BR0206853A - Formulação farmacêutica compreendendo pirazolo[4,3-d]pirimidinas e antagonistas de receptor de endotelina ou tienopirimidinas e antagonistas de receptor de endotelina - Google Patents
Formulação farmacêutica compreendendo pirazolo[4,3-d]pirimidinas e antagonistas de receptor de endotelina ou tienopirimidinas e antagonistas de receptor de endotelinaInfo
- Publication number
- BR0206853A BR0206853A BR0206853-2A BR0206853A BR0206853A BR 0206853 A BR0206853 A BR 0206853A BR 0206853 A BR0206853 A BR 0206853A BR 0206853 A BR0206853 A BR 0206853A
- Authority
- BR
- Brazil
- Prior art keywords
- endothelin receptor
- receptor antagonists
- pyrimidines
- failure
- pharmaceutical formulation
- Prior art date
Links
- 229940118365 Endothelin receptor antagonist Drugs 0.000 title abstract 3
- 239000002308 endothelin receptor antagonist Substances 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 title 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 2
- 206010019280 Heart failures Diseases 0.000 abstract 2
- 102000005962 receptors Human genes 0.000 abstract 2
- 108020003175 receptors Proteins 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000018262 Peripheral vascular disease Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 206010039085 Rhinitis allergic Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 201000009961 allergic asthma Diseases 0.000 abstract 1
- 201000010105 allergic rhinitis Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 208000023819 chronic asthma Diseases 0.000 abstract 1
- 208000019425 cirrhosis of liver Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000002590 phosphodiesterase V inhibitor Substances 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 150000003230 pyrimidines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000012201 sexual and gender identity disease Diseases 0.000 abstract 1
- 208000015891 sexual disease Diseases 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
"FORMULAçãO FARMACêUTICA COMPREENDENDO PIRAZOLO[4,3-D]PIRIMIDINAS E ANTAGONISTAS DE RECEPTOR DE ENDOTELINA OU TIENOPIRIMIDINAS E ANTAGONISTAS DE RECEPTOR DE ENDOTELINA". A presente invenção refere-se a preparação farmacêutica compreendendo pelo menos um inibidor de fosfodiesterase V tem, e/ou sal fisiologicamente aceitável e/ou solvatos deste e pelo menos um antagonista de receptor de endotelina para a preparação de um medicamento para o tratamento de angina, pressão sang³ínea alta, pressão pulmonar alta, insuficiência cardíaca congestiva (CHF), doença pulmonar obstrutiva crónica (COPD), coração pulmonar, insuficiência dextrocardíaca, aterosclerose, condições de patência reduzida dos vasos cardíacos, doenças vasculares periféricas, acidentes vasculares cerebrais, bronquite, asma alérgica, asma crónica, rinite alérgica, glaucoma, síndrome de intestino irritável, tumores, insuficiência renal, cirrose hepática, disfunção erétil e para o tratamento de distúrbios sexuais femininos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE2001104800 DE10104800A1 (de) | 2001-02-02 | 2001-02-02 | Pharmazeutische Formulierungen enthaltend Pyrazolo[4,3-d]pyrimidine und Endothelin-Rezeptor-Antagonisten |
DE2001104801 DE10104801A1 (de) | 2001-02-02 | 2001-02-02 | Pharmazeutische Formulierungen enthaltend Thienopirimidine und Endothelin-Rezeptor-Antagonisten (2) |
DE2001104802 DE10104802A1 (de) | 2001-02-02 | 2001-02-02 | Pharmazeutische Formulierungen enthaltend Thienopirimidine und Endothelin-Rezeptor-Antagonisten (1) |
PCT/EP2002/000256 WO2002062343A2 (en) | 2001-02-02 | 2002-01-14 | PHARMACEUTICAL FORMULATION COMPRISING PYRAZOLO[4,3-d]PYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS OR THIENOPYRIMIDINES AND ENDOTHELIN RECEPTOR ANTAGONISTS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0206853A true BR0206853A (pt) | 2004-01-13 |
