RU2002118304A - Способ подавления чувства страха - Google Patents
Способ подавления чувства страхаInfo
- Publication number
- RU2002118304A RU2002118304A RU2002118304/14A RU2002118304A RU2002118304A RU 2002118304 A RU2002118304 A RU 2002118304A RU 2002118304/14 A RU2002118304/14 A RU 2002118304/14A RU 2002118304 A RU2002118304 A RU 2002118304A RU 2002118304 A RU2002118304 A RU 2002118304A
- Authority
- RU
- Russia
- Prior art keywords
- fear
- way
- suppress feelings
- feelings
- suppress
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 1
- 239000002249 anxiolytic agent Substances 0.000 claims 1
- 230000000949 anxiolytic effect Effects 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Claims (1)
- Способ подавления чувства страха у млекопитающего, заключающийся в системном введении млекопитающему эффективной, но не токсичной анксиолитической дозы 6-гидрокси-8-[4-[4-(2-пиримидинил)-пиперазинил]-бутил]-8-азаспиро[4.5]-7,9-диона или его фармацевтически приемлемой соли присоединения кислоты или его гидрата.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48416100A | 2000-01-18 | 2000-01-18 | |
US09/484,161 | 2000-01-18 | ||
US09/588,221 | 2000-06-06 | ||
US09/588,221 US6150365A (en) | 1999-08-05 | 2000-06-06 | Anxiety method |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2002118304A true RU2002118304A (ru) | 2004-01-10 |
RU2254132C2 RU2254132C2 (ru) | 2005-06-20 |
Family
ID=27047894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2002118304/14A RU2254132C2 (ru) | 2000-01-18 | 2000-10-18 | Способ подавления чувства страха |
Country Status (22)
Country | Link |
---|---|
US (1) | US6150365A (ru) |
EP (1) | EP1248622B1 (ru) |
JP (1) | JP2003520236A (ru) |
KR (1) | KR20020073176A (ru) |
CN (1) | CN1424911A (ru) |
AR (1) | AR028201A1 (ru) |
AT (1) | ATE300302T1 (ru) |
AU (1) | AU775591B2 (ru) |
BR (1) | BR0016971A (ru) |
CA (1) | CA2406732A1 (ru) |
CZ (1) | CZ20022461A3 (ru) |
DE (1) | DE60021609D1 (ru) |
HU (1) | HUP0204285A3 (ru) |
IL (1) | IL150019A0 (ru) |
MX (1) | MXPA02007003A (ru) |
NO (1) | NO20023425L (ru) |
NZ (1) | NZ520823A (ru) |
PL (1) | PL355966A1 (ru) |
RU (1) | RU2254132C2 (ru) |
TW (1) | TWI226831B (ru) |
UY (1) | UY26440A1 (ru) |
WO (1) | WO2001052853A1 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150365A (en) * | 1999-08-05 | 2000-11-21 | Bristol-Myers Squibb Company | Anxiety method |
US20030069251A1 (en) * | 1999-08-05 | 2003-04-10 | Yevich Joseph P. | Antianxiety composition |
US20050137206A1 (en) * | 1999-08-05 | 2005-06-23 | Yevich Joseph P. | Method for treatment of anxiety and depression |
JP2005502318A (ja) * | 2001-03-22 | 2005-01-27 | メルク エンド カムパニー インコーポレーテッド | Mch1r欠損マウス |
US6593331B2 (en) | 2001-04-17 | 2003-07-15 | Laboratories Upsa | Method for treatment of pain |
EP1408979A4 (en) * | 2001-07-24 | 2005-03-23 | Bristol Myers Squibb Co | R-6-HYDROXY-BUSPIRONE |
EP1417203A4 (en) * | 2001-07-24 | 2005-08-10 | Bristol Myers Squibb Co | S-6-HYDROXY-BUSPIRONE |
PL374000A1 (en) * | 2002-08-12 | 2005-09-19 | Bristol-Myers Squibb Company | Improved process for hydroxyazapirones |
US20040147581A1 (en) * | 2002-11-18 | 2004-07-29 | Pharmacia Corporation | Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy |
CA2514574A1 (en) * | 2003-01-30 | 2004-08-12 | Dynogen Pharmaceuticals, Inc. | Use of sodium channel modulators for treating gastrointestinal tract disorders |
BR112013009004B1 (pt) | 2010-10-15 | 2022-05-10 | Contera Pharma Aps | Uso de composição farmacêutica ou kit de partes compreendendo combinações de agonistas dereceptor de serotonina |
