CN104001165B - 包含肺炎球菌抗原的组合物 - Google Patents

包含肺炎球菌抗原的组合物 Download PDF

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Publication number
CN104001165B
CN104001165B CN201410192895.3A CN201410192895A CN104001165B CN 104001165 B CN104001165 B CN 104001165B CN 201410192895 A CN201410192895 A CN 201410192895A CN 104001165 B CN104001165 B CN 104001165B
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China
Prior art keywords
seq
amino acids
preferred
acid sequence
epitope
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Expired - Fee Related
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CN201410192895.3A
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English (en)
Chinese (zh)
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CN104001165A (zh
Inventor
C·多纳蒂
A·穆兹
V·马西格纳尼
F·巴格诺利
P·鲁格洛
M·巴罗奇
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GlaxoSmithKline Biologicals SA
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GlaxoSmithKline Biologicals SA
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CN201410192895.3A 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物 Expired - Fee Related CN104001165B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0714963.6 2007-08-01
GBGB0714963.6A GB0714963D0 (en) 2007-08-01 2007-08-01 Compositions comprising antigens
US96686607P 2007-08-29 2007-08-29
US60/966,866 2007-08-29
CN200880108017A CN101801409A (zh) 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN200880108017A Division CN101801409A (zh) 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物

Publications (2)

Publication Number Publication Date
CN104001165A CN104001165A (zh) 2014-08-27
CN104001165B true CN104001165B (zh) 2018-08-14

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN200880108017A Pending CN101801409A (zh) 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物
CN201410192895.3A Expired - Fee Related CN104001165B (zh) 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN200880108017A Pending CN101801409A (zh) 2007-08-01 2008-08-01 包含肺炎球菌抗原的组合物

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US (2) US20110243976A1 (enExample)
EP (2) EP2197484A2 (enExample)
JP (2) JP2010535025A (enExample)
CN (2) CN101801409A (enExample)
AP (1) AP2010005173A0 (enExample)
AU (1) AU2008281438A1 (enExample)
BR (1) BRPI0813892A2 (enExample)
CA (1) CA2695169A1 (enExample)
CO (1) CO6260103A2 (enExample)
CY (1) CY1117689T1 (enExample)
DK (1) DK2572726T3 (enExample)
EA (1) EA018137B1 (enExample)
ES (1) ES2580957T3 (enExample)
GB (1) GB0714963D0 (enExample)
HR (1) HRP20160685T1 (enExample)
HU (1) HUE029670T2 (enExample)
PL (1) PL2572726T3 (enExample)
PT (1) PT2572726T (enExample)
SI (1) SI2572726T1 (enExample)
WO (1) WO2009016515A2 (enExample)

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GB0714963D0 (en) 2007-09-12
BRPI0813892A2 (pt) 2017-05-09
US20110243976A1 (en) 2011-10-06
HRP20160685T1 (hr) 2016-07-15
WO2009016515A2 (en) 2009-02-05
EA201070200A1 (ru) 2010-08-30
JP2014034578A (ja) 2014-02-24
US20140348868A1 (en) 2014-11-27
SI2572726T1 (sl) 2016-08-31
CN101801409A (zh) 2010-08-11
WO2009016515A3 (en) 2009-08-13
PT2572726T (pt) 2016-08-05
CY1117689T1 (el) 2017-05-17
CA2695169A1 (en) 2009-02-05
CO6260103A2 (es) 2011-03-22
DK2572726T3 (en) 2016-07-04
JP5838193B2 (ja) 2016-01-06
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EA018137B1 (ru) 2013-05-30

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