Family
ID=27214266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0206853-2A BR0206853A (pt) | 2001-02-02 | 2002-01-14 | Formulação farmacêutica compreendendo pirazolo[4,3-d]pirimidinas e antagonistas de receptor de endotelina ou tienopirimidinas e antagonistas de receptor de endotelina |
Country Status (13)
Country | Link |
---|---|
US (1) | US20040063731A1 (pt) |
EP (1) | EP1357915A2 (pt) |
JP (1) | JP2004525890A (pt) |
KR (1) | KR20030071880A (pt) |
CN (1) | CN1489467A (pt) |
BR (1) | BR0206853A (pt) |
CA (1) | CA2437085A1 (pt) |
CZ (1) | CZ20032350A3 (pt) |
HU (1) | HUP0303005A3 (pt) |
MX (1) | MXPA03006802A (pt) |
PL (1) | PL362510A1 (pt) |
SK (1) | SK10782003A3 (pt) |
WO (1) | WO2002062343A2 (pt) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10325813B4 (de) | 2003-06-06 | 2007-12-20 | Universitätsklinikum Freiburg | Prophylaxe und/oder Therapie bei der portalen Hypertonie |
US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
US20060205733A1 (en) * | 2004-08-26 | 2006-09-14 | Encysive Pharmaceuticals | Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof |
WO2006055573A2 (en) * | 2004-11-18 | 2006-05-26 | Schering Corporation | Methods of using pde v inhibitors for the treatment of congestive heart failure |
WO2008088727A2 (en) | 2007-01-12 | 2008-07-24 | Concert Pharmaceuticals, Inc. | Endothelin receptor antagonists |
US8080549B2 (en) * | 2007-01-12 | 2011-12-20 | Concert Pharmaceuticals, Inc. | Endothelin receptor antagonists |
GB201105659D0 (en) | 2011-04-01 | 2011-05-18 | Xention Ltd | Compounds |
CA2842190A1 (en) | 2011-07-19 | 2013-01-24 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
SE542968C2 (en) | 2018-10-26 | 2020-09-22 | Lindahl Anders | Treatment of osteoarthritis |
WO2021087399A1 (en) * | 2019-10-30 | 2021-05-06 | Perfuse Therapeutics, Inc. | Treatment of ocular diseases using endothelin receptor antagonists |
EP4100406A4 (en) | 2020-02-06 | 2023-07-05 | Perfuse Therapeutics, Inc. | COMPOSITIONS FOR THE TREATMENT OF OCULAR DISEASES |
AU2022264036A1 (en) | 2021-04-30 | 2023-11-23 | Perfuse Therapeutics, Inc. | Pharmaceutical compositions and intravitreal drug delivery systems for the treatment of ocular diseases |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9301192D0 (en) * | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
DE19632423A1 (de) * | 1996-08-12 | 1998-02-19 | Merck Patent Gmbh | Thienopyrimidine |
DE19644228A1 (de) * | 1996-10-24 | 1998-04-30 | Merck Patent Gmbh | Thienopyrimidine |
DE19709877A1 (de) * | 1997-03-11 | 1998-09-17 | Bayer Ag | 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate |
US6268388B1 (en) * | 1997-08-22 | 2001-07-31 | Bristol-Myers Squibb Company | Method for preventing or treating erectile dysfunction by administering an endothelin antagonist |
US6037346A (en) * | 1997-10-28 | 2000-03-14 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
AU3713600A (en) * | 1999-03-01 | 2000-09-21 | Nitromed, Inc. | Nitrosated and nitrosylated prostaglandins, compositions and metods of use |
-
2002
- 2002-01-14 HU HU0303005A patent/HUP0303005A3/hu unknown
- 2002-01-14 KR KR10-2003-7010197A patent/KR20030071880A/ko not_active Application Discontinuation
- 2002-01-14 PL PL02362510A patent/PL362510A1/xx unknown
- 2002-01-14 CA CA002437085A patent/CA2437085A1/en not_active Abandoned
- 2002-01-14 CN CNA028044134A patent/CN1489467A/zh active Pending
- 2002-01-14 EP EP02702259A patent/EP1357915A2/en not_active Withdrawn
- 2002-01-14 SK SK1078-2003A patent/SK10782003A3/sk unknown
- 2002-01-14 BR BR0206853-2A patent/BR0206853A/pt not_active Application Discontinuation
