SMT201200017B - Nuovi antagonisti P2X7R e il loro uso. - Google Patents
Nuovi antagonisti P2X7R e il loro uso.Info
- Publication number
- SMT201200017B SMT201200017B SM201200017T SM201200017T SMT201200017B SM T201200017 B SMT201200017 B SM T201200017B SM 201200017 T SM201200017 T SM 201200017T SM 201200017 T SM201200017 T SM 201200017T SM T201200017 B SMT201200017 B SM T201200017B
- Authority
- SM
- San Marino
- Prior art keywords
- new
- p2x7r
- p2x7r antagonists
- antagonists
- acetamide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09005324 | 2009-04-14 | ||
EP10156190A EP2243772B1 (en) | 2009-04-14 | 2010-03-11 | Novel P2X7R antagonists and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
SMT201200017B true SMT201200017B (it) | 2012-07-10 |
Family
ID=42167925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SM201200017T SMT201200017B (it) | 2009-04-14 | 2012-04-25 | Nuovi antagonisti P2X7R e il loro uso. |
Country Status (23)
Country | Link |
---|---|
US (2) | US7919503B2 (it) |
EP (1) | EP2243772B1 (it) |
JP (1) | JP2012523440A (it) |
KR (1) | KR20120006547A (it) |
CN (1) | CN102395562A (it) |
AT (1) | ATE541832T1 (it) |
AU (1) | AU2010237302A1 (it) |
BR (1) | BRPI1014902A2 (it) |
CA (1) | CA2758474A1 (it) |
CY (1) | CY1112758T1 (it) |
DK (1) | DK2243772T3 (it) |
EA (1) | EA201101479A1 (it) |
ES (1) | ES2380908T3 (it) |
HR (1) | HRP20120271T1 (it) |
IL (1) | IL215444A0 (it) |
MX (1) | MX2011010810A (it) |
PL (1) | PL2243772T3 (it) |
PT (1) | PT2243772E (it) |
SG (1) | SG175232A1 (it) |
SI (1) | SI2243772T1 (it) |
SM (1) | SMT201200017B (it) |
WO (1) | WO2010118921A1 (it) |
ZA (1) | ZA201108305B (it) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8828966B2 (en) | 2006-10-03 | 2014-09-09 | Claire Mitchell | Method for treatment of macular degeneration by modulating P2Y12 or P2X7 receptors |
BRPI0910034B1 (pt) | 2008-03-25 | 2022-02-08 | Affectis Pharmaceuticals Ag | Antagonistas do p2x7r e composições farmacêuticas que os compreendem |
US8815892B2 (en) | 2008-03-25 | 2014-08-26 | Affectis Pharmaceuticals Ag | P2X7R antagonists and their use |
AU2011252351A1 (en) * | 2010-05-14 | 2012-10-11 | Affectis Pharmaceuticals Ag | Novel methods for the preparation of P2X7R antagonists |
WO2012110190A1 (en) | 2011-02-17 | 2012-08-23 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163456A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
WO2012163792A1 (en) | 2011-05-27 | 2012-12-06 | Affectis Pharmaceuticals Ag | Novel p2x7r antagonists and their use |
AR087274A1 (es) * | 2011-07-22 | 2014-03-12 | Actelion Pharmaceuticals Ltd | Derivados de amidas heterociclicas como antagonistas de receptores p2x7 |
US20140322193A1 (en) * | 2011-12-02 | 2014-10-30 | Michael Kaleko | Therapies for Disorders of the Cornea and Conjunctiva |
SG11201403933UA (en) | 2012-01-20 | 2014-08-28 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
CA2890886C (en) | 2012-12-12 | 2020-10-27 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
WO2014097140A1 (en) | 2012-12-18 | 2014-06-26 | Actelion Pharmaceuticals Ltd | Indole carboxamide derivatives as p2x7 receptor antagonists |
EP2956457B1 (en) | 2013-01-22 | 2016-11-23 | Actelion Pharmaceuticals Ltd | Heterocyclic amide derivatives as p2x7 receptor antagonists |
