UA106600C2 - Карбоксамідні сполуки і способи їхнього застосування - Google Patents

Карбоксамідні сполуки і способи їхнього застосування

Info

Publication number
UA106600C2
UA106600C2 UAA201110421A UAA201110421A UA106600C2 UA 106600 C2 UA106600 C2 UA 106600C2 UA A201110421 A UAA201110421 A UA A201110421A UA A201110421 A UAA201110421 A UA A201110421A UA 106600 C2 UA106600 C2 UA 106600C2
Authority
UA
Ukraine
Prior art keywords
methods
compounds
carboxamid
compound
ampc
Prior art date
Application number
UAA201110421A
Other languages
English (en)
Inventor
Іхаб С. Дарвіш
Хой Хун
Раджиндер Сінгх
Сян Сюй
Original Assignee
Райджел Фармасьютікалз, Інк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Райджел Фармасьютікалз, Інк. filed Critical Райджел Фармасьютікалз, Інк.
Publication of UA106600C2 publication Critical patent/UA106600C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Plant Pathology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Описані карбоксамідні сполуки, а також фармацевтичні композиції і способи їх використання.Один із варіантів здійснення являє собою сполуку структури (І), де R, R, R, R, Т, р, q, w і х є такими, як описано в цьому документі. У певних варіантах здійснення сполуку, що описується в цьому документі, активує каскад AМРК, і його можна використовувати для лікування пов'язаних з метаболізмом порушень і станів.(I)
UAA201110421A 2009-01-28 2010-01-28 Карбоксамідні сполуки і способи їхнього застосування UA106600C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14798209P 2009-01-28 2009-01-28
PCT/US2010/022411 WO2010088392A1 (en) 2009-01-28 2010-01-28 Carboxamide compounds and methods for using the same

Publications (1)

Publication Number Publication Date
UA106600C2 true UA106600C2 (uk) 2014-09-25

Family

ID=42061132

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201110421A UA106600C2 (uk) 2009-01-28 2010-01-28 Карбоксамідні сполуки і способи їхнього застосування

Country Status (18)

Country Link
US (2) US8362235B2 (uk)
EP (1) EP2391616B1 (uk)
JP (1) JP5658688B2 (uk)
KR (1) KR101693061B1 (uk)
CN (1) CN102365275B (uk)
AU (1) AU2010208247B2 (uk)
BR (1) BRPI1007287B8 (uk)
CA (1) CA2750835C (uk)
EA (1) EA022083B1 (uk)
ES (1) ES2581678T3 (uk)
HK (1) HK1164860A1 (uk)
IL (1) IL214203A (uk)
MX (1) MX2011007639A (uk)
NZ (1) NZ594556A (uk)
SG (1) SG172974A1 (uk)
UA (1) UA106600C2 (uk)
WO (1) WO2010088392A1 (uk)
ZA (1) ZA201105215B (uk)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010011288A (es) 2008-04-23 2010-11-09 Rigel Pharmaceuticals Inc Compuestos de carboxamida para el tratamiento de trastornos metabolicos.
US8796254B2 (en) 2010-03-31 2014-08-05 Rigel Pharmaceuticals, Inc. Methods for using carboxamide, sulfonamide and amine compounds
CN103201267B (zh) 2010-07-29 2016-08-17 里格尔药品股份有限公司 Ampk-激活性杂环化合物以及其使用方法
US9005909B2 (en) 2011-01-06 2015-04-14 Rigel Pharmaceuticals, Inc. Whole blood assay for measuring AMPK activation
US9409884B2 (en) 2012-02-01 2016-08-09 Rigel Pharmaceuticals, Inc. 5- or 6-substituted benzofuran-2-carboxamide compounds and methods for using them
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9394285B2 (en) 2013-03-15 2016-07-19 Pfizer Inc. Indole and indazole compounds that activate AMPK
US20150087673A1 (en) * 2013-09-26 2015-03-26 Rigel Pharmaceuticals, Inc. Methods for using and biomarkers for ampk-activating compounds
JP6664632B2 (ja) 2013-09-30 2020-03-13 国立大学法人 東京大学 アディポネクチン受容体活性化化合物
JP7346425B2 (ja) 2018-01-11 2023-09-19 セントラス セラピューティクス 疾患を治療するためのジヒドロセラミドデサチュラーゼ阻害剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
KR100579792B1 (ko) * 1998-05-13 2006-05-12 동화약품공업주식회사 신규 2,5-피리딘디카복실산 유도체
AU2001287898A1 (en) * 2000-09-22 2002-04-02 Stephen Garland Pyrazolopyridines and pyrazolopyridazines as antidiabetics
TW200503994A (en) * 2003-01-24 2005-02-01 Novartis Ag Organic compounds
PE20071162A1 (es) * 2005-12-21 2007-11-30 Schering Corp Combinacion de un antagonista/agonista inverso de h3 y un supresor del apetito
DE602006021591D1 (de) 2006-12-11 2011-06-09 Genetics Co Inc Aromatische 1,4-DI-Carboxylamide und deren Verwendung
ES2627221T3 (es) 2006-12-28 2017-07-27 Rigel Pharmaceuticals, Inc. Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso
GB0706793D0 (en) * 2007-04-05 2007-05-16 Evotec Ag Compounds
ES2552733T3 (es) 2007-11-16 2015-12-01 Rigel Pharmaceuticals, Inc. Compuestos de carboxamida, sulfonamida y amina para trastornos metabólicos
CA2707047C (en) * 2007-12-12 2017-11-28 Rigel Pharmaceuticals, Inc. Carboxamide, sulfonamide and amine compounds for metabolic disorders
MX2010011288A (es) * 2008-04-23 2010-11-09 Rigel Pharmaceuticals Inc Compuestos de carboxamida para el tratamiento de trastornos metabolicos.
US8796254B2 (en) 2010-03-31 2014-08-05 Rigel Pharmaceuticals, Inc. Methods for using carboxamide, sulfonamide and amine compounds

