CN107847396A - 用于安全的伸缩的卡扣配合在注射剂小瓶上的液体药物转移装置 - Google Patents
用于安全的伸缩的卡扣配合在注射剂小瓶上的液体药物转移装置 Download PDFInfo
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Abstract
液体药物转移装置包括小瓶转接器,该小瓶转接器具有至少两个非邻近的小瓶保持弯曲部件和至少两个非邻近的小瓶导向弯曲部件。该小瓶导向弯曲部件各自被设置有距离小瓶转接器顶壁一定距离的目标设计枢纽区用来在伸缩的卡扣配合在注射剂小瓶上时有目的地在枢纽区转动。小瓶保持弯曲部件可兼作小瓶导向弯曲部件,条件是它们的枢纽区相对于小瓶转接器顶壁在它们的向内突出的小瓶保持肋状物的远侧。
Description
技术领域
本发明涉及用于安全的伸缩的卡扣配合在注射剂小瓶上的液体药物转移装置。
背景技术
ISO 8362-1注射剂容器和配件–部分1:由玻璃管组成的注射剂小瓶使小瓶尺寸、小瓶规格和小瓶公差标准化注射剂小瓶。ISO 8362-1定义了下述术语:小瓶管、小瓶冠以及小瓶管和小瓶冠中间的小瓶颈。小瓶管具有闭端和外直径(OD)d1。小瓶冠具有冠开口和外直径(OD)d2。小瓶颈具有外直径(OD)d3和内直径(ID)d4。小瓶冠具有围绕冠开口的最高小瓶冠边缘和朝向小瓶颈的最低小瓶冠边缘。冠开口具有与小瓶颈相同的内直径。注射剂小瓶具有小瓶颈和小瓶管之间的小瓶肩。小瓶管和小瓶肩在最高小瓶管边缘处接合。该直径具有以下关系:d1>d2>d3>d4。大多数小瓶冠外直径可用于多个小瓶管外直径,例如小瓶冠外直径d2=20mm可用于3个标准的小瓶管外直径d1=22或24或30mm。因此,注射剂小瓶通过它们的小瓶冠外直径(而不是它们的小瓶管外直径)被提到。
液体药物转移装置包括小瓶转接器,该小瓶转接器具有横向的小瓶转接器顶壁、用于刺穿小瓶瓶塞的中空的穿刺插管和向下悬挂的裙。该向下悬挂的裙足够向下延伸用来遮蔽穿刺插管端以防止疏忽的用户与该穿刺插管端接触。该向下悬挂的裙经设计形状和规格以紧贴地伸缩地卡扣配合到特定的小瓶冠外直径上。因此,小瓶转接器以类似于注射剂小瓶的方式按小瓶冠外直径被提及,就小瓶冠外直径而言,小瓶转接器准备在其上伸缩的卡扣配合。为了确保小瓶转接器能够伸缩地卡扣配合到特定的小瓶冠外直径的全部的标准的小瓶管外直径上,它的向下悬挂的裙规格被设计以在小瓶肩上终止。然而,此类向下悬挂的裙并没有帮助用户对齐小瓶转接器与注射剂小瓶同轴,这导致常见的不对准。小瓶转接器相对于注射剂小瓶的不对准通常导致小瓶瓶塞中撕破的形成,尤其在共同拥有的美国专利号8,608,723(Lev et al.,发明名称:具有密封装置的流体转移装置)中讨论的。
共同拥有的美国专利号8,070,739(Zinger et al.,发明名称:用于自动防故障的正确的卡扣配合到药瓶上的液体药物转移装置)公开了经设计以帮助用户对齐小瓶转接器和注射剂小瓶的具有小瓶转接器的液体药物转移装置。该液体药物转移装置包括具有向下悬挂的裙的小瓶转接器,该向下悬挂的裙具有至少两个非邻近的小瓶保持弯曲部件用于卡扣配合在小瓶冠上方用于小瓶保持的目的和至少两个比它们的对应的小瓶保持弯曲部件长的非邻近的小瓶导向弯曲部件用来在注射剂小瓶上卡扣配合小瓶转接器之前相对于注射剂小瓶导向小瓶转接器。
在卡扣配合在注射剂小瓶上期间,该小瓶导向弯曲部件相对于它们的小瓶转接器中心线在它们与它们的小瓶转接器顶壁的连接处向外径向弯曲时通常邻接小瓶肩并且向外径向滑动。该小瓶导向弯曲部件的向外径向滑动取决于具有方便向外径向滑动的陡坡的小瓶肩的斜度。小瓶导向弯曲部件的在它们的与小瓶转接器顶壁的连接处的向外径向弯曲导致与用于将小瓶转接器伸缩地卡扣配合在注射剂小瓶上的手动连接力(manualattachment force)相反的拆除反作用力(detachment reaction force)。注射剂管的直径越大,拆除反作用力越大,其最多导致减弱伸缩的卡扣配合以及在最坏的情况下导致拆除。
再者,小瓶转接器在注射剂小瓶上的伸缩的卡扣配合对于特定的小瓶冠外直径的所有的小瓶管外直径不是一致的,因为针对不同的小瓶管外直径,小瓶导向弯曲部件是径向地向外地不同的弯曲。另外,较大的小瓶管外直径引起小瓶转接器伸缩的卡扣配合在注射剂小瓶上以呈现不适合用户抓住小瓶转接器(例如用于连接和拆除注射器)的抓取面。
因此,有必要提供具有小瓶转接器的液体药物转移装置,该小瓶转接器用于提供安全的伸缩的卡扣配合在特定的小瓶冠外直径的所有的标准的小瓶管外直径的小瓶冠上。
发明内容
本发明针对的是液体药物转移装置,该液体药物转移装置包括经设计用于安全的伸缩的卡扣配合在注射剂小瓶上的小瓶转接器。该液体药物转移装置具有与迄今为止描述的美国专利号8,070,739的液体药物转移装置类似的构造,但是它们的小瓶导向弯曲部件还设置有目标设计的枢纽区(purpose design hinged zone),该目标设计的枢纽区距离小瓶转接器顶壁一定的距离,用于在伸缩的卡扣配合在注射剂小瓶上时有目的的在该枢纽区转动,这与在小瓶转接器顶壁处的弯曲相反。枢纽区阻止小瓶转接器形成了明显的与手动连接力相反的拆除反作用力,这可出现在迄今为止描述的美国专利号8,070,739的液体药物转移装置中。因此,本发明的液体药物转移装置可容易与特定的小瓶冠外直径的所有的小瓶管外直径的注射剂小瓶一起使用。本发明的液体药物转移装置可设置有比它的小瓶保持弯曲部件长的穿刺套管和比它的穿刺套管长的小瓶导向弯曲部件,用于在不有损安全的伸缩的卡扣配合在注射剂小瓶上的情况下遮挡该穿刺套管。
该小瓶导向弯曲部件优选地具有它们的枢纽区,该枢纽区设置在它们的对应的小瓶保持弯曲部件的至少部分地圆周地向内延伸的突出的小瓶保持肋状物的对面,使得将小瓶转接器伸缩地卡扣配合在注射剂小瓶上,而没有卡扣配合在注射剂小瓶上时,小瓶导向弯曲部件也紧贴地围绕小瓶冠。在它们的枢纽区有必要相对于小瓶转接器顶壁设置在它们的至少部分地圆周地向内延伸的突出的小瓶保持肋状物的远侧的条件下,小瓶保持弯曲部件还可通过以类似小瓶导向弯曲部件的方式与枢纽区一起形成兼作小瓶导向弯曲部件。因此,本发明的液体药物转移装置可仅仅被设置有小瓶保持弯曲部件,该小瓶保持弯曲部件具有至少两个兼作具有枢纽区的小瓶导向弯曲部件的小瓶保持弯曲部件。
附图的简要说明
为了理解本发明并且明白它在实践中如何被实施,仅仅借助非限制性实例,现在优选的实例被描述了,参见附图,其中相同的部分被做了同样编号,以及其中:
图1显示了ISO 8362-1部分4规格图,定义了小瓶管外直径d1、小瓶冠外直径d2、小瓶颈外直径d3和小瓶颈内直径d4;
图2是根据美国专利号8,070,739的传统的20mm母小瓶转接器(female vialadapter)的透视图;
图3是沿着图2中的线A-A图2的20mm母小瓶转接器的纵向截面图;
图4是沿着图2中的线A-A的纵向截面图,显示了图2的20mm母小瓶转接器伸缩的卡扣配合在具有小瓶管外直径d1=22mm的20mm注射剂小瓶上;
图5是沿着图2中的线A-A的纵向截面图,显示了图2的20mm母小瓶转接器伸缩的卡扣配合在具有小瓶管外直径d1=30mm的20mm注射剂小瓶上;
图6是根据本发明的第一实施方案的20mm母小瓶转接器的透视图;
图7是沿着图6中的线B-B的图6的20mm母小瓶转接器的纵向截面图;
图8是纵向截面图,显示了在伸缩的卡扣配合在具有小瓶管外直径d1=22mm的20mm注射剂小瓶上之前图6的20mm母小瓶转接器;
图9是纵向截面图,显示了图6的20mm母小瓶转接器伸缩的卡扣配合在图8的注射剂小瓶上;
图10是纵向截面图,显示了在伸缩的卡扣配合在具有小瓶管外直径d1=30mm的20mm注射剂小瓶上之前图6的20mm母小瓶转接器;
图11是纵向截面图,显示了图6的20mm母小瓶转接器伸缩的卡扣配合在图10的注射剂小瓶上;
图12是根据本发明的第二实施方案的20mm母小瓶转接器的透视图;
图13是沿着图12中的线C-C图12的20mm母小瓶转接器的纵向截面图;
图14是根据本发明的第三实施方案的20mm母小瓶转接器的透视图;
图15是沿着图14中的线D-D图14的20mm母小瓶转接器的纵向截面图;
图16是根据本发明的第四实施方案的20mm母小瓶转接器的透视图;
图17是图16的母小瓶转接器的俯视图;
图18是沿着图16中的线E-E图16的20mm母小瓶转接器的纵向截面图;
图19是根据本发明的第五实施方案的通气式20mm母小瓶转接器的透视图;以及
图20是根据本发明的第六实施方案的液体转移装置的透视图。
本发明优选实施方案的详细描述
图1显示了注射剂小瓶10,注射剂小瓶10具有纵向的注射剂小瓶中心线11并且包括一端封闭的小瓶管12、具有冠开口14的管状的小瓶冠13和在小瓶管12和小瓶冠13之间的小瓶颈16。小瓶冠13具有围绕冠开口14的最高小瓶冠边缘17和朝向小瓶颈16的最低小瓶冠边缘18。注射管10包括在小瓶管12和小瓶颈16之间的小瓶肩19。小瓶管12和小瓶肩19在最高小瓶管边缘21处汇合。小瓶管12具有外直径d1。小瓶冠13具有外直径d2。小瓶颈16具有外直径d3和内直径d4。冠开口14具有与小瓶颈16相同的内直径。这些直径具有以下关系:d1>d2>d3>d4。在小瓶冠外直径d2=20mm的条件下,注射管外直径d1可以是以下3个标准直径中的一个:d1=22或24或30mm。图4和图5显示了注射剂小瓶10还包括用于塞住冠开口14的小瓶瓶塞22和密封瓶塞22的铝带23。
图2和图3显示了根据迄今提到的美国专利号8,070,739的传统的液体药物转移装置30,药物转移装置30由用于伸缩的卡扣配合在20mm注射剂小瓶上的母小瓶转接器构成。该母小瓶转接器30具有纵向的小瓶转接器中心线31并且包括横向于纵向的小瓶转接器中心线31的小瓶转接器顶壁32和从小瓶转接器顶壁32向下悬挂的大体上圆柱形裙33用于伸缩地滑动地在其中接收小瓶冠。小瓶转接器顶壁32包括用于刺穿小瓶瓶塞的向下悬挂的中空的穿刺插管34。小瓶转接器顶壁32包括流体转移端口36,流体转移端口36是由与穿刺插管34相对的直立的母鲁尔接头构成并且与穿刺插管34流体连通。穿刺插管34包括具有至少一个用于通到小瓶管的流动孔38的穿刺插管端37。
