YU48951B - ENANTIOSELEKTIVNA SINTEZA JEDINJENJA TIENO (2,3-b)-TIOPIRAN-7,7-DIOKSIDA - Google Patents
ENANTIOSELEKTIVNA SINTEZA JEDINJENJA TIENO (2,3-b)-TIOPIRAN-7,7-DIOKSIDAInfo
- Publication number
- YU48951B YU48951B YU13194A YU13194A YU48951B YU 48951 B YU48951 B YU 48951B YU 13194 A YU13194 A YU 13194A YU 13194 A YU13194 A YU 13194A YU 48951 B YU48951 B YU 48951B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- thiopyran
- thieno
- enantioselective synthesis
- dioxide compounds
- dioxide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Seasonings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Postupak za dobijanje jedinjenja strukturne formule I: i njegove hidrohloridne soli, gde je hiralnost na C-6 fiksna, i zadržan je trans-stereohemijski odnos između C-4 i C-6 supstituenata, jedinjenje je kristalno, a R i R1 su isti ili različiti i oni su C1-3 alkil, naznačen time, što obuhvata stupnjeve: A tretiranje jedinjenja formule II sa nitrilom formule RCN i jakom kiselinom, tako da je količina vode koja je prisutna, u zavisnosti od upotrebljene kiseline, od oko 0,5 do oko 10 tež%, pri čemu se dobija jedinjenje strukture III: B) tretiranje III sa hlorsulfo kiselinom, pri čemu se dobija jedinjenje strukture IV: C) tretiranje IV sa tionil hloridom, pri čemu se dobija jedinjenje strukture V: D) tretiranje V sa amonijakom, pri čemu se dobija jedinjenje strukture VI: E) tretiranje VI sa natrijum borhidridom i jakom kiselinom, ili boran-tetrahidrofuranom, pri čemu se dobija jedinjenje strukture VII: F) izolovanje VII kao maleatne soli VIII; G) konverzija VIII u hidrohloridnu so jedinjenja I; i H) prečišćavanje hidrohloridne soli jedinjenja I. Prijava sadrži još 7 zavisnih zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3552393A | 1993-03-22 | 1993-03-22 | |
| US19588694A | 1994-02-10 | 1994-02-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU13194A YU13194A (sh) | 1997-01-08 |
| YU48951B true YU48951B (sh) | 2003-01-31 |
Family
ID=26712200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU13194A YU48951B (sh) | 1993-03-22 | 1994-03-21 | ENANTIOSELEKTIVNA SINTEZA JEDINJENJA TIENO (2,3-b)-TIOPIRAN-7,7-DIOKSIDA |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5688968A (sh) |
| EP (1) | EP0617037B1 (sh) |
| JP (1) | JP3273096B2 (sh) |
| KR (1) | KR0157162B1 (sh) |
| CN (1) | CN1046732C (sh) |
| AT (1) | ATE163291T1 (sh) |
| AU (1) | AU673409B2 (sh) |
| BR (1) | BR9406017A (sh) |
| CA (1) | CA2119218C (sh) |
| CY (1) | CY2108B1 (sh) |
| CZ (1) | CZ281390B6 (sh) |
| DE (1) | DE69408550T2 (sh) |
| DK (1) | DK0617037T3 (sh) |
| ES (1) | ES2112482T3 (sh) |
| FI (1) | FI107384B (sh) |
| GR (1) | GR3026178T3 (sh) |
| HK (1) | HK1009063A1 (sh) |
| HR (1) | HRP940182B1 (sh) |
| HU (1) | HU217363B (sh) |
| NO (1) | NO313240B1 (sh) |
| NZ (1) | NZ263092A (sh) |
| PL (1) | PL176373B1 (sh) |
| RO (1) | RO115264B1 (sh) |
| SI (1) | SI9420016B (sh) |
| SK (1) | SK280831B6 (sh) |
| TW (1) | TW265343B (sh) |
| UA (1) | UA41921C2 (sh) |
| WO (1) | WO1994021645A1 (sh) |
| YU (1) | YU48951B (sh) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5760249A (en) * | 1995-08-29 | 1998-06-02 | Merck & Co., Inc. | Synthesis of hydroxysulfone and related compounds |
| ES2177415B1 (es) * | 2000-09-04 | 2004-10-16 | Ragactives, S.L. | Procedimiento para la obtencion de 4-alquilamino-5, 6-dihidro-4h-tieno-(2,3b)-tiopiran-2-sulfonamida-7-dioxidos, e intermedios. |
| ES2204306B1 (es) * | 2002-08-16 | 2005-08-01 | Ragactives, S.L. | Formas polimorficas de clorhidrato de dorzolamida, su obtencion y composiciones farmaceuticas que las contienen. |
| EP1611138A1 (en) * | 2003-04-07 | 2006-01-04 | Hetero Drugs Limited | A novel crystalline form of dorzolamide hydrochloride |
| WO2006038222A1 (en) * | 2004-07-09 | 2006-04-13 | Fdc Ltd | AN IMPROVED PROCESS FOR THE PREPARATION OF 5,6 -DIHYDRO -4H-4(S)-ETHYLAMINO-6(S)-METHYLTHIENO[2,3-b] THIOPYRAN-2-SULFONAMIDE- 7,7 -DIOXIDE AND ITS SALT |
| ES2253112B1 (es) * | 2004-11-05 | 2007-03-16 | Ragactives, S.L. | Procedimiento para la obtencion de derivados de 4-(n-alquilamino)-5, 6-dihidro-4h-tieno-(2,3-b)-tiopirano. |
