CN1077798C - 药物组合物 - Google Patents

药物组合物 Download PDF

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Publication number
CN1077798C
CN1077798C CN93100563A CN93100563A CN1077798C CN 1077798 C CN1077798 C CN 1077798C CN 93100563 A CN93100563 A CN 93100563A CN 93100563 A CN93100563 A CN 93100563A CN 1077798 C CN1077798 C CN 1077798C
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CN
China
Prior art keywords
component
described compositions
aforementioned
compositions
cyclosporin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN93100563A
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English (en)
Chinese (zh)
Other versions
CN1079907A (zh
Inventor
B·豪尔
A·迈泽
U·波桑斯基
J·冯德舍
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1077798(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of CN1079907A publication Critical patent/CN1079907A/zh
Application granted granted Critical
Publication of CN1077798C publication Critical patent/CN1077798C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
    • C11C3/06—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils with glycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
CN93100563A 1991-06-27 1993-01-01 药物组合物 Expired - Lifetime CN1077798C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919113872A GB9113872D0 (en) 1991-06-27 1991-06-27 Improvements in or relating to organic compounds
HU9201975A HU216792B (hu) 1991-06-27 1992-06-12 Eljárás hatóanyagként ciklosporinokat tartalmazó mikroemulzió előkoncentrátumok előállítására
HU1975/92 1992-06-12
HU1975/1992 1992-06-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB011219599A Division CN1326982C (zh) 1992-06-12 2001-06-19 玉米油和甘油的酯基转移产物及其制备方法

Publications (2)

Publication Number Publication Date
CN1079907A CN1079907A (zh) 1993-12-29
CN1077798C true CN1077798C (zh) 2002-01-16

Family

ID=10697415

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93100563A Expired - Lifetime CN1077798C (zh) 1991-06-27 1993-01-01 药物组合物

Country Status (38)

Country Link
EP (2) EP0539319B1 (de)
JP (2) JP2653958B2 (de)
KR (3) KR0131064B1 (de)
CN (1) CN1077798C (de)
AT (1) AT403436B (de)
AU (1) AU659460B2 (de)
CA (2) CA2175842C (de)
CH (2) CH684163A5 (de)
CY (1) CY1906A (de)
CZ (1) CZ281790B6 (de)
DE (3) DE4244930C2 (de)
DK (2) DK0953630T3 (de)
EE (1) EE03108B1 (de)
ES (2) ES2142818T3 (de)
FI (2) FI109454B (de)
FR (2) FR2678169B1 (de)
GB (2) GB9113872D0 (de)
GR (1) GR3032366T3 (de)
HK (2) HK57196A (de)
HU (1) HU216792B (de)
IE (1) IE73662B1 (de)
IL (3) IL118546A (de)
IT (1) IT1254401B (de)
LU (1) LU88138A1 (de)
MX (1) MX9203236A (de)
MY (1) MY109512A (de)
NO (2) NO303964B1 (de)
NZ (1) NZ243309A (de)
PH (1) PH30337A (de)
PT (2) PT539319E (de)
RO (2) RO111021B1 (de)
RU (1) RU2143919C1 (de)
SA (1) SA92130213B1 (de)
SK (1) SK278759B6 (de)
TW (1) TW267943B (de)
UA (1) UA35559C2 (de)
UY (1) UY23864A1 (de)
ZA (1) ZA924719B (de)

