CN112839643A - 用于治疗肌肉中脂肪浸润的组合物及方法 - Google Patents
用于治疗肌肉中脂肪浸润的组合物及方法 Download PDFInfo
- Publication number
- CN112839643A CN112839643A CN201980054575.2A CN201980054575A CN112839643A CN 112839643 A CN112839643 A CN 112839643A CN 201980054575 A CN201980054575 A CN 201980054575A CN 112839643 A CN112839643 A CN 112839643A
- Authority
- CN
- China
- Prior art keywords
- amino acid
- muscle
- acid entity
- subject
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003205 muscle Anatomy 0.000 title claims abstract description 209
- 239000000203 mixture Substances 0.000 title claims abstract description 156
- 230000008595 infiltration Effects 0.000 title claims abstract description 155
- 238000001764 infiltration Methods 0.000 title claims abstract description 155
- 238000000034 method Methods 0.000 title claims abstract description 88
- 150000001413 amino acids Chemical class 0.000 claims abstract description 145
- 230000004220 muscle function Effects 0.000 claims abstract description 30
- 206010028289 Muscle atrophy Diseases 0.000 claims abstract description 27
- 201000000585 muscular atrophy Diseases 0.000 claims abstract description 21
- 230000020763 muscle atrophy Effects 0.000 claims abstract description 18
- 229940024606 amino acid Drugs 0.000 claims description 361
- 235000001014 amino acid Nutrition 0.000 claims description 346
- -1 leucine amino acid Chemical class 0.000 claims description 212
- 229960003136 leucine Drugs 0.000 claims description 51
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 49
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 48
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 47
- 150000003839 salts Chemical group 0.000 claims description 46
- 239000004475 Arginine Substances 0.000 claims description 45
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 45
- 229960003121 arginine Drugs 0.000 claims description 45
- 238000001356 surgical procedure Methods 0.000 claims description 44
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 40
- 229960004308 acetylcysteine Drugs 0.000 claims description 37
- 230000002829 reductive effect Effects 0.000 claims description 32
- 229960004295 valine Drugs 0.000 claims description 32
- 239000004473 Threonine Substances 0.000 claims description 31
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 31
- 201000010099 disease Diseases 0.000 claims description 31
- 229960002885 histidine Drugs 0.000 claims description 31
- 229960002898 threonine Drugs 0.000 claims description 31
- 239000004472 Lysine Substances 0.000 claims description 30
- 229960005190 phenylalanine Drugs 0.000 claims description 30
- 239000004474 valine Substances 0.000 claims description 30
- 229960000310 isoleucine Drugs 0.000 claims description 29
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 29
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 27
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 26
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 26
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 26
- 235000014304 histidine Nutrition 0.000 claims description 26
- 235000018977 lysine Nutrition 0.000 claims description 26
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 26
- 235000008729 phenylalanine Nutrition 0.000 claims description 26
- 235000008521 threonine Nutrition 0.000 claims description 26
- 208000024288 Rotator Cuff injury Diseases 0.000 claims description 23
- 208000001076 sarcopenia Diseases 0.000 claims description 23
- 208000021642 Muscular disease Diseases 0.000 claims description 22
- 208000014674 injury Diseases 0.000 claims description 22
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 21
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 21
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 21
- 206010039227 Rotator cuff syndrome Diseases 0.000 claims description 21
- 235000020776 essential amino acid Nutrition 0.000 claims description 20
- 239000003797 essential amino acid Substances 0.000 claims description 20
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 19
- 208000029578 Muscle disease Diseases 0.000 claims description 18
- 208000035475 disorder Diseases 0.000 claims description 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 17
- 201000009623 Myopathy Diseases 0.000 claims description 16
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 201000011510 cancer Diseases 0.000 claims description 16
- 208000010428 Muscle Weakness Diseases 0.000 claims description 14
- 230000032683 aging Effects 0.000 claims description 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 13
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 13
- 206010028372 Muscular weakness Diseases 0.000 claims description 13
- 230000008733 trauma Effects 0.000 claims description 13
- 239000008103 glucose Substances 0.000 claims description 12
- 210000003127 knee Anatomy 0.000 claims description 12
- 238000002595 magnetic resonance imaging Methods 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 208000010392 Bone Fractures Diseases 0.000 claims description 10
- 206010006895 Cachexia Diseases 0.000 claims description 10
- 208000015181 infectious disease Diseases 0.000 claims description 10
- 230000009467 reduction Effects 0.000 claims description 10
- 208000027418 Wounds and injury Diseases 0.000 claims description 9
- 208000011444 chronic liver failure Diseases 0.000 claims description 9
- 210000004185 liver Anatomy 0.000 claims description 9
- 206010003694 Atrophy Diseases 0.000 claims description 8
- 206010057573 Chronic hepatic failure Diseases 0.000 claims description 8
- 208000010334 End Stage Liver Disease Diseases 0.000 claims description 8
- 230000006378 damage Effects 0.000 claims description 8
- 208000007386 hepatic encephalopathy Diseases 0.000 claims description 8
- 210000000513 rotator cuff Anatomy 0.000 claims description 8
- 208000023137 Myotoxicity Diseases 0.000 claims description 7
- 230000037444 atrophy Effects 0.000 claims description 7
- 201000006938 muscular dystrophy Diseases 0.000 claims description 7
- 206010003445 Ascites Diseases 0.000 claims description 6
- 206010009944 Colon cancer Diseases 0.000 claims description 6
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 6
- 208000032843 Hemorrhage Diseases 0.000 claims description 6
- 206010040047 Sepsis Diseases 0.000 claims description 6
- 208000034158 bleeding Diseases 0.000 claims description 6
- 230000000740 bleeding effect Effects 0.000 claims description 6
- 230000034994 death Effects 0.000 claims description 6
- 231100000517 death Toxicity 0.000 claims description 6
- 208000007232 portal hypertension Diseases 0.000 claims description 6
- 230000008439 repair process Effects 0.000 claims description 6
- 210000000988 bone and bone Anatomy 0.000 claims description 5
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 5
- 208000020431 spinal cord injury Diseases 0.000 claims description 5
- 208000008035 Back Pain Diseases 0.000 claims description 4
- 235000019766 L-Lysine Nutrition 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 4
- 206010012601 diabetes mellitus Diseases 0.000 claims description 4
- 229920006226 ethylene-acrylic acid Polymers 0.000 claims description 4
- 208000030159 metabolic disease Diseases 0.000 claims description 4
- 239000011505 plaster Substances 0.000 claims description 4
- 206010006956 Calcium deficiency Diseases 0.000 claims description 3
- 208000037147 Hypercalcaemia Diseases 0.000 claims description 3
- 208000019025 Hypokalemia Diseases 0.000 claims description 3
- 206010021036 Hyponatraemia Diseases 0.000 claims description 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 3
- 235000018417 cysteine Nutrition 0.000 claims description 3
- 208000016097 disease of metabolism Diseases 0.000 claims description 3
- 230000000148 hypercalcaemia Effects 0.000 claims description 3
- 208000030915 hypercalcemia disease Diseases 0.000 claims description 3
- 229930182817 methionine Natural products 0.000 claims description 3
- 208000024896 potassium deficiency disease Diseases 0.000 claims description 3
- 208000006011 Stroke Diseases 0.000 claims description 2
- 230000014759 maintenance of location Effects 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 230000001953 sensory effect Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 229960002743 glutamine Drugs 0.000 description 43
- 235000004554 glutamine Nutrition 0.000 description 41
- 235000009697 arginine Nutrition 0.000 description 38
- 238000011282 treatment Methods 0.000 description 27
- 229960003646 lysine Drugs 0.000 description 26
- 210000002414 leg Anatomy 0.000 description 23
- 239000002243 precursor Substances 0.000 description 20
- 239000000902 placebo Substances 0.000 description 19
- 229940068196 placebo Drugs 0.000 description 19
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 18
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 16
- 230000000694 effects Effects 0.000 description 13
- 239000000835 fiber Substances 0.000 description 13
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 12
- 210000003414 extremity Anatomy 0.000 description 12
- 230000037120 immobility Effects 0.000 description 12
- 230000008859 change Effects 0.000 description 11
- 239000002207 metabolite Substances 0.000 description 11
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 10
- 235000013305 food Nutrition 0.000 description 10
- 208000024891 symptom Diseases 0.000 description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 238000007918 intramuscular administration Methods 0.000 description 9
