PE20141021A1 - DERIVADOS DE TIENO [2,3-d] PIRIMIDINA COMO INHIBIDORES DEL CANAL DE POTASIO - Google Patents
DERIVADOS DE TIENO [2,3-d] PIRIMIDINA COMO INHIBIDORES DEL CANAL DE POTASIOInfo
- Publication number
- PE20141021A1 PE20141021A1 PE2013002093A PE2013002093A PE20141021A1 PE 20141021 A1 PE20141021 A1 PE 20141021A1 PE 2013002093 A PE2013002093 A PE 2013002093A PE 2013002093 A PE2013002093 A PE 2013002093A PE 20141021 A1 PE20141021 A1 PE 20141021A1
- Authority
- PE
- Peru
- Prior art keywords
- potassium channel
- pyrimidine
- inhibitors
- derivatives
- compound
- Prior art date
Links
- 102000004257 Potassium Channel Human genes 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 108020001213 potassium channel Proteins 0.000 title abstract 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1105659.5A GB201105659D0 (en) | 2011-04-01 | 2011-04-01 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20141021A1 true PE20141021A1 (es) | 2014-08-30 |
Family
ID=44071904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013002093A PE20141021A1 (es) | 2011-04-01 | 2012-03-29 | DERIVADOS DE TIENO [2,3-d] PIRIMIDINA COMO INHIBIDORES DEL CANAL DE POTASIO |
Country Status (42)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014078957A1 (en) * | 2012-11-20 | 2014-05-30 | The Royal Institution For The Advancement Of Learning/Mcgill University | Thienopyrimidine inhibitors of farnesyl and/or geranylgeranyl pyrophosphate synthase |
| JP7114076B2 (ja) | 2015-12-22 | 2022-08-08 | シャイ・セラピューティクス・エルエルシー | がん及び炎症性疾患の処置のための化合物 |
| CN106727587A (zh) * | 2016-11-28 | 2017-05-31 | 李娜 | 一种治疗心律失常的药物组合物 |
| CA3066939A1 (en) | 2017-06-21 | 2018-12-27 | SHY Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| EP3898609A1 (en) | 2018-12-19 | 2021-10-27 | Shy Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
Family Cites Families (50)
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| CH317906A (de) | 1953-09-16 | 1956-12-15 | Sandoz Ag | Verfahren zur Herstellung von 1-Amino-4-oxyanthrachinonsulfonsäuren |
| ZA782648B (en) | 1977-05-23 | 1979-06-27 | Ici Australia Ltd | The prevention,control or eradication of infestations of ixodid ticks |
| AU521790B2 (en) | 1977-05-23 | 1982-04-29 | Ici Australia Limited | Process for eradication of ticks |
| DD226893A1 (de) | 1981-12-15 | 1985-09-04 | Ralf Boehm | Verfahren zur herstellung von arylaminosubstituierten thieno 2,3-d pyrimidinen |
| IL112569A (en) | 1994-02-10 | 1999-12-22 | Wyeth John & Brother Ltd | Pharmaceutical compositions comprising cyclohexylamine derivatives certain such novel compounds and their preparation |
| IL112567A (en) | 1994-02-10 | 2000-02-29 | Wyeth John & Brother Ltd | Substituted quinolines their preparation and pharmaceutical compositions containing them |
| IL112566A (en) | 1994-02-10 | 2000-10-31 | Wyeth John & Brother Ltd | Substituted quinolinones and pharmaceutical compositions containing them |
| IL112568A0 (en) | 1994-02-10 | 1995-05-26 | Wyeth John & Brother Ltd | Substituted quinolines, their preparation and pharmaceutical compositions containing them |
| ATE227726T1 (de) | 1995-08-17 | 2002-11-15 | Takeda Chemical Industries Ltd | Thienopyrimidinderivate als endothelin antagonisten |
| US6083986A (en) | 1996-07-26 | 2000-07-04 | Icagen, Inc. | Potassium channel inhibitors |
| SK7599A3 (en) | 1996-07-26 | 1999-07-12 | Nissan Chemical Ind Ltd | Chroman derivatives and pharmaceutical composition containing the same |
| US5935945A (en) | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| US5969017A (en) | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| RU2116309C1 (ru) | 1997-02-13 | 1998-07-27 | Институт медицинской паразитологии и тропической медицины им.Е.И.Марциновского | 4-[(бензо-2,1,3-тиадиазолил-4)амино]-5,6,7,8-тетрагидробензотиено [2,3-d]пиримидин, обладающий противогельминтной активностью при ларвальном альвеолярном эхинококкозе |
