CN103096893B - 甘氨酸转运体-1抑制剂、其制备方法及其用途 - Google Patents

甘氨酸转运体-1抑制剂、其制备方法及其用途 Download PDF

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CN103096893B
CN103096893B CN201180038081.9A CN201180038081A CN103096893B CN 103096893 B CN103096893 B CN 103096893B CN 201180038081 A CN201180038081 A CN 201180038081A CN 103096893 B CN103096893 B CN 103096893B
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methyl
piperazin
cyclohexyl
benzamide
difluoro
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CN103096893A (zh
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C·L·西奥菲
M·A·伍尔夫
P·R·古佐
S·刘
K·萨达拉普里
V·帕塔萨拉蒂
孟俊浩
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Curia Global Inc
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Albany Molecular Research Inc
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CN201180038081.9A 2010-06-04 2011-06-02 甘氨酸转运体-1抑制剂、其制备方法及其用途 Active CN103096893B (zh)

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US8841305B2 (en) * 2008-10-09 2014-09-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Activators of the human pyruvate kinase M2 receptor
CA2758071C (en) 2009-04-06 2018-01-09 Agios Pharmaceuticals, Inc. Pyruvate kinase m2 modulators, therapeutic compositions and related methods of use
ES2619557T3 (es) 2009-05-04 2017-06-26 Agios Pharmaceuticals, Inc. Activadores de PKM2 para uso en el tratamiento del cáncer
EP2448581B1 (en) 2009-06-29 2016-12-07 Agios Pharmaceuticals, Inc. Therapeutic compositions and related methods of use
SG10201403696UA (en) 2009-06-29 2014-10-30 Agios Pharmaceuticals Inc Therapeutic compounds and compositions
WO2011137089A1 (en) 2010-04-29 2011-11-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Activators of human pyruvate kinase
US9045445B2 (en) 2010-06-04 2015-06-02 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
CA2821975A1 (en) 2010-12-17 2012-06-21 Shunqi Yan N-(4-(azetidine-1-carbonyl)phenyl)-(hetero-) arylsulfonamide derivatives as pyruvate kinase m2 pkm2 modulators
WO2012088314A1 (en) 2010-12-21 2012-06-28 Agios Pharmaceuticals, Inc. Bicyclic pkm2 activators
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