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DE69435104D1 (de) 1993-09-28 2008-07-31 Scherer Gmbh R P Herstellung von Weichgelatinekapseln
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
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US5891846A (en) * 1994-02-17 1999-04-06 Shiseido Company, Ltd. Cyclosporin-containing emulsion composition
NZ270145A (en) * 1994-03-01 1996-08-27 Lilly Co Eli Non-aqueous pharmaceutical formulation for oral administration comprising water-insoluble active agent, fatty acid solubilising agent, an oil and a surface active agent
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
ATE181568T1 (de) * 1994-03-31 1999-07-15 Loders Croklaan Bv Öle mit niedrigem gehalt an gesättigter fettsäure
IL129547A (en) 1994-10-26 2001-01-11 Novartis Ag Pharmaceutical compositions comprising a macrolide and an acid
GB2308545B (en) * 1994-10-26 1999-06-02 Novartis Ag Pharmaceutical microemulsion preconcentrates
CA2231404C (en) 1994-11-03 2009-02-17 Arzneimittelwerk Dresden Gmbh Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
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US6258783B1 (en) 1997-04-29 2001-07-10 Bernard Charles Sherman Emulsion preconcentrate comprising a cyclosporin and acetylated monoglyceride
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US6673768B1 (en) 1997-10-16 2004-01-06 Board Of Regents, The University Of Texas System Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating)
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DK0982035T3 (da) * 1998-08-18 2004-06-28 Panacea Biotec Ltd Cyclosporinpræparater
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CN1167462C (zh) * 1999-03-09 2004-09-22 杭州华东医药集团生物工程研究所有限公司 一种含环孢素的药物组合物
US6956048B2 (en) 1999-03-31 2005-10-18 Pharmacia & Upjohn Company Pharmaceutical emulsions for retroviral protease inhibitors
AU2127400A (en) * 1999-11-02 2001-05-14 Cipla Limited A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and process for preparation thereof
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
GB0008785D0 (en) 2000-04-10 2000-05-31 Novartis Ag Organic compounds
EP1307107B1 (de) * 2000-08-08 2005-12-07 Kao Corporation Öl-/fett-zusammensetzung
US7115565B2 (en) 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
BRPI0213658A8 (pt) 2001-10-19 2016-12-06 F Hoffmann La Roche Ltd Método para preparar uma mistura isomérica predeterminada ou não dos análogos de ciclosporina a modificados no resíduo de 1-aminoácido, métodopara produzir uma mistura enriquecida com e-isômero ou com z-isômero de análogos de ciclosporina a modificados no resíduo de 1-aminoácido, mistura de (e) e (z)-isômeros, composição, método para a síntese estereoseletiva do z-isômero de isatx247, método para a preparação de aldeído do ciclosporina a
KR100441167B1 (ko) * 2001-12-27 2004-07-21 씨제이 주식회사 마이크로에멀젼 예비 농축액 조성물
KR100525234B1 (ko) * 2003-02-19 2005-10-28 한국유나이티드제약 주식회사 사이클로스포린 함유 연질캅셀제 및 그 제조방법
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos
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JP4889262B2 (ja) * 2005-08-19 2012-03-07 理研ビタミン株式会社 脂溶性薬剤組成物
MD3347G2 (ro) * 2006-12-26 2008-01-31 Институт Сельскохозяйственной Техники "Mecagro" Procedeu de obţinere a esterilor metilici din ulei de rapiţă
ITPD20070049A1 (it) * 2007-02-14 2008-08-15 Sila S R L Prodotto a base di acido linoleico coniugato e processo per la sua fabbricazione
US8535713B2 (en) 2007-04-04 2013-09-17 Sigmoid Pharma Limited Pharmaceutical cyclosporin compositions
CN101199836B (zh) * 2007-11-07 2011-03-30 安徽省药物研究所 一种阶段释放型环孢素a固体微乳制剂及其微乳固化方法
JP5640079B2 (ja) 2009-05-18 2014-12-10 シグモイド・ファーマ・リミテッドＳｉｇｍｏｉｄ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ 油滴含有組成物
BR112012002963A2 (pt) 2009-08-12 2017-10-24 Sigmoid Pharma Ltd composições imunomoduladoras compreendendo uma matriz de polímero e uma fase oleosa
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
JO3337B1 (ar) 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
FR2971941B1 (fr) 2011-02-24 2013-08-02 Physica Pharma Compositions pharmaceutiques administrables par voie cutanee et destinees au traitement local de la dermatite atopique canine
GB201304662D0 (en) 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
EP3215127B1 (de) 2014-11-07 2020-10-28 Sublimity Therapeutics Limited Cyclosporin enthaltende zusammensetzungen
JPWO2020050182A1 (ja) * 2018-09-06 2020-09-10 株式会社カマタ カプセル充填用液状組成物及びカプセル剤

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GB2228198A (en) * 1989-02-20 1990-08-22 Sandoz Ltd Orally administrable cyclosporin solutions
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Also Published As

Publication number Publication date
FI109454B (fi) 2002-08-15
NO922506D0 (no) 1992-06-25
NO964382D0 (no) 1996-10-15
HUT62201A (en) 1993-04-28
PH30337A (en) 1997-04-02
SK197792A3 (en) 1994-03-09
IL102310A (en) 1997-03-18
EP0539319B1 (de) 1999-12-08
EP0953630A1 (de) 1999-11-03
HK57196A (en) 1996-04-12
EP0953630B1 (de) 2004-09-08
KR100231384B1 (en) 1999-11-15
PT539319E (pt) 2000-05-31
GB2257359B (en) 1996-01-10
CA2175842A1 (en) 1992-12-28
HU9201975D0 (en) 1992-09-28
KR100231385B1 (en) 1999-11-15
IE73662B1 (en) 1997-06-18
FR2685706B1 (de) 1994-12-23
GB2257359A (en) 1993-01-13
ATA129892A (de) 1997-07-15
ES2227921T3 (es) 2005-04-01
IE922082A1 (en) 1992-12-30
ITRM920476A0 (it) 1992-06-23
UY23864A1 (es) 1995-05-29
HU216792B (hu) 1999-08-30
ITRM920476A1 (it) 1993-12-23
KR930000113A (ko) 1993-01-15
CZ197792A3 (en) 1993-01-13
GB9113872D0 (en) 1991-08-14
IL118546A0 (en) 1996-10-16
DE4244930C2 (de) 1999-11-11
GB9213393D0 (en) 1992-08-05
IT1254401B (it) 1995-09-14
MY109512A (en) 1997-02-28
UA35559C2 (uk) 2001-04-16
DE4219526A1 (de) 1993-03-18
RU2143919C1 (ru) 2000-01-10
ES2142818T3 (es) 2000-05-01
AT403436B (de) 1998-02-25
FI961513A0 (fi) 1996-04-03
SK278759B6 (sk) 1998-02-04
EP0539319A2 (de) 1993-04-28
CA2072509C (en) 1996-07-30
CA2072509A1 (en) 1992-12-28
FI961513A (fi) 1996-04-03
PT953630E (pt) 2004-11-30
KR0131064B1 (ko) 1998-04-17
FR2678169A1 (fr) 1992-12-31
JP2653958B2 (ja) 1997-09-17
CY1906A (en) 1992-06-24
MX9203236A (es) 1992-12-01
SA92130213B1 (ar) 2004-07-24
IL102310A0 (en) 1993-01-14
GR3032366T3 (en) 2000-04-27
CN1079907A (zh) 1993-12-29
HK157696A (en) 1996-08-30
NO325267B1 (no) 2008-03-17
RO111110B1 (ro) 1996-06-28
CH685764A5 (de) 1995-09-29
EP0539319A3 (en) 1993-06-09
DK0953630T3 (da) 2004-11-01
DK0539319T3 (da) 2000-05-22
RO111021B1 (ro) 1996-06-28
CH684163A5 (de) 1994-07-29
JPH09118894A (ja) 1997-05-06
NO922506L (no) 1992-12-28
ZA924719B (en) 1993-12-27
CA2175842C (en) 2002-05-07
LU88138A1 (fr) 1994-03-01
TW267943B (de) 1996-01-11
DE4244986B4 (de) 2008-07-24
JP3420897B2 (ja) 2003-06-30
NZ243309A (en) 1995-02-24
NO303964B1 (no) 1998-10-05
AU659460B2 (en) 1995-05-18
JPH05186365A (ja) 1993-07-27
IL118546A (en) 1998-09-24
FI116199B (fi) 2005-10-14
FI922958A (fi) 1992-12-28
NO964382L (no) 1992-12-28
CZ281790B6 (cs) 1997-01-15
DE4219526C2 (de) 1999-04-22
AU1852792A (en) 1993-03-11
FI922958A0 (fi) 1992-06-25
FR2685706A1 (fr) 1993-07-02
FR2678169B1 (fr) 1994-08-26
EE03108B1 (et) 1998-08-17

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