CN115244173A - 用于分离肿瘤浸润淋巴细胞的装置及方法及其用途 - Google Patents

用于分离肿瘤浸润淋巴细胞的装置及方法及其用途 Download PDF

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CN115244173A
CN115244173A CN202080096962.5A CN202080096962A CN115244173A CN 115244173 A CN115244173 A CN 115244173A CN 202080096962 A CN202080096962 A CN 202080096962A CN 115244173 A CN115244173 A CN 115244173A
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tumor
tils
tissue
depolymerization
population
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莱恩·杰斯特
乔安·麦克佛瑞
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British Research Biology Uk Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
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    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
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    • C12N2527/00—Culture process characterised by the use of mechanical forces, e.g. strain, vibration

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CN202080096962.5A 2019-12-20 2020-12-18 用于分离肿瘤浸润淋巴细胞的装置及方法及其用途 Pending CN115244173A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962951559P 2019-12-20 2019-12-20
US62/951,559 2019-12-20
US202062982470P 2020-02-27 2020-02-27
US62/982,470 2020-02-27
US202063047431P 2020-07-02 2020-07-02
US63/047,431 2020-07-02
PCT/GB2020/053315 WO2021123832A1 (en) 2019-12-20 2020-12-18 Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof

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CN115244173A true CN115244173A (zh) 2022-10-25

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US (5) US11767510B2 (enExample)
EP (1) EP4077641A1 (enExample)
JP (1) JP2023507432A (enExample)
KR (1) KR20220119439A (enExample)
CN (1) CN115244173A (enExample)
AU (1) AU2020408017A1 (enExample)
BR (1) BR112022011795A2 (enExample)
CA (1) CA3164986A1 (enExample)
CL (1) CL2022001703A1 (enExample)
IL (1) IL294098A (enExample)
MX (1) MX2022007598A (enExample)
WO (1) WO2021123832A1 (enExample)

Cited By (3)

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CN116179486A (zh) * 2022-12-30 2023-05-30 苏州科为康生物医药科技有限公司 一种肿瘤浸润淋巴细胞的制备方法
CN117305077A (zh) * 2023-09-25 2023-12-29 成都赛恩吉诺生物科技有限公司 一种全封闭式组织解离方法
CN117327563A (zh) * 2023-09-25 2024-01-02 成都赛恩吉诺生物科技有限公司 一种组织解离方法

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