- 210000000689 upper leg Anatomy 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000008901 benefit Effects 0.000 description 8
- 239000003086 colorant Substances 0.000 description 8
- 238000002591 computed tomography Methods 0.000 description 8
- 239000007884 disintegrant Substances 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- 238000011084 recovery Methods 0.000 description 8
- 238000002560 therapeutic procedure Methods 0.000 description 8
- 239000000356 contaminant Substances 0.000 description 7
- 235000015872 dietary supplement Nutrition 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000003599 food sweetener Nutrition 0.000 description 7
- 230000036541 health Effects 0.000 description 7
- 210000001624 hip Anatomy 0.000 description 7
- 239000003642 reactive oxygen metabolite Substances 0.000 description 7
- 239000003765 sweetening agent Substances 0.000 description 7
- 208000002720 Malnutrition Diseases 0.000 description 6
- 230000004900 autophagic degradation Effects 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 6
- 150000005693 branched-chain amino acids Chemical class 0.000 description 6
- 230000003247 decreasing effect Effects 0.000 description 6
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 6
- 230000001071 malnutrition Effects 0.000 description 6
- 235000000824 malnutrition Nutrition 0.000 description 6
- 208000015380 nutritional deficiency disease Diseases 0.000 description 6
- 238000001243 protein synthesis Methods 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 210000003314 quadriceps muscle Anatomy 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 230000014616 translation Effects 0.000 description 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 6
- 241000282414 Homo sapiens Species 0.000 description 5
- 206010022489 Insulin Resistance Diseases 0.000 description 5
- 108010046377 Whey Proteins Proteins 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- 230000001195 anabolic effect Effects 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 235000003642 hunger Nutrition 0.000 description 5
- 230000001976 improved effect Effects 0.000 description 5
- 230000002503 metabolic effect Effects 0.000 description 5
- 230000002438 mitochondrial effect Effects 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 4
- 206010017076 Fracture Diseases 0.000 description 4
- 241000725303 Human immunodeficiency virus Species 0.000 description 4
- 239000004395 L-leucine Substances 0.000 description 4
- 235000019454 L-leucine Nutrition 0.000 description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
- 102000007544 Whey Proteins Human genes 0.000 description 4
- 239000005018 casein Substances 0.000 description 4
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 4
- 235000021240 caseins Nutrition 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 208000037765 diseases and disorders Diseases 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 4
- 238000009547 dual-energy X-ray absorptiometry Methods 0.000 description 4
- 235000013861 fat-free Nutrition 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 210000001087 myotubule Anatomy 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 230000000399 orthopedic effect Effects 0.000 description 4
- 230000001766 physiological effect Effects 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 230000011218 segmentation Effects 0.000 description 4
- 230000035945 sensitivity Effects 0.000 description 4
- 206010007559 Cardiac failure congestive Diseases 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 206010016654 Fibrosis Diseases 0.000 description 3
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 description 3
- 206010019280 Heart failures Diseases 0.000 description 3
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 3
- 229920000881 Modified starch Polymers 0.000 description 3
- 108010056852 Myostatin Proteins 0.000 description 3
- 206010068871 Myotonic dystrophy Diseases 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 235000010358 acesulfame potassium Nutrition 0.000 description 3
- 239000000619 acesulfame-K Substances 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 208000026935 allergic disease Diseases 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 235000021152 breakfast Nutrition 0.000 description 3
- 230000007882 cirrhosis Effects 0.000 description 3
- 230000007012 clinical effect Effects 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 235000007882 dietary composition Nutrition 0.000 description 3
- 239000003623 enhancer Substances 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 235000013376 functional food Nutrition 0.000 description 3
- 229960003180 glutathione Drugs 0.000 description 3
- 210000000527 greater trochanter Anatomy 0.000 description 3
- 239000000314 lubricant Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 210000000715 neuromuscular junction Anatomy 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 230000037351 starvation Effects 0.000 description 3
- 230000007863 steatosis Effects 0.000 description 3
- 231100000240 steatosis hepatitis Toxicity 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 235000021119 whey protein Nutrition 0.000 description 3
- 229920001285 xanthan gum Polymers 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
- 239000000230 xanthan gum Substances 0.000 description 3
- 229940082509 xanthan gum Drugs 0.000 description 3
- OCUSNPIJIZCRSZ-ZTZWCFDHSA-N (2s)-2-amino-3-methylbutanoic acid;(2s)-2-amino-4-methylpentanoic acid;(2s,3s)-2-amino-3-methylpentanoic acid Chemical compound CC(C)[C@H](N)C(O)=O.CC[C@H](C)[C@H](N)C(O)=O.CC(C)C[C@H](N)C(O)=O OCUSNPIJIZCRSZ-ZTZWCFDHSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- KWTQSFXGGICVPE-UHFFFAOYSA-N 2-amino-5-(diaminomethylideneamino)pentanoic acid;hydron;chloride Chemical compound Cl.OC(=O)C(N)CCCN=C(N)N KWTQSFXGGICVPE-UHFFFAOYSA-N 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 2
- 102000014156 AMP-Activated Protein Kinases Human genes 0.000 description 2
- 108010011376 AMP-Activated Protein Kinases Proteins 0.000 description 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 2
- 241000349731 Afzelia bipindensis Species 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 2
- 101710155857 C-C motif chemokine 2 Proteins 0.000 description 2
- 108010074051 C-Reactive Protein Proteins 0.000 description 2
- 102100032752 C-reactive protein Human genes 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 2
- 150000008574 D-amino acids Chemical class 0.000 description 2
- 108010016626 Dipeptides Proteins 0.000 description 2
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 description 2
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 description 2
- 108010024636 Glutathione Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 description 2
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 2
- 101001081567 Homo sapiens Insulin-like growth factor-binding protein 1 Proteins 0.000 description 2
- 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 description 2
- 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 2
- 102100027636 Insulin-like growth factor-binding protein 1 Human genes 0.000 description 2
- 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 description 2
- 102100020881 Interleukin-1 alpha Human genes 0.000 description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- 229930182844 L-isoleucine Natural products 0.000 description 2
- 102000008135 Mechanistic Target of Rapamycin Complex 1 Human genes 0.000 description 2
- 108010035196 Mechanistic Target of Rapamycin Complex 1 Proteins 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- 102000008934 Muscle Proteins Human genes 0.000 description 2
- 108010074084 Muscle Proteins Proteins 0.000 description 2
- 102000036675 Myoglobin Human genes 0.000 description 2
- 108010062374 Myoglobin Proteins 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 244000228451 Stevia rebaudiana Species 0.000 description 2
- 239000004376 Sucralose Substances 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- 208000032109 Transient ischaemic attack Diseases 0.000 description 2
- 235000009499 Vanilla fragrans Nutrition 0.000 description 2
- 244000263375 Vanilla tahitensis Species 0.000 description 2
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 2
- 239000005862 Whey Substances 0.000 description 2
- 210000000593 adipose tissue white Anatomy 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 150000003862 amino acid derivatives Chemical class 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 150000001483 arginine derivatives Chemical class 0.000 description 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 2
- 208000020538 atrophic muscular disease Diseases 0.000 description 2
- 239000000440 bentonite Substances 0.000 description 2
- 229910000278 bentonite Inorganic materials 0.000 description 2
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 235000010980 cellulose Nutrition 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 2
- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 208000020832 chronic kidney disease Diseases 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
- 229940127089 cytotoxic agent Drugs 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000006735 deficit Effects 0.000 description 2
- CZWCKYRVOZZJNM-USOAJAOKSA-N dehydroepiandrosterone sulfate Chemical compound C1[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 CZWCKYRVOZZJNM-USOAJAOKSA-N 0.000 description 2
- QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical compound C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 238000002567 electromyography Methods 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 235000014105 formulated food Nutrition 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 150000002308 glutamine derivatives Chemical class 0.000 description 2
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 229960003444 immunosuppressant agent Drugs 0.000 description 2
- 230000001861 immunosuppressant effect Effects 0.000 description 2
- 239000003018 immunosuppressive agent Substances 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 208000002551 irritable bowel syndrome Diseases 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 208000019423 liver disease Diseases 0.000 description 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 238000001964 muscle biopsy Methods 0.000 description 2
- 230000002232 neuromuscular Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 239000003531 protein hydrolysate Substances 0.000 description 2
- 229940116540 protein supplement Drugs 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 229920003109 sodium starch glycolate Polymers 0.000 description 2
- 239000008109 sodium starch glycolate Substances 0.000 description 2
- 229940079832 sodium starch glycolate Drugs 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 229940032147 starch Drugs 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 235000019408 sucralose Nutrition 0.000 description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 2
- 201000010875 transient cerebral ischemia Diseases 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 description 1
- PWKSKIMOESPYIA-UHFFFAOYSA-N 2-acetamido-3-sulfanylpropanoic acid Chemical compound CC(=O)NC(CS)C(O)=O PWKSKIMOESPYIA-UHFFFAOYSA-N 0.000 description 1
- QDGAVODICPCDMU-UHFFFAOYSA-N 2-amino-3-[3-[bis(2-chloroethyl)amino]phenyl]propanoic acid Chemical compound OC(=O)C(N)CC1=CC=CC(N(CCCl)CCCl)=C1 QDGAVODICPCDMU-UHFFFAOYSA-N 0.000 description 1
- AXFYFNCPONWUHW-UHFFFAOYSA-N 3-hydroxyisovaleric acid Chemical compound CC(C)(O)CC(O)=O AXFYFNCPONWUHW-UHFFFAOYSA-N 0.000 description 1
- ACRRANHJMOPYFZ-UHFFFAOYSA-N 6-methyl-2,2-dioxooxathiazinan-4-one Chemical compound CC1CC(=O)NS(=O)(=O)O1 ACRRANHJMOPYFZ-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 102100030840 AT-rich interactive domain-containing protein 4B Human genes 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 206010002329 Aneurysm Diseases 0.000 description 1
- 108010011485 Aspartame Proteins 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- 208000023328 Basedow disease Diseases 0.000 description 1
- 201000006935 Becker muscular dystrophy Diseases 0.000 description 1
- 241000167854 Bourreria succulenta Species 0.000 description 1
- 101100064557 Caenorhabditis elegans gcn-2 gene Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000011632 Caseins Human genes 0.000 description 1
- 108010076119 Caseins Proteins 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 235000005979 Citrus limon Nutrition 0.000 description 1
- 235000019499 Citrus oil Nutrition 0.000 description 1
- 244000131522 Citrus pyriformis Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 208000019505 Deglutition disease Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 208000017701 Endocrine disease Diseases 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 208000015023 Graves' disease Diseases 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 206010062713 Haemorrhagic diathesis Diseases 0.000 description 1
- 102000001554 Hemoglobins Human genes 0.000 description 1
- 108010054147 Hemoglobins Proteins 0.000 description 1
- 206010020100 Hip fracture Diseases 0.000 description 1
- 101000792935 Homo sapiens AT-rich interactive domain-containing protein 4B Proteins 0.000 description 1
- 229920001908 Hydrogenated starch hydrolysate Polymers 0.000 description 1
- 206010049933 Hypophosphatasia Diseases 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- 229920000161 Locust bean gum Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 244000070406 Malus silvestris Species 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000003505 Myosin Human genes 0.000 description 1
- 108060008487 Myosin Proteins 0.000 description 1
- 201000002481 Myositis Diseases 0.000 description 1
- 125000003047 N-acetyl group Chemical group 0.000 description 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 description 1
- 208000013544 Platelet disease Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 235000009827 Prunus armeniaca Nutrition 0.000 description 1
- 244000018633 Prunus armeniaca Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 229920001131 Pulp (paper) Polymers 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 240000001987 Pyrus communis Species 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 240000007651 Rubus glaucus Species 0.000 description 1
- 235000011034 Rubus glaucus Nutrition 0.000 description 1
- 235000009122 Rubus idaeus Nutrition 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- 235000015125 Sterculia urens Nutrition 0.000 description 1
- 240000001058 Sterculia urens Species 0.000 description 1
- 235000006092 Stevia rebaudiana Nutrition 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 208000021945 Tendon injury Diseases 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 241000219793 Trifolium Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 210000001789 adipocyte Anatomy 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 239000004469 amino acid formulation Substances 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000003263 anabolic agent Substances 0.000 description 1
- 229940070021 anabolic steroids Drugs 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 238000009165 androgen replacement therapy Methods 0.000 description 1
- 239000010617 anise oil Substances 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229960003589 arginine hydrochloride Drugs 0.000 description 1
- 238000011882 arthroplasty Methods 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 229940072107 ascorbate Drugs 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 description 1
- 229910000020 calcium bicarbonate Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000019693 cherries Nutrition 0.000 description 1
- 125000001309 chloro group Chemical class Cl* 0.000 description 1
- 229960004926 chlorobutanol Drugs 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 229960002173 citrulline Drugs 0.000 description 1
- 235000013477 citrulline Nutrition 0.000 description 1
- 239000010500 citrus oil Substances 0.000 description 1
- 230000009852 coagulant defect Effects 0.000 description 1
- 230000001149 cognitive effect Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 229960003624 creatine Drugs 0.000 description 1
- 239000006046 creatine Substances 0.000 description 1
- 235000011950 custard Nutrition 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 201000001981 dermatomyositis Diseases 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940126534 drug product Drugs 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000667 effect on insulin Effects 0.000 description 1
- 230000010102 embolization Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000003195 fascia Anatomy 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 229940051147 fd&c yellow no. 6 Drugs 0.000 description 1
- 230000005294 ferromagnetic effect Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 208000017740 grade III prostatic intraepithelial neoplasia Diseases 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000010651 grapefruit oil Substances 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical group Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 238000011540 hip replacement Methods 0.000 description 1
- 150000002410 histidine derivatives Chemical class 0.000 description 1
- 150000002411 histidines Chemical class 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- 208000003532 hypothyroidism Diseases 0.000 description 1
- 230000002989 hypothyroidism Effects 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000002847 impedance measurement Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 230000007358 intestinal barrier function Effects 0.000 description 1
- 210000001596 intra-abdominal fat Anatomy 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 229960004903 invert sugar Drugs 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 229960000829 kaolin Drugs 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- 150000004715 keto acids Chemical class 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 238000013150 knee replacement Methods 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 150000002613 leucine derivatives Chemical class 0.000 description 1
- 150000002614 leucines Chemical class 0.000 description 1
- 229940059904 light mineral oil Drugs 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 230000013190 lipid storage Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 208000018191 liver inflammation Diseases 0.000 description 1
- 235000010420 locust bean gum Nutrition 0.000 description 1
- 239000000711 locust bean gum Substances 0.000 description 1
- 150000002668 lysine derivatives Chemical class 0.000 description 1
- QWDJLDTYWNBUKE-UHFFFAOYSA-L magnesium bicarbonate Chemical compound [Mg+2].OC([O-])=O.OC([O-])=O QWDJLDTYWNBUKE-UHFFFAOYSA-L 0.000 description 1
- 239000002370 magnesium bicarbonate Substances 0.000 description 1
- 229910000022 magnesium bicarbonate Inorganic materials 0.000 description 1
