CN115867657A - 用于治疗疾患和疾病的opa1反义寡聚物 - Google Patents

用于治疗疾患和疾病的opa1反义寡聚物 Download PDF

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Publication number
CN115867657A
CN115867657A CN202180049789.8A CN202180049789A CN115867657A CN 115867657 A CN115867657 A CN 115867657A CN 202180049789 A CN202180049789 A CN 202180049789A CN 115867657 A CN115867657 A CN 115867657A
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fold
nucleotides
mrna
exon
target portion
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Chinese (zh)
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伊莎贝尔·阿兹纳雷兹
阿迪蒂亚·文卡塔斯
吉恩·里奥
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Stoke Therapeutics Inc
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Stoke Therapeutics Inc
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CN202180049789.8A 2020-05-11 2021-04-30 用于治疗疾患和疾病的opa1反义寡聚物 Pending CN115867657A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063023013P 2020-05-11 2020-05-11
US63/023,013 2020-05-11
US202063112458P 2020-11-11 2020-11-11
US63/112,458 2020-11-11
PCT/US2021/030254 WO2021231107A1 (en) 2020-05-11 2021-04-30 Opa1 antisense oligomers for treatment of conditions and diseases

Publications (1)

Publication Number Publication Date
CN115867657A true CN115867657A (zh) 2023-03-28

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CN202180049789.8A Pending CN115867657A (zh) 2020-05-11 2021-04-30 用于治疗疾患和疾病的opa1反义寡聚物

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Country Link
US (3) US12338437B2 (https=)
EP (1) EP4150092A4 (https=)
JP (1) JP2023525799A (https=)
KR (1) KR20230022409A (https=)
CN (1) CN115867657A (https=)
BR (1) BR112022022889A2 (https=)
CA (1) CA3173647A1 (https=)
IL (1) IL298063A (https=)
MX (1) MX2022014151A (https=)
TW (1) TWI901675B (https=)
WO (1) WO2021231107A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022022889A2 (pt) 2020-05-11 2023-04-04 Stoke Therapeutics Inc Oligômeros antissentido de opa1 para tratamento de condições e doenças
BR112023005748A2 (pt) * 2020-10-02 2023-05-09 Pyc Therapeutics Ltd Tratamento de atrofia óptica
EP4473109A1 (en) * 2022-01-31 2024-12-11 Pyc Therapeutics Limited Method of treatment for optic atrophy
EP4496892A1 (en) * 2022-03-23 2025-01-29 Pyc Therapeutics Limited Methods of treating glaucoma
EP4594505A1 (en) * 2022-09-30 2025-08-06 Centre National de la Recherche Scientifique Therapy by trans-splicing of opa1 pre-messenger rnas for the treatment of diseases associated with opa1 gene mutations
KR20250122542A (ko) * 2022-10-31 2025-08-13 스톡 테라퓨틱스, 인크. 넌센스 매개 rna 분해 기반 병태 및 질환의 치료를 위한 안티센스 올리고머
WO2024221049A1 (en) * 2023-04-28 2024-10-31 PYC Therapeutics Limited Agents and method of treatment for optic conditions
AU2024282117A1 (en) * 2023-05-31 2026-01-08 Stoke Therapeutics, Inc. Opa1 antisense oligomers for treatment of conditions and diseases

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