- 2002-01-14 CZ CZ20032350A patent/CZ20032350A3/cs unknown
- 2002-01-14 MX MXPA03006802A patent/MXPA03006802A/es unknown
- 2002-01-14 US US10/470,763 patent/US20040063731A1/en not_active Abandoned
- 2002-01-14 WO PCT/EP2002/000256 patent/WO2002062343A2/en not_active Application Discontinuation
- 2002-01-14 JP JP2002562350A patent/JP2004525890A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MXPA03006802A (es) | 2003-11-13 |
WO2002062343A2 (en) | 2002-08-15 |
KR20030071880A (ko) | 2003-09-06 |
HUP0303005A3 (en) | 2005-05-30 |
HUP0303005A2 (hu) | 2003-12-29 |
WO2002062343A3 (en) | 2002-11-21 |
EP1357915A2 (en) | 2003-11-05 |
CA2437085A1 (en) | 2002-08-15 |
CZ20032350A3 (en) | 2004-03-17 |
CN1489467A (zh) | 2004-04-14 |
SK10782003A3 (sk) | 2003-12-02 |
PL362510A1 (en) | 2004-11-02 |
JP2004525890A (ja) | 2004-08-26 |
US20040063731A1 (en) | 2004-04-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0206853A (pt) | Formulação farmacêutica compreendendo pirazolo[4,3-d]pirimidinas e antagonistas de receptor de endotelina ou tienopirimidinas e antagonistas de receptor de endotelina | |
HUP0303315A2 (hu) | Pirazolo [4,3-d] pirimidineket és trombózisellenes szereket, kalcium antagonistákat, prosztaglandinokat vagy prosztaglandinszármazékokat tartalmazó gyógyszerkészítmények | |
HUP0400818A2 (hu) | Tieno[2,3-d]pirimidinek alkalmazása és az ezeket tartalmazó gyógyszerkészítmények | |
JP2000001434A (ja) | コルチコトロピン放出因子アンタゴニストを含む医薬組成物 | |
TNSN07050A1 (fr) | Derives de triazolopyridinylsulfanyle servant d'inhibiteurs de kinase map p38 | |
GEP20105025B (en) | Pharmaceutical compositions for treatent of atherosclerosis and related conditions and use thereof for treatment of these diseases | |
KR20010014678A (ko) | 돌연사 방지를 위하여 crf 길항제를 이용한 qt 분산및 심박수 변동성의 개선 | |
WO2002085909A8 (en) | 9-deazaguanine derivatives as inhibitors of gsk-3 | |
US8552016B2 (en) | Anti-cancer cyclopenta(g)quinazoline compounds | |
JP2023518974A (ja) | コロナウイルス感染症による化学感覚機能障害の治療 | |
MD523G2 (ro) | Derivaţi noi ai triazolpirimidinei, antagonişti ai receptorilor angiotensinei II, procedee de preparare a lor, compoziţii farmaceutice ce le conţin | |
WO2002081728A3 (en) | Quinoline inhibitors of hyak1 and hyak3 kinases | |
BR0116849A (pt) | Formulações farmacêuticas compreendendo pirazolo[4,3-d]pirimidinas e nitratos ou tienopirimidinas e nitratos | |
KR20040040457A (ko) | 폐질환 치료방법 | |
EP1949893A3 (en) | Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors | |
EP0662834A1 (en) | Novel epoxide-containing compounds | |
RU2002118304A (ru) | Способ подавления чувства страха | |
BR0116255A (pt) | Formulação farmacêutica compreendendo tienopirimidinas e antitrombóticos, antagonistas de cálcio, prostaglandinas e derivados de prostaglandina (1) | |
BR0211938A (pt) | Composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso do dito composto ou de um sal ou solvato farmaceuticamente aceitável do mesmo, e, método para tratar os distúrbios de fertilidade em pacientes em necessidade do mesmo | |
BR0115187A (pt) | Uso de pirazolo[4,3-d]pirimidinas | |
WO2003020300A1 (en) | Use of cyclopenta[g]quinazoline derivatives for treating cancer | |
US10603321B2 (en) | Small molecules targeting HIV-1 nef | |
ES2384715T3 (es) | Fumarato de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrilo | |
HUP0401368A2 (hu) | Tienopirimidineket és trombózisellenes szereket, kalcium antagonistákat, prosztaglandinokat vagy prosztaglandin származékokat tartalmazó gyógyszerkészítmények | |
TH55360B (th) | สูตรผสมทางเภสัชกรรมซึ่งประกอบรวมด้วยไพราโซโล[4, 3-d]ไพริมิดีนและแอนตะกอนิสต์ของตัวรับเอนโดทีลิน หรือไทอีโนไพริมิดีนและแอนตะกอนิสต์ของตัวรับเอนโดทีลิน |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |