CA2801074A1 - Glycine transporter-1 inhibitors, methods of making them, and uses thereof - Google Patents

Glycine transporter-1 inhibitors, methods of making them, and uses thereof Download PDF

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Publication number
CA2801074A1
CA2801074A1 CA2801074A CA2801074A CA2801074A1 CA 2801074 A1 CA2801074 A1 CA 2801074A1 CA 2801074 A CA2801074 A CA 2801074A CA 2801074 A CA2801074 A CA 2801074A CA 2801074 A1 CA2801074 A1 CA 2801074A1
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Prior art keywords
methyl
piperazin
benzamide
cyclohexyl
difluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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CA2801074A
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English (en)
French (fr)
Inventor
Christopher L. Cioffi
Mark A. Wolf
Peter R. Guzzo
Shuang Liu
Kashinath Sadalapure
Visweswaren Parthasarathy
Jun-Ho Maeng
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Curia Global Inc
Original Assignee
Albany Molecular Research Inc
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Filing date
Publication date
Application filed by Albany Molecular Research Inc filed Critical Albany Molecular Research Inc
Publication of CA2801074A1 publication Critical patent/CA2801074A1/en
Abandoned legal-status Critical Current

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    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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  • Diabetes (AREA)
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  • AIDS & HIV (AREA)
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CA2801074A 2010-06-04 2011-06-02 Glycine transporter-1 inhibitors, methods of making them, and uses thereof Abandoned CA2801074A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35166210P 2010-06-04 2010-06-04
US61/351,662 2010-06-04
PCT/US2011/038939 WO2011153359A1 (en) 2010-06-04 2011-06-02 Glycine transporter-1 inhibitors, methods of making them, and uses thereof

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CA2801074A1 true CA2801074A1 (en) 2011-12-08

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US (1) US9045445B2 (enExample)
EP (1) EP2575815A4 (enExample)
JP (1) JP5813101B2 (enExample)
KR (1) KR20130087002A (enExample)
CN (1) CN103096893B (enExample)
AU (1) AU2011261375B2 (enExample)
CA (1) CA2801074A1 (enExample)
NZ (1) NZ604035A (enExample)
SG (1) SG186885A1 (enExample)
WO (1) WO2011153359A1 (enExample)

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EP2344453B1 (en) * 2008-10-09 2016-12-28 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Activators of human pyruvate kinase
CN102448951B (zh) 2009-04-06 2017-05-10 安吉奥斯医药品有限公司 丙酮酸激酶m2调节剂、治疗组合物和相关使用方法
PL2427441T3 (pl) 2009-05-04 2017-06-30 Agios Pharmaceuticals, Inc. Aktywatory PKM2 do stosowania w leczeniu raka
EP2448581B1 (en) 2009-06-29 2016-12-07 Agios Pharmaceuticals, Inc. Therapeutic compositions and related methods of use
PT2448582T (pt) * 2009-06-29 2017-07-10 Agios Pharmaceuticals Inc Compostos e composições terapêuticas
US20130109672A1 (en) 2010-04-29 2013-05-02 The United States Of America,As Represented By The Secretary, Department Of Health And Human Service Activators of human pyruvate kinase
SG186885A1 (en) 2010-06-04 2013-02-28 Albany Molecular Res Inc Glycine transporter-1 inhibitors, methods of making them, and uses thereof
JP5837091B2 (ja) 2010-12-17 2015-12-24 アジオス ファーマシューティカルズ， インコーポレイテッド ピルビン酸キナーゼｍ２（ｐｋｍ２）調節剤としての新規ｎ−（４−（アゼチジン−１−カルボニル）フェニル）−（ヘテロ−）アリールスルホンアミド誘導体
US9328077B2 (en) 2010-12-21 2016-05-03 Agios Pharmaceuticals, Inc Bicyclic PKM2 activators
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JP5813101B2 (ja) 2015-11-17
JP2013530957A (ja) 2013-08-01
AU2011261375A1 (en) 2012-12-20
US20110312931A1 (en) 2011-12-22
CN103096893B (zh) 2016-05-04
AU2011261375B2 (en) 2016-09-22
US9045445B2 (en) 2015-06-02
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KR20130087002A (ko) 2013-08-05
CN103096893A (zh) 2013-05-08

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