| US6333337B1 (en) | 1998-01-27 | 2001-12-25 | Icagen, Inc. | Potassium channel inhibitors |
| JP2002517385A (ja) | 1998-06-05 | 2002-06-18 | イカゲン インク． | カリウムチャネル阻害剤 |
| WO2000012492A1 (en) | 1998-09-01 | 2000-03-09 | Nissan Chemical Industries, Ltd. | Benzoxazine derivatives |
| US6194458B1 (en) | 1998-10-30 | 2001-02-27 | Merck & Co., Inc. | Benzamide potassium channel inhibitors |
| DE19929076A1 (de) | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| ATE311378T1 (de) | 1999-09-17 | 2005-12-15 | Nissan Chemical Ind Ltd | Benzopyran derivate |
| US6555574B1 (en) | 1999-09-24 | 2003-04-29 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| DE19947457A1 (de) | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
| US6531495B1 (en) | 1999-10-02 | 2003-03-11 | Aventis Pharma Deutschland Gmbh | 2′-Substituted 1,1′-biphenyl-2-carboxamides, processes for their preparation, their use as medicaments, and pharmaceutical preparations comprising them |
| AU7453900A (en) | 1999-10-05 | 2001-05-10 | Nissan Chemical Industries Ltd. | 4-oxybenzopyran derivative |
| US6887870B1 (en) | 1999-10-12 | 2005-05-03 | Bristol-Myers Squibb Company | Heterocyclic sodium/proton exchange inhibitors and method |
| MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
| WO2001046155A1 (en) | 1999-12-21 | 2001-06-28 | Icagen, Inc. | Potassium channel inhibitors |
| JP4854909B2 (ja) | 2000-09-20 | 2012-01-18 | メルク・シャープ・エンド・ドーム・コーポレイション | イソキノリノン系カリウムチャンネル阻害剤 |
| DE10054481A1 (de) | 2000-11-03 | 2002-05-08 | Aventis Pharma Gmbh | Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10059418A1 (de) | 2000-11-30 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10060807A1 (de) | 2000-12-07 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, ortho-substituierte stickstoffhaltige Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10061876A1 (de) | 2000-12-12 | 2002-06-20 | Aventis Pharma Gmbh | Arylierte Furan- und Thiophencarbonsäureamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10104802A1 (de) | 2001-02-02 | 2002-08-08 | Merck Patent Gmbh | Pharmazeutische Formulierungen enthaltend Thienopirimidine und Endothelin-Rezeptor-Antagonisten (1) |
| CA2437085A1 (en) | 2001-02-02 | 2002-08-15 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Pharmaceutical formulation comprising pyrazolo[4,3-d]pyrimidines and endothelin receptor antagonists or thienopyrimidines and endothelin receptor antagonists |
| TW589305B (en) | 2001-02-14 | 2004-06-01 | Nissan Chemical Ind Ltd | 4-aminobenzopyran derivatives |
| DE10121002A1 (de) | 2001-04-28 | 2002-11-14 | Aventis Pharma Gmbh | Verwendung von Anthranilsäureamiden als Medikament zur Behandlung von Arrhythmien sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10121003A1 (de) | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| DE10128331A1 (de) | 2001-06-12 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide mit Heteroarylsulfonyl-Seitenkette, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltende pharmazeutische Zubereitungen |
| US7041700B2 (en) | 2001-06-25 | 2006-05-09 | Nissan Chemical Industries, Ltd. | Substituted benzopyran derivatives against arrhythmia |
| TW200307539A (en) | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| GB0315950D0 (en) | 2003-06-11 | 2003-08-13 | Xention Discovery Ltd | Compounds |
| AU2004247470B2 (en) * | 2003-06-11 | 2009-04-23 | Xention Limited | Thienopyrimidine derivatives as potassium channel inhibitors |
| CN1845918A (zh) * | 2003-07-02 | 2006-10-11 | 沃泰克斯药物股份有限公司 | 可用作电压－门控离子通道调节剂的嘧啶 |
| EP1701961A1 (en) | 2004-01-06 | 2006-09-20 | Taisho Pharmaceutical Co., Ltd | Thienopyrimidine and thienopyridine derivatives substituted with cyclic amino group |
