KR101764952B1 - Ampk-활성화 헤테로시클릭 화합물 및 그의 사용 방법 - Google Patents
Ampk-활성화 헤테로시클릭 화합물 및 그의 사용 방법 Download PDFInfo
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- KR101764952B1 KR101764952B1 KR1020137005054A KR20137005054A KR101764952B1 KR 101764952 B1 KR101764952 B1 KR 101764952B1 KR 1020137005054 A KR1020137005054 A KR 1020137005054A KR 20137005054 A KR20137005054 A KR 20137005054A KR 101764952 B1 KR101764952 B1 KR 101764952B1
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- 0 C[C@@](CCN(*)C1)[C@]1F Chemical compound C[C@@](CCN(*)C1)[C@]1F 0.000 description 12
- KUSONXFGHPWSTO-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1N(C)C(c1ccc(C(N(CC2)CCC2C(c(cc2)ccc2OC)=O)=O)nc1)=O)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1N(C)C(c1ccc(C(N(CC2)CCC2C(c(cc2)ccc2OC)=O)=O)nc1)=O)=O KUSONXFGHPWSTO-UHFFFAOYSA-N 0.000 description 1
- CZYUGTLMFHDODF-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1NC)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1NC)=O CZYUGTLMFHDODF-UHFFFAOYSA-N 0.000 description 1
- APZOOTJWPGQYSZ-UHFFFAOYSA-N CC(C)(C)OC(N(CCC1N)CC1(F)F)=O Chemical compound CC(C)(C)OC(N(CCC1N)CC1(F)F)=O APZOOTJWPGQYSZ-UHFFFAOYSA-N 0.000 description 1
- AWYFKEVKSPPNGV-UHFFFAOYSA-N CC(C)(C)OC(N(CCC1NC(c2ccc(C(N(CC3)CCC3C(c(cc3)ccc3OC)=O)=O)nc2)=O)CC1(F)F)=O Chemical compound CC(C)(C)OC(N(CCC1NC(c2ccc(C(N(CC3)CCC3C(c(cc3)ccc3OC)=O)=O)nc2)=O)CC1(F)F)=O AWYFKEVKSPPNGV-UHFFFAOYSA-N 0.000 description 1
- LPZQCQAJBPSMTD-JTAQYXEDSA-N CC(C)(CCNC(CCCC[C@@H]([C@H]1N2)SC[C@@H]1NC2=O)=O)OCCC(C)(C)OCC(NCC#CC)=O Chemical compound CC(C)(CCNC(CCCC[C@@H]([C@H]1N2)SC[C@@H]1NC2=O)=O)OCCC(C)(C)OCC(NCC#CC)=O LPZQCQAJBPSMTD-JTAQYXEDSA-N 0.000 description 1
- WAWGIARKAXSRCA-UHFFFAOYSA-N N#Cc1ccc(CN(CC2)CCC2NC(c(cc2)ncc2Br)=O)cc1 Chemical compound N#Cc1ccc(CN(CC2)CCC2NC(c(cc2)ncc2Br)=O)cc1 WAWGIARKAXSRCA-UHFFFAOYSA-N 0.000 description 1
- RMRAPVQTYURKPZ-UHFFFAOYSA-N N#Cc1ccc(CN(CC2)CCC2NC(c(cc2)ncc2N(CC2)CCC2Oc(cc2)ccc2C#N)=O)cc1 Chemical compound N#Cc1ccc(CN(CC2)CCC2NC(c(cc2)ncc2N(CC2)CCC2Oc(cc2)ccc2C#N)=O)cc1 RMRAPVQTYURKPZ-UHFFFAOYSA-N 0.000 description 1
- NPRFHMPSSNCLDY-UHFFFAOYSA-N NC1CCN(Cc(cc2)ccc2C#N)CC1 Chemical compound NC1CCN(Cc(cc2)ccc2C#N)CC1 NPRFHMPSSNCLDY-UHFFFAOYSA-N 0.000 description 1
- MNNQIBXLAHVDDL-UHFFFAOYSA-N OC(c(cc1)ncc1Br)=O Chemical compound OC(c(cc1)ncc1Br)=O MNNQIBXLAHVDDL-UHFFFAOYSA-N 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N c1ccncc1 Chemical compound c1ccncc1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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| WO2005061442A1 (en) | 2003-12-12 | 2005-07-07 | Eli Lilly And Company | Opioid receptor antagonists |
| WO2008083124A1 (en) | 2006-12-28 | 2008-07-10 | Rigel Pharmaceuticals, Inc. | N-substituted-heterocycloalkyloxybenzamide compounds and methods of use |
| WO2009065131A1 (en) | 2007-11-16 | 2009-05-22 | Rigel Pharmaceuticals, Inc. | Carboxamide, sulfonamide and amine compounds for metabolic disorders |
| WO2009132136A1 (en) | 2008-04-23 | 2009-10-29 | Rigel Pharmaceuticals, Inc. | Carboxamide compounds for the treatment of metabolic disorders |
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