裙33包括由围绕纵向的小瓶转接器中心线31平均间隔的交替的小瓶保持弯曲部件41和小瓶导向弯曲部件42构成的6个弯曲部件39。在母小瓶转接器30的俯视图中,3个小瓶保持弯曲部件41和3个小瓶导向弯曲部件42围绕纵向的小瓶转接器中心线31占据相同的外围长度。小瓶保持弯曲部件41具有距离小瓶转接器顶壁32长度L1的小瓶保持弯曲部件端(vial retention flex member tips)43。小瓶导向弯曲部件42具有距离小瓶转接器顶壁32的长度L2的小瓶导向弯曲部件端(vial guidance flex member tips)44,其中L2>L1。小瓶保持弯曲部件41具有部分地外围地向内延伸的突出的小瓶保持肋状物(vial retentionribs)46用于卡扣配合在小瓶冠上方用于小瓶保持目的。
图4和5显示了相应地伸缩的卡扣配合在具有22mm小瓶管外直径和30mm小瓶管外直径的20mm注射剂小瓶上的20mm母小瓶转接器30。图4显示了小瓶导向弯曲部件42相对于小瓶转接器中心线31在小瓶转接器顶壁32处稍稍地向外径向地弯曲,类似于美国专利号8,070,739中的图3E所示的。相比图4,图5显示了小瓶导向弯曲部件42相对于小瓶转接器中心线31在小瓶转接器顶壁32处更加径向地向外弯曲。母小瓶转接器30呈现了与手动连接力(A所示)相反的拆除反作用力(D所示)。相比图4的20mm小瓶管外直径,在图5的30mm小瓶管外直径的情况下,用户感受到更大的拆除反作用力D。
图4和图5显示了小瓶保持弯曲部件41和小瓶导向弯曲部件42没有以一致的方式紧贴地包围小瓶冠13。在图4中,因为小瓶管外直径仅仅稍微地大于小瓶冠外直径,在连接和拆除注射器期间,通过用户抓住母小瓶转接器30,两种类型的弯曲部件41和42之间的差别可以想象是不明显的。在图5中,在连接和拆除注射器期间,通过用户抓住母小瓶转接器30,此类向外径向弯曲是很明显的,从而呈现了不适合用户抓住母小瓶转接器30的抓取面。
图6和图7显示了液体药物转移装置50A,液体药物转移装置50A是由用于伸缩的卡扣配合安装在20mm注射剂小瓶10上的母小瓶转接器构成。母小瓶转接器50A具有与母小瓶转接器30类似的构造和用途,因此,相同的部分被同样编号了。母小瓶转接器50A与母小瓶转接器30不同之处在于后者50A具有比小瓶保持弯曲部件41长的穿刺插管34。另外,后者50A包括小瓶导向弯曲部件51,各自具有枢纽区(hinged zone)52,枢纽枢纽区52将每个小瓶导向弯曲部件51划分为邻近小瓶转接器顶壁32的较高小瓶导向弯曲部件部分53和远离小瓶转接器顶壁32的较低小瓶导向弯曲部件部分54。小瓶导向弯曲部件51以距离小瓶转接器顶壁32的长度L3终止在小瓶导向弯曲部件端56,其中L3>L2>L1。
小瓶保持弯曲部件41具有从小瓶转接器顶壁32偏离的部分地圆周地向内延伸的突出的小瓶保持肋状物46。枢纽区52大体上被设置在部分地圆周地向内延伸的突出的小瓶保持肋状物46的对面。因此,在伸缩的卡扣配合母小瓶转接器50A在20mm注射剂小瓶上时,枢纽区52被配置在最低小瓶冠边缘18和最高小瓶管边缘21之间。枢纽区52可被实现,例如通过减小材料厚度,例如通过外部的外围的凹槽57。或者,枢纽区52可通过由两个或以上空间上分隔的枢纽58连接在一起的较高小瓶导向弯曲部件53和较低小瓶导向弯曲部件54实现,如图12和图13中所示的。
图8和图9显示了在伸缩的卡扣配合在注射剂小瓶10(注射剂小瓶10具有20mm小瓶冠外直径和22mm小瓶管外直径)上之前和之后的母小瓶转接器50A。图8显示了随着母小瓶转接器50A接近注射剂小瓶10,小瓶导向弯曲部件51帮助母小瓶转接器50A相对于注射剂小瓶10置于中心位置。在朝向注射剂小瓶10继续按压母小瓶转接器50A时,小瓶导向弯曲部件51最初地滑下铝带23直至它们接触小瓶肩19。小瓶保持弯曲部件41以类似于母小瓶转接器30的方式在它们与小瓶转接器顶壁32的连接处弯曲以卡扣配合在小瓶冠13上。图9显示了由于小瓶导向弯曲部件端56接触小瓶肩19并且朝向最高小瓶管边缘21向外径向滑动而不是在它们与小瓶转接器顶壁32的连接处弯曲,小瓶导向弯曲部件51相对于纵向的小瓶转接器中心线31在它们各自的枢纽区52径向地向外转动。随着他施加连接力A,用户可以感受到轻微的拆除反作用力D。图9显示了较高小瓶导向弯曲部件部分53保持垂直(类似小瓶保持弯曲部件41,与小瓶导向弯曲部件42不同)使得较高小瓶导向弯曲部件部分53和小瓶保持弯曲部件41紧贴地环绕小瓶冠13。
图10和图11对应于图8和图9并且不同之处在于他们显示了在伸缩的卡扣配合在注射剂小瓶10上之前和之后的母小瓶转接器50A,注射剂小瓶10具有相同的20mm小瓶冠外直径但具有30mm的小瓶管外直径。图11显示了由于小瓶导向弯曲部件端56接触小瓶肩19并且朝向最高小瓶管边缘21径向向外滑动,小瓶导向弯曲部件51相对于纵向的小瓶转接器中心线31在它们各自的枢纽区52径向地向外转动。随着他施加连接力A(比图5的拆除反作用力D小很多),用户可以感受到轻微的拆除反作用力D。图11显示了较高小瓶导向弯曲部件部分53保持垂直(类似小瓶保持弯曲部件41,与小瓶导向弯曲部件42不同)使得较高小瓶导向弯曲部件部分53和小瓶保持弯曲部件41紧贴地环绕小瓶冠13。因此,母小瓶转接器50A同样地被用于伸缩的卡扣配合在所有的它的相关的标准的小瓶管外直径22mm、24mm和30mm的20mm注射剂小瓶上。
图14和图15显示了也由母小瓶转接器构成的液体药物转移装置50B,该母小瓶转接器在构造和用途方面类似母小瓶转接器50A,因此,相同的部分被作了同样的编号。后者50B不同于前者50A之处在于后者50B包括6个小瓶保持弯曲部件61并且没有小瓶导向弯曲部件。该6个小瓶保持弯曲部件61各自包括类似枢纽区52的枢纽区62,从而将每个小瓶保持弯曲部件61分成邻近小瓶转接器顶壁32的较高小瓶保持弯曲部件部分63和远离小瓶转接器顶壁32的较低小瓶保持弯曲部件部分64。枢纽区62有必要相对于小瓶转接器顶壁32被设置在向内突出的小瓶保持肋状物46的远侧。小瓶保持弯曲部件61以距离小瓶转接器顶壁32的长度L4终止在小瓶保持弯曲部件端66,其中L4=L3。枢纽区62是由外部的外围的凹槽67构成。
图16到图18显示了液体药物装置50C也由在构造和用途方面类似母小瓶转接器50B的母小瓶转接器构成,因此,相同的部分被作了同样的编号。母小瓶转接器50C不同于母小瓶转接器50B之处在于它包括两个正好相反的小瓶保持弯曲部件61和两个正好相反的小瓶导向弯曲部件71。两个正好相反的小瓶导向弯曲部件71经设计防止在小瓶转接器顶壁32的任何弯曲(其仍然可能在小瓶导向弯曲部件51的情况中发生。此类防止是通过小瓶导向弯曲部件71围绕纵向的小瓶转接器中心线31对向图17的俯视图中至少90°的扇形角实现的。通常,两个小瓶保持弯曲部件61各自对向扇形角α=60°以及两个小瓶导向弯曲部件71各自对向扇形角β=120°。
小瓶导向弯曲部件71各自包括枢纽区72,枢纽区72将各个小瓶导向弯曲部件71分为邻近小瓶转接器顶壁32的较高小瓶导向弯曲部件部分73和远离小瓶转接器顶壁32的一对空间上分隔的较低小瓶导向弯曲部件部分74。小瓶导向弯曲部件71终止在小瓶导向弯曲部件端76。在伸缩的卡扣配合母小瓶转接器50C在注射剂小瓶10上时,由于小瓶导向弯曲部件端76接触小瓶肩19并且朝向最高小瓶管边缘21向外径向滑动,较低小瓶导向弯曲部件部分74相对于纵向的小瓶转接器中心线31在它们的各自的枢纽区72径向地向外转动。
图19显示了根据本发明的教导,由开衩的母小瓶转接器(vented female vialadapter)构成的液体药物转移装置50D。
图20显示了根据本发明的教导,液体药物装置50E由共同拥有的美国专利号6,238,372(Zinger等)公开的流体控制装置构成并且包括小瓶转接器。
虽然本发明的具体实施方案被说明了并且被描述了,各种其它的变化和修改可以被做出而不脱离本发明的精神和范围,对本领域技术人员来说,是显而易见的。
Claims (6)
1.液体药物转移装置,所述液体药物转移装置用于安全的伸缩的卡扣配合在注射剂小瓶上,所述注射剂小瓶具有纵向的注射剂小瓶中心线并且包括一端封闭的小瓶管、具有由小瓶瓶塞塞住的冠开口的管状的小瓶冠、在小瓶管和小瓶冠中间的小瓶颈、在小瓶管和小瓶颈中间的小瓶肩,所述小瓶冠具有朝向所述冠开口的最高小瓶冠边缘和朝向所述小瓶颈的最低小瓶冠边缘,所述小瓶管和所述小瓶肩在最高小瓶管边缘处汇合,
所述小瓶管具有小瓶管外直径d1,所述小瓶冠具有小瓶冠外直径d2,所述小瓶颈具有小瓶颈外直径d3和小瓶颈内直径d4其中d1>d2>d3>d4,以及所述小瓶管外直径d1选自预定范围的至少一个用于小瓶冠外直径d2的小瓶管外直径d1,所述液体药物转移装置包括:
(a)小瓶转接器,所述小瓶转接器具有纵向的小瓶转接器中心线并且包括横向于所述纵向的小瓶转接器中心线的小瓶转接器顶壁,从所述小瓶转接器顶壁向下悬挂的用于伸缩地滑动地在其中接收所述小瓶冠的大体上圆柱形的裙和用于刺穿小瓶瓶塞的中空的穿刺插管,所述穿刺插管具有穿刺插管端,所述穿刺插管端具有至少一个用于通到小瓶管的流体孔,
所述裙包括
i)至少两个非邻近的小瓶保持弯曲部件,所述至少两个非邻近的小瓶保持弯曲部件具有在所述小瓶转接器顶壁的远侧的小瓶保持弯曲部件端,每个所述小瓶保持弯曲部件具有至少部分地圆周地向内延伸的突出的小瓶保持肋状物用于卡扣配合在小瓶冠上方用于小瓶保持目的,以及
ii)至少两个非邻近的小瓶导向弯曲部件,所述至少两个非邻近的小瓶导向弯曲部件至少与所述至少两个非邻近的小瓶保持弯曲部件一样长并且具有在所述小瓶转接器顶壁的远侧的小瓶导向弯曲部件端,
所述至少两个非邻近的小瓶导向弯曲部件各自具有距离所述小瓶转接器顶壁一定距离的沿所述小瓶导向弯曲部件设置的枢纽部分,从而将每个所述小瓶导向弯曲部件分成邻近所述小瓶转接器顶壁的较高小瓶导向弯曲部件部分和在所述小瓶转接器顶壁的远侧的较低小瓶导向弯曲部件部分,
在当伸缩的卡扣配合所述小瓶转接器在注射剂小瓶上时所述小瓶导向弯曲部件端接触所述小瓶肩时,所述至少两个非邻近的小瓶导向弯曲部件相对于纵向的小瓶转接器中心线在它的各自的枢纽区径向地向外转动;以及
(b)与所述穿刺插管流体连通的至少一个流体转移端口。
2.根据权利要求1所述的装置,其特征在于,每个具有枢纽区的所述至少两个非邻近的小瓶导向弯曲部件是由所述至少两个小瓶保持弯曲部件构成以及每个所述枢纽区沿所述小瓶导向弯曲部件相比它的至少部分地圆周地向内延伸的突出的小瓶保持肋状物进一步远离所述小瓶转接器顶壁,使得每个所述的小瓶保持弯曲部件在当伸缩的卡扣配合所述小瓶转接器在注射剂小瓶上时所述小瓶保持弯曲部件端接触小瓶肩时相对于纵向的小瓶转接器中心线在它的各自的枢纽区径向地向外转动。
3.根据权利要求1所述的装置,其特征在于,所述至少两个非邻近的小瓶导向弯曲部件每个具有所述枢纽区,所述枢纽区沿着所述小瓶导向弯曲部件与所述至少部分地圆周地向内延伸的突出的小瓶保持肋状物以同样的距离远离所述小瓶转接器顶壁使得在伸缩的卡扣配合所述小瓶转接器在注射剂小瓶上时,对来自预定范围的至少一个小瓶管外直径d1的每个小瓶管外直径d1来说,所述至少两个较高小瓶导向弯曲部件部分和所述至少两个小瓶保持弯曲部件以一致的方式紧贴地环绕小瓶冠。
4.根据权利要求3所述的装置,其特征在于,每个所述小瓶导向弯曲部件围绕所述纵向的小瓶转接器中心线对向至少90°的扇形角并且包括一对空间上分隔的较低小瓶导向弯曲部件部分。
5.根据权利要求1到4任一项所述的装置,其特征在于,所述枢纽区是由外部的外围的凹槽构成。
6.根据权利要求1到4任一项所述的装置,其特征在于,所述枢纽区是由两个或以上空间上分隔的铰链构成。
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CN202110243235.3A Active CN113143759B (zh) | 2015-07-16 | 2016-07-01 | 用于安全的伸缩的卡扣配合在注射剂小瓶上的液体药物转移装置 |
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US (1) | US10357429B2 (zh) |
EP (1) | EP3319576B1 (zh) |
JP (1) | JP6367512B1 (zh) |
CN (2) | CN113143759B (zh) |
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CN113143759A (zh) | 2021-07-23 |
IL256776A (en) | 2018-03-29 |
EP3319576B1 (en) | 2019-10-02 |
IL256776B (en) | 2021-03-25 |
JP2018524115A (ja) | 2018-08-30 |
EP3319576A1 (en) | 2018-05-16 |
BR112018000062B1 (pt) | 2022-05-03 |
JP6367512B1 (ja) | 2018-08-01 |
CN107847396B (zh) | 2021-04-09 |
BR112018000062A2 (pt) | 2018-09-11 |
US20180193228A1 (en) | 2018-07-12 |
US10357429B2 (en) | 2019-07-23 |
WO2017009822A1 (en) | 2017-01-19 |
CN113143759B (zh) | 2024-01-30 |
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