CN1088698C - 微粒形式的四氢吡啶衍生物 - Google Patents

微粒形式的四氢吡啶衍生物 Download PDF

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Publication number
CN1088698C
CN1088698C CN97180862A CN97180862A CN1088698C CN 1088698 C CN1088698 C CN 1088698C CN 97180862 A CN97180862 A CN 97180862A CN 97180862 A CN97180862 A CN 97180862A CN 1088698 C CN1088698 C CN 1088698C
Authority
CN
China
Prior art keywords
microns
particles
active ingredient
less
microparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97180862A
Other languages
English (en)
Chinese (zh)
Other versions
CN1241179A (zh
Inventor
A·卡隆
J－P·查姆邦
O·莫尼尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of CN1241179A publication Critical patent/CN1241179A/zh
Application granted granted Critical
Publication of CN1088698C publication Critical patent/CN1088698C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN97180862A 1996-12-23 1997-12-23 微粒形式的四氢吡啶衍生物 Expired - Fee Related CN1088698C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR96/15905 1996-12-23
FR9615905A FR2757510B1 (fr) 1996-12-23 1996-12-23 Forme microparticulaire d'un derive de tetrahydropyridine

Publications (2)

Publication Number Publication Date
CN1241179A CN1241179A (zh) 2000-01-12
CN1088698C true CN1088698C (zh) 2002-08-07

Family

ID=9499044

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97180862A Expired - Fee Related CN1088698C (zh) 1996-12-23 1997-12-23 微粒形式的四氢吡啶衍生物

Country Status (37)

Country Link
US (4) US20020028247A1 (enExample)
EP (1) EP0950051B1 (enExample)
JP (2) JP4422214B2 (enExample)
KR (1) KR100455797B1 (enExample)
CN (1) CN1088698C (enExample)
AR (1) AR009673A1 (enExample)
AT (1) ATE250032T1 (enExample)
AU (1) AU730302B2 (enExample)
BR (1) BR9714177A (enExample)
CA (1) CA2275593C (enExample)
CO (1) CO4920213A1 (enExample)
CZ (1) CZ294272B6 (enExample)
DE (1) DE69724999T2 (enExample)
DK (1) DK0950051T3 (enExample)
DZ (1) DZ2386A1 (enExample)
EE (1) EE04112B1 (enExample)
EG (1) EG24749A (enExample)
ES (1) ES2207758T3 (enExample)
FR (1) FR2757510B1 (enExample)
HU (1) HU224348B1 (enExample)
IL (1) IL129937A (enExample)
IN (1) IN186977B (enExample)
IS (1) IS2064B (enExample)
MY (1) MY126298A (enExample)
NO (1) NO311569B1 (enExample)
NZ (1) NZ336129A (enExample)
PL (1) PL190098B1 (enExample)
PT (1) PT950051E (enExample)
RU (1) RU2193031C2 (enExample)
SI (1) SI0950051T1 (enExample)
SK (1) SK283917B6 (enExample)
TR (1) TR199901362T2 (enExample)
TW (1) TW534820B (enExample)
UA (1) UA66776C2 (enExample)
WO (1) WO1998028272A1 (enExample)
YU (1) YU49427B (enExample)
ZA (1) ZA9711579B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0210867A (pt) * 2001-07-06 2004-06-29 Lifecycle Pharma As Processo para a preparação de um material particulado, métodos para aglomeração controlada de um material sólido finamente disperso, para melhorar a biodisponibilidade de uma substância terapêutica e/ou profilaticamente ativa, e para melhorar a vida em prateleira de uma composição farmacêutica, material articulado, composição farmacêutica, uso de um veìculo, material particulado farmacêutico, e, uso de aluminossilicato de magnésio e/ou de aluminometassilicato de magnésio
BE1015641A4 (fr) * 2003-05-26 2005-07-05 Mariani Jean Paul Micronisation 70.
RU2472490C1 (ru) * 2011-08-05 2013-01-20 Открытое акционерное общество "Биосинтез" Средство для лечения кожных гнойных инфекций, составы и способы получения

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0101381A1 (fr) * 1982-08-16 1984-02-22 Sanofi S.A. Trifluorométhylphényltétrahydropyridines à activité anorexigène, un procédé de préparation et compositions pharmaceutiques

