CN1179748C - 冻干形式的稳定的药用组合物 - Google Patents

冻干形式的稳定的药用组合物 Download PDF

Info

Publication number
CN1179748C
CN1179748C CNB008012164A CN00801216A CN1179748C CN 1179748 C CN1179748 C CN 1179748C CN B008012164 A CNB008012164 A CN B008012164A CN 00801216 A CN00801216 A CN 00801216A CN 1179748 C CN1179748 C CN 1179748C
Authority
CN
China
Prior art keywords
substituted
group
compound
pharmaceutical composition
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB008012164A
Other languages
English (en)
Chinese (zh)
Other versions
CN1315865A (zh
Inventor
泽居清治
笠井昭宏
大友和三
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=16210881&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1179748(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of CN1315865A publication Critical patent/CN1315865A/zh
Application granted granted Critical
Publication of CN1179748C publication Critical patent/CN1179748C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB008012164A 1999-07-01 2000-06-29 冻干形式的稳定的药用组合物 Expired - Lifetime CN1179748C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18771399 1999-07-01
JP187713/1999 1999-07-01

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100880760A Division CN100352495C (zh) 1999-07-01 2000-06-29 冻干形式的稳定的药用组合物

Publications (2)

Publication Number Publication Date
CN1315865A CN1315865A (zh) 2001-10-03
CN1179748C true CN1179748C (zh) 2004-12-15

Family

ID=16210881

Family Applications (2)

Application Number Title Priority Date Filing Date
CNB008012164A Expired - Lifetime CN1179748C (zh) 1999-07-01 2000-06-29 冻干形式的稳定的药用组合物
CNB2004100880760A Expired - Lifetime CN100352495C (zh) 1999-07-01 2000-06-29 冻干形式的稳定的药用组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB2004100880760A Expired - Lifetime CN100352495C (zh) 1999-07-01 2000-06-29 冻干形式的稳定的药用组合物

Country Status (28)

Country Link
US (2) US6774104B1 (https=)
EP (1) EP1107777B1 (https=)
JP (2) JP3381722B2 (https=)
KR (1) KR100454784B1 (https=)
CN (2) CN1179748C (https=)
AR (1) AR024634A1 (https=)
AT (1) ATE280583T1 (https=)
AU (1) AU752265B2 (https=)
BR (2) BR0006823A (https=)
CA (1) CA2341568C (https=)
CZ (1) CZ295720B6 (https=)
DE (1) DE60015279T2 (https=)
ES (1) ES2225161T3 (https=)
HK (1) HK1040057B (https=)
HU (1) HU229089B1 (https=)
ID (1) ID29468A (https=)
IL (2) IL141455A0 (https=)
MX (1) MXPA01000601A (https=)
NO (1) NO330353B1 (https=)
NZ (1) NZ510290A (https=)
OA (1) OA11601A (https=)
PL (1) PL200141B1 (https=)
PT (1) PT1107777E (https=)
RU (1) RU2251411C2 (https=)
TR (1) TR200100609T1 (https=)
TW (1) TWI233805B (https=)
WO (1) WO2001002002A1 (https=)
ZA (1) ZA200101589B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980827B2 (en) 2011-01-31 2015-03-17 Shanghai Techwell Biopharmaceutical Co., Ltd. Medicinal composition containing echinocandin antifungal agent micafungin and preparation method and use thereof

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
ITMI20021040A1 (it) * 2002-05-16 2003-11-17 Novuspharma Spa Composizioni farmaceutiche iniettabili di un derivato antracenedionico ad attivita' antitumorale
ATE528003T1 (de) 2002-07-31 2011-10-15 Senju Pharma Co Wässrige, flüssigkeitszubereitungen und lichtstabilisierte wässrige flüssigkeitszubereitungen
US8877168B1 (en) 2002-07-31 2014-11-04 Senju Pharmaceuticals Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
US7119061B2 (en) * 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
US20060074014A1 (en) * 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
AU2003299561A1 (en) * 2002-11-18 2004-06-15 Vicuron Pharmaceuticals Inc. Compositions and methods for treating bacterial infections with protein-dalbavancin complexes
US7612066B2 (en) 2004-03-04 2009-11-03 Eisai R&D Management Co., Ltd. Composition containing benzamidine derivative and method for stabilizing benzamidine derivative
JP2007538046A (ja) * 2004-05-19 2007-12-27 ノイロサーチ アクティーゼルスカブ 新規なアザビシクロアリール誘導体
WO2006053383A1 (en) * 2004-11-22 2006-05-26 Anadis Ltd Bioactive compositions
KR101307999B1 (ko) 2004-12-01 2013-09-12 니폰 조키 세야쿠 가부시키가이샤 건조물 및 그 제조방법
WO2007010995A1 (ja) * 2005-07-20 2007-01-25 Kyowa Medex Co., Ltd. 生体試料中のペプチドの安定化方法
CN1962852B (zh) * 2006-11-27 2011-11-09 西北农林科技大学 红景天多糖在制备抗冻剂中的新用途及其产品和制备方法
CN102614492B (zh) * 2011-01-31 2013-12-11 上海天伟生物制药有限公司 一种含有棘白菌素类抗真菌剂米卡芬净的液体药用组合物
NZ702063A (en) * 2012-05-22 2016-11-25 Paion Uk Ltd Compositions comprising short-acting benzodiazepines
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US9320740B2 (en) 2013-03-15 2016-04-26 Merck Sharp & Dohme Corp. Ceftolozane-tazobactam pharmaceutical compositions
CN110279698B (zh) 2013-03-15 2022-10-28 默沙东有限责任公司 头孢特咯瓒抗生素组合物
CN103330933B (zh) * 2013-04-26 2015-08-05 江苏豪森药业股份有限公司 含有米卡芬净或其盐的药物组合物
CN103330932B (zh) * 2013-04-26 2015-12-23 江苏豪森药业股份有限公司 一种米卡芬净或其盐的药物组合物
ES2978920T3 (es) * 2013-06-05 2024-09-23 Univ British Columbia Compuestos antifibrogénicos, métodos y usos de los mismos
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
KR101611349B1 (ko) 2014-04-14 2016-04-12 신우철 안정성이 개선된 밀크씨슬 엑스의 제형
EP3150621A4 (en) * 2014-05-29 2017-12-27 Shanghai Techwell Biopharmaceutical Co., Ltd Composition of cyclic peptide compound, preparation method for same, and uses thereof
MY190283A (en) * 2014-12-05 2022-04-12 Meiji Seika Pharma Co Ltd Method for producing crystals of diazabicyclooctane derivative and stable lyophilized preparation
ES2777942T3 (es) * 2014-12-31 2022-04-22 Galenicum Health S L U Composiciones farmacéuticas estables que comprenden micafungina
PL3058958T3 (pl) 2015-02-23 2019-02-28 Selectchemie Ag Kompozycja anidulafunginy
WO2018112330A1 (en) 2016-12-16 2018-06-21 Baxter International Inc. Micafungin compositions
US11185527B2 (en) 2017-06-26 2021-11-30 Wayne State University Methods and compositions relating to steroid hormone receptor-dependent cancers
RU2666148C1 (ru) * 2017-10-05 2018-09-06 Общество с ограниченной ответственностью "Новые Антибиотики" Способ получения водорастворимой лиофилизированной формы соли бис(2-тио-4,6-диоксо-1,2,3,4,5,6-гексагидропиримидин-5-ил)-(4-нитрофенил)метана
EP3485873A1 (en) 2017-11-17 2019-05-22 Cadila Healthcare Limited Stable pharmaceutical injectable compositions of micafungin

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03193735A (ja) 1989-12-22 1991-08-23 Shionogi & Co Ltd グリコペプチド系抗生物質の安定化組成物
JPH03240727A (ja) 1990-02-15 1991-10-28 Toyo Jozo Co Ltd ニューモシスチス・カリニ肺炎治療剤
IL98506A (en) * 1990-06-18 1996-09-12 Fujisawa Pharmaceutical Co Cyclic peptide antibiotics processes for the preparation thereof and pharmaceutical compositions containing them
JP3193735B2 (ja) 1991-07-24 2001-07-30 株式会社リコー カラー画像形成装置の搬送装置
RU2095081C1 (ru) * 1991-12-13 1997-11-10 Акционерное общество "Биофа" Фармацевтическая композиция антивирусного действия
JPH0651641A (ja) 1992-07-30 1994-02-25 Olympus Optical Co Ltd 湿式現像装置
JPH06172204A (ja) * 1992-12-09 1994-06-21 Asahi Chem Ind Co Ltd アクレアシン類含有リポソーム製剤およびその製造法
JP3240727B2 (ja) 1993-02-25 2001-12-25 ソニー株式会社 偏平型陰極線管の画像歪補正装置
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
IL109615A (en) * 1993-05-17 2000-12-06 Fujisawa Pharmaceutical Co Cyclic polypeptide derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
RU2165423C2 (ru) * 1994-10-07 2001-04-20 Фудзисава Фармасьютикал Ко., Лтд. Полипептидное соединение, способ его получения и фармацевтическая композиция
GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
US6245349B1 (en) * 1996-02-23 2001-06-12 éLAN CORPORATION PLC Drug delivery compositions suitable for intravenous injection
JP3123078B2 (ja) * 1996-03-08 2001-01-09 藤沢薬品工業株式会社 環状リポペプチド物質の脱アシル化法
PE63998A1 (es) * 1996-04-19 1998-10-30 Merck & Co Inc Composiciones anti-fungosas
JPH09301997A (ja) 1996-05-17 1997-11-25 Yamanouchi Pharmaceut Co Ltd 新規環状ペプチド系化合物
AUPO371596A0 (en) * 1996-11-19 1996-12-12 Fujisawa Pharmaceutical Co., Ltd. New compound
FR2755857B1 (fr) * 1996-11-19 1998-12-24 Rhone Poulenc Rorer Sa Compositions pharmaceutiques stabilisees, a base de quinupristine et de dalfopristine et leur preparation
AUPO381496A0 (en) * 1996-11-25 1996-12-19 Fujisawa Pharmaceutical Co., Ltd. New compound
JPH10279498A (ja) * 1997-04-07 1998-10-20 Nippon Shinyaku Co Ltd 慢性関節リウマチ治療剤
JP3544847B2 (ja) * 1998-01-16 2004-07-21 三菱電機株式会社 光学的情報再生方法および装置
HK1040062A1 (zh) * 1999-03-03 2002-05-24 Eli Lilly And Company 含有成胶束表面活性剂的棘白菌素药物配方
HK1040369A1 (zh) * 1999-03-03 2002-06-07 Eli Lilly And Company 制备药物口服ecb配方和组合物的方法
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8980827B2 (en) 2011-01-31 2015-03-17 Shanghai Techwell Biopharmaceutical Co., Ltd. Medicinal composition containing echinocandin antifungal agent micafungin and preparation method and use thereof

