CN1104432C - 吡咯并三嗪和嘧啶化合物 - Google Patents

吡咯并三嗪和嘧啶化合物 Download PDF

Info

Publication number
CN1104432C
CN1104432C CN97196525A CN97196525A CN1104432C CN 1104432 C CN1104432 C CN 1104432C CN 97196525 A CN97196525 A CN 97196525A CN 97196525 A CN97196525 A CN 97196525A CN 1104432 C CN1104432 C CN 1104432C
Authority
CN
China
Prior art keywords
compound
ome
formula
preferred
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN97196525A
Other languages
English (en)
Chinese (zh)
Other versions
CN1225637A (zh
Inventor
A·G·阿范尼蒂斯
R·J·乔尔瓦特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Priority claimed from US08/899,242 external-priority patent/US6124289A/en
Publication of CN1225637A publication Critical patent/CN1225637A/zh
Application granted granted Critical
Publication of CN1104432C publication Critical patent/CN1104432C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Coloring (AREA)
CN97196525A 1996-07-24 1997-07-23 吡咯并三嗪和嘧啶化合物 Expired - Lifetime CN1104432C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US68604796A 1996-07-24 1996-07-24
US2329096P 1996-07-24 1996-07-24
US08/686,047 1996-07-24
US60/023,290 1996-07-24
US08/899,242 1997-07-23
US08/899,242 US6124289A (en) 1996-07-24 1997-07-23 Azolo triazines and pyrimidines

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN 01120849 Division CN1250223C (zh) 1996-07-24 2001-05-30 吡咯并三嗪和嘧啶化合物
CN 02118589 Division CN1388126A (zh) 1996-07-24 2002-04-25 吡咯并三嗪和嘧啶化合物

Publications (2)

Publication Number Publication Date
CN1225637A CN1225637A (zh) 1999-08-11
CN1104432C true CN1104432C (zh) 2003-04-02

Family

ID=27362048

Family Applications (3)

Application Number Title Priority Date Filing Date
CN97196525A Expired - Lifetime CN1104432C (zh) 1996-07-24 1997-07-23 吡咯并三嗪和嘧啶化合物
CN 01120849 Expired - Lifetime CN1250223C (zh) 1996-07-24 2001-05-30 吡咯并三嗪和嘧啶化合物
CN 02118589 Pending CN1388126A (zh) 1996-07-24 2002-04-25 吡咯并三嗪和嘧啶化合物

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN 01120849 Expired - Lifetime CN1250223C (zh) 1996-07-24 2001-05-30 吡咯并三嗪和嘧啶化合物
CN 02118589 Pending CN1388126A (zh) 1996-07-24 2002-04-25 吡咯并三嗪和嘧啶化合物

Country Status (15)

Country Link
JP (2) JP4704521B2 (fr)
CN (3) CN1104432C (fr)
AR (1) AR049583A2 (fr)
BR (1) BR9710544A (fr)
CA (1) CA2259583C (fr)
CZ (1) CZ299451B6 (fr)
EA (1) EA004403B1 (fr)
EE (1) EE04316B1 (fr)
HR (1) HRP970413A2 (fr)
IL (4) IL127871A0 (fr)
NO (1) NO315610B3 (fr)
NZ (1) NZ333777A (fr)
PL (1) PL195762B1 (fr)
SI (1) SI9720045B (fr)
SK (1) SK286461B6 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103694242A (zh) * 2013-12-10 2014-04-02 中国科学院昆明植物研究所 吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002072202A1 (fr) * 2001-03-13 2002-09-19 Bristol-Myers Squibb Pharma Company 4-(2-butylamino)-2,7-dimethyl-8-(2-methyl-6-methoxypyrid-3-yl) pyrazolo-[1,5-a]-1,3,5-triazine, ses enantiomeres et sels pharmaceutiquement acceptables en tant que ligands du recepteur de la corticoliberine
WO2004110454A1 (fr) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. Composition de traitement ou de prevention de maladies necessitant l'administration d'un agoniste du recepteur a2a de l'adenosine
US7329662B2 (en) * 2003-10-03 2008-02-12 Hoffmann-La Roche Inc. Pyrazolo-pyridine
GB0519957D0 (en) * 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
DK2094709T3 (da) * 2006-09-20 2010-12-06 Lilly Co Eli Thiazol-pyrazolopyrimidiner som CRF1-receptorantagonister
EP3628005A4 (fr) 2017-08-14 2021-01-20 Spruce Biosciences, Inc. Antagonistes du récepteur du facteur de libération de la corticotropine
CN112479956A (zh) * 2019-07-30 2021-03-12 杭州阿诺生物医药科技有限公司 一种用于制备腺苷受体抑制剂中间体的方法
WO2022036123A1 (fr) 2020-08-12 2022-02-17 Spruce Biosciences, Inc. Procédés et compositions pour traiter le syndrome des ovaires polykystiques
US11708372B2 (en) 2021-11-19 2023-07-25 Spruce Biosciences, Inc. Crystalline composition of tildacerfont and methods of use and preparation thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995039A (en) * 1975-05-27 1976-11-30 Merck & Co., Inc. Pyrazolo [1,5-a] [1,3,5] triazines
US4824834A (en) * 1986-10-31 1989-04-25 Otsuka Pharmaceutical Company, Limited Pyrazolotriazine compounds
EP0414200A2 (fr) * 1989-08-25 1991-02-27 Otsuka Pharmaceutical Factory, Inc. Sels de 4-hydroxy-8-(3-alkylinterieur-4-phénylsulfinylphényl)pyrazolo [1,5-a]-1,3,5-triazines optiquement actives et procédé pour leur préparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
US5420128A (en) * 1990-10-09 1995-05-30 Otsuka Pharmaceutical Co., Ltd. Pyrimidine derivatives, method of manufacturing the same, and androgen inhibitor
DE69130683T2 (de) * 1991-04-22 1999-05-06 Otsuka Pharmaceutical Factory, Inc., Naruto, Tokushima PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995039A (en) * 1975-05-27 1976-11-30 Merck & Co., Inc. Pyrazolo [1,5-a] [1,3,5] triazines
US4824834A (en) * 1986-10-31 1989-04-25 Otsuka Pharmaceutical Company, Limited Pyrazolotriazine compounds
EP0414200A2 (fr) * 1989-08-25 1991-02-27 Otsuka Pharmaceutical Factory, Inc. Sels de 4-hydroxy-8-(3-alkylinterieur-4-phénylsulfinylphényl)pyrazolo [1,5-a]-1,3,5-triazines optiquement actives et procédé pour leur préparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103694242A (zh) * 2013-12-10 2014-04-02 中国科学院昆明植物研究所 吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用
CN103694242B (zh) * 2013-12-10 2016-01-06 昆明翔昊科技有限公司 吡唑并嘧啶类化合物及其药物组合物和其在制药中的应用

