fr) * 1980-12-29 1982-07-07 E.I. Du Pont De Nemours And Company 4,5-Diaryl-alpha,alpha-bis-(polyhalométhyl)-2-thiophène-méthan-amines anti-inflammatoires
JPS57134479A (en) * 1980-12-29 1982-08-19 Du Pont Antiinflammatory 4,5-diaryl-alpha,alpha- bis(polyhalomethyl)-2-thiophene methane amines
US4381311A (en) * 1980-12-29 1983-04-26 E. I. Du Pont De Nemours And Company Antiinflammatory 4,5-diaryl-α-(polyhalomethyl)-2-thiophenemethanols
US4432974A (en) * 1982-03-04 1984-02-21 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes
GB9012936D0 (en) * 1990-06-11 1990-08-01 Fujisawa Pharmaceutical Co Thiophene derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
AU2002319627A1 (en) * 2001-07-20 2003-03-03 Merck And Co., Inc. Substituted imidazoles as cannabinoid receptor modulators
AR038966A1 (es) * 2002-03-18 2005-02-02 Solvay Pharm Bv Derivados de tiazol que tienen actividad antagonista, agonista o agonista parcial de cb1
FR2860792B1 (fr) * 2003-10-10 2006-02-24 Sanofi Synthelabo Derives de thiophene-2-carboxamide, leur preparation et leur application en therapeutique
FR2864958B1 (fr) * 2004-01-12 2006-02-24 Sanofi Synthelabo Derive de n-[(1,5-diphenyl-1h-pyrazol-3-yl)methyl] sulfonamide, leur preparation et leur application en therapeutique.
FR2880023B1 (fr) * 2004-12-23 2007-02-23 Sanofi Aventis Sa Derives de n-[(4,5-diphenyl-3-alkyl-2-thienyl) methyl] amine leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
CN101119985A (zh) 2008-02-06
US20070287744A1 (en) 2007-12-13
JP2008527026A (ja) 2008-07-24
US7589120B2 (en) 2009-09-15
CA2595045A1 (fr) 2006-07-27
TW200637838A (en) 2006-11-01
BRPI0606450A2 (pt) 2009-06-30
RU2007131275A (ru) 2009-02-27
AR053116A1 (es) 2007-04-25
KR20070107048A (ko) 2007-11-06
EP1841754A1 (fr) 2007-10-10
MX2007008792A (es) 2007-09-11
WO2006077320A1 (fr) 2006-07-27
AU2006207382A1 (en) 2006-07-27
FR2880890A1 (fr) 2006-07-21
IL184487A0 (en) 2007-10-31
UY29338A1 (es) 2006-08-31

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Effective date: 20120928