CN103201267B - Ampk-激活性杂环化合物以及其使用方法 - Google Patents
Ampk-激活性杂环化合物以及其使用方法 Download PDFInfo
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- CN103201267B CN103201267B CN201180047484.XA CN201180047484A CN103201267B CN 103201267 B CN103201267 B CN 103201267B CN 201180047484 A CN201180047484 A CN 201180047484A CN 103201267 B CN103201267 B CN 103201267B
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- 0 *1C2C1CC*2 Chemical compound *1C2C1CC*2 0.000 description 13
- JITIIJJORCPWRP-UHFFFAOYSA-N CC(C)(C)OC(N(CCC1NC(c2ccc(C(N(CC3)CCC3C(c(cc3)ccc3OC)=O)=C)nc2)=O)CC1(F)F)=O Chemical compound CC(C)(C)OC(N(CCC1NC(c2ccc(C(N(CC3)CCC3C(c(cc3)ccc3OC)=O)=C)nc2)=O)CC1(F)F)=O JITIIJJORCPWRP-UHFFFAOYSA-N 0.000 description 1
- LKDJRGJABJQQDZ-UHFFFAOYSA-N CCCNC(c(nc1)ccc1C(O)=O)=O Chemical compound CCCNC(c(nc1)ccc1C(O)=O)=O LKDJRGJABJQQDZ-UHFFFAOYSA-N 0.000 description 1
- PGHQMRXTAMBTIN-VQCQRNETSA-N COc(cc1)ccc1C(C(CC1)CCN1C(c(cc1)ncc1C(NC(CCNC1)[C@@H]1F)=O)=O)=O Chemical compound COc(cc1)ccc1C(C(CC1)CCN1C(c(cc1)ncc1C(NC(CCNC1)[C@@H]1F)=O)=O)=O PGHQMRXTAMBTIN-VQCQRNETSA-N 0.000 description 1
- UOUKZGRYSNCZPJ-UHFFFAOYSA-O COc(cc1)ccc1[IH](C(CC1)CC[NH+]1C(c(nc1)ccc1C(NC(CCNC1)C1F)=O)=O)=O Chemical compound COc(cc1)ccc1[IH](C(CC1)CC[NH+]1C(c(nc1)ccc1C(NC(CCNC1)C1F)=O)=O)=O UOUKZGRYSNCZPJ-UHFFFAOYSA-O 0.000 description 1
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2016
- 2016-01-12 US US14/993,936 patent/US9663496B2/en not_active Expired - Fee Related
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2017
- 2017-05-23 US US15/603,023 patent/US10377742B2/en active Active
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2019
- 2019-06-25 US US16/451,613 patent/US10941134B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009065131A1 (en) * | 2007-11-16 | 2009-05-22 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| WO2009132136A1 (en) * | 2008-04-23 | 2009-10-29 | Rigel Pharmaceuticals, Inc. | Carboxamide compounds for the treatment of metabolic disorders |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10858359B2 (en) | 2016-06-07 | 2020-12-08 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic ring derivatives useful as SHP2 inhibitors |
| US10988466B2 (en) | 2017-03-23 | 2021-04-27 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic derivatives useful as SHP2 inhibitors |
| US12233062B2 (en) | 2018-09-26 | 2025-02-25 | Jacobio Pharmaceuticals Co., Ltd. | Heterocyclic derivatives useful as SHP2 inhibitors |
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