| JP2008505084A (ja) | 2004-06-29 | 2008-02-21 | アムゲン インコーポレイティッド | フラノピリミジン |
| EP1879899B1 (en) | 2004-12-09 | 2010-08-04 | Xention Limited | Thienopyridine derivatives as potassium channel inhibitors |
| US7576212B2 (en) | 2004-12-09 | 2009-08-18 | Xention Limited | Thieno[2,3-B] pyridines as potassium channel inhibitors |
| US20080108611A1 (en) | 2006-01-19 | 2008-05-08 | Battista Kathleen A | Substituted thienopyrimidine kinase inhibitors |
| KR20090021218A (ko) | 2006-06-12 | 2009-02-27 | 버텍스 파마슈티칼스 인코포레이티드 | 이온 채널의 조절제로서 유용한 티에노피리미딘 |
| DE102009039893B4 (de) | 2009-09-03 | 2012-03-29 | Bundesanstalt für Materialforschung und -Prüfung (BAM) | Verwendung eines Brennstoffs in einem selbstunterhaltenden pulsierenden Sauerstoff-Brennstoff-Verbrennungsprozess |
-
2011
- 2011-04-01 GB GBGB1105659.5A patent/GB201105659D0/en not_active Ceased
-
2012
- 2012-03-29 US US14/008,776 patent/US9249155B2/en not_active Expired - Fee Related
- 2012-03-29 MX MX2013011301A patent/MX335937B/es unknown
- 2012-03-29 BR BR112013025236A patent/BR112013025236A2/pt not_active IP Right Cessation
- 2012-03-29 PE PE2013002093A patent/PE20141021A1/es not_active Application Discontinuation
- 2012-03-29 WO PCT/GB2012/050710 patent/WO2012131379A1/en not_active Ceased
- 2012-03-29 SI SI201230406T patent/SI2694518T1/sl unknown
- 2012-03-29 CN CN201280016323.9A patent/CN103492392B/zh not_active Expired - Fee Related
- 2012-03-29 HU HUE12718725A patent/HUE028438T2/en unknown
- 2012-03-29 SG SG2013071147A patent/SG193578A1/en unknown
- 2012-03-29 PH PH1/2013/501952A patent/PH12013501952A1/en unknown
- 2012-03-29 JP JP2014501722A patent/JP5826374B2/ja not_active Expired - Fee Related
- 2012-03-29 CA CA2831493A patent/CA2831493A1/en not_active Abandoned
- 2012-03-29 EA EA201301111A patent/EA201301111A1/ru unknown
- 2012-03-29 AP AP2013007198A patent/AP2013007198A0/xx unknown
- 2012-03-29 EP EP12718725.0A patent/EP2694518B1/en active Active
- 2012-03-29 CU CUP2013000124A patent/CU24173B1/es unknown
- 2012-03-29 RS RS20150833A patent/RS54458B1/sr unknown
- 2012-03-29 UA UAA201312693A patent/UA110131C2/ru unknown
- 2012-03-29 AU AU2012235882A patent/AU2012235882B2/en not_active Ceased
- 2012-03-29 ME MEP-2015-219A patent/ME02314B/me unknown
- 2012-03-29 MA MA36364A patent/MA35064B1/fr unknown
- 2012-03-29 PL PL12718725T patent/PL2694518T3/pl unknown
- 2012-03-29 KR KR1020137028742A patent/KR20140023332A/ko not_active Ceased
- 2012-03-29 DK DK12718725.0T patent/DK2694518T3/en active
- 2012-03-29 PT PT127187250T patent/PT2694518E/pt unknown
- 2012-03-29 RU RU2013148627/04A patent/RU2013148627A/ru not_active Application Discontinuation
- 2012-03-29 ES ES12718725.0T patent/ES2558563T3/es active Active
- 2012-03-29 HR HRP20151340TT patent/HRP20151340T1/hr unknown
- 2012-03-30 AR ARP120101121A patent/AR088735A1/es unknown
- 2012-03-30 TW TW101111540A patent/TWI516265B/zh not_active IP Right Cessation
-
2013
- 2013-09-19 ZA ZA2013/07085A patent/ZA201307085B/en unknown
- 2013-09-24 TN TNP2013000377A patent/TN2013000377A1/fr unknown
- 2013-09-26 GT GT201300225A patent/GT201300225A/es unknown
- 2013-09-26 CR CR20130488A patent/CR20130488A/es not_active Application Discontinuation
- 2013-09-27 CL CL2013002789A patent/CL2013002789A1/es unknown
- 2013-09-29 IL IL228555A patent/IL228555A0/en unknown
- 2013-09-30 NI NI201300100A patent/NI201300100A/es unknown
- 2013-10-23 EC ECSP13012988 patent/ECSP13012988A/es unknown
- 2013-10-24 CO CO13252150A patent/CO6801756A2/es active IP Right Grant
-
2015
- 2015-12-07 CY CY20151101110T patent/CY1117025T1/el unknown
- 2015-12-22 SM SM201500322T patent/SMT201500322B/it unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |