CN104250302B - 抗pd‑1抗体及其应用 - Google Patents

抗pd‑1抗体及其应用 Download PDF

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Publication number
CN104250302B
CN104250302B CN201310258289.2A CN201310258289A CN104250302B CN 104250302 B CN104250302 B CN 104250302B CN 201310258289 A CN201310258289 A CN 201310258289A CN 104250302 B CN104250302 B CN 104250302B
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China
Prior art keywords
antibody
seq
variable region
chain variable
functional fragment
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CN201310258289.2A
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English (en)
Chinese (zh)
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CN104250302A (zh
Inventor
陈博
武海
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Junshi Bioengineering Co ltd
Shanghai Junshi Biosciences Co Ltd
Original Assignee
Shanghai Jun Shi Biological Engineering Co Ltd
Shanghai Jun Biomedical Polytron Technologies Inc
Suzhou Junmeng Biosciences Co Ltd
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Priority to CN201310258289.2A priority Critical patent/CN104250302B/zh
Application filed by Shanghai Jun Shi Biological Engineering Co Ltd, Shanghai Jun Biomedical Polytron Technologies Inc, Suzhou Junmeng Biosciences Co Ltd filed Critical Shanghai Jun Shi Biological Engineering Co Ltd
Priority to HUE14818708A priority patent/HUE052487T2/hu
Priority to PL14818708T priority patent/PL3026062T3/pl
Priority to US14/392,360 priority patent/US10066013B2/en
Priority to BR112015031883-5A priority patent/BR112015031883A2/pt
Priority to MYPI2015704733A priority patent/MY176822A/en
Priority to EP20189272.6A priority patent/EP3845562A1/en
Priority to ES14818708T priority patent/ES2822927T3/es
Priority to PT148187081T priority patent/PT3026062T/pt
Priority to PCT/CN2014/072574 priority patent/WO2014206107A1/zh
Priority to DK14818708.1T priority patent/DK3026062T3/da
Priority to RU2016102176A priority patent/RU2663795C2/ru
Priority to HRP20201600TT priority patent/HRP20201600T1/hr
Priority to EP14818708.1A priority patent/EP3026062B1/en
Priority to SI201431678T priority patent/SI3026062T1/sl
Priority to JP2016522196A priority patent/JP6681327B2/ja
Publication of CN104250302A publication Critical patent/CN104250302A/zh
Priority to PH12015502819A priority patent/PH12015502819A1/en
Application granted granted Critical
Publication of CN104250302B publication Critical patent/CN104250302B/zh
Priority to US16/045,363 priority patent/US10815302B2/en
Priority to US17/022,719 priority patent/US20210009688A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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CN201310258289.2A 2013-06-26 2013-06-26 抗pd‑1抗体及其应用 Active CN104250302B (zh)

Priority Applications (19)

Application Number Priority Date Filing Date Title
CN201310258289.2A CN104250302B (zh) 2013-06-26 2013-06-26 抗pd‑1抗体及其应用
RU2016102176A RU2663795C2 (ru) 2013-06-26 2014-02-26 Антитело к pd-1 и его применение
US14/392,360 US10066013B2 (en) 2013-06-26 2014-02-26 Anti-PD-1 antibody and use thereof
BR112015031883-5A BR112015031883A2 (pt) 2013-06-26 2014-02-26 anti-pd-1 anticorpo e o uso dele
MYPI2015704733A MY176822A (en) 2013-06-26 2014-02-26 Anti-pd-1 antibody and use thereof
EP20189272.6A EP3845562A1 (en) 2013-06-26 2014-02-26 Anti-pd-1 antibody and use thereof
ES14818708T ES2822927T3 (es) 2013-06-26 2014-02-26 Anticuerpo anti-PD-1 y su uso
EP14818708.1A EP3026062B1 (en) 2013-06-26 2014-02-26 Anti-pd-1 antibody and use thereof
PL14818708T PL3026062T3 (pl) 2013-06-26 2014-02-26 Przeciwciała anty-pd-1 i ich zastosowanie
DK14818708.1T DK3026062T3 (da) 2013-06-26 2014-02-26 Anti-pd-1-antistof og anvendelse deraf
HUE14818708A HUE052487T2 (hu) 2013-06-26 2014-02-26 Anti-PD-1 antitest és annak alkalmazása
PCT/CN2014/072574 WO2014206107A1 (zh) 2013-06-26 2014-02-26 抗pd-1抗体及其应用
PT148187081T PT3026062T (pt) 2013-06-26 2014-02-26 Anticorpo anti-pd-1 e utilização do mesmo
SI201431678T SI3026062T1 (sl) 2013-06-26 2014-02-26 ANTI-PD-1 protitelo in njegova uporaba
JP2016522196A JP6681327B2 (ja) 2013-06-26 2014-02-26 抗ｐｄ−１抗体およびその応用
HRP20201600TT HRP20201600T1 (hr) 2013-06-26 2014-02-26 Anti-pd-1 antitijelo i njegova uporaba
PH12015502819A PH12015502819A1 (en) 2013-06-26 2015-12-18 Anti-pd-1 antibody and use thereof
US16/045,363 US10815302B2 (en) 2013-06-26 2018-07-25 Anti-PD-1 antibody and use thereof
US17/022,719 US20210009688A1 (en) 2013-06-26 2020-09-16 Anti-pd-1 antibody and use thereof

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Application Number Priority Date Filing Date Title
CN201310258289.2A CN104250302B (zh) 2013-06-26 2013-06-26 抗pd‑1抗体及其应用

Publications (2)

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CN104250302A CN104250302A (zh) 2014-12-31
CN104250302B true CN104250302B (zh) 2017-11-14

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EP (2) EP3026062B1 (https=)
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RU2663795C2 (ru) 2018-08-09
CN104250302A (zh) 2014-12-31
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