- 235000014824 magnesium bicarbonate Nutrition 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 229940037627 magnesium lauryl sulfate Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000003818 metabolic dysfunction Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 230000004898 mitochondrial function Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 206010028417 myasthenia gravis Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 208000018360 neuromuscular disease Diseases 0.000 description 1
- 208000021722 neuropathic pain Diseases 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 208000005368 osteomalacia Diseases 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 201000009981 periampullary adenocarcinoma Diseases 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000002993 phenylalanine derivatives Chemical class 0.000 description 1
- 150000002994 phenylalanines Chemical class 0.000 description 1
- RGCLLPNLLBQHPF-HJWRWDBZSA-N phosphamidon Chemical group CCN(CC)C(=O)C(\Cl)=C(/C)OP(=O)(OC)OC RGCLLPNLLBQHPF-HJWRWDBZSA-N 0.000 description 1
- 238000000554 physical therapy Methods 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 208000005987 polymyositis Diseases 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 238000010837 poor prognosis Methods 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 201000005484 prostate carcinoma in situ Diseases 0.000 description 1
- 235000005974 protein supplement Nutrition 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- 208000026775 severe diarrhea Diseases 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 230000022379 skeletal muscle tissue development Effects 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 201000008261 skin carcinoma Diseases 0.000 description 1
- 210000001189 slow twitch fiber Anatomy 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000000264 spin echo pulse sequence Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000012911 target assessment Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 150000003587 threonine derivatives Chemical class 0.000 description 1
- 150000003588 threonines Chemical class 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 238000011883 total knee arthroplasty Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4172—Imidazole-alkanecarboxylic acids, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862687737P | 2018-06-20 | 2018-06-20 | |
| US62/687,737 | 2018-06-20 | ||
| PCT/US2019/037936 WO2019246225A1 (en) | 2018-06-20 | 2019-06-19 | Compositions and methods for the treatment of fat infiltration in muscle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112839643A true CN112839643A (zh) | 2021-05-25 |
Family
ID=67303508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980054575.2A Pending CN112839643A (zh) | 2018-06-20 | 2019-06-19 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10596136B2 (https=) |
| EP (1) | EP3810123A1 (https=) |
| JP (1) | JP2021527670A (https=) |
| CN (1) | CN112839643A (https=) |
| AR (1) | AR115585A1 (https=) |
| MA (1) | MA52971A (https=) |
| TW (1) | TW202015666A (https=) |
| WO (1) | WO2019246225A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| US11617731B2 (en) | 2017-04-28 | 2023-04-04 | Axcella Health, Inc. | Amino acid compositions and their use for the treatment of traumatic brain injury |
| IL296055A (en) | 2017-08-14 | 2022-10-01 | Axcella Health Inc | Amino acid compositions for the treatment of liver disease |
| MA52971A (fr) | 2018-06-20 | 2021-04-28 | Axcella Health Inc | Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle |
| CU20200106A7 (es) | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| CN112823018A (zh) | 2018-06-20 | 2021-05-18 | 胺细拉健康公司 | 制备氨基酸组合物的方法 |
| US20230044475A1 (en) * | 2019-12-23 | 2023-02-09 | Axcella Health Inc. | Compositions and methods involving amino acids for the treatment of fat infiltrations in muscle |
| WO2023009444A1 (en) | 2021-07-26 | 2023-02-02 | Axcella Health Inc. | Amino acid compositions and methods for use in the treatment of post-acute sequelae of covid-19 |
| KR20250028111A (ko) * | 2023-08-21 | 2025-02-28 | 마이오펫 주식회사 | 반려동물용 근감소증의 예방 또는 치료용 약학적 조성물 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049500A (zh) * | 2007-02-15 | 2007-10-10 | 北京苏里曼医药科技有限公司 | 一种氨基酸组合物 |
| WO2017085138A1 (en) * | 2015-11-20 | 2017-05-26 | Nestec S.A. | Methods using whey protein to improve or maintain muscle quality |
| US20170196944A1 (en) * | 2015-09-28 | 2017-07-13 | Robert Portman | Method to reduce muscle atrophy following orthopedic surgery |
| WO2017202939A1 (en) * | 2016-05-27 | 2017-11-30 | Nestec S.A. | Nutritional composition for treating or preventing impaired mobility |
Family Cites Families (318)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US693094A (en) | 1900-08-13 | 1902-02-11 | Hall Signal Co | Signal and signaling-circuit. |
| US2457820A (en) | 1945-12-27 | 1949-01-04 | Merck & Co Inc | Amino acid solution and process for preparing the same |
| US3012926A (en) | 1957-10-17 | 1961-12-12 | Arvin Ind Inc | Method of making quilted padded articles |
| GB1034358A (en) | 1963-05-01 | 1966-06-29 | Chugai Pharmaceutical Co Ltd | Body-protein-biosynthesis promoting composition |
| JPS5133B1 (https=) | 1969-07-25 | 1976-01-05 | ||
| US3832465A (en) | 1971-12-09 | 1974-08-27 | H Ghadimi | Injectable amino acid composition commensurate to the anabolic need of the body and method of using same |
| US3988466A (en) | 1973-06-01 | 1976-10-26 | Kyowa Hakko Kogyo Co., Ltd. | Prevention of gastric lesions |
| US3950529A (en) | 1975-02-03 | 1976-04-13 | Massachusetts General Hospital | Amino acid formulations for patients with liver disease and method of using same |
| JPS52108031A (en) | 1976-03-04 | 1977-09-10 | Masahiro Takizawa | Method of preparation of tooth paste |
| JPS5470158A (en) | 1977-11-14 | 1979-06-05 | Nhk Spring Co Ltd | Cushion and making method thereof |
| JPS5535049A (en) | 1978-09-04 | 1980-03-11 | Otsuka Pharmaceut Factory Inc | Amino acid transfusion for cancerous patient |
| DE2906034C2 (de) | 1979-02-16 | 1985-03-28 | Maggi AG, Kempttal | Verfahren zur Gewinnung von L-Leucin, L-Phenylalanin, L-Tyrosin, L-Cystin und von Gemischen aus L-Leucin und L-Isoleucin |
| CA1184499A (en) | 1981-06-29 | 1985-03-26 | David C. Madsen | Nutritional composition for management of hepatic failure |
| US4898879A (en) | 1981-06-29 | 1990-02-06 | Baxter International Inc. | Nurtitional composition for management of hepatic failure |
| JPS58126767A (ja) | 1982-01-22 | 1983-07-28 | Ajinomoto Co Inc | 肝臓病患者用栄養組成物 |
| US5298493A (en) | 1983-04-20 | 1994-03-29 | Clintec Nutrition Co. | Compound for use in dietetics, reanimation and therapeutics containing protein fractions based on three types of minipeptides |
| CH658165A5 (fr) | 1984-01-04 | 1986-10-31 | Nestle Sa | Produit alimentaire efficace dans le traitement de la lepre. |
| US5034377A (en) | 1984-11-19 | 1991-07-23 | Montefiore Hospital Association Of Western Pennsylvania | Aqueous nutrient compositions comprising oligopeptides |
| US4871550A (en) | 1986-09-05 | 1989-10-03 | Millman Phillip L | Nutrient composition for athletes and method of making and using the same |
| FR2618331B1 (fr) | 1987-07-23 | 1991-10-04 | Synthelabo | Compositions pharmaceutiques utiles pour le traitement de l'uremie |
| US5028622A (en) | 1988-05-06 | 1991-07-02 | Ajinomoto Company, Inc. | Administration of amino acids as treatment for neurodegenerative disorders |
| US5576351A (en) | 1989-12-29 | 1996-11-19 | Mcgaw, Inc. | Use of arginine as an immunostimulator |
| AU650293B2 (en) | 1990-11-01 | 1994-06-16 | Nestec S.A. | High acid system nutritional formulations |
| US5106836A (en) | 1991-02-22 | 1992-04-21 | Clintec Nutrition Co. | Enteral diet |
| US5977073A (en) | 1991-06-06 | 1999-11-02 | Life Sciences' Technologies, Inc. | Nutrient composition for treatment of immune disorders |
| US5780039A (en) | 1992-04-23 | 1998-07-14 | Novartis Nutrition Ag | Orally-ingestible nutrition compositions having improved palatability |
| US5229136A (en) | 1992-05-21 | 1993-07-20 | Clintec Nutrition Co. | Low caloric density enteral formulation designed to reduce diarrhea in tube-fed patients |
| US5276018A (en) | 1992-07-17 | 1994-01-04 | Brigham And Women's Hospital | Composition comprising amino acids and methods for decreasing muscle breakdown |
| DE4229166A1 (de) | 1992-09-01 | 1994-03-03 | Deutsches Krebsforsch | Mittel zur Aufrechterhaltung und/oder Steigerung der Muskelleistung und Körperzellmasse |
| US5356873A (en) | 1992-11-05 | 1994-10-18 | Clintec Nutrition Co. | Method for providing nutritional requirements to patients having a chronic inflammation reaction |
| US5348979A (en) | 1992-12-23 | 1994-09-20 | Iowa State University Research Foundation Inc. | Method of promoting nitrogen retention in humans |
| WO1994014458A1 (en) | 1992-12-23 | 1994-07-07 | Abbott Laboratories | Medical foods for the nutritional support of infant/toddler metabolic diseases |
| US5571783A (en) | 1993-03-09 | 1996-11-05 | Clintec Nutrition Company | Composition and method for treating patients with hepatic disease |
| US5891459A (en) | 1993-06-11 | 1999-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of vascular function by modulation of endogenous nitric oxide production or activity |
| US5712309A (en) | 1993-08-10 | 1998-01-27 | Musashi Pty Ltd. | Composition for treatment of hangovers |
| US5438042B1 (en) | 1993-10-08 | 1997-08-26 | Sandoz Nutrition Ltd | Enteral nutritional composition having amino acid profile |
| AU682894B2 (en) | 1993-10-28 | 1997-10-23 | Institut National De La Recherche Agronomique | Composition based on amino acids intended for the treatment of sepsis or of an attack bringing about an inflammatory reaction, in animals and man |
| US5378722A (en) | 1993-12-03 | 1995-01-03 | Clintec Nutrition Co. | Nutritional compositions for management of nitrogen metabolism |
| US5723446A (en) | 1993-12-23 | 1998-03-03 | Nestec Ltd. | Enteral formulation designed for optimized nutrient absorption and wound healing |
| US5714472A (en) | 1993-12-23 | 1998-02-03 | Nestec Ltd. | Enternal formulation designed for optimized nutrient absorption and wound healing |
| GB9403935D0 (en) | 1994-03-01 | 1994-04-20 | Sandoz Nutrition Ltd | Improvements in or relating to organic compounds |
| US5719133A (en) | 1994-09-21 | 1998-02-17 | Novartis Nutrition Ag | Adolescent dietary composition |
| IT1275434B (it) | 1995-05-19 | 1997-08-07 | Farmila Farma Milano | Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante |
| US5728678A (en) | 1995-06-06 | 1998-03-17 | Nestec Ltd. | Method and composition for providing nutrition to a renal failure patient |
| US5733884A (en) | 1995-11-07 | 1998-03-31 | Nestec Ltd. | Enteral formulation designed for optimized wound healing |
| US6087398A (en) | 1996-03-01 | 2000-07-11 | South Alabama Medical Science Foundation | Sickle cell anemia treatment |
| US5716926A (en) | 1996-07-26 | 1998-02-10 | Paxton K. Beale | Composition of pyruvate and protein and method for increasing protein concentration in a mammal |
| US6096785A (en) | 1996-07-30 | 2000-08-01 | Novartis Nutrition Ag | Amino acid compositions and use thereof in treating renal dysfunction |
| JPH1053521A (ja) | 1996-08-12 | 1998-02-24 | Kagaku Gijutsu Shinko Jigyodan | 脳内グルタミン酸の活性抑制剤および活性増強剤 |
| IT1289754B1 (it) | 1996-12-16 | 1998-10-16 | Professional Dietetics Srl | Composizioni a base di aminoacidi |
| US6013273A (en) | 1997-01-27 | 2000-01-11 | Novartis Nutrition Ag | Treatment of endotoxic shock |
| US5817329A (en) | 1997-02-28 | 1998-10-06 | Gardiner; Paul T. | Nutritional supplement for increased muscle size and strength for body builders |
| EP1123013A1 (en) | 1997-06-02 | 2001-08-16 | Société des Produits Nestlé S.A. | Product and method for providing glutamine |
| US5849335A (en) | 1997-06-02 | 1998-12-15 | Nestec S.A. | Composition and method for providing glutamine |
| US6281244B1 (en) | 1997-06-05 | 2001-08-28 | Novartis Nutrition Ag | Therapeutic use for glycine |
| DE69823739T2 (de) | 1997-06-05 | 2005-04-28 | Novartis Nutrition Ag | Glycin zur Vorbeugung oder Behandlung von Transplantatabstossungen |
| EP0891719A1 (en) | 1997-07-14 | 1999-01-20 | N.V. Nutricia | Nutritional composition containing methionine |
| IT1294227B1 (it) | 1997-08-01 | 1999-03-24 | Sigma Tau Ind Farmaceuti | Composizione farmaceutica contenente l-carnitina o una alcanoil l-carnitina e alcoli alifatici a lunga catena utile per la prevenzione |
| TW473387B (en) | 1997-09-30 | 2002-01-21 | Chugai Pharmaceutical Co Ltd | Pharmaceutical or food compositions for treating hepatic diseases or improving liver functions |
| US6288116B1 (en) | 1998-05-13 | 2001-09-11 | Novartis Nutrition Ag | Method of administration of a nutritional product to a person having renal failure |
| US6203820B1 (en) | 1998-05-28 | 2001-03-20 | Brice E. Vickery | Compositions and methods for enhancing protein anabolism and detoxification |
| US6103748A (en) | 1998-06-19 | 2000-08-15 | Bryan; Thomas B. | Method of treating an autoimmune disorder |
| US6031000A (en) | 1998-06-23 | 2000-02-29 | Iowa State University Research Foundation, Inc. | Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use |
| JP2000072669A (ja) | 1998-08-24 | 2000-03-07 | Inst Of Physical & Chemical Res | アミノ酸・糖組成物 |
| US6458338B1 (en) | 1998-09-22 | 2002-10-01 | Aeropharm Technology Incorporated | Amino acid stabilized medicinal aerosol formulations |
| US20010041187A1 (en) | 1998-10-20 | 2001-11-15 | Carl W Hastings | Performance-enhancing dietary supplement |
| EP1004302A3 (en) | 1998-10-29 | 2003-06-04 | Ajinomoto Co., Inc. | Immunomodulator |
| US6051236A (en) | 1998-11-12 | 2000-04-18 | Pacifichealth Laboratories, Inc. | Composition for optimizing muscle performance during exercise |
| US6143786A (en) | 1999-02-02 | 2000-11-07 | Novartis Nutrition Ag | Oral arginine and insulin secretion |
| US6241996B1 (en) | 1999-04-09 | 2001-06-05 | Novartis Nutrition Ag | Liquid soy nutritional products |
| WO2000064283A1 (en) | 1999-04-27 | 2000-11-02 | International Health Products And Services Ltd. | Supplement for restoring growth hormone levels |
| WO2001026642A2 (en) | 1999-10-08 | 2001-04-19 | Joyce Corinne Bechthold | Methods and compositions for treating neurobehavioral disorders |
| GB9929497D0 (en) | 1999-12-14 | 2000-02-09 | Vitaflo Limited | Improved amino acid mixtures for the treatment and/or management of certain diseases |
| CZ20022927A3 (cs) | 2000-02-01 | 2003-06-18 | Muscletech Research And Development Inc. | Doplňky stravy založené na alfa-lipoové kyselině pro zvýšení čisté svalové hmoty a síly |
| US6833350B2 (en) | 2000-02-04 | 2004-12-21 | Nestec S.A. | Method for maintaining or improving the synthesis of mucins |
| US6521591B1 (en) | 2000-02-10 | 2003-02-18 | N.V. Nutricia | Pharmaceutical composition for muscular anabolism |
| GB0009056D0 (en) | 2000-04-12 | 2000-05-31 | Nestle Sa | Composition comprising free amino acids |
| AU5625001A (en) | 2000-04-18 | 2001-10-30 | Societe Des Produits Nestle S.A. | Nutritional modules |
| US6391332B1 (en) | 2000-04-20 | 2002-05-21 | Baxter International, Inc. | Therapeutic micronutrient composition for severe trauma, burns and critical illness |
| IT1320783B1 (it) | 2000-07-04 | 2003-12-10 | Professional Dietetics Srl | Composizioni a base di aminoacidi, atte al miglioramento delleprestazioni muscolari. |
| IT1320782B1 (it) | 2000-07-04 | 2003-12-10 | Professional Dietetics Srl | Composizioni a base di aminoacidi, atte al trattamentodell'insufficienza cardiaca. |
| US20030187049A1 (en) | 2000-07-04 | 2003-10-02 | Dioguardi Francesco Saverio | Compositions based on aminoacids, suitable for improving muscle performance |
| EP1372641A4 (en) | 2001-03-05 | 2004-08-25 | Stephen P Ernest | ENTERAL FORMULATION |
| ATE441409T1 (de) | 2001-03-15 | 2009-09-15 | Riken | Aminosäurezusammensetzungen zur linderung einer fehlfunktion der leber |
| US20020193342A1 (en) | 2001-05-09 | 2002-12-19 | Hamman John P. | Modifying undesirable tastes |
| ITTO20010580A1 (it) | 2001-06-15 | 2002-12-15 | Professional Dietetics Srl | Composizioni a base di aminoacidi per il miglioramento della funzioneventricolare miocardica in pazienti affetti da diabete. |
| US6864230B2 (en) | 2001-07-31 | 2005-03-08 | Novartis Nutrition Ag | Glutamine rich dietary composition |
| EP1466602A4 (en) | 2001-12-25 | 2006-03-01 | Ajinomoto Kk | ORGAN FIBROSIS INHIBITORS |
| EP1471903B1 (en) | 2002-01-25 | 2019-11-20 | SciMar Ltd. | Use of glutathione synthesis stimulating compounds in reducing insulin resistance |
| JP2003238401A (ja) | 2002-02-20 | 2003-08-27 | Ajinomoto Co Inc | 疾患の治療、改善又は予防用医薬品及び飲食品 |
| US20050176827A1 (en) | 2002-05-10 | 2005-08-11 | Lee Steve S. | Compositions and methods for glycogen synthesis |
| US7338675B2 (en) | 2002-05-10 | 2008-03-04 | Tsi Health Sciences, Inc. | Fenugreek seed bio-active compositions and methods for extracting same |
| US8895059B2 (en) | 2002-06-05 | 2014-11-25 | Ivax Pharmaceuticals S.R.O. | Reduction of cross-linking gelatin in gelatin capsules |
| WO2004019928A1 (ja) | 2002-08-30 | 2004-03-11 | Ajinomoto Co., Inc. | 肝疾患治療剤 |
| US20040087490A1 (en) | 2002-09-20 | 2004-05-06 | Troup John P. | Nutritional compositions |
| US20040057983A1 (en) | 2002-09-25 | 2004-03-25 | David Schmidt | Biomolecular wearable apparatus |
| US7037522B2 (en) | 2002-09-27 | 2006-05-02 | Western Holdings, L.L.C. | Nocturnal muscle enhancing composition and method |
| JP2004123564A (ja) | 2002-09-30 | 2004-04-22 | Inst Of Physical & Chemical Res | 中枢機能改善用アミノ酸組成物 |
| JP2004182705A (ja) | 2002-10-11 | 2004-07-02 | Yasutoshi Koga | ミトコンドリア機能異常に起因する疾患における臨床症状発現の予防・治療用組成物 |
| US7547450B2 (en) | 2002-10-24 | 2009-06-16 | Nestec Ltd. | Senior feline food |
| US8093292B2 (en) | 2002-11-22 | 2012-01-10 | Bionexus, Ltd. | Methods for the treatment of HIV-1 related fat maldistribution, fasting hyperlipidemia and modification of adipocyte physiology |
| US7288570B2 (en) | 2002-12-20 | 2007-10-30 | Nutricia N.V. | Stimulation of in vivo production of proteins |
| US20040120983A1 (en) | 2002-12-23 | 2004-06-24 | Philip Connolly | Nutritional supplement |
| JP4989836B2 (ja) | 2002-12-26 | 2012-08-01 | 大塚製薬株式会社 | 経口栄養剤 |
| EP1582207A4 (en) | 2002-12-26 | 2008-03-05 | Ajinomoto Kk | HEMMER FOR OUTBREAKING AND PROGREDIENCE OF LIVER CANCER |
| JP2006520335A (ja) | 2003-03-18 | 2006-09-07 | ノバルティス アクチエンゲゼルシャフト | 脂肪酸とアミノ酸を含有する組成物 |
| US20040213838A1 (en) | 2003-04-24 | 2004-10-28 | Mazer Terrence B. | Medical food tablets containing free amino acids |
| JP4528925B2 (ja) | 2003-05-30 | 2010-08-25 | 独立行政法人理化学研究所 | アミノ酸組成物及び補液 |
| ES2391558T3 (es) | 2003-06-23 | 2012-11-27 | Nestec S.A. | Suplemento de aminoácidos para un ecosistema microbiótico sano |
| JP2005027524A (ja) | 2003-07-08 | 2005-02-03 | Ajinomoto Co Inc | 経口アミノ酸組成物 |
| WO2005017094A2 (en) | 2003-08-19 | 2005-02-24 | Bioadvantex Pharma Inc. | N-acetyl compositions as adjunct therapy for treatment and prevention of cysteine/glutathione deficiency |
| ITTO20030789A1 (it) | 2003-10-07 | 2005-04-08 | Professional Dietetics Srl | Composizione a base di amino acidi per il trattamento |
| WO2005039318A1 (en) | 2003-10-16 | 2005-05-06 | Nestec S.A. | Nutritional composition against side effects of chemotherapy of radiotherapy |
