CN102977213B - 抗nkg2a 的单克隆抗体 - Google Patents
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- CN102977213B CN102977213B CN201210214930.8A CN201210214930A CN102977213B CN 102977213 B CN102977213 B CN 102977213B CN 201210214930 A CN201210214930 A CN 201210214930A CN 102977213 B CN102977213 B CN 102977213B
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| CA2591059C (en) | 2004-12-28 | 2018-11-06 | Innate Pharma | Monoclonal antibodies against nkg2a |
| EP3050963B1 (en) | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
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| CN101484471B (zh) | 2006-06-30 | 2013-11-06 | 诺沃-诺迪斯克有限公司 | 抗-nkg2a抗体及其用途 |
| US8057795B2 (en) * | 2006-11-21 | 2011-11-15 | Children's Research Institute | Method of reducing the activation of Th2 lymphocytes |
| BRPI0806812B8 (pt) | 2007-01-23 | 2021-09-14 | Chugai Pharmaceutical Co Ltd | Agente para suprimir reação de rejeição crônica e uso de um inibidor de il-6 |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
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| ES2834741T3 (es) | 2007-12-05 | 2021-06-18 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-NR10 y uso del mismo |
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| LT2708559T (lt) | 2008-04-11 | 2018-06-11 | Chugai Seiyaku Kabushiki Kaisha | Antigeną surišanti molekulė, galinti pakartotinai prisijungti prie dviejų ar daugiau antigeno molekulių |
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| KR20160062207A (ko) * | 2008-12-05 | 2016-06-01 | 추가이 세이야쿠 가부시키가이샤 | 항ｎｒ１０ 항체 및 그의 이용 |
| JP2010210772A (ja) * | 2009-03-13 | 2010-09-24 | Dainippon Screen Mfg Co Ltd | 液晶表示装置の製造方法 |
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| JP5837821B2 (ja) * | 2009-09-24 | 2015-12-24 | 中外製薬株式会社 | 抗体定常領域改変体 |
| CN107693791B (zh) | 2010-02-26 | 2022-06-07 | 诺沃—诺迪斯克有限公司 | 包含稳定抗体的组合物 |
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| EP3443981B1 (en) | 2010-06-29 | 2021-03-10 | Centre National de la Recherche Scientifique (CNRS) | Llt-1 antibodies with new functional properties |
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| WO2012172102A1 (en) | 2011-06-17 | 2012-12-20 | Novo Nordisk A/S | Selective elimination of erosive cells |
| US10782290B2 (en) | 2013-06-11 | 2020-09-22 | National Center Of Neurology And Psychiatry | Method for predicting post-therapy prognosis of relapsing-remitting multiple sclerosis (RRMS) patient, and method for determining applicability of novel therapy |
| EP3050896B1 (en) | 2013-09-27 | 2021-07-07 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide heteromultimer |
| EP3186282A1 (en) * | 2014-08-28 | 2017-07-05 | Academisch Ziekenhuis Leiden h.o.d.n. LUMC | Cd94/nkg2a and/or cd94/nkg2b antibody, vaccine combinations |
| CN113929782B (zh) | 2014-09-16 | 2024-06-21 | 依奈特制药公司 | 对淋巴细胞中抑制途径的中和 |
| JP2017538660A (ja) | 2014-09-16 | 2017-12-28 | イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． | 抗ｎｋｇ２ａ抗体を使用した治療計画 |
| EP3659625A1 (en) | 2014-10-23 | 2020-06-03 | Innate Pharma | Treatment of cancers using anti-nkg2a agents |
| BR112017014067B1 (pt) | 2015-02-27 | 2021-01-12 | Chugai Seiyaku Kabushiki Kaisha | usos de um anticorpo receptor de il-6 para no tratamento de doenças relacionadas a il-6 |
| WO2016149103A1 (en) * | 2015-03-13 | 2016-09-22 | The Regents Of The University Of California | Monoclonal antibody for prevention and/or treatment of astrovirus disease |
| US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
