CN103889953B - 作为防乙型肝炎病毒感染的抗病毒剂的氨磺酰苯甲酰胺衍生物 - Google Patents

作为防乙型肝炎病毒感染的抗病毒剂的氨磺酰苯甲酰胺衍生物 Download PDF

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Publication number
CN103889953B
CN103889953B CN201280039363.5A CN201280039363A CN103889953B CN 103889953 B CN103889953 B CN 103889953B CN 201280039363 A CN201280039363 A CN 201280039363A CN 103889953 B CN103889953 B CN 103889953B
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benzamide
fluoro
difluorophenyl
methyl
chloro
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Chinese (zh)
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CN103889953A (zh
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巨涛·郭
晓东·徐
蒂莫西·M·布洛克
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Philadelphia Health & Education Co dba Dressel University Medical School
BARUCH S BLUMBERG INSTITUTE
INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH
Drexel University
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Philadelphia Health & Education Co dba Dressel University Medical School
BARUCH S BLUMBERG INSTITUTE
INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH
Drexel University
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Priority to CN201610312350.0A priority Critical patent/CN106166157B/zh
Publication of CN103889953A publication Critical patent/CN103889953A/zh
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    • C07—ORGANIC CHEMISTRY
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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CN201280039363.5A 2011-07-01 2012-06-29 作为防乙型肝炎病毒感染的抗病毒剂的氨磺酰苯甲酰胺衍生物 Expired - Fee Related CN103889953B (zh)

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US201161503830P 2011-07-01 2011-07-01
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PCT/US2012/044775 WO2013006394A1 (en) 2011-07-01 2012-06-29 Sulfamoylbenzamide derivatives as antiviral agents against hbv infection

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US20160101074A1 (en) 2016-04-14
US20140206666A1 (en) 2014-07-24
US9758477B2 (en) 2017-09-12
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US20190337891A1 (en) 2019-11-07
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