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US562883A (en) * 1896-06-30 Thill-coupling
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
FR2639226B1 (fr) * 1988-11-18 1993-11-05 Sanofi Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles anxio-depressifs
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
ATE175132T1 (de) * 1992-10-26 1999-01-15 Sanol Arznei Schwarz Gmbh Verfahren zur herstellung von mikrokapseln
US5560932A (en) * 1995-01-10 1996-10-01 Nano Systems L.L.C. Microprecipitation of nanoparticulate pharmaceutical agents
US5662883A (en) * 1995-01-10 1997-09-02 Nanosystems L.L.C. Microprecipitation of micro-nanoparticulate pharmaceutical agents
US6489334B2 (en) * 1996-12-23 2002-12-03 Sanofi-Synthelabo Method for the crystallization of a tetrahydropyridin derivative and resulting crystalline forms
FR2763847B1 (fr) * 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
US20020147216A1 (en) * 2000-01-31 2002-10-10 Yuhong Zhou Mucin synthesis inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0101381A1 (fr) * 1982-08-16 1984-02-22 Sanofi S.A. Trifluorométhylphényltétrahydropyridines à activité anorexigène, un procédé de préparation et compositions pharmaceutiques

Also Published As

Publication number Publication date
MY126298A (en) 2006-09-29
NZ336129A (en) 2000-11-24
IL129937A (en) 2002-09-12
CA2275593C (en) 2005-12-20
FR2757510A1 (fr) 1998-06-26
US20100021541A1 (en) 2010-01-28
BR9714177A (pt) 2000-02-29
RU2193031C2 (ru) 2002-11-20
SK283917B6 (sk) 2004-05-04
CZ294272B6 (cs) 2004-11-10
ES2207758T3 (es) 2004-06-01
CN1241179A (zh) 2000-01-12
ATE250032T1 (de) 2003-10-15
JP4422214B2 (ja) 2010-02-24
AU5668598A (en) 1998-07-17
EE9900263A (et) 2000-02-15
IS5077A (is) 1999-06-10
JP2009280581A (ja) 2009-12-03
DE69724999D1 (de) 2003-10-23
ZA9711579B (en) 1998-06-25
PT950051E (pt) 2004-02-27
DK0950051T3 (da) 2004-01-26
KR100455797B1 (ko) 2004-11-06
DE69724999T2 (de) 2004-07-22
AR009673A1 (es) 2000-04-26
CZ229199A3 (cs) 1999-09-15
TR199901362T2 (xx) 1999-09-21
US20080255365A1 (en) 2008-10-16
NO311569B1 (no) 2001-12-10
NO993077L (no) 1999-06-22
YU28899A (sh) 2000-03-21
CA2275593A1 (en) 1998-07-02
HUP0001181A2 (hu) 2000-11-28
DZ2386A1 (fr) 2002-12-28
AU730302B2 (en) 2001-03-01
JP2001507013A (ja) 2001-05-29
UA66776C2 (uk) 2004-06-15
EP0950051A1 (fr) 1999-10-20
TW534820B (en) 2003-06-01
HK1024000A1 (en) 2000-09-29
PL190098B1 (pl) 2005-10-31
WO1998028272A1 (fr) 1998-07-02
EG24749A (en) 2010-07-20
EE04112B1 (et) 2003-08-15
HUP0001181A3 (en) 2003-03-28
US20020192292A1 (en) 2002-12-19
FR2757510B1 (fr) 2000-01-07
SI0950051T1 (en) 2004-02-29
NO993077D0 (no) 1999-06-22
CO4920213A1 (es) 2000-05-29
IS2064B (is) 2005-11-15
IN186977B (enExample) 2001-12-22
EP0950051B1 (fr) 2003-09-17
US20020028247A1 (en) 2002-03-07
PL334276A1 (en) 2000-02-14
KR20000069503A (ko) 2000-11-25
IL129937A0 (en) 2000-02-29
HU224348B1 (hu) 2005-08-29
SK82999A3 (en) 1999-12-10
YU49427B (sh) 2006-01-16

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
CB02 Change of applicant information

Applicant after: SANOFI-SYNTHELABO

Applicant before: Sanofi

COR Change of bibliographic data

Free format text: CORRECT: APPLICANT; FROM: SANOFI CORP. TO: SANOFI SYNTHESIZING LABORATORY

C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: SANOFI. AVENTIS CO., LTD.

Free format text: FORMER NAME OR ADDRESS: SANOFI SYNTHESIZING LABORATORY

CP01 Change in the name or title of a patent holder

Address after: Paris France

Patentee after: SANOFI-AVENTIS

Address before: Paris France

Patentee before: SANOFI-SYNTHELABO

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20020807

Termination date: 20111223