| WO2006070387A1 (en) * | 2004-12-28 | 2006-07-06 | Council Of Scientific And Industrial Research | PROCESS FOR PREPARING 5,6-DIHYDRO-4-(S)-(ETHYLAMINO)-6-(S) METHYL-4H-THIENO[2,3b]THIOPYRAN-2-SULPHONAMIDE-7,7-DIOXIDE HCI |
| US7109353B2 (en) | 2004-12-28 | 2006-09-19 | Council Of Scientific And Industrial Research | Process for preparing 5,6-dihydro-4-(S)-(ethylamino)-6-(S) methyl-4H-thieno[2,3b]thiopyran-2-sulphonamide-7,7-dioxide HCl |
| WO2006074230A2 (en) * | 2005-01-06 | 2006-07-13 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method of making dorzolamide hydrochloride |
| JP2008526780A (ja) * | 2005-01-18 | 2008-07-24 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | ドルゾルアミド塩酸塩の非晶質および結晶質の形態およびそれらを製造する方法 |
| JP2010526127A (ja) | 2007-05-07 | 2010-07-29 | シプラ・リミテッド | ドルゾラミドの製造方法 |
| US8927740B2 (en) | 2011-03-10 | 2015-01-06 | Zach System S.P.A. | Asymmetric reduction process |
| ITMI20121165A1 (it) * | 2012-07-03 | 2014-01-04 | Zach System Spa | Processo di riduzione asimmetrica |
| MX2016004940A (es) * | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Proceso para la preparacion de compuestos plaguicidas. |
| US9102655B2 (en) * | 2013-10-17 | 2015-08-11 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| CN103497202B (zh) * | 2013-10-23 | 2015-12-02 | 武汉武药科技有限公司 | 盐酸多佐胺中间体的合成方法 |
| CN108822127B (zh) * | 2018-05-30 | 2020-05-15 | 沈阳药科大学 | 4-羟亚胺基噻吩并[2,3-b]噻喃-2-甲酰胺类化合物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863922A (en) * | 1984-12-12 | 1989-09-05 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use |
| US4797413A (en) * | 1986-05-14 | 1989-01-10 | Merck & Co., Inc. | Thieno thiopyran sulfonamide derivatives, pharmaceutical compositions and use |
| US4968814A (en) * | 1990-04-18 | 1990-11-06 | Merck & Co., Inc. | (S)-Alkyl 3-(thien-2-ylthio)butyrate and analogs and synthesis thereof |
| US5091409A (en) * | 1990-05-17 | 1992-02-25 | Merck & Co., Inc. | 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides |
-
1994
- 1994-03-15 TW TW083102219A patent/TW265343B/zh not_active IP Right Cessation
- 1994-03-16 BR BR9406017A patent/BR9406017A/pt unknown
- 1994-03-16 PL PL94310633A patent/PL176373B1/pl unknown
- 1994-03-16 KR KR1019950703996A patent/KR0157162B1/ko not_active IP Right Cessation
- 1994-03-16 RO RO95-01639A patent/RO115264B1/ro unknown
- 1994-03-16 SI SI9420016A patent/SI9420016B/sl unknown
- 1994-03-16 UA UA95094239A patent/UA41921C2/uk unknown
- 1994-03-16 NZ NZ263092A patent/NZ263092A/en not_active IP Right Cessation
- 1994-03-16 WO PCT/US1994/002852 patent/WO1994021645A1/en active IP Right Grant
- 1994-03-16 CN CN94191502A patent/CN1046732C/zh not_active Expired - Lifetime
- 1994-03-16 CZ CZ952418A patent/CZ281390B6/cs not_active IP Right Cessation
- 1994-03-16 HU HU9502772A patent/HU217363B/hu unknown
- 1994-03-16 SK SK1169-95A patent/SK280831B6/sk not_active IP Right Cessation
- 1994-03-16 CA CA002119218A patent/CA2119218C/en not_active Expired - Fee Related
- 1994-03-17 ES ES94301933T patent/ES2112482T3/es not_active Expired - Lifetime
- 1994-03-17 AT AT94301933T patent/ATE163291T1/de active
- 1994-03-17 DE DE69408550T patent/DE69408550T2/de not_active Expired - Lifetime
- 1994-03-17 EP EP94301933A patent/EP0617037B1/en not_active Expired - Lifetime
- 1994-03-17 DK DK94301933.1T patent/DK0617037T3/da active
- 1994-03-17 JP JP04730794A patent/JP3273096B2/ja not_active Expired - Lifetime
- 1994-03-18 AU AU57871/94A patent/AU673409B2/en not_active Expired
- 1994-03-21 HR HR08/195,886A patent/HRP940182B1/xx not_active IP Right Cessation
- 1994-03-21 YU YU13194A patent/YU48951B/sh unknown
-
1995
- 1995-01-06 US US08/369,557 patent/US5688968A/en not_active Expired - Fee Related
- 1995-09-20 FI FI954438A patent/FI107384B/fi not_active IP Right Cessation
- 1995-09-21 NO NO19953733A patent/NO313240B1/no not_active IP Right Cessation
-
1998
- 1998-02-19 GR GR980400202T patent/GR3026178T3/el unknown
- 1998-07-23 CY CY9800020A patent/CY2108B1/xx unknown
- 1998-08-07 HK HK98109764A patent/HK1009063A1/xx not_active IP Right Cessation
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