Also Published As

Publication number Publication date
NZ333777A (en) 2000-07-28
HRP970413A2 (en) 1998-10-31
IL164513A0 (en) 2005-12-18
CN1250223C (zh) 2006-04-12
CZ18499A3 (cs) 1999-11-17
IL127871A (en) 2010-04-29
JP2005097257A (ja) 2005-04-14
IL127871A0 (en) 1999-10-28
SK9799A3 (sk) 2005-04-01
EE04316B1 (et) 2004-06-15
NO315610B1 (no) 2003-09-29
SI9720045A (sl) 1999-10-31
EA199900158A1 (ru) 1999-10-28
NO990264L (no) 1999-03-10
CN1327793A (zh) 2001-12-26
CZ299451B6 (cs) 2008-07-30
CN1225637A (zh) 1999-08-11
JP4194539B2 (ja) 2008-12-10
SI9720045B (sl) 2008-02-29
NO315610B3 (no) 2003-09-29
EE9900019A (et) 1999-08-16
EA004403B1 (ru) 2004-04-29
JP2002513382A (ja) 2002-05-08
AR049583A2 (es) 2006-08-16
SK286461B6 (sk) 2008-10-07
IL164513A (en) 2010-04-29
NO990264D0 (no) 1999-01-21
PL195762B1 (pl) 2007-10-31
CN1388126A (zh) 2003-01-01
IL150163A (en) 2010-12-30
BR9710544A (pt) 1999-08-17
PL331523A1 (en) 1999-07-19
JP4704521B2 (ja) 2011-06-15
CA2259583A1 (fr) 1998-01-29
CA2259583C (fr) 2009-11-17

Similar Documents

Publication Publication Date Title
CN1542010A (zh) 吡咯并三嗪和嘧啶化合物
CN1171889C (zh) 作为p38蛋白激酶的抑制剂的杂烷基氨基－取代的双环氮杂环类化合物
US10618901B2 (en) LRRK2 inhibitors for the treatment of Parkinson's disease
CN1188415C (zh) 抑制5型环鸟苷3',5'－单磷酸磷酸二酯酶(cG MP PDE5)并用于治疗性功能障碍的吡唑并嘧啶酮类化合物
CN100351253C (zh) 作为免疫抑制剂的吡咯并[2,3－d]嘧啶化合物
CN1034175C (zh) 吡唑并嘧啶类化合物
CN1269813C (zh) 作为细胞增生抑制剂的咪唑－5－基－2－苯胺基－嘧啶
CN1230184A (zh) 芳氨基稠合的吡啶和嘧啶
CN1549817A (zh) 作为半胱氨酸蛋白酶抑制剂的吡咯并嘧啶化合物
CN1264843C (zh) 具有pde7抑制作用的吡唑并嘧啶酮衍生物
CN101031569A (zh) 作为人磷脂酰肌醇3－激酶δ抑制剂的喹唑啉酮
CN1185232C (zh) αLβ2介导细胞粘连抑制剂
CN1278819A (zh) 作为促肾上腺皮质素释放激素拮抗剂、可用于治疗cns障碍和紧张相关性疾病的杂环基取代的环稠合吡啶和嘧啶
CN1599734A (zh) 作为cxc趋化因子受体拮抗剂的3,4－二取代的马来酰亚胺化合物
CN1703405A (zh) 用作糖原合酶激酶3β抑制剂的氨基苯甲酰胺衍生物
CN1678586A (zh) 取代的喹啉ccr5受体拮抗剂
CN1575177A (zh) Cxcr3拮抗剂
CN1518543A (zh) 吡唑衍生物和它们作为蛋白激酶抑制剂的用途
CN1671696A (zh) 激酶抑制剂
CN1606444A (zh) 人磷脂酰肌醇3－激酶δ抑制剂
CN101031555A (zh) 具有vap－1抑制活性的噻唑衍生物
CN1993359A (zh) 杂环取代的环状脲衍生物、其制备及其作为激酶抑制剂的药物用途
CN1498212A (zh) 新螺三环衍生物及其作为磷酸二酯酶-7抑制剂的应用
CN1906190A (zh) 选择性激酶抑制剂
CN1784409A (zh) 具有crf活性的稠合的嘧啶衍生物

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term

Granted publication date: 20030402

CX01 Expiry of patent term