Also Published As

Publication number Publication date
CN102365275A (zh) 2012-02-29
ZA201105215B (en) 2012-09-26
IL214203A (en) 2015-01-29
JP2012516349A (ja) 2012-07-19
WO2010088392A1 (en) 2010-08-05
SG172974A1 (en) 2011-08-29
MX2011007639A (es) 2011-09-15
EP2391616B1 (en) 2016-03-30
NZ594556A (en) 2013-11-29
CA2750835C (en) 2018-09-04
EP2391616A1 (en) 2011-12-07
HK1164860A1 (zh) 2012-09-28
EA201170979A1 (ru) 2012-02-28
KR20110119755A (ko) 2011-11-02
AU2010208247A1 (en) 2011-08-11
AU2010208247B2 (en) 2015-06-18
BRPI1007287B1 (pt) 2021-03-09
BRPI1007287B8 (pt) 2021-05-25
IL214203A0 (en) 2011-08-31
JP5658688B2 (ja) 2015-01-28
ES2581678T3 (es) 2016-09-06
EA022083B1 (ru) 2015-10-30
US8362235B2 (en) 2013-01-29
US20130131078A1 (en) 2013-05-23
CA2750835A1 (en) 2010-08-05
US8846600B2 (en) 2014-09-30
US20100190802A1 (en) 2010-07-29
KR101693061B1 (ko) 2017-01-04
CN102365275B (zh) 2014-09-24

Similar Documents

Publication Publication Date Title
UA106600C2 (uk) Карбоксамідні сполуки і способи їхнього застосування
EA201390184A1 (ru) Активирующие амрк гетероциклические соединения и способы их использования
EA201300730A1 (ru) Производные индазолилтриазола
MX2010005298A (es) Compuestos de carboxamida, sulfonamida y amina para trastornos metabolicos.
EA201071231A1 (ru) Карбоксамидные соединения для лечения метаболических растройств
EA200800865A1 (ru) Биарилзамещенные гетероциклические ингибиторы lta4h для лечения воспаления
EA201171293A1 (ru) 3-азабицикло[4.1.0]гептаны, применяемые в качестве антагонистов орексина
EA201391822A1 (ru) Новые производные пиридина
EA201071045A1 (ru) Соединения оксадиазоантрацена для лечения диабета
EA201591532A1 (ru) Ингибиторы carm1 и их применение
EA201071040A1 (ru) Новые производные 1-бензил-3-гидроксиметилиндазола и их применение при лечении заболеваний, обусловленных экспрессией mcp-1, cx3cr1 и p40
EA201170051A1 (ru) Гетероциклическое соединение и его применение
MX2010003866A (es) Heteroaril amidas utiles como inhibidores de canales de sodio dependientes de voltaje.
GB0906579D0 (en) Pharmaceuticals, compositions and methods of making and using the same
UA107652C2 (uk) Сполуки карбазолу і терапевтичне застосування вказаних сполук
EA201100750A1 (ru) Замещенные диоксопиперидинилфталимидные производные
SMT201200017B (it) Nuovi antagonisti P2X7R e il loro uso.
TN2015000084A1 (fr) Pyridinones bicycliques nouvelles
EA201070327A1 (ru) Катехоламиновые производные и их пролекарства
MA32544B1 (fr) Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
EA201490152A1 (ru) Антагонисты trpm8 и их применение при лечении
EA201170722A1 (ru) Лактамы в качестве ингибиторов бета-секретазы
EP4327886A3 (en) Pyrimido- pyridazinone compounds and use thereof
ECSP11010849A (es) Polimorfo b de la n-(2-aminofenil)-4-[n-(piridin-3-il) metoxicarbonilamino-metil]benzamida (ms-275)
CY1111588T1 (el) Υποκατεστημενα καρβοξαμιδια ως ανταγωνιστες μεταβολοτροπου υποδοχεα ομαδας ι