| EP1685833A1 (en) | 2003-11-21 | 2006-08-02 | Ajinomoto Co., Inc. | Remedy for diabetes |
| EP1543735B1 (en) | 2003-12-20 | 2015-10-07 | Nestec S.A. | Nutritional composition for wound healing |
| JPWO2005072721A1 (ja) | 2004-01-28 | 2007-09-06 | 味の素株式会社 | 局所脳血流低下に伴う神経系障害の予防または治療のための医薬組成物 |
| CA2558220C (en) | 2004-02-27 | 2012-01-24 | Incorporated Administrative Agency National Agriculture And Food Researc H Organization | Food ingredient including enriched free amino acids and their production method |
| US20050233013A1 (en) | 2004-03-02 | 2005-10-20 | Lee Steve S | Methods for enhancing the transport of glucose for balancing blood sugar levels |
| US20050215640A1 (en) | 2004-03-26 | 2005-09-29 | Baxter Jeffrey H | HMB compositions and uses thereof |
| JP4815752B2 (ja) | 2004-04-01 | 2011-11-16 | 味の素株式会社 | アミノ酸含有飲食品 |
| WO2005110124A1 (en) | 2004-04-15 | 2005-11-24 | Abbott Laboratories | Composition and methods for nutritional management of patients with hepatic disease |
| CN1582912A (zh) | 2004-06-10 | 2005-02-23 | 武汉启瑞科技发展有限公司 | L－鸟氨酸和 l－门冬氨酸组合物 |
| WO2006009975A2 (en) | 2004-06-22 | 2006-01-26 | Maxim Pharmaceuticals, Inc. | Histamine to treat disorders affecting muscle function |
| RU2372900C2 (ru) | 2004-07-14 | 2009-11-20 | Адзиномото Ко., Инк. | Ингибитор возникновения и развития рака печени для применения у пациентов-людей с циррозом печени, положительных по вирусу гепатита с |
| JP2008506771A (ja) | 2004-07-19 | 2008-03-06 | エヌ．ブイ．・ヌートリシア | 血糖値を調節するためのアスパルテートを使用するための調製物 |
| EP1637163A1 (en) | 2004-09-21 | 2006-03-22 | Andreas Kluge | Indicator of therapeutic compliance |
| JP5177785B2 (ja) | 2004-11-02 | 2013-04-10 | 味の素株式会社 | 周術期患者用薬剤 |
| SG158073A1 (en) | 2004-11-26 | 2010-01-29 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| WO2006083381A2 (en) | 2004-12-03 | 2006-08-10 | University Of Maryland, Baltimore | Composition for treating sulfur mustard toxicity and methods of using same |
| JPWO2006061992A1 (ja) | 2004-12-10 | 2008-06-05 | 味の素株式会社 | 肝疾患予防・治療用組成物 |
| US20080114067A1 (en) | 2005-01-31 | 2008-05-15 | Takanobu Yamamoto | Composition for Recovery From or Prevention of Central Nervous System Fatigue |
| US20060198899A1 (en) | 2005-03-01 | 2006-09-07 | Gardiner Paul T | Supplemental dietary composition for supporting muscle growth, recovery and strength |
| CN101175995A (zh) | 2005-03-15 | 2008-05-07 | 雀巢技术公司 | 用于调节维生素c生物利用率的营养组合物 |
| ES2402935T3 (es) | 2005-03-21 | 2013-05-10 | Abbott Laboratories | Composición de aminoácidos para mejorar la tolerancia a la glucosa |
| JP5545424B2 (ja) | 2005-03-29 | 2014-07-09 | 味の素株式会社 | 高齢者の骨格筋量減少を防止又は改善するためのアミノ酸含有組成物 |
| EP2243383A3 (en) | 2005-04-06 | 2011-02-16 | Nestec S.A. | A method and composition for nutritionally improving glucose control and insulin action |
| US8993627B2 (en) | 2005-04-21 | 2015-03-31 | Sentient Lifesciences, Inc. | N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress |
| US20090209647A1 (en) | 2005-06-14 | 2009-08-20 | Nestec S.A. | Nutritional method |
| EP2184062A1 (en) | 2005-06-22 | 2010-05-12 | Ajinomoto Co., Inc. | Use of glutamic acid and a nucleic acid as metabotropic glutamate receptor activators |
| US20100104548A1 (en) | 2005-06-24 | 2010-04-29 | Albert Einstein College Of Medicine Of Yeshiva University | Modulation of amino acid metabolism in the hypothalamus |
| JPWO2007004613A1 (ja) | 2005-07-01 | 2009-01-29 | 味の素株式会社 | 炎症性腸疾患治療薬及びＴＮＦ−α産生抑制剤 |
| JP5682990B2 (ja) | 2005-08-04 | 2015-03-11 | 味の素株式会社 | 酸化型アルブミン低下剤 |
| WO2007018278A1 (ja) | 2005-08-05 | 2007-02-15 | Ajinomoto Co., Inc. | 肝癌発生・進展抑制剤 |
| US8148356B2 (en) | 2005-08-24 | 2012-04-03 | Cumberland Pharmaceuticals, Inc. | Acetylcysteine composition and uses therefor |
| EP1919304B1 (en) | 2005-08-26 | 2011-05-25 | Nestec S.A. | Compositions and methods for improving functional vascular integrity, cellular survival and reducing apoptosis after an ischemic episode in the brain |
| EP1774973A1 (en) | 2005-10-12 | 2007-04-18 | Nutricia N.V. | Leucine rich composition |
| CA2627566A1 (en) | 2005-10-28 | 2007-05-10 | Nestec S.A. | Methods for the use of branched chain amino acids |
| WO2007056176A2 (en) | 2005-11-03 | 2007-05-18 | Southwest Immunology, Inc. | Compositions for preventing and reducing delayed onset muscle soreness |
| US20070243211A1 (en) | 2005-11-07 | 2007-10-18 | Jaffe Russell M | Compositions for regulating metabolic disorders and methods of use thereof |
| RU2414897C2 (ru) | 2005-11-30 | 2011-03-27 | Нестек С.А. | Способы лечения потери мышечной массы |
| ES2548432T3 (es) | 2005-12-19 | 2015-10-16 | Abbott Laboratories | Uso de beta-hidroxi-beta-metilbutirato para modular el desequilibrio en la producción de citoquinas de tipo 1 y tipo 2 |
| RU2437655C2 (ru) | 2006-01-09 | 2011-12-27 | Нестек С.А. | Лечение пациентов, подвергнутых стрессу |
| PL1983849T3 (pl) | 2006-01-20 | 2013-09-30 | Innova Food Ab | Kompozycja spożywcza zawierająca aminokwasy |
| BRPI0706795A2 (pt) | 2006-01-31 | 2011-04-05 | Nestec Sa | composição nutricional para bebês com baixo peso de nascimento |
| US20070270355A1 (en) | 2006-05-11 | 2007-11-22 | Garcia Ramon D | Sport drink containing amino acids and carbohydrates |
| JP5100033B2 (ja) | 2006-05-16 | 2012-12-19 | 大塚製薬株式会社 | 消化管及び腎臓の萎縮抑制剤 |
| US20070286909A1 (en) | 2006-06-07 | 2007-12-13 | Daniel S. Smith | Amino acid compositions |
| US9192593B2 (en) | 2006-08-30 | 2015-11-24 | Ajinomoto Co., Inc. | Amino-acid containing composition for inhibiting accumulation of fat |
| MY146112A (en) | 2006-10-19 | 2012-06-29 | Nestec Sa | Long-term feed - cancer patient |
| US20080102137A1 (en) | 2006-10-31 | 2008-05-01 | Guffey Manning V R | Composition and method for etiological treatment and prevention of diseases and/or complications associated with chronic glucose metabolism destabilization |
| GB0624879D0 (en) | 2006-12-14 | 2007-01-24 | Shs Int Ltd | Treatment of pervasive development disorders |
| EP1932437A1 (en) | 2006-12-15 | 2008-06-18 | Nestec S.A. | Infant formula |
| US20080268038A1 (en) | 2007-04-26 | 2008-10-30 | Wolfe Robert R | Compositions and Approaches for Increasing Diet Induced Thermogenesis, Inducing Weight Loss and Maintaining Muscle Mass and Strength |
| CN101332209B (zh) | 2007-06-25 | 2010-12-08 | 三菱制药（广州）有限公司 | 治疗肝性脑病的复方氨基酸注射液 |
| US8455531B2 (en) | 2007-09-18 | 2013-06-04 | Thermolife International, Llc | Amino acid compositions |
| US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
| KR100970664B1 (ko) | 2007-10-11 | 2010-07-15 | 한화제약주식회사 | Ｌ-오르니틴-ｌ-아스파테이트를 함유한 겔제의 제조방법 및그 겔제 |
| EP2057905A1 (en) | 2007-11-12 | 2009-05-13 | TIMA Foundation | Composition for moderating Triglyceride and Cholesterol Levels |
| CA2706656A1 (en) | 2007-11-26 | 2009-06-04 | Nestec S.A. | Compositions and methods for inhibiting the activation of dsrna-dependent protein kinase and tumor growth inhibition |
| CN101214050B (zh) | 2007-12-28 | 2011-08-31 | 叶高山 | 一种具有提神、抗疲劳、醒酒功能的保健饮料 |
| CA2994586C (en) | 2008-01-04 | 2020-07-21 | Nestec S.A. | Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing cognitive and related functions |
| US7790688B2 (en) | 2008-01-11 | 2010-09-07 | Healthspan Solutions, Llc | Compositions and methods for increasing muscle mass, strength, and functional performance in the elderly |
| US20090186098A1 (en) | 2008-01-18 | 2009-07-23 | Jose Briceno | Sports drink composition |
| ATE523095T1 (de) | 2008-01-25 | 2011-09-15 | Cesar Gallia S R L | Aminosäurenkonzentrat in wässrigem gel und mittels verdünnung besagten konzentrats mit wasser erhaltenes getränk zur bekämpfung von müdigkeit |
| US8716249B2 (en) | 2008-01-31 | 2014-05-06 | Energy Light Llc | Compositions and methods for improving cardiovascular health |
| WO2009100241A2 (en) | 2008-02-05 | 2009-08-13 | Healthspan Solutions, Llc | Systems for and methods of use of therapeutic nutrition for the management of age-associated and age-specific health conditions of the elderly. |
| AU2009210728B2 (en) | 2008-02-07 | 2014-06-19 | Société des Produits Nestlé S.A. | Compositions and methods for influencing recovery from strenuous physical activity |
| EP2098126A1 (en) | 2008-03-03 | 2009-09-09 | Nestec S.A. | Carbohydrate Bar |
| EP2098124A1 (en) | 2008-03-03 | 2009-09-09 | Nestec S.A. | Carbohydrate gel |
| CN102316730A (zh) | 2008-05-09 | 2012-01-11 | 天雅瑞药业有限公司 | 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释 |
| US20090306209A1 (en) | 2008-06-04 | 2009-12-10 | Daugherty F Joseph | Enteric-coated formulations of polyethylene glycol and one or more soluble amino acids for oral ingestion and enhanced uptake of same |
| US20100021573A1 (en) | 2008-07-22 | 2010-01-28 | Michael J Gonzalez | Compositions and methods for the prevention of cardiovascular disease |
| EP2165713B1 (en) | 2008-09-19 | 2012-11-14 | Nestec S.A. | Whey and thymus function |
| EP3011843A1 (en) | 2008-09-19 | 2016-04-27 | Nestec S.A. | Nutritional support of the immune system during anti-cancer treatment |
| WO2010050168A1 (ja) | 2008-10-27 | 2010-05-06 | 味の素株式会社 | バリン、イソロイシン、ロイシン固溶体およびその製造方法 |
| US8362080B2 (en) | 2008-12-18 | 2013-01-29 | Baylor College Of Medicine | Increasing glutathione levels for therapy |
| US9314444B2 (en) | 2009-01-12 | 2016-04-19 | Biokier, Inc. | Composition and method for treatment of NASH |
| RS56054B1 (sr) | 2009-01-12 | 2017-09-29 | Biokier Inc | Smeša i metod za lečenje dijabetesa |
| US20120178672A1 (en) | 2009-03-18 | 2012-07-12 | Wolfe Robert R | Compositions and Methods for Sparing Muscle in Renal Insufficiency and During Hemodialysis |
| WO2010108542A1 (en) | 2009-03-25 | 2010-09-30 | Nestec S.A. | A natural taste enhancing savoury base and a process for its preparation |
| CA2757373C (en) | 2009-04-03 | 2018-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| WO2010126353A1 (en) | 2009-04-27 | 2010-11-04 | N.V. Nutricia | Pea-based protein mixture and use thereof in a liquid nutritional composition suitable for enteral feeding |
| US8703719B1 (en) | 2009-05-18 | 2014-04-22 | Bio-Engineered Supplements And Nutrition, Inc. | Method and composition for improved muscle performance |
| EA201691430A1 (ru) | 2009-06-08 | 2017-02-28 | ЮСиЭл БИЗНЕС ПиЭлСи | Лечение портальной гипертензии и восстановление функции печени с помощью l-орнитинфенилацетата |
| WO2010143939A1 (en) | 2009-06-09 | 2010-12-16 | N.V. Nutricia | Nutrition for improving muscle strength in elderly |
| JP2012533627A (ja) | 2009-07-20 | 2012-12-27 | ネステク ソシエテ アノニム | 機能状態の喪失を減弱する方法 |
| WO2011030104A1 (en) | 2009-09-09 | 2011-03-17 | Rajiv Jalan | Phenylacetate and/or phenylbutyrate (not ornithine) for reducing portal blood pressure |
| CN101664384B (zh) | 2009-09-18 | 2011-09-14 | 杭州市第六人民医院 | N-乙酰半胱氨酸盐木糖醇注射液及其制备方法和应用 |
| CN102711800A (zh) | 2009-09-23 | 2012-10-03 | 拜奥基尔公司 | 治疗糖尿病的组合物和方法 |
| WO2011044230A2 (en) | 2009-10-06 | 2011-04-14 | Goldstein Glenn A | N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions |
| WO2011043647A1 (en) | 2009-10-09 | 2011-04-14 | N.V. Nutricia | Amino acid composition with improved dispersibility |
| EP2327315B1 (en) | 2009-11-29 | 2013-10-09 | Nestec S.A. | Dosing protocols for increasing protein synthesis in an active individual |
| EP2327316B1 (en) | 2009-11-29 | 2016-11-16 | Premier Nutrition Corporation | Method of enhancing muscle protein synthesis |
| WO2011078654A1 (en) | 2009-12-24 | 2011-06-30 | N.V. Nutricia | Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis |
| JP2011132174A (ja) | 2009-12-24 | 2011-07-07 | Kirin Holdings Co Ltd | 持久力向上剤 |
| WO2011097273A1 (en) | 2010-02-02 | 2011-08-11 | Martek Biosciences Corporation | Methods and compositions for treating non-alcoholic fatty liver disease with docosahexaenoic acid and n-acetyl lcystenine |
| CA2792396C (en) | 2010-03-12 | 2018-09-11 | Nestec S.A. | Compositions for masking the flavor of nutrients and methods for making same |
| WO2011119023A1 (en) | 2010-03-26 | 2011-09-29 | N.V. Nutricia | Low protein infant formula with increased essential amino acids |
| US20130210715A1 (en) | 2010-04-26 | 2013-08-15 | Nestec S.A. | Nutritional compositions and methods for weaning from parenteral nutrition to enteral nutrition |
| US8840950B2 (en) | 2010-05-26 | 2014-09-23 | Jacqueline M. Hibbert | Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore |
| WO2012005568A1 (en) | 2010-07-07 | 2012-01-12 | N.V. Nutricia | Nutritional composition for the stimulation of muscle protein synthesis |
| KR101213825B1 (ko) | 2010-07-16 | 2012-12-18 | 서울대학교산학협력단 | 세린을 유효성분으로 함유하는 지방간 질환의 예방 및 치료용 조성물 |
| MY173215A (en) | 2010-07-21 | 2020-01-06 | Cumberland Pharmaceuticals Inc | Acetylcysteine compositions and methods of use thereof |
| US20120020947A1 (en) | 2010-07-22 | 2012-01-26 | Northern Innovations And Formulations Corp. | Compositions and methods for increasing lean muscle mass after exercise |
| CN101912394B (zh) | 2010-08-06 | 2013-11-06 | 岳茂兴 | 一种用于治疗凝血障碍出血的药物组合物及其用途 |
| MX360062B (es) | 2010-10-06 | 2018-10-22 | Ocera Therapeutics Inc | Metodos de elaboracion de fenilacetato de l-ornitina. |
| EP2444083A1 (en) | 2010-10-21 | 2012-04-25 | Nestec S.A. | Cysteine and food intake |
| SG191315A1 (en) | 2010-12-22 | 2013-07-31 | Abbott Lab | Nutritional products comprising calcium beta-hydroxy-beta methylbutyrate and conjugated linoleic acid |
| CA2821312A1 (en) | 2010-12-27 | 2012-07-05 | Abbott Laboratories | Methods for facilitating muscle recovery after a period of disuse using beta-hydroxy-beta-methylbutyrate |
| WO2012097061A1 (en) | 2011-01-13 | 2012-07-19 | Abbott Laboratories | Nutritional compositions and methods for improving skeletal muscle protein metabolism |
| RU2597793C2 (ru) | 2011-01-25 | 2016-09-20 | Нестек С.А. | Способы и композиции для лечения, ослабления или предотвращения ухудшения зрительной системы животных |
| RU2491062C2 (ru) | 2011-03-16 | 2013-08-27 | Общество С Ограниченной Ответственностью "Биотехнологии Пущино" | Композиции протекторов острых и хронических печеночных энцелопатий и способ лечения острых и хронических печеночных энцелопатий |
| JP2014515011A (ja) | 2011-03-18 | 2014-06-26 | ネステク ソシエテ アノニム | 加齢に伴う疾病を改善するのに有用な組成物及び方法 |
| US11235008B2 (en) | 2011-03-31 | 2022-02-01 | Ganeden Biotech, Inc. | Probiotic sports nutrition compositions |
| CN102327259A (zh) | 2011-03-31 | 2012-01-25 | 姜国辉 | 具有显著化学性肝损伤保护功能的复合生物制剂 |
| EP2696868A1 (en) | 2011-04-12 | 2014-02-19 | Nestec S.A. | Nutritional compositions including branched chain fatty acids and methods of using same |
| CN103491804A (zh) | 2011-04-18 | 2014-01-01 | 雀巢产品技术援助有限公司 | 具有α-HICA 和二十碳五烯酸的营养组合物 |
| US20120270860A1 (en) | 2011-04-19 | 2012-10-25 | Gihyun Yoon | Methods for treating or preventing alcohol-related disorders or craving-related disorders |
| JP2014513527A (ja) | 2011-04-21 | 2014-06-05 | ネステク ソシエテ アノニム | パフォーマンス向上のための栄養組成物並びにその作製及び使用方法 |
| US8828426B2 (en) | 2011-06-07 | 2014-09-09 | Zx Pharma, Llc | Multiparticulate L-carnitine compositions and related methods |
| US20140135396A1 (en) | 2011-07-05 | 2014-05-15 | Beth Israel Deaconess Medical Center, Inc. | Treatment of Acetaminophen-Induced Liver Damage by the Administration of Modulators of Nitric Oxide |
| BR112014002779A2 (pt) | 2011-08-08 | 2017-02-21 | Ajinomoto Kk | composição contendo aminoácido para o melhoramento da recuperação a partir de fadiga muscular |
| HK1199378A1 (en) | 2011-08-19 | 2015-07-03 | Musclepharm Corporation | Compositions and methods for use in promoting lean body mass |
| EP2574333B1 (en) | 2011-09-27 | 2017-01-11 | Friulchem SpA | N-acetylcysteine effervescent tablet and its therapeutical applications |
| EP2580967A1 (en) | 2011-10-11 | 2013-04-17 | Nestec S.A. | Accelerating muscle recovery after immobilization-induced muscle atrophy |
| EP2583563A1 (en) | 2011-10-21 | 2013-04-24 | Nestec S.A. | Whey protein micelles against muscle atrophy and sarcopenia |
| EP2583565A1 (en) | 2011-10-21 | 2013-04-24 | Nestec S.A. | Use of whey protein micelles for enhancing energy expenditure and satiety |
| US9364463B2 (en) | 2011-11-18 | 2016-06-14 | Board Of Trustees Of The University Of Arkansas | Use of amino acid supplementation for improved muscle recovery |
| CN108478551A (zh) | 2011-11-21 | 2018-09-04 | 埃默斯医疗股份有限公司 | 用于治疗糖尿病和相关病症的方法和组合物 |
| WO2013081154A1 (ja) | 2011-12-02 | 2013-06-06 | 味の素株式会社 | キナーゼ阻害剤の副作用低減剤 |
| AU2013210373A1 (en) | 2012-01-19 | 2014-09-04 | Shoichi Shirotake | Antibacterial agent against plant disease-causing bacteria |
| US9198454B2 (en) | 2012-03-08 | 2015-12-01 | Nusirt Sciences, Inc. | Compositions, methods, and kits for regulating energy metabolism |
| WO2013188258A1 (en) | 2012-06-11 | 2013-12-19 | Abbott Laboratories | Use of hmb to improve health outcomes for hospitalized patients |
| JP6368306B2 (ja) | 2012-07-31 | 2018-08-01 | ネステク ソシエテ アノニム | 炎症性腸疾患（ｉｂｄ）患者の筋骨格の健康を促進させるための栄養組成物 |
| CA2884717A1 (en) | 2012-09-14 | 2014-03-20 | Nestec S.A. | Novel flavour compositions with improved flavour and/or flavour shelf-life |
| US8747921B2 (en) | 2012-09-19 | 2014-06-10 | Quality Ip Holdings, Inc. | Methods for improving health in humans |
| US9198889B2 (en) | 2012-09-19 | 2015-12-01 | Quality IP Holdings, LLC | Methods for treating post-traumatic stress disorder |
| US9066953B2 (en) | 2012-09-20 | 2015-06-30 | Quality IP Holdings, LLC | Methods for increasing endurance and fat metabolism in humans |
| CN102961377A (zh) | 2012-11-08 | 2013-03-13 | 湖北一半天制药有限公司 | 复方氨基酸注射液（20aa）的制备方法 |
| ES2633769T3 (es) | 2012-12-04 | 2017-09-25 | Nestec S.A. | Hexanoilglicina como biomarcador para la predisposición al aumento de peso y a la obesidad |
| CA2899925A1 (en) | 2013-02-04 | 2014-08-07 | Seres Therapeutics, Inc. | Compositions and methods for inhibition of pathogenic bacterial growth |
| KR101969199B1 (ko) | 2013-03-11 | 2019-04-15 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 폐 기능의 개선 및 방사선 유발된 폐 합병증의 예방 및/또는 치료를 위한 물질 및 방법 |
| CN105228627B (zh) | 2013-03-15 | 2018-07-13 | 纽斯尔特科学公司 | 亮氨酸和烟酸降低脂质水平 |
| CN105246357A (zh) | 2013-03-26 | 2016-01-13 | 普瑞米尔营养公司 | 提高组合训练后肌肉蛋白质合成的方法 |
| ES2617714T5 (es) | 2013-04-15 | 2021-02-11 | Nestle Sa | Empleo de la proteína de suero en combinación con la estimulación eléctrica muscular |
| ES2844199T3 (es) | 2013-04-16 | 2021-07-21 | Childrens Hospital Philadelphia | Composiciones y métodos para el tratamiento de lesiones cerebrales |
| WO2014191856A1 (en) | 2013-05-31 | 2014-12-04 | Nestec S.A. | Methods for enhancement of muscle protein synthesis |
| EP3019024B1 (en) | 2013-06-28 | 2017-02-01 | Nestec S.A. | Compositions and methods for enhancing exercise performance |
| WO2015015149A1 (en) | 2013-07-31 | 2015-02-05 | Leeds Metropolitan University | Dietary supplement |
| US20180125926A1 (en) | 2013-09-25 | 2018-05-10 | Axcella Health Inc. | Compositions and Formulations and Methods of Production and Use Thereof |
| EP3048904A2 (en) | 2013-09-25 | 2016-08-03 | Pronutria Biosciences, Inc. | Compositions and formulations for treatment of gastrointestinal tract malabsorption diseases and inflammatory conditions and methods of production and use thereof |
| EP3054938A1 (en) | 2013-10-09 | 2016-08-17 | Nestec S.A. | Compositions comprising citrulline and leucine and their use in the treatment of diabetes and metabolic syndrome |
| WO2015061607A1 (en) | 2013-10-23 | 2015-04-30 | Whitehead Institute For Biomedical Research | Mtorc1 modulation by amino acids and uses thereof |