| BR112017022101A2 (pt) | 2015-04-14 | 2018-07-31 | Chugai Seiyaku Kabushiki Kaisha | composição farmacêutica para prevenção e/ou tratamento de dermatite atópica contendo antagonista de il-31 como ingrediente ativo |
| PL3299810T3 (pl) | 2015-05-19 | 2021-12-13 | National Center Of Neurology And Psychiatry | Sposób określania zastosowania nowej terapii u pacjentów ze stwardnieniem rozsianym (sm) |
| CA2990520C (en) | 2015-07-24 | 2023-06-27 | Innate Pharma | Methods for detecting tissue infiltrating nk cells |
| WO2017115773A1 (ja) | 2015-12-28 | 2017-07-06 | 中外製薬株式会社 | Ｆｃ領域含有ポリペプチドの精製を効率化するための方法 |
| PT3405495T (pt) * | 2016-01-21 | 2021-05-14 | Innate Pharma | Neutralização de vias inibidoras em linfócitos |
| DE102017001875A1 (de) * | 2017-02-27 | 2018-08-30 | Wolfgang Würfel | Medikament zur Malignombehandlung |
| JP7185884B2 (ja) | 2017-05-02 | 2022-12-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| US11795222B2 (en) | 2018-03-13 | 2023-10-24 | Innate Pharma | Treatment of head and neck cancer |
| TW202003565A (zh) | 2018-03-23 | 2020-01-16 | 美商必治妥美雅史谷比公司 | 抗mica及/或micb抗體及其用途 |
| WO2020094071A1 (zh) * | 2018-11-07 | 2020-05-14 | 上海怀越生物科技有限公司 | Nkg2a抗体及其制备方法和应用 |
| WO2020102501A1 (en) | 2018-11-16 | 2020-05-22 | Bristol-Myers Squibb Company | Anti-nkg2a antibodies and uses thereof |
| CN109833480B (zh) * | 2019-03-22 | 2021-09-07 | 中国科学院上海巴斯德研究所 | 靶向nk细胞免疫检查点治疗感染性疾病的方法 |
| CN113874035A (zh) * | 2019-03-29 | 2021-12-31 | 德伦生物公司 | 降低大颗粒淋巴细胞和自然杀伤细胞水平的方法 |
| WO2020243570A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Cell localization signature and combination therapy |
| EP3976832A1 (en) | 2019-05-30 | 2022-04-06 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
| WO2020243563A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Multi-tumor gene signatures for suitability to immuno-oncology therapy |
| WO2020261219A1 (en) | 2019-06-27 | 2020-12-30 | Crispr Therapeutics Ag | Use of chimeric antigen receptor t cells and nk cell inhibitors for treating cancer |
| BR112022006590A2 (pt) | 2019-11-20 | 2022-06-28 | Chugai Pharmaceutical Co Ltd | Preparação contendo anticorpos |
| WO2021260657A1 (en) | 2020-06-26 | 2021-12-30 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| JP2023538955A (ja) | 2020-08-31 | 2023-09-12 | ブリストル－マイヤーズ スクイブ カンパニー | 細胞局在シグネチャーおよび免疫療法 |
| US11795228B2 (en) | 2020-09-30 | 2023-10-24 | Dren Bio, Inc. | Anti-CD94 antibodies and methods of use thereof |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| WO2022146947A1 (en) | 2020-12-28 | 2022-07-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| WO2022146948A1 (en) | 2020-12-28 | 2022-07-07 | Bristol-Myers Squibb Company | Subcutaneous administration of pd1/pd-l1 antibodies |
| WO2022212876A1 (en) | 2021-04-02 | 2022-10-06 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| WO2023178329A1 (en) | 2022-03-18 | 2023-09-21 | Bristol-Myers Squibb Company | Methods of isolating polypeptides |
| WO2023235847A1 (en) | 2022-06-02 | 2023-12-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| WO2024056010A1 (zh) * | 2022-09-16 | 2024-03-21 | 北京三诺佳邑生物技术有限责任公司 | 特异性识别nkg2a的抗体及其应用 |
| WO2024159059A1 (en) * | 2023-01-27 | 2024-08-02 | Exelixis, Inc. | Nkg2a binding agents and uses thereof |
| WO2024196952A1 (en) | 2023-03-20 | 2024-09-26 | Bristol-Myers Squibb Company | Tumor subtype assessment for cancer therapy |