JP6282016B2 (ja) | 2013-01-22 | 2018-02-21 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | P2x7受容体アンタゴニストとしての複素環アミド誘導体 |
WO2014182601A1 (en) | 2013-05-08 | 2014-11-13 | Children's Medical Center Corporation | A method of preventing and treating type 1 diabetes, allograft rejection and lung fibrosis (by targeting the atp/p2x7r axis) |
WO2020150417A2 (en) * | 2019-01-17 | 2020-07-23 | Ifm Due, Inc. | Compounds and compositions for treating conditions associated with sting activity |
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-
2010
- 2010-03-11 EP EP10156190A patent/EP2243772B1/en not_active Not-in-force
- 2010-03-11 BR BRPI1014902A patent/BRPI1014902A2/pt not_active IP Right Cessation
- 2010-03-11 EA EA201101479A patent/EA201101479A1/ru unknown
- 2010-03-11 DK DK10156190.0T patent/DK2243772T3/da active
- 2010-03-11 PL PL10156190T patent/PL2243772T3/pl unknown
- 2010-03-11 WO PCT/EP2010/053097 patent/WO2010118921A1/en active Application Filing
- 2010-03-11 MX MX2011010810A patent/MX2011010810A/es active IP Right Grant
- 2010-03-11 AU AU2010237302A patent/AU2010237302A1/en not_active Abandoned
- 2010-03-11 PT PT10156190T patent/PT2243772E/pt unknown
- 2010-03-11 SG SG2011075140A patent/SG175232A1/en unknown
- 2010-03-11 JP JP2012505103A patent/JP2012523440A/ja active Pending
- 2010-03-11 KR KR1020117026988A patent/KR20120006547A/ko not_active Application Discontinuation
- 2010-03-11 SI SI201030020T patent/SI2243772T1/sl unknown
- 2010-03-11 AT AT10156190T patent/ATE541832T1/de active
- 2010-03-11 CN CN2010800166929A patent/CN102395562A/zh active Pending
- 2010-03-11 ES ES10156190T patent/ES2380908T3/es active Active
- 2010-03-11 CA CA2758474A patent/CA2758474A1/en not_active Abandoned
- 2010-04-12 US US12/758,557 patent/US7919503B2/en not_active Expired - Fee Related
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2011
- 2011-02-25 US US13/035,614 patent/US8268861B2/en not_active Expired - Fee Related
- 2011-09-27 IL IL215444A patent/IL215444A0/en unknown
- 2011-11-11 ZA ZA2011/08305A patent/ZA201108305B/en unknown
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2012
- 2012-03-27 HR HR20120271T patent/HRP20120271T1/hr unknown
- 2012-04-04 CY CY20121100340T patent/CY1112758T1/el unknown
- 2012-04-25 SM SM201200017T patent/SMT201200017B/it unknown
Also Published As
Publication number | Publication date |
---|---|
ES2380908T3 (es) | 2012-05-21 |
PL2243772T3 (pl) | 2012-05-31 |
MX2011010810A (es) | 2012-01-12 |
JP2012523440A (ja) | 2012-10-04 |
KR20120006547A (ko) | 2012-01-18 |
ZA201108305B (en) | 2012-08-29 |
EA201101479A1 (ru) | 2012-05-30 |
ATE541832T1 (de) | 2012-02-15 |
US20110212992A1 (en) | 2011-09-01 |
HRP20120271T1 (hr) | 2012-04-30 |
DK2243772T3 (da) | 2012-02-13 |
EP2243772B1 (en) | 2012-01-18 |
EP2243772A1 (en) | 2010-10-27 |
US7919503B2 (en) | 2011-04-05 |
SI2243772T1 (sl) | 2012-05-31 |
CY1112758T1 (el) | 2016-02-10 |
BRPI1014902A2 (pt) | 2016-04-19 |
CN102395562A (zh) | 2012-03-28 |
SG175232A1 (en) | 2011-12-29 |
CA2758474A1 (en) | 2010-10-21 |
US20100267762A1 (en) | 2010-10-21 |
PT2243772E (pt) | 2012-03-28 |
US8268861B2 (en) | 2012-09-18 |
WO2010118921A1 (en) | 2010-10-21 |
IL215444A0 (en) | 2011-12-29 |
AU2010237302A1 (en) | 2011-12-01 |
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