| EP3110507B1 (en) | 2014-02-27 | 2020-11-18 | NuSirt Sciences, Inc. | Compositions and methods for the reduction or prevention of hepatic steatosis |
| GB2523578A (en) | 2014-02-28 | 2015-09-02 | Daniel Nelson | A nutritional supplement |
| WO2015161448A1 (en) | 2014-04-22 | 2015-10-29 | Wuhan Ll Science And Technology Development Co., Ltd. | Ornithine-containing or aspartate-containing compositions and the uses thereof |
| CN105092753B (zh) | 2014-05-20 | 2016-09-07 | 中国科学院大连化学物理研究所 | 组合型胺类代谢标志物的应用及试剂盒 |
| WO2016003263A1 (en) | 2014-07-01 | 2016-01-07 | N.V. Nutricia | Amino acid based diet with improved taste |
| US10217645B2 (en) | 2014-07-25 | 2019-02-26 | Versum Materials Us, Llc | Chemical mechanical polishing (CMP) of cobalt-containing substrate |
| US20160158305A1 (en) | 2014-09-19 | 2016-06-09 | Chip E. Thomson | Additives and supplements |
| WO2016058919A1 (en) | 2014-10-14 | 2016-04-21 | Nestec S.A. | Improvement in muscle functionality of elderly males |
| US10039735B2 (en) | 2014-11-24 | 2018-08-07 | Ucl Business Plc | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| UA120627C2 (uk) | 2014-12-04 | 2020-01-10 | Профешенал Дайатетікс С.П.А. | Композиція на основі амінокислоти для відновлення фіброеластину в дермальній сполучній тканині |
| US10894024B2 (en) | 2014-12-08 | 2021-01-19 | Synaptamine, Inc. | Anti-RDS compounds and method of manufacture and administration thereof to induce dopamine homeostatis |
| EP3034074A1 (en) | 2014-12-18 | 2016-06-22 | Universitat De València, Estudi General | Compound for treatment of myotonic dystrophy type 1 |
| JP6959136B2 (ja) | 2015-01-23 | 2021-11-02 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 患者の示差的な栄養所要量の決定方法 |
| AU2016208455A1 (en) | 2015-01-23 | 2017-06-15 | Société des Produits Nestlé S.A. | Nutritional composition useful in the treatment of IBD patients |
| US20170368026A1 (en) | 2015-01-23 | 2017-12-28 | Nestec S.A. | Promotion of healing of intestinal mucosa using proline, serine and threonine |
| US20180021278A1 (en) | 2015-01-23 | 2018-01-25 | Nestec S.A. | Treatment or prevention of inflammation using serine |
| JP6847668B2 (ja) | 2015-01-27 | 2021-03-24 | 昇一 城武 | ナノ粒子を有効成分とする皮膚炎の治療又は予防剤 |
| BR112017014924A2 (pt) | 2015-02-13 | 2018-03-20 | Nestec Sa | Tratamento ou prevenção de caquexia induzida por cirurgia e/ou expressão de células supressoras de origem mieloide e citoquinas pró- inflamatórias |
| US20180036270A1 (en) | 2015-02-13 | 2018-02-08 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | A method of protecting against carbonyl stress induced ischemia-reperfusion injury in the diabetic brain via administration of n-acetylcysteine |
| FR3032883B1 (fr) | 2015-02-24 | 2017-03-17 | International Nutrition Res Company | Composition pour la prevention et le traitement de la steatose et de la steatohepatite metaboliques |
| US20160302451A1 (en) | 2015-04-16 | 2016-10-20 | Michael Hudnall | Medical Food for Patients with Chronic Liver Disease |
| RU2755904C2 (ru) | 2015-04-20 | 2021-09-22 | Осера Терапьютикс, Инк. | Составы l-орнитин фенилацетата |
| US10123985B2 (en) | 2015-06-08 | 2018-11-13 | Whitehead Institute For Biomedical Research | Therapeutic strategies for treating mitochondrial disorders |
| ES2860427T3 (es) | 2015-06-22 | 2021-10-05 | Nestle Sa | Composiciones y métodos para mejorar la neurogénesis en animales |
| MX380541B (es) | 2015-06-30 | 2025-03-12 | Soc Des Produits Nestle S A Star | Composición adecuada para proteger microorganismos. |
| RU2755478C2 (ru) | 2015-07-15 | 2021-09-16 | Юниджен, Инк. | Композиции, способы и медицинские композиции для лечения и поддержания здоровья печени |
| ES2875601T3 (es) | 2015-08-14 | 2021-11-10 | Nestle Sa | Composiciones alimentarias semihúmedas que mantienen una textura blanda |
| EP3337473A4 (en) | 2015-08-18 | 2019-04-17 | Ocera Therapeutics, Inc. | TREATMENT AND PREVENTION OF MUSCLE WOUND BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE |
| US11019817B2 (en) | 2015-08-25 | 2021-06-01 | Shoichi Shirotake | Antimicrobial agent against germs which has excellent plant disease control effect |
| US20170079897A1 (en) | 2015-09-20 | 2017-03-23 | Matthew Brissette MINUS | Composition for hair application and methods of hair care |
| AU2016325556B2 (en) | 2015-09-25 | 2023-02-16 | Ocera Therapeutics, Inc. | Treatment and prevention of neuronal cell loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
| AU2016353350B2 (en) | 2015-11-13 | 2021-09-23 | Ocera Therapeutics, Inc. | Formulation of L-ornithine phenylacetate |
| GB2561747B (en) | 2015-12-21 | 2021-05-12 | Nanjing Jianrong Bio Tech Co Ltd | Composition for treating motor neuron diseases and use thereof |
| EA201891592A1 (ru) | 2016-01-08 | 2019-02-28 | КОЛОНАРИКОНСЕПТС ЭлЭлСи | Основанная на пищевых продуктах доставка терапевтического агента для лечения печеночной энцефалопатии |
| GB201600990D0 (en) | 2016-01-19 | 2016-03-02 | Abbott Lab | Pharmaceutical or nutritional combination |
| US20190133147A1 (en) | 2016-05-11 | 2019-05-09 | Tsubo Solutions Pty Ltd | Confectionery product |
| PL238958B1 (pl) | 2016-06-29 | 2021-10-25 | Olimp Laboratories Spolka Z Ograniczona Odpowiedzialnoscia | Kompozycja aminokwasowa do stosowania przed wysiłkiem fizycznym |
| US20180015122A1 (en) | 2016-07-14 | 2018-01-18 | Companion Supplements, LLC | Pharmaceutical composition effective in preventing adverse effects associated with the use of glucocorticoids |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| JOP20190147A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض واضطرابات العضلات |
| SE540582C2 (en) | 2016-12-22 | 2018-10-02 | Scandibio Therapeutics Ab | Substances for treatment of fatty liver-related conditions |
| CN106632605B (zh) | 2016-12-22 | 2020-06-16 | 浙江海洋大学 | 利用金枪鱼下脚料制备的具有肝损伤修复作用的活性肽 |
| KR20190119046A (ko) | 2017-01-19 | 2019-10-21 | 오톨로직 파마슈틱스, 인크. | N-아세틸시스테인의 제제 및 이의 용도 |
| US11617731B2 (en) | 2017-04-28 | 2023-04-04 | Axcella Health, Inc. | Amino acid compositions and their use for the treatment of traumatic brain injury |
| CN107242552A (zh) | 2017-07-07 | 2017-10-13 | 上海东锦食品集团有限公司 | 具有缓解体力疲劳及增强免疫力功能的保健食品组合物 |
| WO2019036442A1 (en) | 2017-08-14 | 2019-02-21 | Axcella Health Inc. | AMINO ACIDS BRANCHED FOR THE TREATMENT OF NEURONAL INJURY |
| IL296055A (en) | 2017-08-14 | 2022-10-01 | Axcella Health Inc | Amino acid compositions for the treatment of liver disease |
| CN108041501A (zh) | 2017-12-22 | 2018-05-18 | 北京康比特体育科技股份有限公司 | 一种促进疲劳恢复的蛋白组合物及其制备方法 |
| CU20200106A7 (es) | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| WO2019246221A1 (en) | 2018-06-20 | 2019-12-26 | Axcella Health Inc. | Compositions and methods for the treatment of liver diseases and disorders |
| JOP20200324A1 (ar) | 2018-06-20 | 2020-12-14 | Axcella Health Inc | تركيبات للعلاج والصحة تحتوي على أحماض أمينية ذات طعم مُر |
| CN112823018A (zh) | 2018-06-20 | 2021-05-18 | 胺细拉健康公司 | 制备氨基酸组合物的方法 |
| MA52971A (fr) | 2018-06-20 | 2021-04-28 | Axcella Health Inc | Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle |
| CN108524453A (zh) | 2018-07-05 | 2018-09-14 | 扬子江药业集团广州海瑞药业有限公司 | 一种门冬氨酸鸟氨酸的药物组合物 |
-
2019
- 2019-06-19 MA MA052971A patent/MA52971A/fr unknown
- 2019-06-19 JP JP2020570746A patent/JP2021527670A/ja active Pending
- 2019-06-19 AR ARP190101699A patent/AR115585A1/es not_active Application Discontinuation
- 2019-06-19 WO PCT/US2019/037936 patent/WO2019246225A1/en not_active Ceased
- 2019-06-19 CN CN201980054575.2A patent/CN112839643A/zh active Pending
- 2019-06-19 US US16/446,328 patent/US10596136B2/en active Active
- 2019-06-19 EP EP19740442.9A patent/EP3810123A1/en not_active Withdrawn
- 2019-06-20 TW TW108121573A patent/TW202015666A/zh unknown
-
2020
- 2020-02-07 US US16/784,453 patent/US10973793B2/en active Active
-
2021
- 2021-03-02 US US17/189,884 patent/US11833127B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101049500A (zh) * | 2007-02-15 | 2007-10-10 | 北京苏里曼医药科技有限公司 | 一种氨基酸组合物 |
| US20170196944A1 (en) * | 2015-09-28 | 2017-07-13 | Robert Portman | Method to reduce muscle atrophy following orthopedic surgery |
| WO2017085138A1 (en) * | 2015-11-20 | 2017-05-26 | Nestec S.A. | Methods using whey protein to improve or maintain muscle quality |
| WO2017202939A1 (en) * | 2016-05-27 | 2017-11-30 | Nestec S.A. | Nutritional composition for treating or preventing impaired mobility |
Also Published As
| Publication number | Publication date |
|---|---|
| US11833127B2 (en) | 2023-12-05 |
| JP2021527670A (ja) | 2021-10-14 |
| US20200281882A1 (en) | 2020-09-10 |
| US20210290573A1 (en) | 2021-09-23 |
| EP3810123A1 (en) | 2021-04-28 |
| AR115585A1 (es) | 2021-02-03 |
| US10596136B2 (en) | 2020-03-24 |
| MA52971A (fr) | 2021-04-28 |
| US20200016104A1 (en) | 2020-01-16 |
| WO2019246225A1 (en) | 2019-12-26 |
| US10973793B2 (en) | 2021-04-13 |
| TW202015666A (zh) | 2020-05-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112839643A (zh) | 用于治疗肌肉中脂肪浸润的组合物及方法 | |
| US11571404B2 (en) | Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting | |
| TWI780096B (zh) | 胺基酸組合物及肌肉疾病與病症之治療方法 | |
| JP2012131819A (ja) | 高齢者の骨格筋量減少を防止又は改善するためのアミノ酸含有組成物 | |
| WO2021178860A1 (en) | Amino acid compositions and methods for muscle and myotube modulation | |
| US20230044475A1 (en) | Compositions and methods involving amino acids for the treatment of fat infiltrations in muscle | |
| OA20063A (en) | Amino acid compositions for the treatment of liver disease. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20210525 |
|
| WD01 | Invention patent application deemed withdrawn after publication |