Also Published As

Publication number Publication date
CN100352495C (zh) 2007-12-05
CZ295720B6 (cs) 2005-10-12
EP1107777B1 (en) 2004-10-27
BRPI0006823B1 (pt) 2020-01-07
TWI233805B (en) 2005-06-11
NO330353B1 (no) 2011-04-04
HK1080724A1 (zh) 2006-05-04
RU2251411C2 (ru) 2005-05-10
ES2225161T3 (es) 2005-03-16
CN1315865A (zh) 2001-10-03
JP2003503462A (ja) 2003-01-28
CA2341568C (en) 2011-10-25
HK1040057B (zh) 2005-08-05
IL141455A0 (en) 2002-03-10
HK1040057A1 (en) 2002-05-24
DE60015279D1 (de) 2004-12-02
CN1636591A (zh) 2005-07-13
WO2001002002A1 (en) 2001-01-11
BR0006823A (pt) 2001-06-05
PL346297A1 (en) 2002-01-28
ZA200101589B (en) 2002-09-02
AU5572200A (en) 2001-01-22
ID29468A (id) 2001-08-30
NO20010893L (no) 2001-04-24
OA11601A (en) 2004-07-30
IL141455A (en) 2006-12-31
ATE280583T1 (de) 2004-11-15
NZ510290A (en) 2003-07-25
US7112565B2 (en) 2006-09-26
PT1107777E (pt) 2005-01-31
DE60015279T2 (de) 2005-05-25
BRPI0006823B8 (pt) 2021-05-25
KR100454784B1 (ko) 2004-11-05
HU229089B1 (en) 2013-07-29
PL200141B1 (pl) 2008-12-31
EP1107777A1 (en) 2001-06-20
AU752265B2 (en) 2002-09-12
JP4691866B2 (ja) 2011-06-01
AR024634A1 (es) 2002-10-16
HUP0103740A2 (hu) 2002-02-28
JP3381722B2 (ja) 2003-03-04
JP2002363097A (ja) 2002-12-18
CA2341568A1 (en) 2001-01-11
CZ20011186A3 (cs) 2001-09-12
TR200100609T1 (tr) 2001-07-23
US20040157769A1 (en) 2004-08-12
US6774104B1 (en) 2004-08-10
NO20010893D0 (no) 2001-02-22
KR20010072903A (ko) 2001-07-31
HUP0103740A3 (en) 2002-08-28
MXPA01000601A (es) 2002-04-08

Similar Documents

Publication Publication Date Title
CN1179748C (zh) 冻干形式的稳定的药用组合物
CN1367703A (zh) Hgf冻干制剂
CN1180846C (zh) 含有双膦酸或其盐的,用于皮下给药的凝胶体状药物组合物
CN1173739C (zh) 含人生长激素的水性药物组合物
CN1010279B (zh) 含有斯波胍灵活性成分的注射用药物组合物的制备方法
CN1871014A (zh) 含有前列腺素的药物组合物
CN1646172A (zh) 包含喜树碱衍生物的液体制剂以及冻干该制剂制得的药物组合物
CN1792362A (zh) 阿比朵尔及其盐的静脉给药制剂及制备方法
CN1438886A (zh) 滴眼液
JP2004506017A (ja) 抗真菌剤組合せ使用
CN1146417C (zh) 以奎纽普汀和达尔福普汀为主要成分的稳定药物组合物及其制备
CN1183908C (zh) 一种尼莫地平的注射用药物组合物及其制备方法
CN1513547A (zh) 含有睫状神经营养因子类似物的稳定药剂
CN1820751A (zh) 替罗非班粉针剂及其制备方法
CN1283245C (zh) 硝酸异山梨酯的冻干粉针及其制备方法
CN1082368C (zh) 人绒毛膜促性腺激素液体制剂
CN1812794A (zh) 溶液药用组合物
CN1634055A (zh) 含鲁比特康的注射用制剂
WO2002053584A1 (en) Stabilized pharmaceutical composition in lyophilized form
CN101062028A (zh) 一种含紫杉烷类化合物的组合物、其制备方法和用途
HK1080724B (en) Stabilized pharmaceutical composition in lyophilized form
HK1022832B (en) Stabilised pharmaceutical compositions, with quinupristine and dalfopristine base and their preparation

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: ASTELLAS PHARMA INC.

Free format text: FORMER NAME OR ADDRESS: FUJISAWA PHARMACEUTICAL CO., LTD.

CP03 Change of name, title or address

Address after: Tokyo, Japan

Patentee after: Yamanouchi Pharma Co., Ltd.

Address before: Osaka City, Osaka of Japan

Patentee before: Fujisawa Pharmaceutical Co., Ltd.

CX01 Expiry of patent term

Granted publication date: 20041215

CX01 Expiry of patent term