CN104471380B - 分析装置以及分析方法 - Google Patents

分析装置以及分析方法 Download PDF

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Publication number
CN104471380B
CN104471380B CN201380035891.8A CN201380035891A CN104471380B CN 104471380 B CN104471380 B CN 104471380B CN 201380035891 A CN201380035891 A CN 201380035891A CN 104471380 B CN104471380 B CN 104471380B
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support substrate
magnetic
magnetic particles
analysis device
magnetic field
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CN104471380A (zh
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滨崎孝伸
斋藤俊郎
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Hitachi High Tech Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6489—Photoluminescence of semiconductors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201380035891.8A 2012-07-06 2013-06-12 分析装置以及分析方法 Active CN104471380B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012151993 2012-07-06
JP2012-151993 2012-07-06
PCT/JP2013/066143 WO2014007034A1 (ja) 2012-07-06 2013-06-12 分析装置及び分析方法

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CN104471380A CN104471380A (zh) 2015-03-25
CN104471380B true CN104471380B (zh) 2017-11-17

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US (1) US9964539B2 (OSRAM)
EP (1) EP2871464B1 (OSRAM)
JP (1) JP5998217B2 (OSRAM)
CN (1) CN104471380B (OSRAM)
IN (1) IN2014DN11191A (OSRAM)
WO (1) WO2014007034A1 (OSRAM)

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US10690663B2 (en) 2015-03-26 2020-06-23 Koninklijke Philips N.V. Manufacturing of a biosensor cartridge
FR3036492B1 (fr) * 2015-05-21 2017-05-12 Ifp Energies Now Systeme de mesure de la quantite de nano-cristaux semi-conducteurs presents dans un fluide
PL413909A1 (pl) 2015-09-15 2017-03-27 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Sposób detekcji i selekcji komórek hybrydomalnych produkujących pożądane przeciwciała
JP6783154B2 (ja) * 2016-01-31 2020-11-11 アークレイ株式会社 分析装置
JP7130919B2 (ja) 2016-03-11 2022-09-06 三菱瓦斯化学株式会社 生体物質固定化方法
KR102026521B1 (ko) * 2016-05-26 2019-09-30 서울대학교산학협력단 비대칭 입자를 이용한 표적 물질 검출 키트 및 방법
EP3532821A4 (en) * 2016-10-26 2020-06-24 Integrated Nano-Technologies, Inc. SYSTEMS AND METHODS FOR OPTICAL DETECTION OF BIOMOLECULAR TARGETS
CA3060696A1 (en) * 2017-05-08 2018-11-15 Majed El-Dweik Apparatus and method for detecting microbial contamination
CN107290534A (zh) * 2017-07-12 2017-10-24 华讯方舟科技有限公司 一种血液细胞捕获芯片及方法
US11041756B2 (en) 2017-10-20 2021-06-22 Charted Scientific Inc. Method and apparatus of filtering light using a spectrometer enhanced with additional spectral filters with optical analysis of fluorescence and scattered light from particles suspended in a liquid medium using confocal and non confocal illumination and imaging
US10585028B2 (en) 2017-10-20 2020-03-10 Charted Scientific, Inc. Method and apparatus for optical analysis
JP7369017B2 (ja) * 2018-11-26 2023-10-25 デンカ株式会社 コロイド粒子を用いた被検物質検出増感法
JPWO2020145124A1 (ja) * 2019-01-09 2021-10-07 株式会社日立ハイテク 核酸分析用基板、核酸分析用フローセル、及び画像解析方法
WO2021006356A1 (ja) * 2019-07-11 2021-01-14 シチズン時計株式会社 被測定物質の検知装置
CN113376146A (zh) * 2020-02-25 2021-09-10 上海交通大学 适于生物分子多重检测的检测颗粒及其制备方法与应用
CN117136639A (zh) * 2022-03-24 2023-11-28 京东方科技集团股份有限公司 量子点发光器件及量子点层图案化的方法

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WO2005093416A1 (ja) * 2004-03-26 2005-10-06 Japan Science And Technology Agency ビーズ配置用基板およびそれを用いたビーズ配置方法
CN101472940A (zh) * 2006-04-18 2009-07-01 先进液体逻辑公司 基于小滴的生物化学
CN101454653A (zh) * 2006-05-17 2009-06-10 卢米尼克斯股份有限公司 用于分析荧光标记颗粒的基于芯片的流式细胞器类系统
CN101715552A (zh) * 2006-11-24 2010-05-26 新加坡科技研究局 用于处理液滴中样品的仪器及其使用方法
CN101970111A (zh) * 2007-06-21 2011-02-09 简·探针公司 用于执行处理的仪器和容器
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CN102066547A (zh) * 2008-04-15 2011-05-18 东曹株式会社 细胞筛选装置、及使用其的细胞筛选方法
CN101793899A (zh) * 2009-02-04 2010-08-04 中国科学院电子学研究所 一种检测脑钠肽的光学生物传感器及试剂制备方法

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Publication number Publication date
JP5998217B2 (ja) 2016-09-28
US20150153335A1 (en) 2015-06-04
IN2014DN11191A (OSRAM) 2015-10-02
WO2014007034A1 (ja) 2014-01-09
EP2871464A4 (en) 2016-01-27
US9964539B2 (en) 2018-05-08
EP2871464B1 (en) 2021-07-28
JPWO2014007034A1 (ja) 2016-06-02
CN104471380A (zh) 2015-03-25
EP2871464A1 (en) 2015-05-13

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