CN1046732C - 5,6－二氢－(S)－4－(乙氨基)－(S)－6－甲基－4H－噻吩并[2,3－b]噻喃－2－氨磺酰7,7－二氧化物和相关化合物的对称选择合成 - Google Patents

5,6－二氢－(S)－4－(乙氨基)－(S)－6－甲基－4H－噻吩并[2,3－b]噻喃－2－氨磺酰7,7－二氧化物和相关化合物的对称选择合成 Download PDF

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Publication number
CN1046732C
CN1046732C CN94191502A CN94191502A CN1046732C CN 1046732 C CN1046732 C CN 1046732C CN 94191502 A CN94191502 A CN 94191502A CN 94191502 A CN94191502 A CN 94191502A CN 1046732 C CN1046732 C CN 1046732C
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China
Prior art keywords
compound
acid
formula
mixture
methyl
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Expired - Lifetime
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CN94191502A
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English (en)
Chinese (zh)
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CN1119866A (zh
Inventor
P·索哈
D·J·马思里
T·J·布拉罗克
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Merck Sharp and Dohme LLC
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Merck and Co Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN94191502A 1993-03-22 1994-03-16 5,6－二氢－(S)－4－(乙氨基)－(S)－6－甲基－4H－噻吩并[2,3－b]噻喃－2－氨磺酰7,7－二氧化物和相关化合物的对称选择合成 Expired - Lifetime CN1046732C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3552393A 1993-03-22 1993-03-22
US035,523 1993-03-22
US19588694A 1994-02-10 1994-02-10
US195,886 1994-02-10

Publications (2)

Publication Number Publication Date
CN1119866A CN1119866A (zh) 1996-04-03
CN1046732C true CN1046732C (zh) 1999-11-24

Family

ID=26712200

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94191502A Expired - Lifetime CN1046732C (zh) 1993-03-22 1994-03-16 5,6－二氢－(S)－4－(乙氨基)－(S)－6－甲基－4H－噻吩并[2,3－b]噻喃－2－氨磺酰7,7－二氧化物和相关化合物的对称选择合成

Country Status (29)

Country Link
US (1) US5688968A (cg-RX-API-DMAC7.html)
EP (1) EP0617037B1 (cg-RX-API-DMAC7.html)
JP (1) JP3273096B2 (cg-RX-API-DMAC7.html)
KR (1) KR0157162B1 (cg-RX-API-DMAC7.html)
CN (1) CN1046732C (cg-RX-API-DMAC7.html)
AT (1) ATE163291T1 (cg-RX-API-DMAC7.html)
AU (1) AU673409B2 (cg-RX-API-DMAC7.html)
BR (1) BR9406017A (cg-RX-API-DMAC7.html)
CA (1) CA2119218C (cg-RX-API-DMAC7.html)
CY (1) CY2108B1 (cg-RX-API-DMAC7.html)
CZ (1) CZ281390B6 (cg-RX-API-DMAC7.html)
DE (1) DE69408550T2 (cg-RX-API-DMAC7.html)
DK (1) DK0617037T3 (cg-RX-API-DMAC7.html)
ES (1) ES2112482T3 (cg-RX-API-DMAC7.html)
FI (1) FI107384B (cg-RX-API-DMAC7.html)
GR (1) GR3026178T3 (cg-RX-API-DMAC7.html)
HK (1) HK1009063A1 (cg-RX-API-DMAC7.html)
HR (1) HRP940182B1 (cg-RX-API-DMAC7.html)
HU (1) HU217363B (cg-RX-API-DMAC7.html)
NO (1) NO313240B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ263092A (cg-RX-API-DMAC7.html)
PL (1) PL176373B1 (cg-RX-API-DMAC7.html)
RO (1) RO115264B1 (cg-RX-API-DMAC7.html)
SI (1) SI9420016B (cg-RX-API-DMAC7.html)
SK (1) SK280831B6 (cg-RX-API-DMAC7.html)
TW (1) TW265343B (cg-RX-API-DMAC7.html)
UA (1) UA41921C2 (cg-RX-API-DMAC7.html)
WO (1) WO1994021645A1 (cg-RX-API-DMAC7.html)
YU (1) YU48951B (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760249A (en) * 1995-08-29 1998-06-02 Merck & Co., Inc. Synthesis of hydroxysulfone and related compounds
ES2177415B1 (es) * 2000-09-04 2004-10-16 Ragactives, S.L. Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios.
ES2204306B1 (es) * 2002-08-16 2005-08-01 Ragactives, S.L. Formas polimorficas de clorhidrato de dorzolamida, su obtencion y composiciones farmaceuticas que las contienen.
EP1611138A1 (en) * 2003-04-07 2006-01-04 Hetero Drugs Limited A novel crystalline form of dorzolamide hydrochloride
US8198316B2 (en) * 2004-07-09 2012-06-12 Fdc Ltd Process for the preparation of 5,6 -dihydro -4H-4(S)-ethylamino-6(S)-methylthieno[2,3-b] thiopyran-2-sulfonamide- 7,7 -dioxide and its salt
ES2253112B1 (es) * 2004-11-05 2007-03-16 Ragactives, S.L. Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano.
AU2004326111A1 (en) * 2004-12-28 2006-07-06 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCI
US7109353B2 (en) 2004-12-28 2006-09-19 Council Of Scientific And Industrial Research Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl
EP1753769A2 (en) * 2005-01-06 2007-02-21 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method of making dorzolamide hydrochloride
EP1838717A2 (en) * 2005-01-18 2007-10-03 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Amorphous and crystalline forms of dorzolamide hydrochloride and processes of making same
KR20100031571A (ko) * 2007-05-07 2010-03-23 시플라 리미티드 도르졸라미드의 제조방법
EP2683724B1 (en) 2011-03-10 2015-05-06 ZaCh System S.p.A. Asymmetric reduction process
ITMI20121165A1 (it) * 2012-07-03 2014-01-04 Zach System Spa Processo di riduzione asimmetrica
CN105636444B (zh) * 2013-10-17 2018-04-27 美国陶氏益农公司 制备杀虫化合物的方法
KR20160074543A (ko) * 2013-10-17 2016-06-28 다우 아그로사이언시즈 엘엘씨 살충성 화합물의 제조 방법
CN103497202B (zh) * 2013-10-23 2015-12-02 武汉武药科技有限公司 盐酸多佐胺中间体的合成方法
CN108822127B (zh) * 2018-05-30 2020-05-15 沈阳药科大学 4-羟亚胺基噻吩并[2,3-b]噻喃-2-甲酰胺类化合物及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
EP0457586A1 (en) * 1990-05-17 1991-11-21 Merck & Co. Inc. 4-alkylamino-6-(C3-5-hydrocarbyl)thieno [2,3-B] thiopyran-2-sulfonamide-7,7-dioxides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4968814A (en) * 1990-04-18 1990-11-06 Merck & Co., Inc. (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797413A (en) * 1986-05-14 1989-01-10 Merck & Co., Inc. Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use
US4797413B1 (cg-RX-API-DMAC7.html) * 1986-05-14 1992-11-24 Merck & Co Inc
EP0457586A1 (en) * 1990-05-17 1991-11-21 Merck & Co. Inc. 4-alkylamino-6-(C3-5-hydrocarbyl)thieno [2,3-B] thiopyran-2-sulfonamide-7,7-dioxides

