CN103492392B - 噻吩并[2,3-d]嘧啶衍生物及其用于治疗心律失常的用途 - Google Patents

噻吩并[2,3-d]嘧啶衍生物及其用于治疗心律失常的用途 Download PDF

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Publication number
CN103492392B
CN103492392B CN201280016323.9A CN201280016323A CN103492392B CN 103492392 B CN103492392 B CN 103492392B CN 201280016323 A CN201280016323 A CN 201280016323A CN 103492392 B CN103492392 B CN 103492392B
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Prior art keywords
compound
formula
acid
compounds
thieno
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Expired - Fee Related
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CN201280016323.9A
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English (en)
Chinese (zh)
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CN103492392A (zh
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D·E·约翰
J·福特
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Xention Ltd
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Xention Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280016323.9A 2011-04-01 2012-03-29 噻吩并[2,3-d]嘧啶衍生物及其用于治疗心律失常的用途 Expired - Fee Related CN103492392B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1105659.5 2011-04-01
GBGB1105659.5A GB201105659D0 (en) 2011-04-01 2011-04-01 Compounds
PCT/GB2012/050710 WO2012131379A1 (en) 2011-04-01 2012-03-29 Thieno [2, 3 -d] pyrimidine derivatives and their use to treat arrhythmia

Publications (2)

Publication Number Publication Date
CN103492392A CN103492392A (zh) 2014-01-01
CN103492392B true CN103492392B (zh) 2015-11-25

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CN201280016323.9A Expired - Fee Related CN103492392B (zh) 2011-04-01 2012-03-29 噻吩并[2,3-d]嘧啶衍生物及其用于治疗心律失常的用途

Country Status (42)

Country Link
US (1) US9249155B2 (enExample)
EP (1) EP2694518B1 (enExample)
JP (1) JP5826374B2 (enExample)
KR (1) KR20140023332A (enExample)
CN (1) CN103492392B (enExample)
AP (1) AP2013007198A0 (enExample)
AR (1) AR088735A1 (enExample)
AU (1) AU2012235882B2 (enExample)
BR (1) BR112013025236A2 (enExample)
CA (1) CA2831493A1 (enExample)
CL (1) CL2013002789A1 (enExample)
CO (1) CO6801756A2 (enExample)
CR (1) CR20130488A (enExample)
CU (1) CU24173B1 (enExample)
CY (1) CY1117025T1 (enExample)
DK (1) DK2694518T3 (enExample)
EA (1) EA201301111A1 (enExample)
EC (1) ECSP13012988A (enExample)
ES (1) ES2558563T3 (enExample)
GB (1) GB201105659D0 (enExample)
GT (1) GT201300225A (enExample)
HR (1) HRP20151340T1 (enExample)
HU (1) HUE028438T2 (enExample)
IL (1) IL228555A0 (enExample)
MA (1) MA35064B1 (enExample)
ME (1) ME02314B (enExample)
MX (1) MX335937B (enExample)
NI (1) NI201300100A (enExample)
PE (1) PE20141021A1 (enExample)
PH (1) PH12013501952A1 (enExample)
PL (1) PL2694518T3 (enExample)
PT (1) PT2694518E (enExample)
RS (1) RS54458B1 (enExample)
RU (1) RU2013148627A (enExample)
SG (1) SG193578A1 (enExample)
SI (1) SI2694518T1 (enExample)
SM (1) SMT201500322B (enExample)
TN (1) TN2013000377A1 (enExample)
TW (1) TWI516265B (enExample)
UA (1) UA110131C2 (enExample)
WO (1) WO2012131379A1 (enExample)
ZA (1) ZA201307085B (enExample)

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
EP2922858A4 (en) * 2012-11-20 2016-06-15 Univ Mcgill THIENOPYRIMIDININHIBITORS OF FARNESYL AND / OR GERANYL GERANYL PYROPHOSPHATE SYNTHASE
CN109311868B (zh) 2015-12-22 2022-04-01 尚医治疗有限责任公司 用于治疗癌症和炎性疾病的化合物
CN106727587A (zh) * 2016-11-28 2017-05-31 李娜 一种治疗心律失常的药物组合物
IL271230B2 (en) 2017-06-21 2024-06-01 SHY Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
JP7407461B2 (ja) 2018-12-19 2024-01-04 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物

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Also Published As

Publication number Publication date
SMT201500322B (it) 2016-02-25
MA35064B1 (fr) 2014-04-03
HK1193806A1 (zh) 2014-10-03
NZ615621A (en) 2015-01-30
ECSP13012988A (es) 2013-12-31
HUE028438T2 (en) 2017-02-28
JP5826374B2 (ja) 2015-12-02
US20140206703A1 (en) 2014-07-24
HRP20151340T1 (hr) 2016-02-26
US9249155B2 (en) 2016-02-02
ES2558563T3 (es) 2016-02-05
DK2694518T3 (en) 2015-11-09
AU2012235882A1 (en) 2013-05-02
PH12013501952A1 (en) 2018-04-11
ZA201307085B (en) 2015-04-29
EP2694518A1 (en) 2014-02-12
EA201301111A1 (ru) 2014-02-28
HK1193096A1 (zh) 2014-09-12
RS54458B1 (sr) 2016-06-30
GB201105659D0 (en) 2011-05-18
AR088735A1 (es) 2014-07-02
IL228555A0 (en) 2013-12-31
JP2014509637A (ja) 2014-04-21
CU20130124A7 (es) 2014-01-29
CO6801756A2 (es) 2013-11-29
ME02314B (me) 2016-06-20
BR112013025236A2 (pt) 2019-09-24
EP2694518B1 (en) 2015-10-07
KR20140023332A (ko) 2014-02-26
AU2012235882B2 (en) 2015-08-06
CL2013002789A1 (es) 2014-07-18
CY1117025T1 (el) 2017-04-05
NI201300100A (es) 2014-01-07
CU24173B1 (es) 2016-04-25
CA2831493A1 (en) 2012-10-04
MX335937B (es) 2016-01-04
PT2694518E (pt) 2016-02-05
UA110131C2 (ru) 2015-11-25
TW201244720A (en) 2012-11-16
MX2013011301A (es) 2014-04-16
RU2013148627A (ru) 2015-05-10
TN2013000377A1 (en) 2015-01-20
SI2694518T1 (sl) 2016-02-29
SG193578A1 (en) 2013-10-30
AP2013007198A0 (en) 2013-10-31
TWI516265B (zh) 2016-01-11
WO2012131379A1 (en) 2012-10-04
GT201300225A (es) 2014-12-30
PE20141021A1 (es) 2014-08-30
CN103492392A (zh) 2014-01-01
PL2694518T3 (pl) 2016-03-31
CR20130488A (es) 2013-12-06

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