| CN117143815B (zh) * | 2023-10-30 | 2024-01-26 | 再少年(北京)生物科技有限公司 | 工程化记忆样nk细胞的制备方法及应用 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| FR2604092B1 (fr) | 1986-09-19 | 1990-04-13 | Immunotech Sa | Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo |
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| JP3095168B2 (ja) | 1988-02-05 | 2000-10-03 | エル． モリソン，シェリー | ドメイン‐変性不変部を有する抗体 |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| JPH03112485A (ja) | 1989-09-22 | 1991-05-14 | Olympus Optical Co Ltd | Ｈｌａ―ｃ遺伝子およびｄｎａプローブ並びに形質転換細胞 |
| JPH03112486A (ja) | 1989-09-22 | 1991-05-14 | Olympus Optical Co Ltd | Ｈｌａ―ｂ３５遺伝子およびｄｎａプローブ並びに形質転換細胞 |
| JPH03112487A (ja) | 1989-09-22 | 1991-05-14 | Olympus Optical Co Ltd | ＨＬＡ―Ｂｗ５３遺伝子およびＤＮＡプローブ並びに形質転換細胞 |
| JPH03112484A (ja) | 1989-09-26 | 1991-05-14 | Nisshin Seito Kk | 新規制限酵素及びその製造方法 |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| JP3112484B2 (ja) | 1990-01-17 | 2000-11-27 | テルモ株式会社 | 医療容器 |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| JP3112487B2 (ja) | 1990-10-12 | 2000-11-27 | オリンパス光学工業株式会社 | 画像フリーズ用信号処理装置 |
| JP3112485B2 (ja) | 1991-01-22 | 2000-11-27 | オリンパス光学工業株式会社 | 立体電子スチルカメラ |
| JP3112486B2 (ja) | 1991-02-06 | 2000-11-27 | 大日本印刷株式会社 | 感圧複写紙 |
| WO1993006213A1 (en) * | 1991-09-23 | 1993-04-01 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5660827A (en) | 1992-03-05 | 1997-08-26 | Board Of Regents, The University Of Texas System | Antibodies that bind to endoglin |
| US5489525A (en) | 1992-10-08 | 1996-02-06 | The United States Of America As Represented By The Department Of Health And Human Services | Monoclonal antibodies to prostate cells |
| DE614989T1 (de) | 1993-02-17 | 1995-09-28 | Morphosys Proteinoptimierung | Verfahren für in vivo Selektion von Ligandenbindende Proteine. |
| CA2163345A1 (en) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Antibodies |
| US5539094A (en) | 1993-11-12 | 1996-07-23 | La Jolla Cancer Research Foundation | DNA encoding Bcl-2-associated proteins |
| US5583034A (en) | 1994-02-22 | 1996-12-10 | La Jolla Institute For Allergy And Immunology | Enhancement of adoptosis using antisense oligonucleotides |
| KR100261941B1 (ko) | 1994-07-13 | 2000-07-15 | 나가야마 오사무 | 사람의 인터루킨-8에 대한 재구성 사람항체 |
| US5876950A (en) | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
| DE69737867T2 (de) | 1996-05-03 | 2007-10-18 | Immunomedics, Inc. | Zielgerichtete kombinations-immuntherapie für krebs |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| US6750044B1 (en) | 1996-10-17 | 2004-06-15 | Genentech, Inc. | Variants of vascular endothelial cell growth factor having antagonistic properties, nucleic acids encoding the same and host cells comprising those nucleic acids |
| GB9725764D0 (en) | 1997-12-04 | 1998-02-04 | Isis Innovation | HLA-E binding |
| CA2372053C (en) | 1999-04-28 | 2008-09-02 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
| DK1240326T3 (da) | 1999-11-15 | 2009-06-02 | Innate Pharma | Udlösende receptor der er involveret i naturlig cytotoxicitet medieret af humane naturlige dræberceller og antistoffer som identificerer denne receptor |
| PL358215A1 (en) | 2000-03-24 | 2004-08-09 | Micromet Ag | Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex |
| US6999941B1 (en) | 2000-07-11 | 2006-02-14 | Amazon.Com, Inc. | Providing gift clustering functionality to assist a user in ordering multiple items for a recipient |
| AU1922902A (en) * | 2000-12-18 | 2002-07-01 | Inst Nat Sante Rech Med | Novel means for the diagnosis and therapy of CTCL |
| US20030095965A1 (en) | 2001-05-02 | 2003-05-22 | Katrien Van Beneden | Antibodies to Ly49E and CD94/NKG2 receptors |
| AU2002325333B2 (en) | 2001-07-19 | 2008-04-03 | Innate Pharma | NTB-A, a surface molecule involved in natural killer cells activity |
| CN1555272A (zh) | 2001-07-31 | 2004-12-15 | �ո��� | 调节免疫应答的组合物和方法 |
| WO2003095965A2 (en) | 2002-05-13 | 2003-11-20 | Envirotech Products Limited | Tank valve testing method |
| US7351803B2 (en) | 2002-05-30 | 2008-04-01 | Macrogenics, Inc. | CD16A binding proteins and use for the treatment of immune disorders |
| DK1517921T3 (da) | 2002-06-28 | 2006-10-09 | Domantis Ltd | Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf |
| PT1572744E (pt) | 2002-12-16 | 2010-09-07 | Genentech Inc | Variantes de imunoglobulina e utilizações destas |
| CN1748143A (zh) | 2002-12-16 | 2006-03-15 | 健泰科生物技术公司 | 表达人cd20和/或cd16的转基因小鼠 |
| CN104645327A (zh) | 2003-07-24 | 2015-05-27 | 依奈特制药公司 | 使用nk细胞增效化合物提高治疗性抗体功效的方法和组合物 |
| WO2005115517A2 (en) | 2004-04-28 | 2005-12-08 | Joslin Diabetes Center, Inc. | Methods of treating diabetes |
| WO2005105849A1 (en) | 2004-04-30 | 2005-11-10 | Innate Pharma | Compositions and methods for treating proliferative disorders such as nk-type ldgl |
| CN101107269B (zh) | 2004-12-28 | 2012-10-31 | 依奈特制药公司 | 抗nkg2a的单克隆抗体 |
| CA2591059C (en) | 2004-12-28 | 2018-11-06 | Innate Pharma | Monoclonal antibodies against nkg2a |
| JP3112487U (ja) | 2005-05-13 | 2005-08-18 | 株式会社國光社 | 手動式篩い器 |
| JP3112484U (ja) | 2005-05-13 | 2005-08-18 | 浩志 柯 | 熱交換器の構造 |
| JP3112486U (ja) | 2005-05-13 | 2005-08-18 | 高北 孝 | 履物整頓具 |
| WO2007042573A2 (en) | 2005-10-14 | 2007-04-19 | Innate Pharma | Compositions and methods for treating proliferative disorders |
| CN101484471B (zh) | 2006-06-30 | 2013-11-06 | 诺沃-诺迪斯克有限公司 | 抗-nkg2a抗体及其用途 |
| BRPI0908508A2 (pt) | 2008-01-24 | 2016-03-22 | Novo Nordisk As | anticorpo monoclonal nkg2a anti-humano humanizado |
| CN107693791B (zh) | 2010-02-26 | 2022-06-07 | 诺沃—诺迪斯克有限公司 | 包含稳定抗体的组合物 |
| WO2012172102A1 (en) | 2011-06-17 | 2012-12-20 | Novo Nordisk A/S | Selective elimination of erosive cells |
-
2005
- 2005-12-27 CA CA2591059A patent/CA2591059C/en active Active
- 2005-12-27 EP EP11185913.8A patent/EP2476705B1/en not_active Revoked
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- 2005-12-27 AU AU2005321017A patent/AU2005321017B2/en active Active
- 2005-12-27 DK DK05825249.5T patent/DK1831258T4/da active
-
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- 2007-06-21 IL IL184152A patent/IL184152A/en active IP Right Grant
- 2007-12-13 HK HK07113629.5A patent/HK1108458A1/zh unknown
-
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- 2011-02-28 US US13/036,240 patent/US20110229486A1/en not_active Abandoned
-
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- 2012-10-11 JP JP2012226151A patent/JP6054129B2/ja active Active
-
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- 2015-01-12 US US14/594,322 patent/US20150132316A1/en not_active Abandoned
- 2015-01-12 US US14/594,353 patent/US10160810B2/en active Active
-
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- 2018-12-20 US US16/226,742 patent/US20190135938A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| Human natural killer cells with polyclonal lectin and immunoglobulinlike receptors develop from single hematopoietic stem cells with preferential expression of NKG2Aand KIR2DL2/L3/S2;Jeffrey S. Miller and Valarie McCullar;《BLOOD》;20010801;第98卷(第3期);706 * |
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