IN2014DN09571A (ru) | 2012-04-18 | 2015-07-17 | Contera Pharma Aps | |
PT3160464T (pt) | 2014-06-26 | 2018-10-12 | Contera Pharma Aps | 6-hidroxibuspirona para uso no tratamento de transtornos do movimento |
CA3030089C (en) | 2016-07-11 | 2024-04-23 | Contera Pharma Aps | Pulsatile drug delivery system for treating morning akinesia |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
US4182763A (en) * | 1978-05-22 | 1980-01-08 | Mead Johnson & Company | Buspirone anti-anxiety method |
US4409223A (en) * | 1982-08-06 | 1983-10-11 | Riblet Leslie A | Anxiolytic method |
US5633009A (en) * | 1990-11-28 | 1997-05-27 | Sano Corporation | Transdermal administration of azapirones |
US5431922A (en) * | 1991-03-05 | 1995-07-11 | Bristol-Myers Squibb Company | Method for administration of buspirone |
WO1998024411A2 (en) * | 1996-12-04 | 1998-06-11 | Bristol-Myers Squibb Company | Method for oral administration of buspirone |
US6150365A (en) * | 1999-08-05 | 2000-11-21 | Bristol-Myers Squibb Company | Anxiety method |
-
2000
- 2000-06-06 US US09/588,221 patent/US6150365A/en not_active Expired - Fee Related
- 2000-10-18 DE DE60021609T patent/DE60021609D1/de not_active Expired - Lifetime
- 2000-10-18 BR BR0016971-4A patent/BR0016971A/pt not_active IP Right Cessation
- 2000-10-18 JP JP2001552900A patent/JP2003520236A/ja active Pending
- 2000-10-18 KR KR1020027009260A patent/KR20020073176A/ko not_active Application Discontinuation
- 2000-10-18 WO PCT/US2000/028800 patent/WO2001052853A1/en active IP Right Grant
- 2000-10-18 CN CN00818472A patent/CN1424911A/zh active Pending
- 2000-10-18 AU AU12130/01A patent/AU775591B2/en not_active Ceased
- 2000-10-18 HU HU0204285A patent/HUP0204285A3/hu unknown
- 2000-10-18 CZ CZ20022461A patent/CZ20022461A3/cs unknown
- 2000-10-18 NZ NZ520823A patent/NZ520823A/en unknown
- 2000-10-18 PL PL00355966A patent/PL355966A1/xx not_active Application Discontinuation
- 2000-10-18 MX MXPA02007003A patent/MXPA02007003A/es unknown
- 2000-10-18 EP EP00973636A patent/EP1248622B1/en not_active Expired - Lifetime
- 2000-10-18 IL IL15001900A patent/IL150019A0/xx unknown
- 2000-10-18 RU RU2002118304/14A patent/RU2254132C2/ru not_active IP Right Cessation
- 2000-10-18 AT AT00973636T patent/ATE300302T1/de not_active IP Right Cessation
- 2000-10-18 CA CA002406732A patent/CA2406732A1/en not_active Abandoned
- 2000-11-13 TW TW089124000A patent/TWI226831B/zh active
- 2000-11-16 UY UY26440A patent/UY26440A1/es not_active Application Discontinuation
-
2001
- 2001-01-18 AR ARP010100231A patent/AR028201A1/es unknown
-
2002
- 2002-07-17 NO NO20023425A patent/NO20023425L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2003520236A (ja) | 2003-07-02 |
HUP0204285A3 (en) | 2004-07-28 |
UY26440A1 (es) | 2001-08-27 |
IL150019A0 (en) | 2002-12-01 |
NO20023425D0 (no) | 2002-07-17 |
HUP0204285A2 (en) | 2003-05-28 |
ATE300302T1 (de) | 2005-08-15 |
WO2001052853A1 (en) | 2001-07-26 |
PL355966A1 (en) | 2004-05-31 |
CZ20022461A3 (cs) | 2003-09-17 |
MXPA02007003A (es) | 2003-01-28 |
BR0016971A (pt) | 2002-10-15 |
CA2406732A1 (en) | 2001-07-26 |
AU775591B2 (en) | 2004-08-05 |
US6150365A (en) | 2000-11-21 |
EP1248622B1 (en) | 2005-07-27 |
AU1213001A (en) | 2001-07-31 |
NO20023425L (no) | 2002-09-05 |
AR028201A1 (es) | 2003-04-30 |
KR20020073176A (ko) | 2002-09-19 |
EP1248622A1 (en) | 2002-10-16 |
DE60021609D1 (de) | 2005-09-01 |
EP1248622A4 (en) | 2004-02-04 |
RU2254132C2 (ru) | 2005-06-20 |
NZ520823A (en) | 2004-05-28 |
TWI226831B (en) | 2005-01-21 |
CN1424911A (zh) | 2003-06-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20051019 |