Also Published As

Publication number Publication date
SK116995A3 (en) 1997-06-04
NO953733L (no) 1995-09-21
CY2108B1 (en) 2002-04-26
NZ263092A (en) 1997-12-19
AU5787194A (en) 1994-09-29
YU13194A (sh) 1997-01-08
HU217363B (hu) 2000-01-28
SI9420016A (en) 1996-06-30
ES2112482T3 (es) 1998-04-01
CA2119218C (en) 2000-02-15
PL176373B1 (pl) 1999-05-31
SK280831B6 (sk) 2000-08-14
FI107384B (fi) 2001-07-31
DK0617037T3 (da) 1998-03-16
NO953733D0 (no) 1995-09-21
FI954438A0 (fi) 1995-09-20
JP3273096B2 (ja) 2002-04-08
BR9406017A (pt) 1995-12-19
WO1994021645A1 (en) 1994-09-29
YU48951B (sh) 2003-01-31
CN1119866A (zh) 1996-04-03
SI9420016B (sl) 2002-12-31
EP0617037A1 (en) 1994-09-28
JPH06298767A (ja) 1994-10-25
CZ281390B6 (cs) 1996-09-11
FI954438L (fi) 1995-09-20
HRP940182B1 (en) 2000-02-29
UA41921C2 (uk) 2001-10-15
TW265343B (cg-RX-API-DMAC7.html) 1995-12-11
HU9502772D0 (en) 1995-11-28
RO115264B1 (ro) 1999-12-30
AU673409B2 (en) 1996-11-07
US5688968A (en) 1997-11-18
PL310633A1 (en) 1995-12-27
HRP940182A2 (en) 1996-08-31
DE69408550D1 (de) 1998-03-26
DE69408550T2 (de) 1998-08-27
HK1009063A1 (en) 1999-05-21
KR0157162B1 (ko) 1998-11-16
GR3026178T3 (en) 1998-05-29
CA2119218A1 (en) 1994-09-23
ATE163291T1 (de) 1998-03-15
HUT72676A (en) 1996-05-28
EP0617037B1 (en) 1998-02-18
NO313240B1 (no) 2002-09-02
CZ241895A3 (en) 1996-01-17

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Granted publication date: 19991124